WO2002080841A3 - Antibacterial oxazolidinones with a cyclic sulphilimine or sulphoximine - Google Patents

Antibacterial oxazolidinones with a cyclic sulphilimine or sulphoximine Download PDF

Info

Publication number
WO2002080841A3
WO2002080841A3 PCT/GB2002/001615 GB0201615W WO02080841A3 WO 2002080841 A3 WO2002080841 A3 WO 2002080841A3 GB 0201615 W GB0201615 W GB 0201615W WO 02080841 A3 WO02080841 A3 WO 02080841A3
Authority
WO
WIPO (PCT)
Prior art keywords
sulphilimine
sulphoximine
cyclic
alkyl
hydrogen
Prior art date
Application number
PCT/GB2002/001615
Other languages
French (fr)
Other versions
WO2002080841A2 (en
Inventor
Michael John Betts
Michael Lingard Swain
Neil James Hales
Hoan Khai Huynh
Original Assignee
Astrazeneca Ab
Astrazeneca Uk Ltd
Michael John Betts
Michael Lingard Swain
Neil James Hales
Hoan Khai Huynh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Astrazeneca Uk Ltd, Michael John Betts, Michael Lingard Swain, Neil James Hales, Hoan Khai Huynh filed Critical Astrazeneca Ab
Priority to AU2002308000A priority Critical patent/AU2002308000A1/en
Publication of WO2002080841A2 publication Critical patent/WO2002080841A2/en
Publication of WO2002080841A3 publication Critical patent/WO2002080841A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Compounds of formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example; T is selected, for example, from a group of formula (TA1) or (TA2), wherein, for example, X1m is O= and X2m is R2s-(E)ms-N-; wherein E is an electron withdrawing group, for example, -SO2- or -CO-; and, for example, R2s is hydrogen or (1-6C)alkyl; and, for example, HET(AR) is a 5 or 6 membered aromatic or heteroaromatic ring; and Y is NH and , for example, Z is hydrogen or -COR5 or CSR5, wherein R5 is, for example (1-6C)alkyl; are useful as pharmaceutical agents; and processes for their manufacture and pharmaceutical compositions containing them are described.
PCT/GB2002/001615 2001-04-07 2002-04-03 Antibacterial oxazolidinones with a cyclic sulphilimine or sulphoximine WO2002080841A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002308000A AU2002308000A1 (en) 2001-04-07 2002-04-03 Antibacterial oxazolidinones with a cyclic sulphilimine or sulphoximine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0108764.2A GB0108764D0 (en) 2001-04-07 2001-04-07 Chemical compounds
GB0108764.2 2001-04-07

Publications (2)

Publication Number Publication Date
WO2002080841A2 WO2002080841A2 (en) 2002-10-17
WO2002080841A3 true WO2002080841A3 (en) 2003-02-27

Family

ID=9912442

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/001615 WO2002080841A2 (en) 2001-04-07 2002-04-03 Antibacterial oxazolidinones with a cyclic sulphilimine or sulphoximine

Country Status (3)

Country Link
AU (1) AU2002308000A1 (en)
GB (1) GB0108764D0 (en)
WO (1) WO2002080841A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1427711T1 (en) 2001-09-11 2005-12-31 Astrazeneca Ab Oxazolidinone and/or isoxazoline derivatives as antibacterial agents
EP1443930A1 (en) 2001-10-25 2004-08-11 AstraZeneca AB Isoxazoline derivatives useful as antimicrobials
PL372191A1 (en) 2002-02-28 2005-07-11 Astrazeneca Ab 3-cyclyl-5-(nitrogen-containing 5-membered ring) methyl-oxazolidinone derivatives and their use as antibacterial agents
BR0308018A (en) 2002-02-28 2005-01-04 Astrazeneca Ab A compound or a pharmaceutically acceptable salt thereof or an in vivo hydrolysable ester thereof, prodrug, method for producing an antibacterial effect on a warm-blooded animal, use of a compound or a pharmaceutically acceptable salt thereof or an in vivo hydrolyzable ester thereof, pharmaceutical composition, and process for the preparation of a compound or a pharmaceutically acceptable salt thereof or an in vivo hydrolysable ester thereof
AR043050A1 (en) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc BIFunctional HETEROCICLICAL COMPOUNDS AND METHODS TO PREPARE AND USE THE SAME
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
CA2528089C (en) 2003-06-03 2015-11-24 Rib-X Pharmaceuticals, Inc. Biaryl heterocyclic compounds and methods of making and using the same
US7265140B2 (en) * 2003-09-23 2007-09-04 Pfizer Inc Acyloxymethylcarbamate prodrugs of oxazolidinones
TW200526649A (en) 2003-12-17 2005-08-16 Rib X Pharmaceuticals Inc Halogenated biaryl heterocyclic compounds and methods of making and using the same
US8202843B2 (en) 2004-02-27 2012-06-19 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
US8399660B2 (en) 2005-06-08 2013-03-19 Rib-X Pharmaceuticals, Inc. Process for the synthesis of triazoles
KR20210038632A (en) 2018-07-25 2021-04-07 카딜라 핼쓰캐어 리미티드 Novel compounds for the treatment of mammalian infections
WO2020234636A1 (en) 2019-05-17 2020-11-26 Cadila Healthcare Limited Novel compounds for the treatment of mammalian infections
WO2021184339A1 (en) * 2020-03-20 2021-09-23 Merck Sharp & Dohme Corp. Oxazolidinone compound and methods of use thereof as an antibacterial agent

