EP0578776A4 - Inhibition d'un retrovirus a l'aide d'acides nucleiques non codants s'hybridant sur des sequences d'encapsidation. - Google Patents

Inhibition d'un retrovirus a l'aide d'acides nucleiques non codants s'hybridant sur des sequences d'encapsidation.

Info

Publication number
EP0578776A4
EP0578776A4 EP92910993A EP92910993A EP0578776A4 EP 0578776 A4 EP0578776 A4 EP 0578776A4 EP 92910993 A EP92910993 A EP 92910993A EP 92910993 A EP92910993 A EP 92910993A EP 0578776 A4 EP0578776 A4 EP 0578776A4
Authority
EP
European Patent Office
Prior art keywords
retrovirus
inhibition
antisense nucleic
nucleic acids
acids complementary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP92910993A
Other languages
German (de)
English (en)
Other versions
EP0578776A1 (fr
Inventor
Thomas E Wagner
Lei Han
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EDISON ANIMAL BIOTECHNOLOGY CE
EDISON ANIMAL BIOTECH CENTER
Original Assignee
EDISON ANIMAL BIOTECHNOLOGY CE
EDISON ANIMAL BIOTECH CENTER
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EDISON ANIMAL BIOTECHNOLOGY CE, EDISON ANIMAL BIOTECH CENTER filed Critical EDISON ANIMAL BIOTECHNOLOGY CE
Publication of EP0578776A1 publication Critical patent/EP0578776A1/fr
Publication of EP0578776A4 publication Critical patent/EP0578776A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

Cette invention concerne des molécules d'acide nucléique non codantes qui ne s'hybrident pratiquement que sur la séquence d'encapsidation d'un retrovirus et qui inhibent par conséquent l'encapsidation de l'ARN du génome du rétrovirus. Les molecules non codantes peuvent être de l'ADN, de l'ARN, ou des analogues de ces derniers. On peut administrer les molécules non codantes sous forme médicamenteuse ou bien l'individu devant être protégé peut être soumis à des manipulations génétiques afin d'exprimer un ARN non codant.
EP92910993A 1991-04-05 1992-04-03 Inhibition d'un retrovirus a l'aide d'acides nucleiques non codants s'hybridant sur des sequences d'encapsidation. Withdrawn EP0578776A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US680873 1984-12-12
US68087391A 1991-04-05 1991-04-05

Publications (2)

Publication Number Publication Date
EP0578776A1 EP0578776A1 (fr) 1994-01-19
EP0578776A4 true EP0578776A4 (fr) 1995-04-12

Family

ID=24732881

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92910993A Withdrawn EP0578776A4 (fr) 1991-04-05 1992-04-03 Inhibition d'un retrovirus a l'aide d'acides nucleiques non codants s'hybridant sur des sequences d'encapsidation.

Country Status (5)

