WO1995029662A3 - Vaccine against gram-negative bacterial infections - Google Patents

Vaccine against gram-negative bacterial infections Download PDF

Info

Publication number
WO1995029662A3
WO1995029662A3 PCT/US1995/004446 US9504446W WO9529662A3 WO 1995029662 A3 WO1995029662 A3 WO 1995029662A3 US 9504446 W US9504446 W US 9504446W WO 9529662 A3 WO9529662 A3 WO 9529662A3
Authority
WO
WIPO (PCT)
Prior art keywords
bacterial infections
negative bacterial
gram
vaccine
lps
Prior art date
Application number
PCT/US1995/004446
Other languages
French (fr)
Other versions
WO1995029662A2 (en
Inventor
Apurba Bhattacharjee
Alan Cross
Erald Sadoff
Wendell Zollinger
Original Assignee
Us Army
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Army filed Critical Us Army
Priority to DE69506212T priority Critical patent/DE69506212T2/en
Priority to AU23560/95A priority patent/AU2356095A/en
Priority to DK95917557T priority patent/DK0710118T3/en
Priority to EP95917557A priority patent/EP0710118B1/en
Publication of WO1995029662A2 publication Critical patent/WO1995029662A2/en
Publication of WO1995029662A3 publication Critical patent/WO1995029662A3/en
Priority to GR990400574T priority patent/GR3029477T3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/095Neisseria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/025Enterobacteriales, e.g. Enterobacter
    • A61K39/0258Escherichia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00Drug, bio-affecting and body treating compositions
    • Y10S424/803Antibody or antigen-binding fragment thereof that binds gram-negative bacteria
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806Antigenic peptides or proteins
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82Proteins from microorganisms
    • Y10S530/825Bacteria

Abstract

A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LPS derived from E. coli and purified outer membrane protein derived from N. meningitidis. The same vaccine will also actively immunize a host subject against Gram-negative bacterial infections and LPS-mediated pathology. Meningococcal infections are included among those Gram-negative bacterial infections protected against by the vaccine.
PCT/US1995/004446 1994-04-20 1995-04-20 Vaccine against gram-negative bacterial infections WO1995029662A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE69506212T DE69506212T2 (en) 1994-04-20 1995-04-20 VACCINE AGAINST GRAM-NEGATIVE BACTERIAL INFECTIONS
AU23560/95A AU2356095A (en) 1994-04-20 1995-04-20 Vaccine against gram-negative bacterial infections
DK95917557T DK0710118T3 (en) 1994-04-20 1995-04-20 Vaccine against infections with gram-negative bacteria
EP95917557A EP0710118B1 (en) 1994-04-20 1995-04-20 Vaccine against gram-negative bacterial infections
GR990400574T GR3029477T3 (en) 1994-04-20 1999-02-24 Vaccine against gram-negative bacterial infections

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23040294A 1994-04-20 1994-04-20
US08/230,402 1994-04-20

Publications (2)

Publication Number Publication Date
WO1995029662A2 WO1995029662A2 (en) 1995-11-09
WO1995029662A3 true WO1995029662A3 (en) 1995-11-30

Family

ID=22865082

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/004446 WO1995029662A2 (en) 1994-04-20 1995-04-20 Vaccine against gram-negative bacterial infections

Country Status (9)

