WO2011139832A3 - Method for treating mycobacterial infections - Google Patents

Method for treating mycobacterial infections Download PDF

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Publication number
WO2011139832A3
WO2011139832A3 PCT/US2011/034319 US2011034319W WO2011139832A3 WO 2011139832 A3 WO2011139832 A3 WO 2011139832A3 US 2011034319 W US2011034319 W US 2011034319W WO 2011139832 A3 WO2011139832 A3 WO 2011139832A3
Authority
WO
WIPO (PCT)
Prior art keywords
mycobacterial infections
treating mycobacterial
mediated
mycobacteria
infections
Prior art date
Application number
PCT/US2011/034319
Other languages
French (fr)
Other versions
WO2011139832A2 (en
Inventor
Joseph A. Devito
Joyce A. Sutcliffe
Original Assignee
Rib-X Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rib-X Pharmaceuticals, Inc. filed Critical Rib-X Pharmaceuticals, Inc.
Publication of WO2011139832A2 publication Critical patent/WO2011139832A2/en
Publication of WO2011139832A3 publication Critical patent/WO2011139832A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/422Oxazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics

Abstract

The present invention relates to methods for treating mycobacterial infections, for example infections caused or mediated by Mycobacterium tuberculosis or nontuberculous mycobacteria and in particular those infections caused or mediated by resistant or highly virulent strains of mycobacteria, using a safe and effective amount of an antibiotic compound.
PCT/US2011/034319 2010-04-28 2011-04-28 Method for treating mycobacterial infections WO2011139832A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32877510P 2010-04-28 2010-04-28
US61/328,775 2010-04-28

Publications (2)

Publication Number Publication Date
WO2011139832A2 WO2011139832A2 (en) 2011-11-10
WO2011139832A3 true WO2011139832A3 (en) 2012-04-05

Family

ID=44904382

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/034319 WO2011139832A2 (en) 2010-04-28 2011-04-28 Method for treating mycobacterial infections

Country Status (1)

Country Link
WO (1) WO2011139832A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016061772A1 (en) 2014-10-22 2016-04-28 Merck Sharp & Dohme Corp. Nargenicin compounds and uses thereof as antibacterial agents
MX2017006319A (en) * 2014-11-14 2017-08-10 Melinta Therapeutics Inc Method for treating, preventing, or reducing the risk of skin infection.
EP4324824A2 (en) * 2015-10-14 2024-02-21 The Global Alliance for TB Drug Development, Inc. Combination antibacterial composition and short-course antibacterial regimen
US20170333400A1 (en) * 2016-05-17 2017-11-23 Melinta Therapeutics, Inc. Topical formulations of biaryl heterocyclic compounds and methods of use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007133803A2 (en) * 2006-05-15 2007-11-22 Rib-X Pharmaceuticals, Inc. Treatment of mycobacterial infections
WO2008085913A1 (en) * 2007-01-04 2008-07-17 Rib-X Pharmaceuticals, Inc. Methods for treating, preventing, or reducing the risk of opthalmic, otic, and nasal infections

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007133803A2 (en) * 2006-05-15 2007-11-22 Rib-X Pharmaceuticals, Inc. Treatment of mycobacterial infections
WO2008085913A1 (en) * 2007-01-04 2008-07-17 Rib-X Pharmaceuticals, Inc. Methods for treating, preventing, or reducing the risk of opthalmic, otic, and nasal infections

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FORTUN J. ET AL.: "Linezolid for the treatment of multidrug-resistant tuberculosis", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 56, 2005, pages 180 - 185 *
SKRIPKIN, E. ET AL.: "Rd-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 52, no. 10, 2008, pages 3550 - 3557 *
ZHOU, J. ET AL.: "Design at the atomic level: Design of biaryloxazolidinones as potent orally active antibiotics", BIOORGANIC& MEDICINAL CHEMISTRY LETTERS, vol. 18, 2008, pages 6175 - 6178, XP025646301, DOI: doi:10.1016/j.bmcl.2008.10.011 *

Also Published As

Publication number Publication date
WO2011139832A2 (en) 2011-11-10

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