US20110118843A1 - Intervertebral implant - Google Patents

Intervertebral implant Download PDF

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Publication number
US20110118843A1
US20110118843A1 US13/012,626 US201113012626A US2011118843A1 US 20110118843 A1 US20110118843 A1 US 20110118843A1 US 201113012626 A US201113012626 A US 201113012626A US 2011118843 A1 US2011118843 A1 US 2011118843A1
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US
United States
Prior art keywords
dimensional body
screw holes
front plate
plate
angled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US13/012,626
Inventor
Claude Mathieu
Christopher Marden John Cain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DePuy Spine LLC
DePuy Synthes Products Inc
Original Assignee
Synthes USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27740041&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20110118843(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synthes USA LLC filed Critical Synthes USA LLC
Priority to US13/012,626 priority Critical patent/US20110118843A1/en
Publication of US20110118843A1 publication Critical patent/US20110118843A1/en
Priority to US13/284,762 priority patent/US20120109313A1/en
Priority to US13/284,726 priority patent/US20120109309A1/en
Priority to US13/284,755 priority patent/US20120109312A1/en
Priority to US13/284,742 priority patent/US20120101581A1/en
Priority to US13/284,747 priority patent/US9572681B2/en
Priority to US13/284,731 priority patent/US20120109310A1/en
Assigned to DePuy Synthes Products, LLC reassignment DePuy Synthes Products, LLC CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: HAND INNOVATIONS LLC
Assigned to HAND INNOVATIONS LLC reassignment HAND INNOVATIONS LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DEPUY SPINE, LLC
Assigned to DEPUY SPINE, LLC reassignment DEPUY SPINE, LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SYNTHES USA, LLC
Assigned to SYNTHES USA, LLC reassignment SYNTHES USA, LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SYNTHES GMBH
Assigned to SYNTHES (USA) reassignment SYNTHES (USA) ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CAIN, CHRISTOPHER MARDEN JOHN, MATHIEU, CLAUDE
Assigned to SYNTHES USA, LLC reassignment SYNTHES USA, LLC CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: SYNTHES (U.S.A.)
Assigned to SYNTHES GMBH reassignment SYNTHES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SYNTHES (USA)
Assigned to DePuy Synthes Products, Inc. reassignment DePuy Synthes Products, Inc. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: DePuy Synthes Products, LLC
Priority to US15/401,713 priority patent/US10492922B2/en
Assigned to HAND INNOVATIONS LLC reassignment HAND INNOVATIONS LLC CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT APPL. NO. 13/486,591 PREVIOUSLY RECORDED AT REEL: 030359 FRAME: 0001. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Assignors: DEPUY SPINE, LLC
Assigned to DEPUY SPINE, LLC reassignment DEPUY SPINE, LLC CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT APPLICATION NO. US 13/486,591 PREVIOUSLY RECORDED ON REEL 030358 FRAME 0945. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Assignors: SYNTHES USA, LLC
Priority to US16/672,620 priority patent/US20200060844A1/en
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
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    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
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    • A61F2/44Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/4455Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
    • A61F2/4465Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages having a circular or kidney shaped cross-section substantially perpendicular to the axis of the spine
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    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/80Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
    • A61B17/8052Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates immobilised relative to screws by interlocking form of the heads and plate holes, e.g. conical or threaded
    • AHUMAN NECESSITIES
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
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    • A61F2/442Intervertebral or spinal discs, e.g. resilient
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
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    • A61F2/44Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/4455Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/44Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/4455Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
    • A61F2/447Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages substantially parallelepipedal, e.g. having a rectangular or trapezoidal cross-section
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86Pins or screws or threaded wires; nuts therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/30004Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30593Special structural features of bone or joint prostheses not otherwise provided for hollow
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30772Apertures or holes, e.g. of circular cross section
    • A61F2002/30774Apertures or holes, e.g. of circular cross section internally-threaded
    • AHUMAN NECESSITIES
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    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30772Apertures or holes, e.g. of circular cross section
    • A61F2002/30777Oblong apertures
    • AHUMAN NECESSITIES
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30772Apertures or holes, e.g. of circular cross section
    • A61F2002/3079Stepped or enlarged apertures, e.g. having discrete diameter changes
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    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30841Sharp anchoring protrusions for impaction into the bone, e.g. sharp pins, spikes
    • AHUMAN NECESSITIES
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    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
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    • A61F2250/0014Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
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    • A61F2310/00005The prosthesis being constructed from a particular material
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Definitions

