US20120271225A1 - Device for the planar treatment of areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric pressure plasma - Google Patents

Device for the planar treatment of areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric pressure plasma Download PDF

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Publication number
US20120271225A1
US20120271225A1 US13/392,221 US201013392221A US2012271225A1 US 20120271225 A1 US20120271225 A1 US 20120271225A1 US 201013392221 A US201013392221 A US 201013392221A US 2012271225 A1 US2012271225 A1 US 2012271225A1
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United States
Prior art keywords
flexible
plasma
electrode
dielectric
atmospheric pressure
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Abandoned
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US13/392,221
Inventor
Manfred Stieber
Klaus-Dieter Weltmann
Stefan Horn
Ronny Brandenburg
Thomas Von Woedtke
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INP GREIFSWALD LEIBNIZ-INSTITUT fur PLASMAFORSCHUNG und TECHNOLOGIE EV
INP Greifswald Leibniz Institut fur Plasmaforschung und Technologie eV
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Neoplas GmbH
INP Greifswald Leibniz Institut fur Plasmaforschung und Technologie eV
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Application filed by Neoplas GmbH, INP Greifswald Leibniz Institut fur Plasmaforschung und Technologie eV filed Critical Neoplas GmbH
Assigned to NEOPLAS GMBH, INP GREIFSWALD LEIBNIZ-INSTITUT FUER PLASMAFORSCHUNG UND TECHNOLOGIE E.V. reassignment NEOPLAS GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: STIEBER, MANFRED, WELTMANN, KLAUS-DIETER, VON WOEDTKE, THOMAS, HORN, STEFAN, BRANDENBURG, RONNY
Publication of US20120271225A1 publication Critical patent/US20120271225A1/en
Assigned to INP GREIFSWALD LEIBNIZ-INSTITUT FUER PLASMAFORSCHUNG UND TECHNOLOGIE E.V. reassignment INP GREIFSWALD LEIBNIZ-INSTITUT FUER PLASMAFORSCHUNG UND TECHNOLOGIE E.V. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: NEOPLAS GMBH
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/042—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating using additional gas becoming plasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/44—Applying ionised fluids
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/2406—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
    • H05H1/2439—Surface discharges, e.g. air flow control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577—Ablation
    • A61B2018/00583—Coblation, i.e. ablation using a cold plasma
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2240/00—Testing
    • H05H2240/20—Non-thermal plasma
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2245/00—Applications of plasma devices
    • H05H2245/30—Medical applications
    • H05H2245/32—Surgery, e.g. scalpels, blades or bistoury; Treatments inside the body
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2245/00—Applications of plasma devices
    • H05H2245/30—Medical applications
    • H05H2245/34—Skin treatments, e.g. disinfection or wound treatment

