WO2007138381A3 - Phosphonated oxazolidinones and uses thereof for the prevention and treatment of bone and joint infections - Google Patents

Phosphonated oxazolidinones and uses thereof for the prevention and treatment of bone and joint infections Download PDF

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Publication number
WO2007138381A3
WO2007138381A3 PCT/IB2006/004233 IB2006004233W WO2007138381A3 WO 2007138381 A3 WO2007138381 A3 WO 2007138381A3 IB 2006004233 W IB2006004233 W IB 2006004233W WO 2007138381 A3 WO2007138381 A3 WO 2007138381A3
Authority
WO
WIPO (PCT)
Prior art keywords
bone
prevention
treatment
phosphonated
oxazolidinones
Prior art date
Application number
PCT/IB2006/004233
Other languages
French (fr)
Other versions
WO2007138381A2 (en
Inventor
Daniel Delorme
Tom Houghton
Yanick Lafontaine
Kelly Tanaka
Evelyne Dietrick
Ting Kang
Far Adel Rafai
Original Assignee
Targanta Therapeutics Inc
Daniel Delorme
Tom Houghton
Yanick Lafontaine
Kelly Tanaka
Evelyne Dietrick
Ting Kang
Far Adel Rafai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Targanta Therapeutics Inc, Daniel Delorme, Tom Houghton, Yanick Lafontaine, Kelly Tanaka, Evelyne Dietrick, Ting Kang, Far Adel Rafai filed Critical Targanta Therapeutics Inc
Publication of WO2007138381A2 publication Critical patent/WO2007138381A2/en
Publication of WO2007138381A3 publication Critical patent/WO2007138381A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Abstract

The invention relates to bisphosphonated derivatives of oxazolidmones represented by formula (I) where A is an oxazolidmone antimicrobial molecule, B is a phosphonated group and L is bond or a linker for covalently coupling B to A These derivatives are useful as antibiotics for the prevention and/or treatment of bone and joint infections, especially osteomyelitis [B- L-]n- A (I)
PCT/IB2006/004233 2005-10-14 2006-10-13 Phosphonated oxazolidinones and uses thereof for the prevention and treatment of bone and joint infections WO2007138381A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72620205P 2005-10-14 2005-10-14
US60/726,202 2005-10-14

Publications (2)

Publication Number Publication Date
WO2007138381A2 WO2007138381A2 (en) 2007-12-06
WO2007138381A3 true WO2007138381A3 (en) 2008-04-17

Family

ID=38779030

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/004233 WO2007138381A2 (en) 2005-10-14 2006-10-13 Phosphonated oxazolidinones and uses thereof for the prevention and treatment of bone and joint infections

Country Status (1)