  • the present invention relates to an intervertebral implant.
  • Such an intervertebral implant is known from the British patent document 2,207,607 A which discloses a horseshoe implant structure having a plurality of cylindrical holes. These holes are fitted with inner, smooth surfaces and comprise only one stop for the heads of the bone screws to be inserted into them.
  • This design incurs the drawback that the inserted affixation screws may be anchored into the bone only by their shanks, a rigid connection with the horseshoe shaped intervertebral implant being lacking.
  • the intervertebral implant becomes displaceable relative to the screw and the bone screws may then migrate while endangering the blood vessels.
  • the loosening of the intervertebral implant may entail pseudoarthrosis.
  • the objective of the present invention is palliation.
  • This invention creates an intervertebral implant which is able to rigidly connect to bone affixation means in a manner that even in the event of bone structure weakening, loosening between the intervertebral implant and the bone affixation means shall be precluded.
  • the advantages offered by the present invention substantially are attained by the rigid, that is by the firm connection between the intervertebral implant and the longitudinal affixing elements. Basically two different embodiment modes are available to attain said rigid connection.
  • At least one of the boreholes shall be internally threaded.
  • a matching bone screw fitted with a thread head may be rigidly screwed into the implant.
  • a front plate is mounted at the front surface of the three dimensional (3D) implant structure so as to be configured vertically to the horizontal center plane of the intervertebral implant, said boreholes passing through said front plate and receiving the anchored longitudinal affixation elements.
  • the above design of the present invention offers the advantage that the intervertebral implant shall be implanted in a single step and hence in a simple and quicker manner.
  • the invention offers a further advantage in that the intervertebral implant shall be affixed as frontally to the vertebra as possible, namely at a place where good bone material may be expected to be.
  • anterior displacement is restricted without thereby incurring greater danger to the surrounding structures than when using a state of the art intervertebral implant.
  • the load still is being borne by the compressed vertebral implant, not by the front plate or the affixation screws.
  • the front plate is displaceably configured in the 3D implant structure in order that it may move vertically relative to this 3D implant structure. “Stress shielding” is attained in this manner (namely protection from or neutralization of mechanical stresses), and as a result the end plates may gradually match the intervertebral implant during the healing process.
  • the front plate is made of a material different from that of the 3D implant structure.
  • At least one borehole tapers conically towards its underside and as a result a bone screw fitted with a matching conical head may be rigidly anchored in said borehole.
  • the conical borehole exhibits a cone angle smaller than the resultant angle of friction.
  • the borehole's conicity shall be 1:3.75 to 1:20, preferably 1:5 to 1:15.
  • the intervertebral implant side faces shall all be substantially convex.
  • intervertebral implant's top and/or undersides are not planar but convex. In this manner better matching to the end plates of the adjacent vertebras may be attained.
  • the boreholes preferably shall not pass through the left and right intervertebral implant side faces. Preferably again no borehole shall run through the front surface.
  • At least two boreholes shall be mutually parallel. This features facilitates inserting the vertebral implant during implantation.
  • At least two boreholes shall run in mutually divergent manner as seen from the front side.
  • the bone screws shall move into a vertebral region offering better bone quality than found at the vertebra's center.
  • the borehole axes subtend an angle of 25 degrees to 70 degrees, preferably 35 degrees to 55 degrees with the horizontal center plane. This feature offers improved access for screw insertion.
  • the boreholes shall not cross the horizontal center plane.
  • two, three, four or even more longitudinal affixation elements may rigidly connected to the intervertebral implant; appropriately at least one affixation element shall pass through the top side and at least one affixation element shall pass through the intervertebral implant side.
  • the longitudinal affixation elements shall be bone screws comprising a head and a shank, said head preferably being fitted with an external thread that matches the inner thread of the intervertebral implant's borehole.
