WO2005116023A8 - 3- {4- (pyridin-3-yl) phenyl} -5- (1h-1, 2, 3-triazol-1-ylmethyl) -1, 3-oxazolidin-2-ones as antibacterial agents - Google Patents

3- {4- (pyridin-3-yl) phenyl} -5- (1h-1, 2, 3-triazol-1-ylmethyl) -1, 3-oxazolidin-2-ones as antibacterial agents

Info

Publication number
WO2005116023A8
WO2005116023A8 PCT/GB2005/002055 GB2005002055W WO2005116023A8 WO 2005116023 A8 WO2005116023 A8 WO 2005116023A8 GB 2005002055 W GB2005002055 W GB 2005002055W WO 2005116023 A8 WO2005116023 A8 WO 2005116023A8
Authority
WO
WIPO (PCT)
Prior art keywords
oxazolidin
triazol
ylmethyl
pyridin
ones
Prior art date
Application number
PCT/GB2005/002055
Other languages
French (fr)
Other versions
WO2005116023A1 (en
Inventor
Michael Barry Gravestock
Folkert Reck
Fei Zhou
Original Assignee
Astrazeneca Ab
Astrazeneca Uk Ltd
Michael Barry Gravestock
Folkert Reck
Fei Zhou
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0411592A external-priority patent/GB0411592D0/en
Priority claimed from GB0500053A external-priority patent/GB0500053D0/en
Priority to BRPI0511524-8A priority Critical patent/BRPI0511524A/en
Priority to JP2007514088A priority patent/JP2008500318A/en
Priority to CA002567929A priority patent/CA2567929A1/en
Priority to AU2005247670A priority patent/AU2005247670A1/en
Application filed by Astrazeneca Ab, Astrazeneca Uk Ltd, Michael Barry Gravestock, Folkert Reck, Fei Zhou filed Critical Astrazeneca Ab
Priority to US11/569,208 priority patent/US20080021071A1/en
Priority to EP05746538A priority patent/EP1753755A1/en
Publication of WO2005116023A1 publication Critical patent/WO2005116023A1/en
Priority to IL179347A priority patent/IL179347A0/en
Priority to NO20065902A priority patent/NO20065902L/en
Publication of WO2005116023A8 publication Critical patent/WO2005116023A8/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Abstract

Compounds of formula (I), as well as pharmaceutically-acceptable salts and pro-drugs thereof, are disclosed wherein R1, R2, R3, and R4 are defined herein. Also disclosed are processes for making compounds of formula (I) as well as methods of using compounds of formula (I) for treating bacterial infections.
PCT/GB2005/002055 2004-05-25 2005-05-24 3- {4- (pyridin-3-yl) phenyl} -5- (1h-1, 2, 3-triazol-1-ylmethyl) -1, 3-oxazolidin-2-ones as antibacterial agents WO2005116023A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP05746538A EP1753755A1 (en) 2004-05-25 2005-05-24 3- {4- (pyridin-3-yl) phenyl} -5- (1h-1, 2, 3-triazol-1-ylmethyl) -1, 3-oxazolidin-2-ones as antibacterial agents
US11/569,208 US20080021071A1 (en) 2004-05-25 2005-05-24 3-{4-(Pyridin-3-Yl) Phenyl}-5-(1H-1,2,3-Triazol-1-Ylmethyl)-1,3-Oxazolidin-2-Ones as Antibacterial Agents
JP2007514088A JP2008500318A (en) 2004-05-25 2005-05-24 3- {4- (Pyridin-3-yl) phenyl} -5- (1H-1,2,3-triazol-1-ylmethyl) -1,3-oxazolidine-2-one as an antibacterial agent
CA002567929A CA2567929A1 (en) 2004-05-25 2005-05-24 3- {4- (pyridin-3-yl) phenyl} -5- (1h-1, 2, 3-triazol-1-ylmethyl) -1, 3-oxazolidin-2-ones as antibacterial agents
AU2005247670A AU2005247670A1 (en) 2004-05-25 2005-05-24 3- {4- (pyridin-3-yl) phenyl} -5- (1H-1, 2, 3-triazol-1-ylmethyl) -1, 3-oxazolidin-2-ones as antibacterial agents
BRPI0511524-8A BRPI0511524A (en) 2004-05-25 2005-05-24 compound or a pharmaceutically acceptable salt thereof, prodrug, method for producing an antibacterial effect on a warm-blooded animal, compound or a pharmaceutically acceptable salt thereof, or an in vivo hydrolysable ester thereof, use of a compound or a pharmaceutically acceptable salt thereof, or an in vivo hydrolysable ester thereof, a pharmaceutical composition, and process for the preparation of a compound or a pharmaceutically acceptable salt thereof, or an in vivo hydrolysable ester thereof
IL179347A IL179347A0 (en) 2004-05-25 2006-11-16 3-{4-(pyridin-3-yl)phenyl}-5-(1h-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-ones as antibacterial agents
NO20065902A NO20065902L (en) 2004-05-25 2006-12-19 3- {4- (Pyridin-3-yl) phenyl} -5- (1H-, 1,2,3-triazol-1-ylmethyl) -1,3-oxazolidin-2-one as antibacterial agents

