WO2000044420A1 - Pompe a perfusion a mecanisme doseur et technique associee - Google Patents

Pompe a perfusion a mecanisme doseur et technique associee Download PDF

Info

Publication number
WO2000044420A1
WO2000044420A1 PCT/US1999/028885 US9928885W WO0044420A1 WO 2000044420 A1 WO2000044420 A1 WO 2000044420A1 US 9928885 W US9928885 W US 9928885W WO 0044420 A1 WO0044420 A1 WO 0044420A1
Authority
WO
WIPO (PCT)
Prior art keywords
pump head
liquid
pump
outlet
inlet
Prior art date
Application number
PCT/US1999/028885
Other languages
English (en)
Inventor
Stephen O. Ross
Original Assignee
Baxter International Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter International Inc. filed Critical Baxter International Inc.
Priority to AU31121/00A priority Critical patent/AU3112100A/en
Priority to BR9909316-2A priority patent/BR9909316A/pt
Priority to JP2000595722A priority patent/JP2002535554A/ja
Priority to EP99965142A priority patent/EP1067975A1/fr
Priority to KR1020007010914A priority patent/KR20010042349A/ko
Priority to CA002323201A priority patent/CA2323201A1/fr
Priority to HU0102219A priority patent/HUP0102219A3/hu
Priority to PL99343117A priority patent/PL343117A1/xx
Publication of WO2000044420A1 publication Critical patent/WO2000044420A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps

Definitions

  • the present invention is directed toward infusion pumps, and more particularly toward a metered dose infusion pump, an administration set for an infusion pump and method for delivering a select volume of fluids for intravascular injection into a patient.
  • infusion pumping devices for intravascular delivery of fluids to patients in hospitals or other patient care locations has increased dramatically in recent years.
  • Infusion pumps have replaced gravity controlled infusion systems in many applications because of their greater accuracy of delivery rates and dosages and their ability to permit varying medication delivery profiles to optimize medication effectiveness.
  • Infusion pumps have been particularly useful for delivering dangerous medications to patients over an extended period of time in precisely measured and timed volumes to maximize drug effectiveness and patient safety.
  • the present invention is directed toward overcoming one or more of the problems discussed above.
  • a first aspect of the present invention is an intravascular administration set including an axially actuated reciprocating pump head having a pump head inlet and a pump head outlet.
  • An inlet tube has a first end attached to the pump head inlet and a second end adapted for coupling with a liquid reservoir.
  • An outlet tube has a first end coupled to the pump head outlet and a second end adapted for coupling in liquid communication with a blood vessel of a patient.
  • the pump head inlet and the pump head outlet of the reciprocating pump head are preferably disposed axially of the pump head.
  • the administration set may include a liquid reservoir connected to the second end of the inlet tube, with the liquid reservoir consisting of a syringe.
  • the axially actuated reciprocating pump head includes a piston slidably received in the cylinder, the piston being movable within the cylinder between a discharged position and a recharged position to draw liquid into the pump head inlet and discharge liquid from the pump head outlet.
  • a control valve is provided in fluid communication with the cylinder to promote the flow of liquid into the cylinder exclusively from the pump head inlet as the piston moves from the discharged position to the recharged position and to promote the flow of liquid exclusively out of the pump head outlet as the piston moves from the recharged position to the discharged position.
  • a linkage is attached to the piston for moving the piston between the discharged and the recharged positions and the linkage is configured for engagement with a linear reciprocating drive.
  • a second aspect of the present invention is an intravascular infusion pump including an axially actuated reciprocating pump head having a pump head inlet and a pump head outlet.
  • a housing includes a pump head receptacle receiving the pump head.
  • a liquid reservoir is coupled in liquid communication to the pump inlet by an inlet tube.
  • An outlet tube has a first end coupled in liquid communication with the pump head outlet and a second end adapted for coupling in liquid communication with a blood vessel of a patient.
  • a linear reciprocating drive within the housing is operatively associated with the pump head to drive the pump head.
  • the liquid reservoir is also contained within the housing.
  • a controller is operatively associated with the reciprocating linear drive for controlling programmed operation of the pump head to deliver a desired output profile.
  • the axially actuated reciprocating pump head includes a piston slidably received in the cylinder, the piston being movable axially within the cylinder between a discharged position and a recharged position to draw liquid into the pump head inlet and discharge liquid from the pump head outlet.
  • a control valve in liquid communication with the cylinder causes the flow of liquid into the cylinder exclusively from the pump head inlet as the piston moves from the discharged position to the recharged position and causes the flow of liquid exclusively out of the pump head outlet as the piston moves from the recharged position to the discharged position.
  • a linkage attached to the piston moves the piston between the discharged position and the recharged position. The linkage is engaged with the linear reciprocating drive.
  • the linear reciprocating drive preferably includes an electric motor having a rotating drive shaft and a rotary to linear converter operatively associated with the drive shaft and the axially actuated reciprocating pump head to drive the pump head.
  • the rotary to linear converter may comprise a cam eccentrically attached to the drive shaft of the electric motor and a cam follower biased into contact with the edge of the cam.
  • a third aspect of the present invention is a method of intravascular infusion of liquids to a patient.
  • the method includes providing an axially actuated reciprocating pump head having a pump head inlet and a pump head outlet and providing inlet and outlet tubes.
  • a first end of the inlet tube is coupled in liquid communication with the pump head inlet and a second head of the inlet tube is coupled in liquid communication with the liquid reservoir.
  • the first end of the outlet tube is coupled in liquid communication with the pump head outlet and the second end is coupled in liquid communication with a blood vessel of a patient.
  • the reciprocating linear drive is linked in operative association with the pump head and actuated to drive liquid from the liquid reservoir to the blood vessel of a patient.
  • the axially actuated reciprocating pump head is a nasal metered dose spray pump mechanism including an atomizer and the method further includes disabling the atomizer.
  • the intravascular administration set of the present invention utilizes and extremely light weight axially actuated reciprocating pump head that has been used for administration of aerosols to the noses of patients for years in tens of millions of manually actuated reciprocating nasal metered dose spray pumps.
  • the pump head is available off the shelf in virtually unlimited quantities, making it extremely low cost.
  • the simple pump head mechanism has proved its accuracy and reliability in millions of applications. Because of its low cost, the administration set is readily disposable, therefore furthering sanitary and safety objectives.
  • the extreme light weight of the pump head facilitates its use with ambulatory infusion pumps.
  • an infusion pump utilizing the pump head can provide substantially continuous flows of liquid or bolus infusions of liquid. It can also deliver highly accurate volumes of liquid over a large number of cycles of actuation of the pump head.
  • Fig 1 is a schematic diagram illustrating an intravascular infusion pump of the present invention
  • Fig. 2 is a perspective view of an embodiment of intravascular infusion pump of the present invention utilizing a syringe reservoir
  • Fig. 3 is a perspective view the pump mechanics and administration set of the intravascular infusion pump of Fig. 2;
  • Fig. 4 is an exploded view of a representative axially reciprocating pump head deployed in the intravascular infusion pump of the present invention.
  • the intravascular infusion pump 10 of the present invention is shown in schematic form in Fig. 1.
  • the intravascular infusion pump 10 consists of a pump body 12 and an administration set 14.
  • the administration set 14 consists of a pump head 16 which receives liquid from a reservoir 18 through an inlet tube 20 and delivers liquid through an outlet tube 22 to a patient interface 24 in liquid communication with a blood vessel of a patient.
  • the patient interface may be a needle, catheter or any other suitable device known in the art.
  • An air-eliminating filter 26 is preferably provided in liquid communication with the outlet tube to remove any air bubbles which may have been introduced into the liquid prior to introduction of the liquid to the patient.
  • the pump head 16 most preferably consists of an axially actuated reciprocating pump head with a pump head inlet 28 coupled in liquid communication to the inlet tube 20 and a pump head outlet 30 coupled in liquid communication with the outlet tube 22.
  • the pump head inlet 28 and outlet 30 are preferably coaxial.
  • the pump head 16 consists of an off the shelf nasal metered dose spray pump mechanism that has been modified to deactivate any atomizer so that air is not introduced into the liquid being pumped through the metered dose spray pump.
  • a nasal metered dose spray pump is described in Haber et al., U.S. Patent No. 5,433,191, the disclosure of which is incorporated in its entirety herein.
  • suitable nasal metered dose spray pump mechanisms include those manufactured by Pfeiffer of Germany, including model no. 10358BSK 5635 (100 uL) and model no. 6958.59002/6000 (50 uL).
  • Each of these representative pump heads have coaxial pump inlets and outlets and are actuated by axial reciprocation.
  • the pump body 12 includes a housing 36 for encasing the pump electronics and drive apparatus.
  • a controller 38 is provided in the housing for controlling operation of the pump drive.
  • the controller 38 preferably includes microprocessor and memory programmable with selected functions for controlling and monitoring operation of the pumping mechanism and administering a select delivery profile of liquid to a patient.
  • various logic circuits could perform the functions of the controller, only such circuits would not have advantage of being reprogrammable as is the case with a microprocessor and associated memory.
  • the controller 38 is coupled by connector 40 to drive 42 which includes an encoder 44.
  • the encoder 44 is in turn coupled to the controller by connector 46.
  • the drive can be any suitable drive for providing linear reciprocating actuation to the pump head 16.
  • the function of the encoder 44 is to provide a signal to the controller 38 indicative of the number of drive cycles and therefore pump head actuations to monitor pump output.
  • the drive 42 is an electric motor and the encoder is a Hall sensor.
  • the drive shaft 48 of the electric motor is coupled to a rotary to linear converter 50 which in turn is operatively associated with the axially actuated reciprocating pump head 16 by linkage 52 which may, for example, be a cam follower or the like.
  • the drive 42 could be an electric solenoid or pneumatically actuated cylinder capable of directly imparting linear reciprocation to the pump head 16.
  • the pump body 12 also preferably includes a receptacle 53 for receiving the pump head 16 and the other components of the administration set 14 and for retaining the administration set 14 in operative association with the pump drive apparatus and sensors described below.
  • the pump body 12 also includes a variety of sensors.
  • a position sensor 54 is connected to the controller by connector 56 sends a signal to the controller indicating the pump head 16 is properly positioned in the receptacle 53.
  • the controller is programmed so that if such a signal is not received, an appropriate warning signal is provided to the user.
  • An outlet pressure sensor 58 is connected to the controller by connector 60.
  • the outlet pressure sensor is operatively associated with the outlet tube 22 of the administration set 14 for detecting increases in pressure within the outlet tube 22 indicative of a downstream occlusion.
  • An inlet pressure sensor 62 is joined to the controller by connector 64 and is operatively associated with the inlet tube 20 for sensing decreases in pressure in the inlet tube
  • the controller 38 is joined by connector 66 to power supply 68.
  • the power supply 68 may be a battery or a connection to a standard ac outlet including an appropriate ac/dc adapter.
  • a further sensor may be provided in association with the power supply to sense electrical power status. All of the sensors provide signals through their respective connectors to the controller 38.
  • the controller 38 is appropriately programmed to receive and process the sensor signals it receives. The appropriate displays or alarms are conveyed to the user through the display 70 connected to the controller by the connector 72.
  • the display conveys useful information to the pump user such as pump rate, volume pumped, delivery profile and the like.
  • the display may be a conventional LCD dot matrix display.
  • User inputs 74 are coupled to the controller by connector 76. Through the inputs the user dictates pump operation.
  • the controller 38 responds to the various inputs and controls the pumping mechanism accordingly.
  • the infusion pump 10 may be designed as a disposable with the administration set 14 permanently enclosed in the housing 36. Obviously, such an embodiment would eliminate the need for a position sensor 54. Alternatively, the pump body is reusable and the administration set is a disposable.
  • a syringe pump embodiment 80 of the intravascular infusion pump of the present invention is illustrated in Fig. 2.
  • the syringe pump embodiment 80 has a rigid housing 82 which includes an enclosure 84 encasing the pump mechanics and electronics.
  • a display 86 such as a conventional LCD dot matrix display and a variety of inputs 88 are in the cover 90 of the enclosure 84.
  • the housing also defines a elongate receptacle 92 for receiving the administration set 14.
  • the administration set 14 consists of a syringe 94 joined by an inlet tube 96 to an actually reciprocating pumping head 98 and an outlet tube 100 connected to the pump head outlet of the pump head 98.
  • Syringe 94 is of conventional construction well known in the art.
  • Syringe 24 includes a cylinder 102 having an open distal end 104 which receives a plunger 106.
  • the proximal end of the cylinder 102 defines an outlet 108 for liquid contained in the cylinder 102.
  • liquid may be drawn into the cylinder through the outlet 108 by withdrawing the plunger 106 or expunged by inserting the plunger.
  • the administration set 14 downstream from the syringe along with the pump mechanics are shown in greater detail in Fig. 3.
  • the axially reciprocating pump head 98 includes a coaxial pump head inlet 110 and pump head outlet 112. Inlet tube 96 is connected to the pump head inlet 110 and outlet tube 100 is connected to the pump head outlet 112.
  • the axially reciprocating pump head 98 which is shown in an exploded view in Fig. 3, consists of a cylinder 1 14 which defines a pump chamber and a piston 116 (see, Fig. 3) which reciprocatingly slides within the cylinder 114 between a discharged position with the volume of the pump chamber at a minimum and a recharged position with the volume of the pump chamber at a maximum.
  • the piston 116 is actuated by a linkage 118 that also defines the pump head outlet 112.
  • the linkage further includes and push plate 120 for facilitating actuation of the linkage as will be described in greater detail below.
  • the push plate 120 is shown as a separate element from the linkage 118 in Fig. 4.
  • the administration set is maintained in operative association with the pump drive by means of a holding block 126.
  • the holding block 126 defines a bracket 128 which receives the cylinder 1 14 of the axially reciprocating pump head 98.
  • a push capture plate adapter 124 is received within a slot 130 defined in the holding block 126.
  • a cam follower 132 rides within the gap 134 in the block 126 and is reciprocatingly linearly actuated in the directions of the arrow 136 by a cam 138 eccentrically mounted to a shaft 140 of an electric motor 142.
  • the cam follower 132 reciprocates linearly along the axis of the axially actuated pump head 98 by engagement of the cam follower with the edge of the cam 138.
  • a spring may be used to bias the cam follower into contact with a cam.
  • the distal end of the cam follower 132 defines a slot 144 which receives the linkage 118 of the administration set and acts against the push plate 120 to axially actuate the pump head 98.
  • the outlet tube 100 is preferably a standard IV tube, which is typically made of poly vinyl chloride (PVC).
  • the outlet tube 100 may include a silicone section 122 which is joined to the main body of the outlet tube 100 by the capture plate/adapter 124.
  • the PVC IV tube (or the silicone section 122) is received between a force sense resistor 144 which functions as the outlet pressure sensor 58 described above with regard to Fig. 1.
  • the force sense resistor detects expansion of the tube associated with an increase in pressure caused by a downstream occlusion and sends a signal to the controller when a select pressure is exceeded.
  • a representative axially actuated reciprocating pump head 98 is shown exploded in Fig. 3.
  • the pump head 98 includes a cylinder 114 within which rides the piston 116. More particularly, a ball 146 is received in the cylinder 114 and abuts a reduced diameter portion 148 in the cylinder 114.
  • a spring 150 is next received within the cylinder and it abuts a flange (not shown) within the cylinder adjacent to the reduced diameter portion 148.
  • a stem 152 is axially inserted within the cylinder and engages a distal end of the spring 150.
  • the piston 1 16 is received over the stem 150 as is the linkage 118.
  • the orifice 154 within the linkage 1 18 defines a conduit which feeds liquid to the pump head outlet 112.
  • a cap 156 engages with a flange 158 on the cylinder 114 to maintain the various components of the axially reciprocating pump head 98 in their assembled position.
  • the push plate 120 receives the distal end of the linkage 118 in the hole 159 which terminates the pump head outlet 118.
  • the pump head pumps fluid through the cylinder by axially depressing the linkage 118 via the push plate 120 into the cylinder which moves the piston 116 to a discharged position.
  • the piston 116 Upon relaxing the axial force on the linkage 118, the piston 116 is biased to a recharged position by the spring 150.
  • the ball 146 occludes the pump inlet 110 at the reduced diameter portion 148.
  • the pump head discharge stroke can be a series of incremental segments of a full discharge strike to provide small volume bolus dosages or can be a continuous full discharge stroke with a rapid return to provide a substantially continuous liquid flow.
  • the cam profile may be designed to allow the spring in the pump head mechanism to substantially instantaneously move the pump plunger from the discharged to the recharged position and begin another discharge portion of the pump stroke.
  • the syringe 94 could be replaced with a standard IV bag.
  • the supply of liquid could be remote from the pump housing and delivered to the administration set 14 through the inlet tube 96 coupled to a remote reservoir.
  • the infusion pump and administration set of the present invention utilize a standardized pump head which has been shown through millions of uses as a nasal metered dose spray pump to be accurate and highly reliable. As a result, the cost of the administration set is minimized without sacrificing accuracy or reliability.
  • the simple linear actuation of the pump head makes it operable with many different forms of reciprocating linear drives including very simple, inexpensive and highly reliable mechanisms.
  • the administration set may be deployed with a pump unit including a preprogrammed microprocessor which enables infusion of a variety of delivery profiles.

Abstract

L'invention concerne un ensemble d'administration intravasculaire (14) comprenant une tête (98) de pompe à mouvements alternatifs axiaux, qui présente un orifice d'entrée (110) et un orifice de sortie (112). Une tubulure d'entrée (96) a une première extrémité fixée sur l'orifice d'entrée (110) de la tête de pompe et une seconde extrémité conçue pour être couplée à un réservoir de liquide. Une tubulure de sortie (100) a une première extrémité couplée à l'orifice de sortie (112) de la tête de pompe et une seconde extrémité conçue pour être mise en communication liquidienne avec un vaisseau sanguin d'un patient. L'orifice d'entrée (110) et l'orifice de sortie (118) de la tête (98) de la pompe à mouvements alternatifs axiaux sont disposés axialement par rapport à ladite tête (98). Une pompe à perfusion intravasculaire (80) comprend ledit ensemble d'administration (14) et un mécanisme d'entraînement à mouvements alternatifs linéaires (132), fonctionnellement associé à la tête (98) de pompe. Le réservoir de liquide peut être un seringue (94), dans laquelle le liquide est pompé par l'application d'une pression négative au niveau de l'orifice de sortie (108) de ladite seringue. L'invention concerne également une technique d'injection intravasculaire de liquide, faisant appel à l'ensemble d'administration (14) et au mécanisme d'entraînement à mouvements alternatifs linéaires (132).
PCT/US1999/028885 1999-02-01 1999-12-03 Pompe a perfusion a mecanisme doseur et technique associee WO2000044420A1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU31121/00A AU3112100A (en) 1999-02-01 1999-12-03 Metered dose infusion pump and method
BR9909316-2A BR9909316A (pt) 1999-02-01 1999-12-03 Conjunto para administração intravascular, bomba de infusão intravascular, e, processo de infusão intravascular de lìquidos a um paciente
JP2000595722A JP2002535554A (ja) 1999-02-01 1999-12-03 計量用量注入ポンプおよび方法
EP99965142A EP1067975A1 (fr) 1999-02-01 1999-12-03 Pompe a perfusion a mecanisme doseur et technique associee
KR1020007010914A KR20010042349A (ko) 1999-02-01 1999-12-03 계량된 복용량을 주입하는 펌프 및 방법
CA002323201A CA2323201A1 (fr) 1999-02-01 1999-12-03 Pompe a perfusion a mecanisme doseur et technique associee
HU0102219A HUP0102219A3 (en) 1999-02-01 1999-12-03 Metered dose infusion pump and method
PL99343117A PL343117A1 (en) 1999-02-01 1999-12-03 Metered dose infusion pump and method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24337399A 1999-02-01 1999-02-01
US09/243,373 1999-02-01

Publications (1)

Publication Number Publication Date
WO2000044420A1 true WO2000044420A1 (fr) 2000-08-03

Family

ID=22918508

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/028885 WO2000044420A1 (fr) 1999-02-01 1999-12-03 Pompe a perfusion a mecanisme doseur et technique associee

Country Status (15)

Country Link
EP (1) EP1067975A1 (fr)
JP (1) JP2002535554A (fr)
KR (1) KR20010042349A (fr)
CN (1) CN1295486A (fr)
AR (1) AR022464A1 (fr)
AU (1) AU3112100A (fr)
BR (1) BR9909316A (fr)
CA (1) CA2323201A1 (fr)
CO (1) CO5221118A1 (fr)
HU (1) HUP0102219A3 (fr)
PL (1) PL343117A1 (fr)
TR (1) TR200002802T1 (fr)
TW (1) TW418102B (fr)
WO (1) WO2000044420A1 (fr)
ZA (1) ZA200004468B (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100473363B1 (ko) * 2000-10-28 2005-03-07 김용년 액체공급장치
EP1535637A1 (fr) * 2003-11-28 2005-06-01 Woo Young Medical Co., Ltd. Appareil à perfusion automatique
KR100924947B1 (ko) 2007-08-09 2009-11-06 주식회사 씨피엘 의료용 펌프
WO2011044294A1 (fr) * 2009-10-06 2011-04-14 Flex Partners, Inc. Systèmes d'administration de fluide de précision
US9033920B2 (en) 2003-10-02 2015-05-19 Medtronic, Inc. Determining catheter status
US9044537B2 (en) 2007-03-30 2015-06-02 Medtronic, Inc. Devices and methods for detecting catheter complications
US9138537B2 (en) 2003-10-02 2015-09-22 Medtronic, Inc. Determining catheter status

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014104857A1 (fr) * 2012-12-28 2014-07-03 메디칸(주) Pompe de pression statique et de dosage
CN104033348B (zh) * 2014-06-09 2016-09-21 四川大学 数字定量连续注液泵
KR102378501B1 (ko) * 2019-12-17 2022-03-25 이오플로우(주) 구동 시간 대칭 알고리즘이 적용된 약액 주입 장치, 구동 시간 대칭화 방법 및 이의 기록매체
CN112283061B (zh) * 2020-10-29 2021-08-10 上海大学 一种基于可溶性气体溶解提供驱动的微流控被动泵
CN112472979A (zh) * 2020-12-02 2021-03-12 中国人民解放军陆军军医大学第一附属医院 婴幼儿微量给药设备

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FR2300576A1 (fr) * 1975-02-12 1976-09-10 Giraux Jean Pompe medicale a ligne-cassette compacte, dispositif peristaltique a ressort-lame
EP0372863A2 (fr) * 1988-12-02 1990-06-13 Ivac Corporation Fixation de sécurité commandée par le patient pour un système de perfusion de médicaments analgésiques
EP0447985A1 (fr) * 1990-03-15 1991-09-25 Abbott Laboratories Pompe volumétrique
EP0654278A2 (fr) * 1993-11-23 1995-05-24 Sarcos Group Pompe volumétrique et soupape
US5433191A (en) 1992-05-15 1995-07-18 Habley Medical Technology Corp. Medication sprayer
US5582593A (en) * 1994-07-21 1996-12-10 Hultman; Barry W. Ambulatory medication delivery system
WO1997042410A1 (fr) * 1996-05-06 1997-11-13 Sarcos, Inc. Pompe volumetrique ambulatoire jetable commandee par microprocesseur

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2300576A1 (fr) * 1975-02-12 1976-09-10 Giraux Jean Pompe medicale a ligne-cassette compacte, dispositif peristaltique a ressort-lame
EP0372863A2 (fr) * 1988-12-02 1990-06-13 Ivac Corporation Fixation de sécurité commandée par le patient pour un système de perfusion de médicaments analgésiques
EP0447985A1 (fr) * 1990-03-15 1991-09-25 Abbott Laboratories Pompe volumétrique
US5433191A (en) 1992-05-15 1995-07-18 Habley Medical Technology Corp. Medication sprayer
EP0654278A2 (fr) * 1993-11-23 1995-05-24 Sarcos Group Pompe volumétrique et soupape
US5582593A (en) * 1994-07-21 1996-12-10 Hultman; Barry W. Ambulatory medication delivery system
WO1997042410A1 (fr) * 1996-05-06 1997-11-13 Sarcos, Inc. Pompe volumetrique ambulatoire jetable commandee par microprocesseur

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100473363B1 (ko) * 2000-10-28 2005-03-07 김용년 액체공급장치
US9033920B2 (en) 2003-10-02 2015-05-19 Medtronic, Inc. Determining catheter status
US9138537B2 (en) 2003-10-02 2015-09-22 Medtronic, Inc. Determining catheter status
US10357620B2 (en) 2003-10-02 2019-07-23 Medtronic, Inc. Determining catheter status
EP1535637A1 (fr) * 2003-11-28 2005-06-01 Woo Young Medical Co., Ltd. Appareil à perfusion automatique
US9044537B2 (en) 2007-03-30 2015-06-02 Medtronic, Inc. Devices and methods for detecting catheter complications
KR100924947B1 (ko) 2007-08-09 2009-11-06 주식회사 씨피엘 의료용 펌프
WO2011044294A1 (fr) * 2009-10-06 2011-04-14 Flex Partners, Inc. Systèmes d'administration de fluide de précision
US9095650B2 (en) 2009-10-06 2015-08-04 Flex Partners, Inc. Precision fluid delivery systems

Also Published As

Publication number Publication date
HUP0102219A3 (en) 2001-12-28
CO5221118A1 (es) 2002-11-28
TW418102B (en) 2001-01-11
AR022464A1 (es) 2002-09-04
HUP0102219A2 (hu) 2001-10-28
EP1067975A1 (fr) 2001-01-17
PL343117A1 (en) 2001-07-30
CN1295486A (zh) 2001-05-16
TR200002802T1 (tr) 2000-12-21
AU3112100A (en) 2000-08-18
CA2323201A1 (fr) 2000-08-03
ZA200004468B (en) 2001-03-06
KR20010042349A (ko) 2001-05-25
JP2002535554A (ja) 2002-10-22
BR9909316A (pt) 2000-11-21

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