Definitions

  • the invention relates to a device for surface treatment of areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric-pressure plasma.
  • the centerpiece of the device is a special electrode arrangement for generating a dielectric barrier surface discharge, which can be applied flexibly onto arbitrarily curved surfaces.
  • this invention it is possible to generate, in the region of diseased skin or mucous membrane parts of the human body, in the immediate proximity of the skin or mucous membrane surface or of wounds, a superficial plasma for treatment of diseased areas, which plasma is safe as regards the stress on the skin or mucous membrane due to temperature and electrical voltages.
  • plasma technology for applications of this type is rated as sufficiently important that an independent discipline known as plasma medicine is now beginning to develop on the international front.
  • plasma-based therapeutic approaches of this type can be systematically developed and employed, suitable plasma sources are needed that on the one hand work painlessly and ensure that the tissue to be treated is not harmed by temperature, desiccation or electrical voltages, and on the other hand can be used flexibly for large-area applications for various body regions under variable plasma conditions.
  • Devices for plasma treatment of living tissue with non-thermal atmospheric plasmas have been proposed in several publications (DE 3618412 A1, WO 2004/105810 A1, WO 2006/116252 A2).
  • the devices described in these publications are equipped with rigid electrode systems or nozzles for generation of atmospheric-pressure plasmas in the region of the tissue surfaces to be treated, and so they permit only local treatment of relatively small areas.
  • the object of the invention was to find a technical solution for generation of a superficial plasma that makes it possible to treat relatively large areas of body parts, especially of arbitrarily curved areas of human or animal skin or mucous membrane.
  • an electrode system for generating a dielectric barrier surface discharge is provided that on the one hand is composed of flexible materials, so that it can be conformed to curved surfaces, and on the other hand has an outer, electrically conductive surface, which is used as a grounded electrode and is structured in such a way that dielectric barrier surface discharges can form in the interstices of the structure that remain open.
  • a substantial advantage of the invention that is important especially for wound healing is the fact among others that, because of the design as a cuff that conforms to the body, the treated area is covered and thus is protected from desiccation, whereby the moist environment necessary according to the prior art for wound healing is better assured than during the application of open, rigid electrode systems with a gas flow that may be necessary.
  • the design as a DBD (dielectric barrier discharge) without or with a small gas flow also counteracts the danger of desiccation.
  • the elastic electrode system can also be configured as a shapeable (inflatable) volume (for example, as a silicone ball), in such a way that treatments on the one hand of the mucous membrane surfaces of body cavities and on the other hand of arbitrarily shaped skin or mucous membrane areas can be performed with the plasma generated on the inner or outer surface of this electrode system.
  • a shapeable (inflatable) volume for example, as a silicone ball
  • This arrangement offers the possibility of a combination with catheters, endoscopes and surgical instruments. It works both at atmospheric pressure and at slight overpressure or underpressure, with use of different gases or gas mixtures, if appropriate in combination with the transport of active substances, and is usable for diverse applications toward decontamination, sterilization, antisepsis, wound healing, etc., both in medicine and in other areas of the life sciences. Slight overpressure or underpressure means that only minor deviations from atmospheric pressure are involved here.
  • Subject matter of the invention is also a method for treating areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric-pressure plasma.
  • the inventive method consists in the fact that an electrode system of flexible materials for generating a dielectric barrier surface discharge is provided, so that it can be conformed to curved surfaces, and that the electrode system has an outer, electrically conductive surface, which is used and structured as a grounded electrode, wherein a dielectric barrier surface discharge is generated in the interstices of the structure that remain open.
  • the elastic materials for electrodes and dielectric into a surface with a closed volume, preferably a silicone balloon, and to ignite a plasma both on the inside of the hollow body and on the outside.
  • FIGS. 1 and 2 show the basic structure of the inventive device. Of those, FIG. 2 is the assembled planar electrode arrangement while FIG. 1 represents an exploded view of this arrangement for demonstration purposes.
  • FIG. 3 shows an exemplary embodiment in curved form with a gas port for the optional supply of a process gas
  • FIG. 4 shows an exemplary embodiment of an arm cuff.
  • the basic structure of an electrode system configured as a shapeable silicone ball is schematically illustrated in FIG. 5
  • the application of such an inflatable plasma source for treating the inner surface of body cavities in combination with an endoscope is schematically illustrated in FIGS. 6 a and 6 b.
  • Flexible insulating material such as elastomer, silicone film
  • Flexible high-voltage electrode such as metal gauze, metal foil, electrically conductive elastomer

Abstract

The invention relates to a device, preferably a collar, for treating areas of human or animal skin or mucous membrane with a cold atmospheric pressure plasma by creating a dielectrically hindered surface discharge, comprising at least one flexible insulating material (1), a flexible high-voltage electrode (2), a flexible dielectric (3), a flexible grounded electrode (4) and a gas supply (7), characterized in that the flexible high-voltage electrode (2) is embedded in the insulating elastomer (3), having the effect of a dielectric, and the grounded electrode (4) is applied to the elastomer surface facing the surface to be treated.