Country Link
US (3) US7025963B1 (en)
EP (1) EP0710118B1 (en)
AT (1) ATE173634T1 (en)
AU (1) AU2356095A (en)
DE (1) DE69506212T2 (en)
DK (1) DK0710118T3 (en)
ES (1) ES2128055T3 (en)
GR (1) GR3029477T3 (en)
WO (1) WO1995029662A2 (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2289760A1 (en) * 1997-05-16 1998-11-19 Medical Defense Technologies, Llc. Vaccine against lipopolysaccharide core
US6749831B1 (en) 1997-05-16 2004-06-15 Medical Defense Technology, Llc Vaccine against lipopolysaccharide core
US20070026021A1 (en) * 1998-05-01 2007-02-01 Chiron S.R.I. Neisseria meningitidis antigens and compositions
NZ532665A (en) 1998-05-01 2005-11-25 Inst Genomic Research Neisseria meningitidis antigens and compositions
CA2332963C (en) 1998-05-29 2013-07-23 Chiron Corporation Combination meningitidis b/c vaccines
CA2929348A1 (en) 1999-05-19 2000-11-30 Novartis Vaccines And Diagnostics S.R.L. Combination neisserial compositions
ES2559317T3 (en) * 1999-10-29 2016-02-11 Glaxosmithkline Biologicals Sa Neisseria antigenic peptides
GB9928196D0 (en) * 1999-11-29 2000-01-26 Chiron Spa Combinations of B, C and other antigens
DK2289545T3 (en) * 2000-01-17 2016-09-05 Glaxosmithkline Biologicals Sa Supplemented OMV vaccine against meningococcus
MX339524B (en) * 2001-10-11 2016-05-30 Wyeth Corp Novel immunogenic compositions for the prevention and treatment of meningococcal disease.
GB0220194D0 (en) * 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
US8828226B2 (en) 2003-03-01 2014-09-09 The Trustees Of Boston University System for assessing the efficacy of stored red blood cells using microvascular networks
GB0316560D0 (en) 2003-07-15 2003-08-20 Chiron Srl Vesicle filtration
GB0419627D0 (en) * 2004-09-03 2004-10-06 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
GB0424092D0 (en) 2004-10-29 2004-12-01 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
US9616116B2 (en) * 2005-10-24 2017-04-11 University Of Maryland, Baltimore Detoxified endotoxin immunogenic compositions and uses thereof
US20090220522A1 (en) * 2005-10-24 2009-09-03 Cross Alan S Detoxified Endotoxin Vaccine and Adjuvant and Uses thereof
WO2010027499A2 (en) * 2008-09-05 2010-03-11 University Of Massachusetts Medical School Methods, compositions and vaccines relating to neisseria meningitidis antibodies
US8258705B2 (en) * 2009-04-29 2012-09-04 Hubbell Incorporated Scotopically enhanced emergency light and control thereof
US8535421B2 (en) 2009-10-12 2013-09-17 New Health Sciences, Inc. Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities
JP2013507447A (en) 2009-10-12 2013-03-04 ニュー ヘルス サイエンシーズ、インク. Oxygen depletion device and method for removing oxygen from red blood cells
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
US9339025B2 (en) 2010-08-25 2016-05-17 New Health Sciences, Inc. Method for enhancing red blood cell quality and survival during storage
AU2011300418B2 (en) 2010-09-10 2016-05-12 Glaxosmithkline Biologicals Sa Meningococcus overexpressing NadA and/or NHBA and outer membrane vesicles derived therefrom
EP4218412A1 (en) 2010-11-05 2023-08-02 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US9067004B2 (en) 2011-03-28 2015-06-30 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
WO2013023156A1 (en) 2011-08-10 2013-02-14 New Health Sciences, Inc. Integrated leukocyte, oxygen and/or co2 depletion, and plasma separation filter device
SA115360586B1 (en) 2012-03-09 2017-04-12 فايزر انك Neisseria meningitidis compositions and methods thereof
RU2662970C2 (en) 2012-09-18 2018-07-31 Новартис Аг Outer membrane vesicles
EP3967143A1 (en) 2013-02-28 2022-03-16 Hemanext Inc. Gas addition device for blood treatment and corresponding method
EP3041502A2 (en) 2013-09-08 2016-07-13 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
AU2016228993B2 (en) 2015-03-10 2022-02-10 Hemanext Inc. Oxygen reduction disposable kits, devices and methods of use thereof
IL285359B2 (en) 2015-04-23 2024-01-01 Hemanext Inc Anaerobic blood storage containers
EP3297641A4 (en) 2015-05-18 2019-02-06 New Health Sciences, Inc. Methods for the storage of whole blood, and compositions thereof
PT3463466T (en) 2016-05-27 2022-04-04 Hemanext Inc Anaerobic blood storage and pathogen inactivation method

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0109688A2 (en) * 1982-11-23 1984-05-30 The Wellcome Foundation Limited Improved complexes, processes for obtaining them and formulations containing such complexes
US4707543A (en) * 1985-09-17 1987-11-17 The United States Of America As Represented By The Secretary Of The Army Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines
WO1987007148A1 (en) * 1986-05-23 1987-12-03 Midcon Labs, Inc. Co-vaccination using non-o-carbohydrate side-chain gram-negative bacteria preparation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB109688A (en) 1916-11-04 1917-09-27 Herbert Senior Vincent Improvements in Steam Jacketed Heating or Boiling Pans and like Receptacles.
US4918163A (en) * 1985-09-27 1990-04-17 Pfizer Inc. Monoclonal antibodies specific for lipid-A determinants of gram negative bacteria
US4929604A (en) * 1986-05-28 1990-05-29 Board Of Regents, The University Of Texas System Lipopolysaccharides of reduced toxicity and the production thereof
US4912094B1 (en) * 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
GB8918232D0 (en) * 1989-08-10 1989-09-20 Opal Stephen M Pharmaceutical product for the treatment of septic shock