  • a bone screw shall be used of which the head tapers conically in the direction of the shank, the head's conicity corresponding to that of the intervertebral implant's borehole.
  • At least two longitudinal affixation elements pass through the top side and at least two longitudinal affixation elements pass through the underside. In this manner the intervertebral implant is optimally anchored into the adjacent vertebras.
  • the screw-shaped longitudinal affixation elements exhibit a self-boring and self-tapping external thread.
  • the longitudinal affixation elements also may be designed as unthreaded cylindrical pins fitted with a boring tip, preferably in the form of a trocar.
  • the longitudinal affixation elements are spiral springs; lastly said longitudinal affixation elements also may be designed as single or multi-wing spiral blades.
  • the longitudinal affixation element tip may be anchored in the structure of the intervertebral implant, as a result of which the head of the longitudinal affixation element may be anchored in the adjacent vertebra.
  • the longitudinal affixation element head exhibits a widened diameter; also a support disk is provided for said head to rest against the vertebra.
  • the intervertebral implant may be made of any physiologically compatible material, though appropriately the implant structure shall consist of a physiologically compatible plastic, preferably an unreinforced plastic.
  • a physiologically compatible plastic preferably an unreinforced plastic.
  • the advantage offered by the invention over the already known, fiber-reinforced plastics used in implantology is that no reinforcing fibers will be bared—an eventuality that would be clinically disadvantageous.
  • Appropriately bone screws consisting of non-reinforced plastic of which the external threads exhibit load bevels of 11 degrees to 14 degrees, preferably 12 degrees to 13 degrees, may be used in such an implant structure.
  • the relatively small slope of the load bevel implements high clamping forces, as a result of which radial elongation and danger of cracking of the plastic are reduced.
  • the bone screws' external thread exhibits the bones at an angular pitch of 6 degrees to 10 degrees, preferably 7 degrees to 9 degrees. This particular angular pitch produces thread self-locking and prevent
  • the borehole may be in the form of a metal bush fitted with an inner thread for the purpose of improving anchoring the bone screw in the plastic implant structure.
  • the intervertebral implant also may consist partly of plastic and, in the borehole zones, of metal. This design offers improved guidance and anchoring of the bone screw in the intervertebral implant.
  • the inside borehole walls are smooth, the thread head of a metallic, longitudinal affixation element cutting or tapping into said smooth wall.
  • FIG. 1 is a perspective view including a partial section of the intervertebral implant with inserted bone screws
  • FIG. 2 is a front view of the intervertebral implant of FIG. 1 ,
  • FIG. 3 is a side view of the intervertebral implant of FIG. 1 .
  • FIG. 4 is a top view of the intervertebral implant of FIG. 1 .
  • FIG. 5 is a front view of the intervertebral implant with a front insert, in partial section,
  • FIG. 6 is a vertical, longitudinal section of the intervertebral implant of FIG. 5 .
  • FIG. 7 is a horizontal cross-section of the intervertebral implant of FIG. 5 .
  • the intervertebral implant of FIGS. 1 through 4 consists of a 3D structure 10 exhibiting both a convex top side 1 and a convex underside 2 , the two sides each being designed to rest against the end plates of two adjacent vertebras.
  • the top side 1 and the underside 2 may be topographically shaped and be fitted with grooves, ribs or teeth, or their surfaces may be merely roughened.
  • the 3D implant structure 10 moreover comprises a left side face 3 and a right side face 4 , also a front face 5 and a rear face 6 .
  • the implant structure 10 also may be hollow and its outer surface may comprise perforations.
  • the implant structure 10 comprises a plurality of boreholes 9 passing through it and receiving longitudinal affixation elements 20 . Preferably four such boreholes 9 shall be provided.
  • At least one of the boreholes 9 is designed in a way that the longitudinal affixation element 20 received therein may be rigidly connected to the intervertebral implant.
  • the boreholes 9 are conical for that purpose.
  • the affixation elements 20 are bone screws having a head 21 and a tip 22 .
  • the head 21 conically tapers toward the shank 23 , the conicity of the head 21 corresponding to the conicity of the borehole 9 .
  • the four boreholes 9 may be fitted with inner threads 11 .
  • the 3D structure 10 is fitted at its front face 5 with a preferably metallic insert 8 into which the affixation elements 20 may be anchored.
  • the insert 8 is mounted in vertically displaceable manner in the 3D structure 10 .

