WO2005061468A8 - Halogenated biaryl heterocyclic compounds and methods of making and using the same - Google Patents

Halogenated biaryl heterocyclic compounds and methods of making and using the same

Info

Publication number
WO2005061468A8
WO2005061468A8 PCT/US2004/039988 US2004039988W WO2005061468A8 WO 2005061468 A8 WO2005061468 A8 WO 2005061468A8 US 2004039988 W US2004039988 W US 2004039988W WO 2005061468 A8 WO2005061468 A8 WO 2005061468A8
Authority
WO
WIPO (PCT)
Prior art keywords
making
methods
same
heterocyclic compounds
halogenated
Prior art date
Application number
PCT/US2004/039988
Other languages
French (fr)
Other versions
WO2005061468A1 (en
Inventor
Shili Chen
Jiacheng Zhou
Yunsheng Wu
Deping Wang
Joseph M Salvino
Adegboyega K Oyelere
Rongliang Lou
Ashoke Bhattacharjee
Yi Chen
Original Assignee
Rib X Pharmaceuticals Inc
Shili Chen
Jiacheng Zhou
Yunsheng Wu
Deping Wang
Joseph M Salvino
Adegboyega K Oyelere
Rongliang Lou
Ashoke Bhattacharjee
Yi Chen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rib X Pharmaceuticals Inc, Shili Chen, Jiacheng Zhou, Yunsheng Wu, Deping Wang, Joseph M Salvino, Adegboyega K Oyelere, Rongliang Lou, Ashoke Bhattacharjee, Yi Chen filed Critical Rib X Pharmaceuticals Inc
Priority to JP2006545691A priority Critical patent/JP2007514782A/en
Priority to EP04812498A priority patent/EP1713785A1/en
Publication of WO2005061468A1 publication Critical patent/WO2005061468A1/en
Publication of WO2005061468A8 publication Critical patent/WO2005061468A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having at least one halogenated hydrocarbon moiety, a biaryl moiety, and at least one heterocyclic moiety, that are useful as such agents. Formula (I), wherein Het-CH2-R3 is selected form the group consisting of: Formula (II); A and B independently are selected from the group consisting of phenyl, pyridyl, pyrazinyl, pirimidinyl, and pyridazinyl; M is a halogenated C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl group.
PCT/US2004/039988 2003-12-17 2004-12-01 Halogenated biaryl heterocyclic compounds and methods of making and using the same WO2005061468A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2006545691A JP2007514782A (en) 2003-12-17 2004-12-01 Halogenated biaryl heterocyclic compounds and methods for making and using the same
EP04812498A EP1713785A1 (en) 2003-12-17 2004-12-01 Halogenated biaryl heterocyclic compounds and methods of making and using the same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US53037103P 2003-12-17 2003-12-17
US60/530,371 2003-12-17
US57626704P 2004-06-02 2004-06-02
US60/576,267 2004-06-02

Publications (2)

Publication Number Publication Date
WO2005061468A1 WO2005061468A1 (en) 2005-07-07
WO2005061468A8 true WO2005061468A8 (en) 2005-09-09

Family

ID=34713773

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/039988 WO2005061468A1 (en) 2003-12-17 2004-12-01 Halogenated biaryl heterocyclic compounds and methods of making and using the same

Country Status (6)

Country Link
US (2) US7129259B2 (en)
EP (1) EP1713785A1 (en)
JP (1) JP2007514782A (en)
AR (1) AR046782A1 (en)
TW (1) TW200526649A (en)
WO (1) WO2005061468A1 (en)

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Also Published As

Publication number Publication date
TW200526649A (en) 2005-08-16
EP1713785A1 (en) 2006-10-25
US20060148869A1 (en) 2006-07-06
AR046782A1 (en) 2005-12-21
WO2005061468A1 (en) 2005-07-07
JP2007514782A (en) 2007-06-07
US7129259B2 (en) 2006-10-31
US20050153971A1 (en) 2005-07-14

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