WO2004007489A3 - Antibacterial substituted cyanomethyl (ene) piperidinophenyl oxazolidinones, process or their preparation, and pharmaceutical compositions containing them - Google Patents

Antibacterial substituted cyanomethyl (ene) piperidinophenyl oxazolidinones, process or their preparation, and pharmaceutical compositions containing them Download PDF

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Publication number
WO2004007489A3
WO2004007489A3 PCT/IN2003/000238 IN0300238W WO2004007489A3 WO 2004007489 A3 WO2004007489 A3 WO 2004007489A3 IN 0300238 W IN0300238 W IN 0300238W WO 2004007489 A3 WO2004007489 A3 WO 2004007489A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions containing
ene
preparation
pharmaceutical compositions
derivatives
Prior art date
Application number
PCT/IN2003/000238
Other languages
French (fr)
Other versions
WO2004007489A2 (en
Inventor
Mahesh V Patel
Prasad K Deshpande
Milind D Sindkhedkar
Shrikant V Gupte
Yati Chugh
Nitin Shetty
Milind C Shukla
Ravindra D Yeole
Souza Noel J De
Original Assignee
Mahesh V Patel
Prasad K Deshpande
Milind D Sindkhedkar
Shrikant V Gupte
Yati Chugh
Nitin Shetty
Milind C Shukla
Ravindra D Yeole
Souza Noel J De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mahesh V Patel, Prasad K Deshpande, Milind D Sindkhedkar, Shrikant V Gupte, Yati Chugh, Nitin Shetty, Milind C Shukla, Ravindra D Yeole, Souza Noel J De filed Critical Mahesh V Patel
Priority to AU2003272071A priority Critical patent/AU2003272071A1/en
Priority to EP03753912A priority patent/EP1565461A2/en
Priority to CA002492194A priority patent/CA2492194A1/en
Publication of WO2004007489A2 publication Critical patent/WO2004007489A2/en
Publication of WO2004007489A3 publication Critical patent/WO2004007489A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

The present invention provides agents having high antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel cyano-(substituted)-methylenepiperidinophenyl oxazolidinone derivatives, processes for making the compounds, as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.
PCT/IN2003/000238 2002-07-11 2003-07-10 Antibacterial substituted cyanomethyl (ene) piperidinophenyl oxazolidinones, process or their preparation, and pharmaceutical compositions containing them WO2004007489A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2003272071A AU2003272071A1 (en) 2002-07-11 2003-07-10 Antibacterial substituted cyanomethyl (ene) piperidinophenyl oxazolidinones, process or their preparation, and pharmaceutical compositions containing them
EP03753912A EP1565461A2 (en) 2002-07-11 2003-07-10 Antibacterial substituted cyanomethyl(ene)piperidinophenyl oxazolidinones, process for their preparation, and pharmaceutical compositions containing them
CA002492194A CA2492194A1 (en) 2002-07-11 2003-07-10 Antibacterial cyano-(substituted)-methylenepiperidinophenyl oxazolidinones targeting multiple ribonucleoproteins sites

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39516402P 2002-07-11 2002-07-11
US60/395,164 2002-07-11

Publications (2)

Publication Number Publication Date
WO2004007489A2 WO2004007489A2 (en) 2004-01-22
WO2004007489A3 true WO2004007489A3 (en) 2004-03-18

Family

ID=30115825

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2003/000238 WO2004007489A2 (en) 2002-07-11 2003-07-10 Antibacterial substituted cyanomethyl (ene) piperidinophenyl oxazolidinones, process or their preparation, and pharmaceutical compositions containing them

Country Status (4)

Country Link
EP (1) EP1565461A2 (en)
AU (1) AU2003272071A1 (en)
CA (1) CA2492194A1 (en)
WO (1) WO2004007489A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0413838A (en) * 2003-08-25 2006-10-24 Warner Lambert Co antimicrobial aryloxazolidinone compounds
US7687627B2 (en) * 2003-09-08 2010-03-30 Wockhardt Limited Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy
EP1745784A1 (en) * 2005-06-27 2007-01-24 Ferrer Internacional, S.A. Oxazolidinone derivatives and use thereof as antibiotics
WO2007132314A2 (en) * 2006-05-09 2007-11-22 Wockhardt Ltd Substituted piperidino phenyloxazolidinones
EP2069339B1 (en) * 2006-09-25 2011-05-18 Wockhardt Research Centre Substituted piperidinophenyl oxazolidinones
CA2816515A1 (en) 2010-11-03 2012-05-10 Wockhardt Limited Process for the preparation of phosphoric acid mono-(1-{4-[(s)-5-(acetylaminomethyl)-2-oxo-oxazolidin-3-yl]-2,6-difluorophenyl}-4-methoxymethylpiperidin-4-yl) ester
JP2012153674A (en) * 2011-01-28 2012-08-16 Astellas Pharma Inc Method for producing di(arylamino)aryl compound and synthetic intermediate for the method
WO2015173664A1 (en) 2014-05-14 2015-11-19 Wockhardt Limited Process for the preparation of (5s)-n-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
CN115010754B (en) * 2022-07-25 2024-02-02 苏州昊帆生物股份有限公司 Preparation method of diethyl (1-cyanoethyl) phosphate

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995025106A1 (en) * 1994-03-15 1995-09-21 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions containing them
WO1996013502A1 (en) * 1994-10-26 1996-05-09 Pharmacia & Upjohn Company Phenyloxazolidinone antimicrobials
US5668286A (en) * 1994-03-15 1997-09-16 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions containing them
WO2001058885A1 (en) * 2000-02-10 2001-08-16 Pharmacia & Upjohn Company Oxazolidinone thioamides with piperazine amide substituents
EP1130016A1 (en) * 1998-11-11 2001-09-05 Hokuriku Seiyaku Co., Ltd. Thiocarbamic acid derivatives

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995025106A1 (en) * 1994-03-15 1995-09-21 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions containing them
US5668286A (en) * 1994-03-15 1997-09-16 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions containing them
EP0750618B1 (en) * 1994-03-15 2003-02-19 PHARMACIA & UPJOHN COMPANY Oxazolidinone derivatives and pharmaceutical compositions containing them
WO1996013502A1 (en) * 1994-10-26 1996-05-09 Pharmacia & Upjohn Company Phenyloxazolidinone antimicrobials
EP1130016A1 (en) * 1998-11-11 2001-09-05 Hokuriku Seiyaku Co., Ltd. Thiocarbamic acid derivatives
WO2001058885A1 (en) * 2000-02-10 2001-08-16 Pharmacia & Upjohn Company Oxazolidinone thioamides with piperazine amide substituents

Also Published As

Publication number Publication date
AU2003272071A1 (en) 2004-02-02
AU2003272071A8 (en) 2004-02-02
WO2004007489A2 (en) 2004-01-22
EP1565461A2 (en) 2005-08-24
CA2492194A1 (en) 2004-01-22

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