Abstract

The intervertebral implant is in the form of a three-dimensional structure (10) comprising (a) a top side (1) and an underside (2) which are designed to rest against the end plates of two adjacent vertebras, (b) a left side face (3) and a right side face (4), (c) a front face (5) and a rear face (6), (d) a horizontal center plane situated between the top side (1) and the underside (2), (e) a vertical center plane (8) situated between the left side face (3) and the right side face (8) and (f) a plurality of boreholes (9) passing through the implant structure (10) that are designed to receive longitudinal affixation elements (20), the axes (19) of said elements intersecting the horizontal center plane (7). At least one of the boreholes (9) is designed in a manner that the affixation element (10) received in it can be rigidly connected to the intervertebral implant. Said connection is implemented using a thread or by matching conical surfaces.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • This application is a continuation of U.S. patent application Ser. No. 12/574,222, filed Oct. 6, 2009, which is a continuation of U.S. patent application Ser. No. 11/751,757, filed May 22, 2007, now U.S. Pat. No. 7,618,456, which is a continuation of U.S. patent application Ser. No. 10/923,534, filed Aug. 19, 2004, now U.S. Pat. No. 7,232,464, which is a continuation of International Application No. PCT/CH02/00099, filed Feb. 19, 2002. The entire contents of these applications are expressly incorporated herein by reference thereto.
  • FIELD OF THE INVENTION
  • The present invention relates to an intervertebral implant.
  • BACKGROUND OF THE INVENTION
  • Such an intervertebral implant is known from the British patent document 2,207,607 A which discloses a horseshoe implant structure having a plurality of cylindrical holes. These holes are fitted with inner, smooth surfaces and comprise only one stop for the heads of the bone screws to be inserted into them. This design incurs the drawback that the inserted affixation screws may be anchored into the bone only by their shanks, a rigid connection with the horseshoe shaped intervertebral implant being lacking. As soon as the anchoring of the bone screw in the bone is weakened, the intervertebral implant becomes displaceable relative to the screw and the bone screws may then migrate while endangering the blood vessels. Moreover the loosening of the intervertebral implant may entail pseudoarthrosis.
  • The above cited state of the art is intended merely to elucidate the background of the present invention but it does imply that the cited state of the art had actually been made public or was publicly known at the time of this application or at the time of its priority.
  • BRIEF SUMMARY OF THE INVENTION
  • The objective of the present invention is palliation. This invention creates an intervertebral implant which is able to rigidly connect to bone affixation means in a manner that even in the event of bone structure weakening, loosening between the intervertebral implant and the bone affixation means shall be precluded.
  • The above problem is solved in the present invention by an intervertebral implant exhibiting the features of claim 1.
  • The advantages offered by the present invention substantially are attained by the rigid, that is by the firm connection between the intervertebral implant and the longitudinal affixing elements. Basically two different embodiment modes are available to attain said rigid connection.
  • In a first embodiment mode, at least one of the boreholes shall be internally threaded. In this case a matching bone screw fitted with a thread head may be rigidly screwed into the implant.
  • As regards a second embodiment mode, a front plate is mounted at the front surface of the three dimensional (3D) implant structure so as to be configured vertically to the horizontal center plane of the intervertebral implant, said boreholes passing through said front plate and receiving the anchored longitudinal affixation elements. Compared to the state of the art of a two-part implant, wherein a front plate is implanted in a separate operational step, the above design of the present invention offers the advantage that the intervertebral implant shall be implanted in a single step and hence in a simple and quicker manner. The invention offers a further advantage in that the intervertebral implant shall be affixed as frontally to the vertebra as possible, namely at a place where good bone material may be expected to be. As a result anterior displacement is restricted without thereby incurring greater danger to the surrounding structures than when using a state of the art intervertebral implant. The load still is being borne by the compressed vertebral implant, not by the front plate or the affixation screws.
  • In yet another embodiment mode of the present invention, the front plate is displaceably configured in the 3D implant structure in order that it may move vertically relative to this 3D implant structure. “Stress shielding” is attained in this manner (namely protection from or neutralization of mechanical stresses), and as a result the end plates may gradually match the intervertebral implant during the healing process.
  • As regards a further embodiment, the front plate is made of a material different from that of the 3D implant structure.
  • As regards a further embodiment of the present invention, at least one borehole tapers conically towards its underside and as a result a bone screw fitted with a matching conical head may be rigidly anchored in said borehole. Preferably the conical borehole exhibits a cone angle smaller than the resultant angle of friction. Appropriately the borehole's conicity shall be 1:3.75 to 1:20, preferably 1:5 to 1:15.
  • As regards a further embodiment mode of the present invention, the intervertebral implant side faces shall all be substantially convex.
  • Appropriately the intervertebral implant's top and/or undersides are not planar but convex. In this manner better matching to the end plates of the adjacent vertebras may be attained.
  • The boreholes preferably shall not pass through the left and right intervertebral implant side faces. Preferably again no borehole shall run through the front surface.
  • As regards a further preferred embodiment mode of the present invention, at least two boreholes shall be mutually parallel. This features facilitates inserting the vertebral implant during implantation.
  • As regards another preferred embodiment mode of the present invention, at least two boreholes shall run in mutually divergent manner as seen from the front side. As a result the bone screws shall move into a vertebral region offering better bone quality than found at the vertebra's center. Appropriately the borehole axes subtend an angle of 25 degrees to 70 degrees, preferably 35 degrees to 55 degrees with the horizontal center plane. This feature offers improved access for screw insertion.
  • As regards a further embodiment mode of the present invention, the boreholes shall not cross the horizontal center plane.
  • Depending on circumstance, two, three, four or even more longitudinal affixation elements may rigidly connected to the intervertebral implant; appropriately at least one affixation element shall pass through the top side and at least one affixation element shall pass through the intervertebral implant side.
  • Preferably the longitudinal affixation elements shall be bone screws comprising a head and a shank, said head preferably being fitted with an external thread that matches the inner thread of the intervertebral implant's borehole. As regards a second appropriate connection, preferably a bone screw shall be used of which the head tapers conically in the direction of the shank, the head's conicity corresponding to that of the intervertebral implant's borehole.
  • Regarding a further embodiment mode, at least two longitudinal affixation elements pass through the top side and at least two longitudinal affixation elements pass through the underside. In this manner the intervertebral implant is optimally anchored into the adjacent vertebras.
  • Preferably the screw-shaped longitudinal affixation elements exhibit a self-boring and self-tapping external thread. The longitudinal affixation elements also may be designed as unthreaded cylindrical pins fitted with a boring tip, preferably in the form of a trocar.
  • In another embodiment variation, the longitudinal affixation elements are spiral springs; lastly said longitudinal affixation elements also may be designed as single or multi-wing spiral blades.
  • In a further embodiment mode of the present invention, the longitudinal affixation element tip may be anchored in the structure of the intervertebral implant, as a result of which the head of the longitudinal affixation element may be anchored in the adjacent vertebra.
  • In a further embodiment mode of the present invention, the longitudinal affixation element head exhibits a widened diameter; also a support disk is provided for said head to rest against the vertebra.
  • The intervertebral implant may be made of any physiologically compatible material, though appropriately the implant structure shall consist of a physiologically compatible plastic, preferably an unreinforced plastic. The advantage offered by the invention over the already known, fiber-reinforced plastics used in implantology is that no reinforcing fibers will be bared—an eventuality that would be clinically disadvantageous. Appropriately bone screws consisting of non-reinforced plastic of which the external threads exhibit load bevels of 11 degrees to 14 degrees, preferably 12 degrees to 13 degrees, may be used in such an implant structure. The relatively small slope of the load bevel implements high clamping forces, as a result of which radial elongation and danger of cracking of the plastic are reduced. Appropriately the bone screws' external thread exhibits the bones at an angular pitch of 6 degrees to 10 degrees, preferably 7 degrees to 9 degrees. This particular angular pitch produces thread self-locking and prevents the bone screw from loosening on its own.
  • The borehole may be in the form of a metal bush fitted with an inner thread for the purpose of improving anchoring the bone screw in the plastic implant structure. The intervertebral implant also may consist partly of plastic and, in the borehole zones, of metal. This design offers improved guidance and anchoring of the bone screw in the intervertebral implant.
  • As regards a further preferred embodiment mode, the inside borehole walls are smooth, the thread head of a metallic, longitudinal affixation element cutting or tapping into said smooth wall.
  • BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS
  • The present invention and further embodiment modes of it are elucidated below in relation to the partly schematic representation of two illustrative embodiments.
  • FIG. 1 is a perspective view including a partial section of the intervertebral implant with inserted bone screws,
  • FIG. 2 is a front view of the intervertebral implant of FIG. 1,
  • FIG. 3 is a side view of the intervertebral implant of FIG. 1,
  • FIG. 4 is a top view of the intervertebral implant of FIG. 1,
  • FIG. 5 is a front view of the intervertebral implant with a front insert, in partial section,
  • FIG. 6 is a vertical, longitudinal section of the intervertebral implant of FIG. 5, and
  • FIG. 7 is a horizontal cross-section of the intervertebral implant of FIG. 5.
  • DETAILED DESCRIPTION OF THE INVENTION
  • The intervertebral implant of FIGS. 1 through 4 consists of a 3D structure 10 exhibiting both a convex top side 1 and a convex underside 2, the two sides each being designed to rest against the end plates of two adjacent vertebras. To attain improved anchoring, the top side 1 and the underside 2 may be topographically shaped and be fitted with grooves, ribs or teeth, or their surfaces may be merely roughened.
  • The 3D implant structure 10 moreover comprises a left side face 3 and a right side face 4, also a front face 5 and a rear face 6. The implant structure 10 also may be hollow and its outer surface may comprise perforations.
  • The implant structure 10 comprises a plurality of boreholes 9 passing through it and receiving longitudinal affixation elements 20. Preferably four such boreholes 9 shall be provided.
  • At least one of the boreholes 9 is designed in a way that the longitudinal affixation element 20 received therein may be rigidly connected to the intervertebral implant. The boreholes 9 are conical for that purpose.
  • Preferably the affixation elements 20 are bone screws having a head 21 and a tip 22. The head 21 conically tapers toward the shank 23, the conicity of the head 21 corresponding to the conicity of the borehole 9. Moreover the four boreholes 9 may be fitted with inner threads 11.
  • As regards the embodiment variation shown in FIGS. 5 through 7, the 3D structure 10 is fitted at its front face 5 with a preferably metallic insert 8 into which the affixation elements 20 may be anchored. The insert 8 is mounted in vertically displaceable manner in the 3D structure 10.
  • While the invention has been shown and described herein with reference to particular embodiments, it is to be understood that the various additions, substitutions, or modifications of form, structure, arrangement, proportions, materials, and components and otherwise, used in the practice and which are particularly adapted to specific environments and operative requirements, may be made to the described embodiments without departing from the spirit and scope of the present invention. Accordingly, it should be understood that the embodiments disclosed herein are merely illustrative of the principles of the invention. Various other modifications may be made by those skilled in the art which will embody the principles of the invention and fall within the spirit and the scope thereof.

Claims (33)

1. A bone stabilizing system for stabilizing first and second vertebrae in a spinal column comprising:
a plurality of bone screws having a threaded shaft and a head, the shaft having a longitudinal central axis;
a three dimensional body configured for insertion between the endplates of vertebrae, the three dimensional body having an upper surface for abutting the endplate of the first vertebrae, a lower surface for abutting the endplate of the second vertebrae, a front surface, and a horizontal center plane between the upper and lower surface; and
a front plate having a top surface and a bottom surface, the plate coupleable to the body such that the bottom surface is adjacent to and at least partially overlies the front surface, the plate having a plurality of screw holes for receiving the shafts of the screws, the screw holes extending through the plate and having a central axis, at least two screw holes extending through the plate at an angle such that the central axis of the screw hole ranges from about 25° to about 70° with respect to the horizontal center plane or a plane parallel to the horizontal center plane.
2. The system of claim 1, wherein the three dimensional body has a plurality of boreholes, the boreholes extending from the front surface to at least one of the upper surface and the lower surface.
3. The system of claim 2, wherein, when the plate is coupled to the three-dimensional body, the three-dimensional body and at least one of the angled screw holes in the front plate is configured and oriented such that one of the screws inserted into that angled screw hole pierces at least partially at least one of the upper surface and the lower surface of the three-dimensional body.
4. The system of claim 1, wherein, when the front plate is secured to the three-dimensional body, the central axis of at least one of the angled screw holes extends toward the upper surface of the three-dimensional body and the axis of at least one of the angled screw holes extends toward the lower surface of the three-dimensional body.
5. The system of claim 1, wherein the three-dimensional body is made from a non-metallic material.
6. The system of claim 5, wherein the front plate is formed of a metallic material.
7. The system of claim 1 wherein the front plate has a superior surface and an inferior surface and a height between the superior surface and the inferior surface and wherein the front surface of the three-dimensional body has a height between the upper surface and lower surface that is substantially equal to the height of the front plate.
8. The system of claim 1, wherein the first plate has a superior surface and an inferior surface and a height between the superior surface and the inferior surface and the three-dimensional body has a height between the upper surface and lower surface, wherein the maximum height of the three-dimensional body is substantially equal to or greater than the height of the front plate.
9. The system of claim 1, wherein the three-dimensional body further includes at least one borehole in communication with the front surface and one of the upper surface or the lower surface and the front plate is couplable with the three dimensional body so that at least one of the angled screw holes formed in the front plate aligns with the at least one borehole in the three-dimensional body so that one of the bone screws is insertable through the angled screw hole formed in the plate, through the recess formed in the three dimensional bodies and into one of the vertebrae.
10. The system of claim 1, wherein the three dimensional body includes at least one through hole extending from the upper surface to the lower surface.
11. The system of claim 1, wherein at least one of the angled screw holes formed in the front plate is conically shaped such that it tapers conically towards the front plate's bottom surface.
12. The system of claim 1, wherein one of the angled screw holes in the front plate includes internal threads, and at least a portion of the head of one of the bone screws has external threads for engaging the internal thread of the angled screw hole.
13. The system of claim 1, wherein at least one the angled screw holes in the front plate has internal threads and that threaded portion is conically tapered and wherein a plurality of the bone screws have at least a portion of their heads externally threaded.
14. The system of claim 1, wherein one of the upper and lower surfaces of the three-dimensional body is convex.
15. The system of claim 1, wherein the front plate has a plurality of angular screw holes and the three-dimensional body has a plurality of boreholes for alignment with the angular screw holes wherein the angular screw holes when aligned with the boreholes form passages for the screws that diverge as the passages extend away from the front surface into the three-dimensional body.
16. The system of claim 1, wherein the front plate has a plurality of angular screw holes and the three-dimensional body has a plurality of boreholes for alignment with the angular screw holes, wherein the angular screw holes when aligned with the boreholes form passages for the screws that are parallel as they extend away from the front surface into the three-dimensional body.
17. The system of claim 1, wherein the three dimensional body further has a convex left side surface, a convex right side surface and a back surface.
18. The system of claim 2, wherein the three-dimensional body further includes a left-side surface, a convex right side surface and a back surface, and the three-dimensional body does not have boreholes to receive screws that pass through either the left side or the right side.
19. The system of claim 1, wherein the three-dimensional body has angular boreholes that extend from the front face to at least one of the upper surface and the lower surface and the boreholes do not cross the horizontal plane.
20. A spine stabilizing system for stabilizing first and second vertebrae in a spinal column comprising:
a plurality of bone screws having a threaded shaft and a head, the shaft having a longitudinal central axis;
a three dimensional body formed of plastic configured for insertion between endplates of the first and second vertebrae, the three dimensional body having an upper surface for abutting the endplate of a first vertebrae, a lower surface for abutting the endplate of a second vertebrae, a front surface, and a horizontal center plane between the upper and lower surface; and
a front plate formed of a metallic material having a top surface, a bottom surface, a superior surface and an inferior surface, the plate couplable to the three dimensional body such that the bottom surface overlies the front surface, the plate having a plurality of screw holes for receiving there through the shaft of the screws, the screw holes having a central axis and extending through the plate at an angle such that the central axis of the screw hole ranges from about 25° to about 70° with respect to the horizontal center plane or a plane parallel to the horizontal center plane,
wherein a first angled screw hole is angled in the front plate toward the superior surface of the front plate and the second angled screw hole is angled in the front plate toward the inferior surface of the front plate.
21. The system of claim 20, wherein at least one of the angled screw holes includes internal threads.
22. The system of claim 20, wherein at least one of the screws includes external threading at least partially on its head.
23. The system of claim 20, wherein the height of the front plate is substantially equal to the height of the front surface of the three-dimensional body.
24. The system of claim 20, wherein the three dimensional body has a horizontal middle plane between the upper surface and the lower surface, and the front plate is coupleable to the three dimensional body such that the axis of at least two angled screw holes define an angle ranging from about 25° to about 70° with the horizontal middle plane.
25. A spine stabilizing system for stabilizing first and second vertebrae in a spinal column comprising:
a plurality of bone screws having a threaded shaft and a head, the shaft having a longitudinal central axis;
a three dimensional body configured for insertion between endplates of the first and second vertebrae, the three dimensional body having an upper surface for abutting the endplate of a first vertebrae, a lower surface for abutting the endplate of a second vertebrae, a left side surface and a right side surface, a front surface and a back surface, the three dimensional body having a horizontal central plane between the upper and lower surface, the three-dimensional body having a plurality of boreholes for receiving there through the screws, at least one borehole extending from the front surface to the upper surface of the three dimensional body and at least one borehole extending from the front surface to the lower surface of the three dimensional body, each borehole having a central axis wherein each central axis is at an angle in the range of about 25° to about 70° relative to the horizontal middle plane of the body.
26. The system of claim 25, wherein the plurality of bore holes are aligned in the front surface in a horizontal line.
27. The system of claim 25, further comprising:
a front plate having a top surface, a bottom surface, a superior surface and an inferior surface, the plate couplable to the three dimensional body such that the bottom surface overlies the front surface, the plate having a plurality of screw holes for receiving there through the shaft of the screws, the screw holes having a central axis, at least two of the plurality of screw holes extending through the front plate so that the axis of the screw hole is at an angle that is substantially equal to the angle of the boreholes in the three-dimensional body,
wherein the position and orientation of the front plate is such that the at least two angled boreholes in the three dimensional body are aligned with the at least two angled screw holes in the front plate so that the screws are insertable in the front plate so that its shaft extends out of respective upper and lower surfaces of the three-dimensional body.
28. The system of claim 27, wherein when the plate is coupled to the three-dimensional body, the three-dimensional body and at least one of the screw holes in the front plate are configured and oriented such that one of the screws inserted into the angled screw hole pierces at least partially one of the upper or lower surfaces of the three-dimensional body.
29. The system of claim 25, wherein the three dimensional body is formed of a non-metallic material.
30. The system of claim 25, wherein the three dimensional body includes at least one through hole extending from the upper surface to the lower surface.
31. The system of claim 27, wherein at least one of the angled screw holes formed in the front plate is conically shaped.
32. The system of claim 25, wherein one of the upper and lower surfaces of the three-dimensional body is convex.
33. The system of claim 25, wherein at least one of the upper surface and the lower surface includes one of the group of grooves, ribs, teeth and roughened surface portion to improve anchoring of the three-dimensional body with the vertebrae.
US13/012,626 2002-02-19 2011-01-24 Intervertebral implant Abandoned US20110118843A1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US13/012,626 US20110118843A1 (en) 2002-02-19 2011-01-24 Intervertebral implant
US13/284,742 US20120101581A1 (en) 2002-02-19 2011-10-28 Intervertebral implant
US13/284,747 US9572681B2 (en) 2002-02-19 2011-10-28 Intervertebral implant
US13/284,731 US20120109310A1 (en) 2002-02-19 2011-10-28 Intervertebral Implant
US13/284,762 US20120109313A1 (en) 2002-02-19 2011-10-28 Intervertebral Implant
US13/284,726 US20120109309A1 (en) 2002-02-19 2011-10-28 Intervertebral implant
US13/284,755 US20120109312A1 (en) 2002-02-19 2011-10-28 Intervertebral implant
US15/401,713 US10492922B2 (en) 2002-02-19 2017-01-09 Intervertebral implant
US16/672,620 US20200060844A1 (en) 2002-02-19 2019-11-04 Intervertebral implant