Description

  • The invention relates to a device for surface treatment of areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric-pressure plasma. The centerpiece of the device is a special electrode arrangement for generating a dielectric barrier surface discharge, which can be applied flexibly onto arbitrarily curved surfaces. On the basis of this invention, it is possible to generate, in the region of diseased skin or mucous membrane parts of the human body, in the immediate proximity of the skin or mucous membrane surface or of wounds, a superficial plasma for treatment of diseased areas, which plasma is safe as regards the stress on the skin or mucous membrane due to temperature and electrical voltages.
    • PRIOR ART
  • As the result of scientific studies of recent years, new application possibilities are now being opened up in some areas of biology and medicine for plasma technology, which has already proved to be a key technology for diverse applications of surface treatments in industry ([1] M. Laroussi, “Low-Temperature Plasmas for Medicine?”, IEEE Transactions on Plasma Science 2009, 37, 714-725; [2] M. Kong et al., Plasma medicine: an introductory review”, New Journal of Physics 2009, 11, 115012; [3] G. Lloyd et al., “Gas Plasma: Medical Uses and Developments in Wound Care”, Plasma Processes and Polymers 2010, 7, 194-211).
  • The potential of plasma technology for applications of this type is rated as sufficiently important that an independent discipline known as plasma medicine is now beginning to develop on the international front. One of its substantial objectives, for example, is the development of innovative therapeutic methods for treating skin or mucous membrane diseases and chronic wounds with cold atmospheric-pressure plasmas, on the basis of the interaction of antiseptic plasma effect and stimulation of new growth of healthy tissue by the plasma.
  • In order that plasma-based therapeutic approaches of this type can be systematically developed and employed, suitable plasma sources are needed that on the one hand work painlessly and ensure that the tissue to be treated is not harmed by temperature, desiccation or electrical voltages, and on the other hand can be used flexibly for large-area applications for various body regions under variable plasma conditions.
  • Devices for plasma treatment of living tissue with non-thermal atmospheric plasmas have been proposed in several publications (DE 3618412 A1, WO 2004/105810 A1, WO 2006/116252 A2). The devices described in these publications are equipped with rigid electrode systems or nozzles for generation of atmospheric-pressure plasmas in the region of the tissue surfaces to be treated, and so they permit only local treatment of relatively small areas.
    • OBJECT OF THE INVENTION
  • The object of the invention was to find a technical solution for generation of a superficial plasma that makes it possible to treat relatively large areas of body parts, especially of arbitrarily curved areas of human or animal skin or mucous membrane.
    • OUTLINE OF THE INVENTION
  • The object is achieved according to the features of the claims. According to the invention, an electrode system for generating a dielectric barrier surface discharge is provided that on the one hand is composed of flexible materials, so that it can be conformed to curved surfaces, and on the other hand has an outer, electrically conductive surface, which is used as a grounded electrode and is structured in such a way that dielectric barrier surface discharges can form in the interstices of the structure that remain open.
  • A substantial advantage of the invention that is important especially for wound healing is the fact among others that, because of the design as a cuff that conforms to the body, the treated area is covered and thus is protected from desiccation, whereby the moist environment necessary according to the prior art for wound healing is better assured than during the application of open, rigid electrode systems with a gas flow that may be necessary. The design as a DBD (dielectric barrier discharge) without or with a small gas flow also counteracts the danger of desiccation.
  • A further advantage of the invention is that the elastic electrode system can also be configured as a shapeable (inflatable) volume (for example, as a silicone ball), in such a way that treatments on the one hand of the mucous membrane surfaces of body cavities and on the other hand of arbitrarily shaped skin or mucous membrane areas can be performed with the plasma generated on the inner or outer surface of this electrode system.
  • This arrangement offers the possibility of a combination with catheters, endoscopes and surgical instruments. It works both at atmospheric pressure and at slight overpressure or underpressure, with use of different gases or gas mixtures, if appropriate in combination with the transport of active substances, and is usable for diverse applications toward decontamination, sterilization, antisepsis, wound healing, etc., both in medicine and in other areas of the life sciences. Slight overpressure or underpressure means that only minor deviations from atmospheric pressure are involved here.
  • Subject matter of the invention is also a method for treating areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric-pressure plasma. The inventive method consists in the fact that an electrode system of flexible materials for generating a dielectric barrier surface discharge is provided, so that it can be conformed to curved surfaces, and that the electrode system has an outer, electrically conductive surface, which is used and structured as a grounded electrode, wherein a dielectric barrier surface discharge is generated in the interstices of the structure that remain open.
  • In a preferred embodiment of the method, it is possible to shape the elastic materials for electrodes and dielectric into a surface with a closed volume, preferably a silicone balloon, and to ignite a plasma both on the inside of the hollow body and on the outside.
    • EXAMPLES
  • The invention will be explained in more detail on the basis of figures, without being restricted to these figures.
  • For this purpose FIGS. 1 and 2 show the basic structure of the inventive device. Of those, FIG. 2 is the assembled planar electrode arrangement while FIG. 1 represents an exploded view of this arrangement for demonstration purposes. FIG. 3 shows an exemplary embodiment in curved form with a gas port for the optional supply of a process gas, and FIG. 4 shows an exemplary embodiment of an arm cuff. The basic structure of an electrode system configured as a shapeable silicone ball is schematically illustrated in FIG. 5, and the application of such an inflatable plasma source for treating the inner surface of body cavities in combination with an endoscope is schematically illustrated in FIGS. 6 a and 6 b.
    • REFERENCE NUMERAL LIST
  • The following reference numerals are used for the attached drawings:
  • 1 Flexible insulating material (such as elastomer, silicone film)
  • 2 Flexible high-voltage electrode (such as metal gauze, metal foil, electrically conductive elastomer)
  • 3 Flexible dielectric (such as elastomer, silicone film)
  • 4 Grounded electrode: flexible and structured (such as metal gauze, structured metal foil, structured electrically conductive elastomer)
  • 5 Electrical connecting cable
  • 6 Insulating elastomer with embedded flexible high-voltage electrode
  • 7 Gas supply
  • 8 Arm cuff
  • 9 Balloon of elastic materials (dielectric with embedded electrodes)
  • 10 Body cavity
  • 11 Endoscope coupling