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0411592A GB0411592D0 (en) 2004-05-25 2004-05-25 Chemical compounds
GB0411592.9 2004-05-25
GB0500053.4 2005-01-05
GB0500053A GB0500053D0 (en) 2005-01-05 2005-01-05 Chemical compounds

Publications (2)

Publication Number Publication Date
WO2005116023A1 WO2005116023A1 (en) 2005-12-08
WO2005116023A8 true WO2005116023A8 (en) 2007-01-11

Family

ID=34968777

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2005/002055 WO2005116023A1 (en) 2004-05-25 2005-05-24 3- {4- (pyridin-3-yl) phenyl} -5- (1h-1, 2, 3-triazol-1-ylmethyl) -1, 3-oxazolidin-2-ones as antibacterial agents

Country Status (9)

Country Link
US (1) US20080021071A1 (en)
EP (1) EP1753755A1 (en)
JP (1) JP2008500318A (en)
AU (1) AU2005247670A1 (en)
BR (1) BRPI0511524A (en)
CA (1) CA2567929A1 (en)
IL (1) IL179347A0 (en)
NO (1) NO20065902L (en)
WO (1) WO2005116023A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100854211B1 (en) * 2003-12-18 2008-08-26 동아제약주식회사 Novel oxazolidinone derivatives, a process for the preparation thereof and pharmaceutical composition comprising the same for antibiotics
CN106220621B (en) 2008-10-10 2019-06-11 默沙东公司 Prepare the method for oxazolidinones and the composition containing oxazolidinones
KR101739923B1 (en) 2009-02-03 2017-05-25 머크 샤프 앤드 돔 코포레이션 Crystalline form of R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate
US8580767B2 (en) * 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
CN102260277B (en) * 2010-05-24 2013-07-24 中国科学院上海药物研究所 Novel benzoxazine oxazolidinone compound as well as preparation method thereof and purpose thereof
WO2013169651A1 (en) * 2012-05-07 2013-11-14 The University Of North Carolina At Chapel Hill Direct anti-markovnikov addition of acids to alkenes
US10017441B2 (en) 2013-05-02 2018-07-10 The University Of North Carolina At Chapel Hill Direct anti-markovnikov addition of acids to alkenes
WO2016061772A1 (en) 2014-10-22 2016-04-28 Merck Sharp & Dohme Corp. Nargenicin compounds and uses thereof as antibacterial agents
CN109219594B (en) 2016-03-31 2022-10-11 英克特诺治疗公司 Indoline analogue and application thereof
BR112022025918A2 (en) * 2020-06-18 2023-03-14 Akagera Medicines Inc OXAZOLIDINONE COMPOUNDS, LIPOSOMAL COMPOSITIONS COMPRISING OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254577A (en) * 1988-07-29 1993-10-19 The Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
MXPA02012045A (en) * 2000-06-05 2003-10-15 Dong A Pharm Co Ltd Novel oxazolidinone derivatives and a process for the preparation thereof.
CN1649866A (en) * 2002-02-28 2005-08-03 阿斯特拉曾尼卡有限公司 3-cyclyl-5-(nitrogen-containing 5-membered ring) methyl-oxazolidinone derivatives and their use as antibacterial agents
US7498350B2 (en) * 2002-11-28 2009-03-03 Astrazeneca Ab Oxazolidinones as antibacterial agents
US6969726B2 (en) * 2003-06-03 2005-11-29 Rib X Pharmaceuticals Inc Biaryl heterocyclic compounds and methods of making and using the same
US20070185132A1 (en) * 2003-07-02 2007-08-09 Yasumichi Fukuda Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereo
US7129259B2 (en) * 2003-12-17 2006-10-31 Rib-X Pharmaceuticals, Inc. Halogenated biaryl heterocyclic compounds and methods of making and using the same

Also Published As

Publication number Publication date
JP2008500318A (en) 2008-01-10
CA2567929A1 (en) 2005-12-08
EP1753755A1 (en) 2007-02-21
IL179347A0 (en) 2007-03-08
NO20065902L (en) 2007-02-20
WO2005116023A1 (en) 2005-12-08
AU2005247670A1 (en) 2005-12-08
US20080021071A1 (en) 2008-01-24
BRPI0511524A (en) 2007-12-26

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