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007271A1 (en) * 1993-09-09 1995-03-16 The Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
WO1997009328A1 (en) * 1995-09-01 1997-03-13 Pharmacia & Upjohn Company Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings
WO1997030995A1 (en) * 1996-02-24 1997-08-28 Zeneca Limited Antibiotic oxazolidinone derivatives
WO2001046185A1 (en) * 1999-12-21 2001-06-28 Pharmacia & Upjohn Company Oxazolidinones having a sulfoximine functionality and their use as antimicrobial agents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007271A1 (en) * 1993-09-09 1995-03-16 The Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
WO1997009328A1 (en) * 1995-09-01 1997-03-13 Pharmacia & Upjohn Company Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings
WO1997030995A1 (en) * 1996-02-24 1997-08-28 Zeneca Limited Antibiotic oxazolidinone derivatives
WO2001046185A1 (en) * 1999-12-21 2001-06-28 Pharmacia & Upjohn Company Oxazolidinones having a sulfoximine functionality and their use as antimicrobial agents

Also Published As

Publication number Publication date
WO2002080841A2 (en) 2002-10-17
AU2002308000A1 (en) 2002-10-21
GB0108764D0 (en) 2001-05-30

Similar Documents

Publication Publication Date Title
WO2002080841A3 (en) Antibacterial oxazolidinones with a cyclic sulphilimine or sulphoximine
AU1714801A (en) Substituted isoxazolines and their use as antibacterial agents
DE60212959D1 (en) A SULFONIMIDE GROUP CONTAINING OXAZOLIDINONE AS ANTIBIOTICS
EP0480044A4 (en) Novel 4h-3,1-benzoxazin-4-one derivative
BG105001A (en) Oxazolidinone derivatives, process for their preparartion and pharmaceutical compositions containing them
GB0009803D0 (en) Chemical compounds
WO2002051819A3 (en) Heterocyclic compounds having antibacterial activity, process for their preparation and pharmaceutical compositions containing them
HK1083097A1 (en) Hydroxymethyl substituted dihydroisoxazole derivatives useful as antibiotic agents
EP1134214A4 (en) Picolinamide derivatives and pest controllers containing the same as the active ingredient
NO970512L (en) Novel heteroaryl-oxazolidinones
WO2003082205A3 (en) Compounds and methods
EP1386915A4 (en) Azole compounds, process for preparation of the same and use thereof
WO2003064429A1 (en) Thienopyrimidines, process for preparing the same and use thereof
DE69332259T2 (en) Condensed thiadiazole derivatives, process for their preparation and their use
EP1375484A4 (en) Carboxylic acids
NO965459L (en) 2-ureido-benzamide
CA2327775A1 (en) 15-membered lactams ketolides with antibacterial activity
WO2003053971A8 (en) Pyridoquinoxaline antivirals
EP1474426B8 (en) Process for making carbapenem compounds
DE69814800T2 (en) EPOXYSUCCINAMIDE DERIVATIVES OR THEIR SALTS
WO2003031414A1 (en) Novel heterocyclic compound and anti-inflammatory agent
AU8454998A (en) (hetero)aryl-sulfonamide derivatives, their preparation and their use as factor xa inhibitors
WO2003080631A3 (en) Plasma carboxypeptidase b inhibitors
EP1449435A4 (en) Anthelmintic composition
EP1674454A4 (en) SUBSTITUTED 2-AMINO- 1,2,4 TRIAZOLO 1,5-a PYRIMIDINE DERIVATIVE AND USE THEREOF

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP