WO1995029662A3 - Vaccine against gram-negative bacterial infections - Google Patents

Vaccine against gram-negative bacterial infections Download PDF

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Publication number
WO1995029662A3
WO1995029662A3 PCT/US1995/004446 US9504446W WO9529662A3 WO 1995029662 A3 WO1995029662 A3 WO 1995029662A3 US 9504446 W US9504446 W US 9504446W WO 9529662 A3 WO9529662 A3 WO 9529662A3
Authority
WO
WIPO (PCT)
Prior art keywords
bacterial infections
negative bacterial
gram
vaccine
lps
Prior art date
Application number
PCT/US1995/004446
Other languages
French (fr)
Other versions
WO1995029662A2 (en
Inventor
Apurba Bhattacharjee
Alan Cross
Erald Sadoff
Wendell Zollinger
Original Assignee
Us Army
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Army filed Critical Us Army
Priority to EP95917557A priority Critical patent/EP0710118B1/en
Priority to DE69506212T priority patent/DE69506212T2/en
Priority to DK95917557T priority patent/DK0710118T3/en
Priority to AU23560/95A priority patent/AU2356095A/en
Publication of WO1995029662A2 publication Critical patent/WO1995029662A2/en
Publication of WO1995029662A3 publication Critical patent/WO1995029662A3/en
Priority to GR990400574T priority patent/GR3029477T3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/095Neisseria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/025Enterobacteriales, e.g. Enterobacter
    • A61K39/0258Escherichia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00Drug, bio-affecting and body treating compositions
    • Y10S424/803Antibody or antigen-binding fragment thereof that binds gram-negative bacteria
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806Antigenic peptides or proteins
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82Proteins from microorganisms
    • Y10S530/825Bacteria

Abstract

A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LPS derived from E. coli and purified outer membrane protein derived from N. meningitidis. The same vaccine will also actively immunize a host subject against Gram-negative bacterial infections and LPS-mediated pathology. Meningococcal infections are included among those Gram-negative bacterial infections protected against by the vaccine.
PCT/US1995/004446 1994-04-20 1995-04-20 Vaccine against gram-negative bacterial infections WO1995029662A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP95917557A EP0710118B1 (en) 1994-04-20 1995-04-20 Vaccine against gram-negative bacterial infections
DE69506212T DE69506212T2 (en) 1994-04-20 1995-04-20 VACCINE AGAINST GRAM-NEGATIVE BACTERIAL INFECTIONS
DK95917557T DK0710118T3 (en) 1994-04-20 1995-04-20 Vaccine against infections with gram-negative bacteria
AU23560/95A AU2356095A (en) 1994-04-20 1995-04-20 Vaccine against gram-negative bacterial infections
GR990400574T GR3029477T3 (en) 1994-04-20 1999-02-24 Vaccine against gram-negative bacterial infections

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23040294A 1994-04-20 1994-04-20
US08/230,402 1994-04-20

Publications (2)

Publication Number Publication Date
WO1995029662A2 WO1995029662A2 (en) 1995-11-09
WO1995029662A3 true WO1995029662A3 (en) 1995-11-30

Family

ID=22865082

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/004446 WO1995029662A2 (en) 1994-04-20 1995-04-20 Vaccine against gram-negative bacterial infections

Country Status (9)

Country Link
US (3) US7025963B1 (en)
EP (1) EP0710118B1 (en)
AT (1) ATE173634T1 (en)
AU (1) AU2356095A (en)
DE (1) DE69506212T2 (en)
DK (1) DK0710118T3 (en)
ES (1) ES2128055T3 (en)
GR (1) GR3029477T3 (en)
WO (1) WO1995029662A2 (en)

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Publication number Priority date Publication date Assignee Title
US6749831B1 (en) 1997-05-16 2004-06-15 Medical Defense Technology, Llc Vaccine against lipopolysaccharide core
JP2001527562A (en) * 1997-05-16 2001-12-25 メディカル ディフェンス テクノロジーズ エルエルシー Vaccine against lipopolysaccharide core
EP2261339B1 (en) 1998-05-01 2017-03-22 GlaxoSmithKline Biologicals SA Neisseria meningitidis antigens and compositions
US20070026021A1 (en) * 1998-05-01 2007-02-01 Chiron S.R.I. Neisseria meningitidis antigens and compositions
EP1079857B1 (en) 1998-05-29 2006-11-29 Novartis Vaccines and Diagnostics, Inc. Combination meningitidis b/c vaccines
EP2258851A1 (en) 1999-05-19 2010-12-08 Novartis Vaccines and Diagnostics S.r.l. Combination neisserial compositions
BR0015137A (en) * 1999-10-29 2003-03-25 Chiron Spa Neisserial antigenic peptides
GB9928196D0 (en) * 1999-11-29 2000-01-26 Chiron Spa Combinations of B, C and other antigens
RU2279889C2 (en) * 2000-01-17 2006-07-20 Чирон С.Р.Л. OUTER MEMBRANE VESICLE VACCINE (OMV) CONTAINING PROTEINS OF SEROGROUP B N.Meningitis OUTER MEMBRANE
MX339524B (en) * 2001-10-11 2016-05-30 Wyeth Corp Novel immunogenic compositions for the prevention and treatment of meningococcal disease.
GB0220194D0 (en) * 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
US8828226B2 (en) 2003-03-01 2014-09-09 The Trustees Of Boston University System for assessing the efficacy of stored red blood cells using microvascular networks
GB0316560D0 (en) 2003-07-15 2003-08-20 Chiron Srl Vesicle filtration
GB0419627D0 (en) * 2004-09-03 2004-10-06 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
GB0424092D0 (en) 2004-10-29 2004-12-01 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
US20090220522A1 (en) * 2005-10-24 2009-09-03 Cross Alan S Detoxified Endotoxin Vaccine and Adjuvant and Uses thereof
US9616116B2 (en) * 2005-10-24 2017-04-11 University Of Maryland, Baltimore Detoxified endotoxin immunogenic compositions and uses thereof
WO2010027499A2 (en) * 2008-09-05 2010-03-11 University Of Massachusetts Medical School Methods, compositions and vaccines relating to neisseria meningitidis antibodies
US8258705B2 (en) * 2009-04-29 2012-09-04 Hubbell Incorporated Scotopically enhanced emergency light and control thereof
WO2011046963A1 (en) 2009-10-12 2011-04-21 New Health Sciences, Inc. Oxygen depletion devices and methods for removing oxygen from red blood cells
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
WO2011046841A1 (en) 2009-10-12 2011-04-21 New Health Sciences, Inc. Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities
WO2012027582A1 (en) 2010-08-25 2012-03-01 New Health Sciences Method for enhancing red blood cell quality and survival during storage
EP2613805B1 (en) 2010-09-10 2019-10-23 GlaxoSmithKline Biologicals SA Meningococcus overexpressing nada and/or nhba and outer membrane vesicles derived therefrom
WO2012061731A1 (en) 2010-11-05 2012-05-10 New Health Sciences Irradiation of red blood cells and anaerobic storage
US9067004B2 (en) 2011-03-28 2015-06-30 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
CA2844449A1 (en) 2011-08-10 2013-02-14 New Health Sciences, Inc. Integrated leukocyte, oxygen and/or co2 depletion, and plasma separation filter device
SA115360586B1 (en) 2012-03-09 2017-04-12 فايزر انك Neisseria meningitidis compositions and methods thereof
AU2013320313B2 (en) 2012-09-18 2018-07-12 Glaxosmithkline Biologicals Sa Outer membrane vesicles
CA3205441A1 (en) 2013-02-28 2014-09-04 Hemanext Inc. Gas depletion and gas addition devices for blood treatment
RU2662968C2 (en) 2013-09-08 2018-07-31 Пфайзер Инк. Immunogenic composition for neisseria meningitidis (options)
CA2978940C (en) 2015-03-10 2023-10-17 New Health Sciences, Inc. Oxygen reduction disposable kits, devices and methods of use thereof
WO2016172645A1 (en) 2015-04-23 2016-10-27 New Health Sciences, Inc. Anaerobic blood storage containers
WO2016187353A1 (en) 2015-05-18 2016-11-24 New Health Sciences, Inc. Methods for the storage of whole blood, and compositions thereof
CN109195632A (en) 2016-05-27 2019-01-11 新健康科学股份有限公司 Anaerobism blood storage and pathogen method for deactivating

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0109688A2 (en) * 1982-11-23 1984-05-30 The Wellcome Foundation Limited Improved complexes, processes for obtaining them and formulations containing such complexes
US4707543A (en) * 1985-09-17 1987-11-17 The United States Of America As Represented By The Secretary Of The Army Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines
WO1987007148A1 (en) * 1986-05-23 1987-12-03 Midcon Labs, Inc. Co-vaccination using non-o-carbohydrate side-chain gram-negative bacteria preparation

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GB109688A (en) 1916-11-04 1917-09-27 Herbert Senior Vincent Improvements in Steam Jacketed Heating or Boiling Pans and like Receptacles.
US4918163A (en) * 1985-09-27 1990-04-17 Pfizer Inc. Monoclonal antibodies specific for lipid-A determinants of gram negative bacteria
US4929604A (en) * 1986-05-28 1990-05-29 Board Of Regents, The University Of Texas System Lipopolysaccharides of reduced toxicity and the production thereof
US4912094B1 (en) * 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
GB8918232D0 (en) * 1989-08-10 1989-09-20 Opal Stephen M Pharmaceutical product for the treatment of septic shock

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0109688A2 (en) * 1982-11-23 1984-05-30 The Wellcome Foundation Limited Improved complexes, processes for obtaining them and formulations containing such complexes
US4707543A (en) * 1985-09-17 1987-11-17 The United States Of America As Represented By The Secretary Of The Army Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines
WO1987007148A1 (en) * 1986-05-23 1987-12-03 Midcon Labs, Inc. Co-vaccination using non-o-carbohydrate side-chain gram-negative bacteria preparation

Also Published As

Publication number Publication date
US7235644B2 (en) 2007-06-26
AU2356095A (en) 1995-11-29
US20060159702A1 (en) 2006-07-20
EP0710118B1 (en) 1998-11-25
EP0710118A1 (en) 1996-05-08
ES2128055T3 (en) 1999-05-01
DK0710118T3 (en) 1999-08-09
US7025963B1 (en) 2006-04-11
ATE173634T1 (en) 1998-12-15
WO1995029662A2 (en) 1995-11-09
GR3029477T3 (en) 1999-05-28
DE69506212T2 (en) 1999-08-05
US7018636B1 (en) 2006-03-28
DE69506212D1 (en) 1999-01-07

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