WO2003093247A3 - Antibacterial agents - Google Patents

Antibacterial agents Download PDF

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Publication number
WO2003093247A3
WO2003093247A3 PCT/IB2003/001571 IB0301571W WO03093247A3 WO 2003093247 A3 WO2003093247 A3 WO 2003093247A3 IB 0301571 W IB0301571 W IB 0301571W WO 03093247 A3 WO03093247 A3 WO 03093247A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibacterial agents
derivatives
pharmaceutically acceptable
present
provides novel
Prior art date
Application number
PCT/IB2003/001571
Other languages
French (fr)
Other versions
WO2003093247A2 (en
Inventor
Shiv Kumar Agarwal
Surendrakumar Satyanara Pandey
Original Assignee
Orchid Chemicals & Pharm Ltd
Shiv Kumar Agarwal
Surendrakumar Satyanara Pandey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Chemicals & Pharm Ltd, Shiv Kumar Agarwal, Surendrakumar Satyanara Pandey filed Critical Orchid Chemicals & Pharm Ltd
Priority to AU2003224345A priority Critical patent/AU2003224345A1/en
Publication of WO2003093247A2 publication Critical patent/WO2003093247A2/en
Publication of WO2003093247A3 publication Critical patent/WO2003093247A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

The present invention provides novel oxazolidinone derivatives of the formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention more particularly provides novel oxazolidinone derivatives of the general formula (I).
PCT/IB2003/001571 2002-04-30 2003-04-25 Antibacterial agents WO2003093247A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003224345A AU2003224345A1 (en) 2002-04-30 2003-04-25 Antibacterial agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN329CH2002 2002-04-30
IN329/MAS/2002 2002-04-30

Publications (2)

Publication Number Publication Date
WO2003093247A2 WO2003093247A2 (en) 2003-11-13
WO2003093247A3 true WO2003093247A3 (en) 2003-12-24

Family

ID=29287797

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2003/001571 WO2003093247A2 (en) 2002-04-30 2003-04-25 Antibacterial agents

Country Status (2)

Country Link
AU (1) AU2003224345A1 (en)
WO (1) WO2003093247A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7232212B2 (en) 2015-07-17 2023-03-02 ザ グローバル アライアンス フォー ティービー ドラッグ デベロップメント， インコーポレイテッド Substituted phenyloxazolidinones for antimicrobial therapy

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7217726B2 (en) * 2002-08-22 2007-05-15 Orchid Chemicals & Pharmaceuticals Limited Antibacterial agents
EP1866295A2 (en) * 2005-02-24 2007-12-19 Teva Pharmaceutical Industries Ltd Processes for the preparation of linezolid intermediate
DE602006010702D1 (en) 2005-06-29 2010-01-07 Pharmacia & Upjohn Co Llc HOMOMORPHOLINOXAZOLIDINONE AS ANTIBACTERIAL AGENT
WO2008090570A1 (en) * 2007-01-25 2008-07-31 Panacea Biotec Ltd Novel antimicrobials
CL2008001003A1 (en) * 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd COMPOUNDS DERIVED FROM OXAZOLIDINONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO PREPARE A MEDICINAL PRODUCT TO TREAT A BACTERIAL INFECTION.
WO2017156519A1 (en) * 2016-03-11 2017-09-14 The Board Of Trustees Of The University Of Illinois Small-molecules active against gram-negative bacteria
US11274106B2 (en) 2017-06-23 2022-03-15 The Board Of Trustees Of The University Of Illinois Topoisomerase inhibitors with antibacterial and anticancer activity
CN107382893B (en) * 2017-07-18 2020-04-28 郑州大学 Linezolid base cation amphiphilic compound with antibacterial activity and preparation method thereof

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007271A1 (en) * 1993-09-09 1995-03-16 The Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
WO1998001446A1 (en) * 1996-07-06 1998-01-15 Zeneca Limited Substituted piperazinyl-phenyl-oxazolidinone derivatives and their use as anti-bacterial agents
WO2001042242A1 (en) * 1999-08-12 2001-06-14 Ortho-Mcneil Pharmaceutical, Inc. Antibacterial heterobicyclic substituted phenyl oxazolidinones
WO2001098297A2 (en) * 2000-06-16 2001-12-27 Pharmacia & Up John Company A thiazine oxazolidinone
WO2002002095A2 (en) * 2000-06-30 2002-01-10 Pharmacia & Upjohn Company Compositions for treating bacterial infections containing oxazolidinone compound, sulbactam and an ampicillin
WO2002006278A1 (en) * 2000-07-17 2002-01-24 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
WO2002064574A2 (en) * 2001-02-07 2002-08-22 Ortho-Mcneil Pharmaceutical, Inc. Pyridoarylphenyl oxazolidinone antibacterials, and related compositions and methods

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007271A1 (en) * 1993-09-09 1995-03-16 The Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
WO1998001446A1 (en) * 1996-07-06 1998-01-15 Zeneca Limited Substituted piperazinyl-phenyl-oxazolidinone derivatives and their use as anti-bacterial agents
WO2001042242A1 (en) * 1999-08-12 2001-06-14 Ortho-Mcneil Pharmaceutical, Inc. Antibacterial heterobicyclic substituted phenyl oxazolidinones
WO2001098297A2 (en) * 2000-06-16 2001-12-27 Pharmacia & Up John Company A thiazine oxazolidinone
WO2002002095A2 (en) * 2000-06-30 2002-01-10 Pharmacia & Upjohn Company Compositions for treating bacterial infections containing oxazolidinone compound, sulbactam and an ampicillin
WO2002006278A1 (en) * 2000-07-17 2002-01-24 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
WO2002064574A2 (en) * 2001-02-07 2002-08-22 Ortho-Mcneil Pharmaceutical, Inc. Pyridoarylphenyl oxazolidinone antibacterials, and related compositions and methods

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PAE A N ET AL: "Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 9, no. 18, 20 September 1999 (1999-09-20), pages 2679 - 2684, XP004179951, ISSN: 0960-894X *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7232212B2 (en) 2015-07-17 2023-03-02 ザ グローバル アライアンス フォー ティービー ドラッグ デベロップメント， インコーポレイテッド Substituted phenyloxazolidinones for antimicrobial therapy

Also Published As

Publication number Publication date
AU2003224345A1 (en) 2003-11-17
AU2003224345A8 (en) 2003-11-17
WO2003093247A2 (en) 2003-11-13

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