Country Link
WO (1) WO2007138381A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100854211B1 (en) 2003-12-18 2008-08-26 동아제약주식회사 Novel oxazolidinone derivatives, a process for the preparation thereof and pharmaceutical composition comprising the same for antibiotics
CA2645031A1 (en) 2006-03-07 2007-09-13 Bristol-Myers Squibb Company Pyrrolotriazine aniline prodrug compounds useful as kinase inhibitors
WO2008077241A1 (en) * 2006-12-22 2008-07-03 Targanta Therapeutics, Inc. Phosphonated glycopeptide and lipoglycopeptide antibiotics and uses thereof for the prevention and treatment of bone and joint infections
WO2009116090A2 (en) * 2008-03-18 2009-09-24 Panacea Biotec Limited Novel antimicrobials
EP2757104B1 (en) 2008-10-10 2019-08-14 Merck Sharp & Dohme Corp. Compounds used in the synthesis of oxazolidinones
CU24089B1 (en) 2009-02-03 2015-04-29 Trius Therapeutics CRYSTALLINE FORM OF DIHYDROGEN PHOSPHATE R) -3- (4- (2- (2-METHYLTRETAZOL-5-IL) -3-FLUOROPHENYL) -5-HYDROXIMETHYL OXAZOLIDIN-2-ONA
US8580767B2 (en) 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
WO2020005964A1 (en) * 2018-06-26 2020-01-02 Frank Hallock Ebetino Bone targeted antimicrobial oxazolidinone related compounds, formulations thereof, and uses thereof
CN110483431A (en) * 2019-09-04 2019-11-22 桂林南药股份有限公司 Linezolid impurity compound, preparation method and its application
CN112142795A (en) * 2020-10-19 2020-12-29 成都纽瑞特医疗科技股份有限公司 Selenazole diphosphonic acid compound and preparation method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040156A1 (en) * 1995-06-07 1996-12-19 Elizanor Biopharmaceuticals, Inc. Diphosphonate derivatives of therapeutic agents
WO1998015560A1 (en) * 1996-10-09 1998-04-16 Elizanor Biopharmaceuticals, Inc. Diphosphonate therapeutic compounds
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
WO1999037630A1 (en) * 1998-01-23 1999-07-29 Versicor, Inc. Oxazolidinone combinatorial libraries, compositions and methods of preparation
US20010041689A1 (en) * 1998-04-02 2001-11-15 Nelly Padioukova Bisphosphonate conjugates and methods of making and using the same
US20050026864A1 (en) * 1998-04-02 2005-02-03 H.B.F. Dixon Bisphosphonate conjugates and methods of making and using the same

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040156A1 (en) * 1995-06-07 1996-12-19 Elizanor Biopharmaceuticals, Inc. Diphosphonate derivatives of therapeutic agents
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
WO1998015560A1 (en) * 1996-10-09 1998-04-16 Elizanor Biopharmaceuticals, Inc. Diphosphonate therapeutic compounds
WO1999037630A1 (en) * 1998-01-23 1999-07-29 Versicor, Inc. Oxazolidinone combinatorial libraries, compositions and methods of preparation
US20010041689A1 (en) * 1998-04-02 2001-11-15 Nelly Padioukova Bisphosphonate conjugates and methods of making and using the same
US20050026864A1 (en) * 1998-04-02 2005-02-03 H.B.F. Dixon Bisphosphonate conjugates and methods of making and using the same

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BUXTON T.B. ET AL.: "Bisphosphonate-ciprofloxacin bound to Skelite is a prototype for enhancing experimental local antibiotic delivery to injured bone", BRITISH JOURNAL OF SURGERY, vol. 91, no. 9, 2004, pages 1192 - 1196 *
HERCZEGH P. ET AL.: "Osteoadsorptive Bisphosphonate Derivatives of Fluoroquinolone Antibacterials", J. MED. CHEM., vol. 45, no. 11, 2002, pages 2338 - 2341 *
HWANG J.-M. ET AL.: "Synthesis of Oxazolidinone Phosphonate Derivatives, Part I", BULL. KOREAN CHEM. SOC., vol. 25, no. 9, 2004, pages 1326 - 1330 *
HWANG J.-M. ET AL.: "Synthesis of Oxazolidinone Phosphonate Derivatives, Part II", BULL. KOREAN CHEM. SOC., vol. 28, no. 5, 2007, pages 821 - 826 *
HWANG J.-M. ET AL.: "Synthesis of Oxazolidinone Phosphonates as Antibacterial Agents", J. IND. ENG. CHEM., vol. 13, no. 3, 2007, pages 474 - 479 *
JUNG K.-Y. ET AL.: "Synthesis of biologically active phosphonate oxazolidinone derivatives", 229TH ACS NATIONAL MEETING, SAN DIEGO, CA, 13 March 2005 (2005-03-13) - 17 March 2005 (2005-03-17) *
PIEPER T. ET AL.: "Bisphosphonate-linked quinolones and sulphonamides with affinity to hydroxylapatite", JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 59, no. 2-3, 1995, pages 213 *

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Publication number Publication date
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