WO2009063505A3 - Process for preparation of (s) (n-[[3-[3-fluoro-4-(4-morpholinyl) hen l -2-oxo-5-oxazolidin l methyl]acetamide - Google Patents
Process for preparation of (s) (n-[[3-[3-fluoro-4-(4-morpholinyl) hen l -2-oxo-5-oxazolidin l methyl]acetamide Download PDFInfo
- Publication number
- WO2009063505A3 WO2009063505A3 PCT/IN2008/000647 IN2008000647W WO2009063505A3 WO 2009063505 A3 WO2009063505 A3 WO 2009063505A3 IN 2008000647 W IN2008000647 W IN 2008000647W WO 2009063505 A3 WO2009063505 A3 WO 2009063505A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- oxo
- fluoro
- morpholinyl
- acetamide
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
Abstract
The present invention provides novel process for preparation of (S)-N-[[3-[3-Fluoro-4-(4- morpholinyl)phenyl]-2-oxo-5-oxazolidinyl] methyl] -acetamide which comprises combining (R)-N-[3-[3-fluoro-4-morpholinyl phenyl]-2-oxo-5-oxazolidinyl]methylazide in suitable solvent, acetylating agent and acid in presence of a catalyst.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2003/MUM/2007 | 2007-10-08 | ||
IN2003MU2007 | 2007-10-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009063505A2 WO2009063505A2 (en) | 2009-05-22 |
WO2009063505A3 true WO2009063505A3 (en) | 2009-11-12 |
Family
ID=40564952
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2008/000647 WO2009063505A2 (en) | 2007-10-08 | 2008-10-07 | Process for preparation of (s) (n-[[3-[3-fluoro-4-(4-morpholinyl) hen l -2-oxo-5-oxazolidin l methyl]acetamide |
Country Status (1)
Country | Link |
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WO (1) | WO2009063505A2 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011050826A1 (en) | 2009-10-28 | 2011-05-05 | Synthon B.V. | Process for making crystalline form a of linezolid |
EP2516408A1 (en) * | 2009-12-26 | 2012-10-31 | Alembic Pharmaceuticals Limited | Process for the preparation of linezolid |
CN103140487A (en) | 2010-08-11 | 2013-06-05 | 斯索恩有限公司 | Process for making linezolid |
EP2603506A1 (en) | 2010-08-11 | 2013-06-19 | Synthon BV | Process for making linezolid |
ES2555139T3 (en) | 2011-02-24 | 2015-12-29 | Lee Pharma Limited | New procedure for the preparation of Linezolid and its new intermediates |
EP2683696A1 (en) | 2011-03-09 | 2014-01-15 | Synthon BV | Process for making crystalline form a of linezolid |
CN102766106A (en) * | 2011-05-03 | 2012-11-07 | 江苏豪森医药集团有限公司 | Novel crystal form of linezolid and preparation method thereof |
CN102260222B (en) * | 2011-05-20 | 2015-05-13 | 上海医药工业研究院 | Linezolid crystal form V and preparation method thereof |
CN102321040B (en) * | 2011-07-14 | 2013-08-21 | 扬子江药业集团南京海陵药业有限公司 | Method for preparing linezolid intermediate and linezolid |
CN102321041B (en) * | 2011-07-20 | 2013-09-25 | 华润赛科药业有限责任公司 | Preparation method of linezolid |
CN102993192B (en) * | 2011-09-14 | 2016-06-08 | 南开大学 | A kind of oxazolidinone compounds and its preparation method and application |
WO2013072923A1 (en) | 2011-09-19 | 2013-05-23 | Cadila Healthcare Limited | Process for the preparation of crystalline linezolid |
WO2013111048A1 (en) * | 2012-01-24 | 2013-08-01 | Jubilant Life Sciences Limited | Improved process for the preparation of stable crystalline form-i of linezolid, substantially free of residual solvent |
ITMI20120655A1 (en) * | 2012-04-19 | 2013-10-20 | Bioindustria Lab Italiano M Edicinali Spa | PROCEDURE FOR THE PREPARATION OF LINEZOLID |
WO2014045292A1 (en) * | 2012-09-20 | 2014-03-27 | Symed Labs Limited | Improved process for the preparation of linezolid intermediate |
EP2917189B1 (en) | 2012-11-09 | 2016-08-17 | Synthon BV | Process for making linezolid |
CN105111160B (en) * | 2015-09-11 | 2017-04-12 | 浙江新东港药业股份有限公司 | Linezolid preparation method |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995007271A1 (en) * | 1993-09-09 | 1995-03-16 | The Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
WO2006110155A1 (en) * | 2004-06-29 | 2006-10-19 | Teva Pharmaceutical Industries Ltd | Solid forms of linezolid and processes for preparation thereof |
-
2008
- 2008-10-07 WO PCT/IN2008/000647 patent/WO2009063505A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995007271A1 (en) * | 1993-09-09 | 1995-03-16 | The Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
WO2006110155A1 (en) * | 2004-06-29 | 2006-10-19 | Teva Pharmaceutical Industries Ltd | Solid forms of linezolid and processes for preparation thereof |
Non-Patent Citations (2)
Title |
---|
ERIC F. V. SCRIVEN, KENNETH TURNBULL: "Azides: Their Preparation and Synthetic Uses", CHEMICAL REVIEWS, vol. 88, no. 2, 1988, pages 297 - 368, XP002525610 * |
LOHRAY B B ET AL: "A Short Synthesis of Oxazolidinone Derivatives Linezolid and Eperezolid: A New Class of Antibacterials", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, vol. 40, no. 26, 25 June 1999 (1999-06-25), pages 4855 - 4856, XP004168663, ISSN: 0040-4039 * |
Also Published As
Publication number | Publication date |
---|---|
WO2009063505A2 (en) | 2009-05-22 |
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