WO2010042887A3 - Methods for preparing oxazolidinones and compositions containing them - Google Patents

Methods for preparing oxazolidinones and compositions containing them Download PDF

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Publication number
WO2010042887A3
WO2010042887A3 PCT/US2009/060267 US2009060267W WO2010042887A3 WO 2010042887 A3 WO2010042887 A3 WO 2010042887A3 US 2009060267 W US2009060267 W US 2009060267W WO 2010042887 A3 WO2010042887 A3 WO 2010042887A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compositions containing
preparing
oxazolidinones
preparing oxazolidinones
Prior art date
Application number
PCT/US2009/060267
Other languages
French (fr)
Other versions
WO2010042887A2 (en
Inventor
Carrie A. Costello
Jaqueline A. Simson
Robert J. Duguid
Douglas Phillipson
Original Assignee
Trius Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trius Therapeutics filed Critical Trius Therapeutics
Priority to KR1020117010217A priority Critical patent/KR101674146B1/en
Priority to JP2011531233A priority patent/JP5773875B2/en
Priority to CN200980140144.4A priority patent/CN102177156B/en
Priority to EP09749235.9A priority patent/EP2346858B1/en
Priority to CA2738671A priority patent/CA2738671C/en
Priority to ES09749235T priority patent/ES2748505T3/en
Priority to MX2011003820A priority patent/MX2011003820A/en
Priority to EP14159112.3A priority patent/EP2757104B1/en
Priority to AU2009303301A priority patent/AU2009303301B2/en
Priority to RU2011115109/04A priority patent/RU2556234C2/en
Priority to MX2014004600A priority patent/MX366793B/en
Publication of WO2010042887A2 publication Critical patent/WO2010042887A2/en
Publication of WO2010042887A3 publication Critical patent/WO2010042887A3/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/422Oxazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02Boron compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Abstract

Methods of preparing a class of oxazolidinones useful to impede bacterial growth are disclosed.
PCT/US2009/060267 2008-10-10 2009-10-09 Methods for preparing oxazolidinones and compositions containing them WO2010042887A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
KR1020117010217A KR101674146B1 (en) 2008-10-10 2009-10-09 Methods for preparing oxazolidinones and compositions containing them
JP2011531233A JP5773875B2 (en) 2008-10-10 2009-10-09 Methods of preparing oxazolidinones and compositions containing them
CN200980140144.4A CN102177156B (en) 2008-10-10 2009-10-09 Prepare the method for (oxazolidinon-5-yl-methyl)-2-thiophene-carboxamides and the composition containing (oxazolidinon-5-yl-methyl)-2-thiophene-carboxamides
EP09749235.9A EP2346858B1 (en) 2008-10-10 2009-10-09 Methods for preparing oxazolidinones and compositions containing them
CA2738671A CA2738671C (en) 2008-10-10 2009-10-09 Methods for preparing oxazolidinones and compositions containing them
ES09749235T ES2748505T3 (en) 2008-10-10 2009-10-09 Methods for the preparation of oxazolidinones and compositions containing them
MX2011003820A MX2011003820A (en) 2008-10-10 2009-10-09 Methods for preparing oxazolidinones and compositions containing them.
EP14159112.3A EP2757104B1 (en) 2008-10-10 2009-10-09 Compounds used in the synthesis of oxazolidinones
AU2009303301A AU2009303301B2 (en) 2008-10-10 2009-10-09 Methods for preparing oxazolidinones and compositions containing them
RU2011115109/04A RU2556234C2 (en) 2008-10-10 2009-10-09 Methods of producing oxazolidinones and compositions containing same
MX2014004600A MX366793B (en) 2008-10-10 2009-10-09 Methods for preparing oxazolidinones and compositions containing them.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10446908P 2008-10-10 2008-10-10
US61/104,469 2008-10-10

Publications (2)

Publication Number Publication Date
WO2010042887A2 WO2010042887A2 (en) 2010-04-15
WO2010042887A3 true WO2010042887A3 (en) 2010-06-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/060267 WO2010042887A2 (en) 2008-10-10 2009-10-09 Methods for preparing oxazolidinones and compositions containing them

Country Status (13)

Country Link
US (2) US8604209B2 (en)
EP (2) EP2346858B1 (en)
JP (1) JP5773875B2 (en)
KR (1) KR101674146B1 (en)
CN (2) CN106220621B (en)
AU (1) AU2009303301B2 (en)
CA (1) CA2738671C (en)
ES (2) ES2748505T3 (en)
HK (2) HK1200169A1 (en)
MX (2) MX366793B (en)
RU (2) RU2556234C2 (en)
SG (2) SG195544A1 (en)
WO (1) WO2010042887A2 (en)

Cited By (1)

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RU2659792C1 (en) * 2008-10-10 2018-07-04 Мерк Шарп Энд Домэ Корп. Oxazolidinones and the method of their cleaning

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KR101739923B1 (en) 2009-02-03 2017-05-25 머크 샤프 앤드 돔 코포레이션 Crystalline form of R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate
US8580767B2 (en) * 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
US20120065170A1 (en) 2010-09-10 2012-03-15 Micurx Pharmaceuticals, Inc. Antimicrobial Cyclocarbonyl Heterocyclic Compounds For Treatment Of Bacterial Infections
WO2016009401A2 (en) * 2014-07-18 2016-01-21 Dr. Reddy's Laboratories Limited Preparation of tedizolid phosphate
CN105367547B (en) * 2014-08-19 2019-04-23 北京桦冠生物技术有限公司 A kind of new synthesis process of oxazoline ketone antibiotic
WO2016041505A1 (en) * 2014-09-17 2016-03-24 正大天晴药业集团股份有限公司 Tedizolid phosphate, intermediate and preparation method thereof
CN104496979A (en) * 2014-09-17 2015-04-08 博瑞生物医药技术(苏州)有限公司 Method for preparing oxazolidinone compound and intermediate thereof
CN104327119A (en) * 2014-10-17 2015-02-04 苏州明锐医药科技有限公司 Preparation method of tedizolid phosphate
WO2016088101A1 (en) * 2014-12-05 2016-06-09 Sun Pharmaceutical Industries Limited Processes for the preparation of tedizolid phosphate and its intermediates
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CN104558034A (en) * 2015-01-21 2015-04-29 齐鲁制药有限公司 Novel crystal form of tedizolid phosphate disodium salt and preparation method of novel crystal form
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CN106146485B (en) * 2015-04-01 2021-04-30 上海迪赛诺化学制药有限公司 Method for preparing tedizolid and tedizolid crystal obtained by method
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CN106317114B (en) * 2015-07-02 2018-11-20 南京优科制药有限公司 A kind of preparation method of Tedizolid Phosphate
CN105131037B (en) * 2015-07-28 2017-05-03 济南爱思医药科技有限公司 Preparation method for high-purity tedizolid phosphate
CN106632298B (en) * 2015-11-03 2021-06-01 上海科胜药物研发有限公司 Preparation method and intermediate of tedizolid
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