Claims (19)

1. A device, comprising:
at least one flexible insulating material (1);
a planar flexible high-voltage electrode (2);
a flexible dielectric (3);
a planar flexible grounded electrode (4); and
a gas supply (7),
wherein the flexible high-voltage electrode (2) is embedded in between the flexible insulating material (1) and the flexible dielectric (3), and the grounded electrode (4) is applied on a surface elastomer surface that faces a surface to be treated by the device, and
wherein the device generates a dielectric barrier surface discharge, to form a cold atmospheric pressure plasma.
2. The device of claim 1, wherein the grounded electrode (4) is has a stripe structure or grid structure comprising interstices therein that remain open, so that the dielectric barrier surface discharge can form in the interstices.
3. The device of claim 1, further comprising:
an electrical connecting cable (5).
4. The device of claim 1, wherein the flexible high-voltage electrode (2) is a metal gauze, a metal foil, a thin film comprising a metal, or a thin film comprising a conductive elastomer.
5. The device of claim 1, wherein the grounded electrode (4) is a metal gauze, a stripe or grid structure film comprising a metal, or a stripe or grid film structure comprising a conductive elastomer.
6. The device of claim 1, wherein the electrodes and dielectric comprise an elastic material and can be shaped to form a hollow body comprising a closed volume, and
wherein a plasma can be ignited both on the inside and the outside of the hollow body.
7. The device of claim 6, in the form of a silicone balloon.
8. The device of claim 6, in the form of at least one selected from the group consisting of a catheter, an endoscope, and a surgical instrument component.
9. The device of claim 1, which can be conformed flexibly to an arbitrarily curved surface.
10. The device of claim 1, in the form of a flexible cuff, a medical strip, or a wound covering.
11. The device of claim 10, in the form of an arm or a leg cuff.
12. The device of claim 10, in the form of a medical strip, wherein the medical strip comprises an adhesive point.
13. The device of claim 10, in the form of a wound covering, which covers a relatively large skin area and is fixed by an additional bandage.
14. The device of claim 1, comprising, as a power source:
a simple, inexpensive power-supply unit with small geometric dimensions, or
a battery.
15. The device claim 14, wherein the power-supply unit can optionally be operated in a pulsed mode of operation to regulate an intensity of the plasma.
16. A method for treating skin or a mucous membrane, the method comprising:
generating a dielectric barrier surface discharge with an electrode system, to form a cold atmospheric pressure plasma; and
administering the plasma to the skin or a mucous membrane of a human or animal subject in need thereof,
wherein the electrode system comprises a flexible material, such that the electrode system can be conformed to a curved surface, and an outer, electrically conductive surface, which is structured as a grounded electrode, wherein a dielectric barrier surface discharge is generated in the interstices of the structure that remain open.
17. The method of claim 16, wherein the electrodes and dielectric comprises an elastic material, and can be shaped to form hollow body comprising a closed volume, and
wherein a plasma is ignited both on the inside and the outside of the hollow body.
18. The method of claim 16, wherein the generating is performed both at atmospheric pressure and at slight overpressure or underpressure, or with a gas mixture.
19. A method for healing a wound, the method comprising:
generating a dielectric barrier surface discharge with the electrode system of claim 1, to form a cold atmospheric pressure plasma; and
administering the plasma to a patient in need thereof.
US13/392,221 2009-08-25 2010-07-27 Device for the planar treatment of areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric pressure plasma Abandoned US20120271225A1 (en)

Applications Claiming Priority (3)

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DE202009011521U DE202009011521U1 (en) 2009-08-25 2009-08-25 Plasma cuff
DE202009011521.6 2009-08-25
PCT/EP2010/060859 WO2011023478A1 (en) 2009-08-25 2010-07-27 Device for the planar treatment of areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric pressure plasma

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US14/732,387 Active 2032-01-07 US10265116B2 (en) 2009-08-25 2015-06-05 Device for the planar treatment of areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric pressure plasma
US16/285,254 Active 2030-09-30 US11006995B2 (en) 2009-08-25 2019-02-26 Device for the planar treatment of areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric pressure plasma

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US16/285,254 Active 2030-09-30 US11006995B2 (en) 2009-08-25 2019-02-26 Device for the planar treatment of areas of human or animal skin or mucous membrane surfaces by means of a cold atmospheric pressure plasma

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EP (1) EP2471348B1 (en)
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WO (1) WO2011023478A1 (en)

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