Country Link
EP (1) EP0578776A4 (fr)
JP (1) JPH06506599A (fr)
AU (1) AU655279B2 (fr)
CA (1) CA2107789A1 (fr)
WO (1) WO1992017211A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4126484A1 (de) * 1991-08-10 1993-02-11 Bayer Ag Expressionsvektoren und deren verwendung zur darstellung hiv-resistenter menschlicher zellen fuer therapeutische anwendungen
DE4225094A1 (de) * 1992-04-28 1993-11-04 Frank Andreas Harald Meyer Medikament zur gentherapeutischen behandlung von menschen, tieren und pflanzen, insbesondere zur blockierung der virenvermehrung und der tumorgene sowie verfahren zur herstellung des medikaments
AU692423B2 (en) 1992-09-25 1998-06-11 Institut National De La Sante Et De La Recherche Medicale Adenovirus vectors for the transfer of foreign genes into cells of the central nervous system, particularly in brain
EP0598935A1 (fr) * 1992-11-24 1994-06-01 Bayer Ag Vecteurs d'expression et leur utilisation pour la production de cellules humaines résistantes à HIV pour utilisation thérapeutique
US5583035A (en) * 1992-12-07 1996-12-10 Bayer Aktiengesellschaft HIV antisense expression vectors
FR2702152B1 (fr) * 1993-03-03 1995-05-24 Inst Nat Sante Rech Med Virus recombinants et leur utilisation en thérapie génique.
PT1298208E (pt) * 1994-01-05 2006-10-31 Gene Shears Pty Ltd Ribozimas que abordam selectivamente uma sequencia tat do hiv
US5712384A (en) * 1994-01-05 1998-01-27 Gene Shears Pty Ltd. Ribozymes targeting retroviral packaging sequence expression constructs and recombinant retroviruses containing such constructs
KR100696410B1 (ko) * 1994-01-05 2008-11-07 진 쉬어즈 피티와이., 엘티디. 레트로바이러스 패키징 서열 발현 제작물을 표적으로 하는 리보자임 및 그러한 제작물을 가진 재조합 레트로바이러스
WO1995027783A1 (fr) * 1994-04-06 1995-10-19 Joshi Sukhwal Sadna Inhibition de la multiplication du vih-1 dans des cellules de mammiferes
US20020058636A1 (en) * 1994-09-21 2002-05-16 Geoffrey P. Symonds Ribozymes targeting the retroviral packaging sequence expression constructs and recombinant retroviruses containing such constructs
EP1414996B1 (fr) 2001-07-10 2010-12-01 Johnson & Johnson Research Pty Limited Procedes de modification genetique des cellules progenitrices hematopoietiques et utilisation des cellules modifiees
US7994144B2 (en) 2001-07-10 2011-08-09 Johnson & Johnson Research Pty, Limited Process for the preparation of a composition of genetically modified hematopoietic progenitor cells

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4740463A (en) * 1984-04-13 1988-04-26 Massachusetts Institute Of Technology Methods and artificial genes for antagonizing the function of an oncogene
WO1988010311A1 (fr) * 1987-06-26 1988-12-29 Syntro Corporation Cytomegalovirus humain recombinant contenant des genes etrangers et son utilisation
WO1989008146A1 (fr) * 1988-02-26 1989-09-08 Worcester Foundation For Experimental Biology Inhibition du htlv-iii par des oligonucleotides exogenes
EP0331939A2 (fr) * 1988-02-16 1989-09-13 Greatbatch Gen-Aid, Ltd Procédé et compositions pour conférer de la résistance aux infections rétrovirales

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4757055A (en) * 1980-11-12 1988-07-12 The Johns Hopkins University Method for selectively controlling unwanted expression or function of foreign nucleic acids in animal or mammalian cells

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4740463A (en) * 1984-04-13 1988-04-26 Massachusetts Institute Of Technology Methods and artificial genes for antagonizing the function of an oncogene
WO1988010311A1 (fr) * 1987-06-26 1988-12-29 Syntro Corporation Cytomegalovirus humain recombinant contenant des genes etrangers et son utilisation
EP0331939A2 (fr) * 1988-02-16 1989-09-13 Greatbatch Gen-Aid, Ltd Procédé et compositions pour conférer de la résistance aux infections rétrovirales
WO1989008146A1 (fr) * 1988-02-26 1989-09-08 Worcester Foundation For Experimental Biology Inhibition du htlv-iii par des oligonucleotides exogenes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HAN L ET AL: "INHIBITION OF MOLONEY MURINE LEUKEMIA VIRUS-INDUCED LEUKEMIA IN TRANSGENIC MICE EXPRESSING ANTISENSE RNA COMPLEMENTARY TO THE RETROVIRAL PACKAGING SEQUENCES.", PROC NATL ACAD SCI U S A 88 (10). 1991. 4313-4317. *
SANFORD, J.: "Applying the PDR principle to AIDS", J. THEOR. BIOL., vol. 130, 1988, pages 469 - 480 *
See also references of WO9217211A1 *

Also Published As

Publication number Publication date
EP0578776A1 (fr) 1994-01-19
JPH06506599A (ja) 1994-07-28
WO1992017211A1 (fr) 1992-10-15
AU1778092A (en) 1992-11-02
CA2107789A1 (fr) 1992-10-06
AU655279B2 (en) 1994-12-15

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