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0109688A2 (en) * 1982-11-23 1984-05-30 The Wellcome Foundation Limited Improved complexes, processes for obtaining them and formulations containing such complexes
US4707543A (en) * 1985-09-17 1987-11-17 The United States Of America As Represented By The Secretary Of The Army Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines
WO1987007148A1 (en) * 1986-05-23 1987-12-03 Midcon Labs, Inc. Co-vaccination using non-o-carbohydrate side-chain gram-negative bacteria preparation

Also Published As

Publication number Publication date
US7235644B2 (en) 2007-06-26
EP0710118B1 (en) 1998-11-25
US7018636B1 (en) 2006-03-28
AU2356095A (en) 1995-11-29
ES2128055T3 (en) 1999-05-01
GR3029477T3 (en) 1999-05-28
EP0710118A1 (en) 1996-05-08
DE69506212T2 (en) 1999-08-05
ATE173634T1 (en) 1998-12-15
DK0710118T3 (en) 1999-08-09
US7025963B1 (en) 2006-04-11
WO1995029662A2 (en) 1995-11-09
US20060159702A1 (en) 2006-07-20
DE69506212D1 (en) 1999-01-07

Similar Documents

Publication Publication Date Title
WO1995029662A3 (en) Vaccine against gram-negative bacterial infections
AU6236396A (en) Omp26 antigen from haemophilus influenzae
EP1792994A3 (en) Vaccines of bacterial outer membrane vesicles
DK0754050T3 (en) Anti-gram-positive bacterial methods and materials
ATE352314T1 (en) ACTIVE IMMUNIZATION AGAINST A SIDEROPHORE RECEPTOR PROTEIN
DE69533673D1 (en) TREATMENT AND PREVENTION OF HELICOBACTER INFECTIONS
PL332540A1 (en) Method of inducing active immunity using a vaccine conjugate
IL156942A0 (en) Compounds, pharmaceutical compositions and methods for treatment of bacteremia and/or septicemia
AR010218A1 (en) A FAMILY OF MULTI-UNIT BACTERIAL PROTEINS
ATE75752T1 (en) ANTIBIOTIC.
Williams et al. Protein antigens of Staphylococcus epidermidis grown under iron-restricted conditions in human peritoneal dialysate
Samuelson et al. Characterization of Haemophilus influenzae isolates from the respiratory tract of patients with primary antibody deficiencies: evidence for persistent colonizations
ATE356633T1 (en) VACCIN FOR AN UNTYPABLE HAEMOPHILUS INFLUENZAE STRAIN
Anwar et al. Antibody response to acute Pseudomonas aeruginosa infection in a burn wound
WO2001040473A3 (en) Pseudomonas aeruginosa antigens
DK0776214T3 (en) Antibacterial preparation containing multimeric alpha-lactalbumin
El-Shahawy et al. Peritoneal dialysis-associated peritonitis caused by Alcaligenes xylosoxidans
NZ332809A (en) Immunogenic complex comprising a oligo- or polysaccharide epitope and a carrier protein with a portion of an OmpA-type outer membrane protein of a bacterial and vaccines of such complexes containing same
CA2142638A1 (en) Antibiotic wap-8294a, method for preparing the same and antibacterial composition
Rupp et al. Hemagglutination by Staphylococcus aureus strains responsible for human bacteremia or bovine mastitis
PT852497E (en) UTILIZATION OF PROSTANE DERIVATIVES AND THEIR COMBINATION WITH ANTIBIOTICS IN THE TREATMENT OF BACTERIAL INFECTIONS
Lång et al. The maltose-inducible 43 kDa major outer membrane protein in Vibrio cholerae is immunogenic and common to different isolates
RU95120818A (en) CELLLESS ANTISTAPHYLO-COCK VACCINE FOR TREATMENT OF CHRONIC STAIL-COCK INFECTION
WO2001096380A8 (en) IMMUNIZATION OF DAIRY CATTLE WITH Mig PROTEIN

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA FI JP KR NO

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

WWE Wipo information: entry into national phase

Ref document number: 1995917557

Country of ref document: EP

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWP Wipo information: published in national office

Ref document number: 1995917557

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: CA

WWG Wipo information: grant in national office

Ref document number: 1995917557

Country of ref document: EP