Applications Claiming Priority (5)

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PCT/CH2002/000099 WO2003070128A1 (en) 2002-02-19 2002-02-19 Intervertebral implant
US10/923,534 US7232464B2 (en) 2002-02-19 2004-08-19 Intervertebral implant
US11/751,757 US7618456B2 (en) 2002-02-19 2007-05-22 Intervertebral implant
US12/574,222 US7875076B2 (en) 2002-02-19 2009-10-06 Intervertebral implant
US13/012,626 US20110118843A1 (en) 2002-02-19 2011-01-24 Intervertebral implant

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US12/574,222 Continuation US7875076B2 (en) 2002-02-19 2009-10-06 Intervertebral implant

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US13/284,755 Continuation US20120109312A1 (en) 2002-02-19 2011-10-28 Intervertebral implant
US13/284,747 Continuation US9572681B2 (en) 2002-02-19 2011-10-28 Intervertebral implant
US13/284,726 Continuation US20120109309A1 (en) 2002-02-19 2011-10-28 Intervertebral implant
US13/284,742 Continuation US20120101581A1 (en) 2002-02-19 2011-10-28 Intervertebral implant
US13/284,731 Continuation US20120109310A1 (en) 2002-02-19 2011-10-28 Intervertebral Implant
US13/284,762 Continuation US20120109313A1 (en) 2002-02-19 2011-10-28 Intervertebral Implant

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US10/923,534 Expired - Lifetime US7232464B2 (en) 2002-02-19 2004-08-19 Intervertebral implant
US11/751,757 Expired - Lifetime US7618456B2 (en) 2002-02-19 2007-05-22 Intervertebral implant
US12/574,222 Expired - Fee Related US7875076B2 (en) 2002-02-19 2009-10-06 Intervertebral implant
US13/012,626 Abandoned US20110118843A1 (en) 2002-02-19 2011-01-24 Intervertebral implant
US13/284,747 Expired - Lifetime US9572681B2 (en) 2002-02-19 2011-10-28 Intervertebral implant
US13/284,726 Abandoned US20120109309A1 (en) 2002-02-19 2011-10-28 Intervertebral implant
US13/284,731 Abandoned US20120109310A1 (en) 2002-02-19 2011-10-28 Intervertebral Implant
US13/284,742 Abandoned US20120101581A1 (en) 2002-02-19 2011-10-28 Intervertebral implant
US13/284,755 Abandoned US20120109312A1 (en) 2002-02-19 2011-10-28 Intervertebral implant
US13/284,762 Abandoned US20120109313A1 (en) 2002-02-19 2011-10-28 Intervertebral Implant
US15/401,713 Expired - Lifetime US10492922B2 (en) 2002-02-19 2017-01-09 Intervertebral implant
US16/672,620 Pending US20200060844A1 (en) 2002-02-19 2019-11-04 Intervertebral implant

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US11/751,757 Expired - Lifetime US7618456B2 (en) 2002-02-19 2007-05-22 Intervertebral implant
US12/574,222 Expired - Fee Related US7875076B2 (en) 2002-02-19 2009-10-06 Intervertebral implant

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US13/284,726 Abandoned US20120109309A1 (en) 2002-02-19 2011-10-28 Intervertebral implant
US13/284,731 Abandoned US20120109310A1 (en) 2002-02-19 2011-10-28 Intervertebral Implant
US13/284,742 Abandoned US20120101581A1 (en) 2002-02-19 2011-10-28 Intervertebral implant
US13/284,755 Abandoned US20120109312A1 (en) 2002-02-19 2011-10-28 Intervertebral implant
US13/284,762 Abandoned US20120109313A1 (en) 2002-02-19 2011-10-28 Intervertebral Implant
US15/401,713 Expired - Lifetime US10492922B2 (en) 2002-02-19 2017-01-09 Intervertebral implant
US16/672,620 Pending US20200060844A1 (en) 2002-02-19 2019-11-04 Intervertebral implant

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