DE69812773D1 - Methode zur de novo Peptidsequenz-Bestimmung - Google Patents

Methode zur de novo Peptidsequenz-Bestimmung

Info

Publication number
DE69812773D1
DE69812773D1 DE69812773T DE69812773T DE69812773D1 DE 69812773 D1 DE69812773 D1 DE 69812773D1 DE 69812773 T DE69812773 T DE 69812773T DE 69812773 T DE69812773 T DE 69812773T DE 69812773 D1 DE69812773 D1 DE 69812773D1
Authority
DE
Germany
Prior art keywords
peptide sequence
sequence determination
novo peptide
novo
determination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69812773T
Other languages
English (en)
Inventor
Rajesh Bhikhu Parekh
Sally Barbara Prime
Nick Sinclair Wedd
Robert Reid Townsend
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford Glycosciences UK Ltd
Original Assignee
Oxford Glycosciences UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford Glycosciences UK Ltd filed Critical Oxford Glycosciences UK Ltd
Application granted granted Critical
Publication of DE69812773D1 publication Critical patent/DE69812773D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
DE69812773T 1997-05-22 1998-05-22 Methode zur de novo Peptidsequenz-Bestimmung Expired - Lifetime DE69812773D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9710582.9A GB9710582D0 (en) 1997-05-22 1997-05-22 A method for de novo peptide sequence determination

Publications (1)

Publication Number Publication Date
DE69812773D1 true DE69812773D1 (de) 2003-05-08

Family

ID=10812887

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69812773T Expired - Lifetime DE69812773D1 (de) 1997-05-22 1998-05-22 Methode zur de novo Peptidsequenz-Bestimmung

Country Status (8)

Country Link
US (1) US6582965B1 (de)
EP (1) EP0887646B1 (de)
JP (1) JP2002505740A (de)
AU (1) AU7540398A (de)
CA (1) CA2290591A1 (de)
DE (1) DE69812773D1 (de)
GB (2) GB9710582D0 (de)
WO (1) WO1998053323A2 (de)

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DE60026452T2 (de) 1999-04-06 2006-08-10 Micromass Uk Ltd. Verfahren zur Identifizierung von Peptidensequenzen und Proteinensequenzen mittels Massenspektromterie
AU2001269058A1 (en) * 2000-06-07 2001-12-17 Basf Aktiengesellschaft Method for the qualitative and quantitative analysis of complex mixtures of chemical compounds, using maldi-tof mass spectrometry
EP2479578A1 (de) * 2000-10-19 2012-07-25 Target Discovery, Inc. Massendefektkennzeichnung zur Bestimmung von Oligomersequenzen
US6829539B2 (en) 2001-04-13 2004-12-07 The Institute For Systems Biology Methods for quantification and de novo polypeptide sequencing by mass spectrometry
US7409296B2 (en) * 2002-07-29 2008-08-05 Geneva Bioinformatics (Genebio), S.A. System and method for scoring peptide matches
US6891154B2 (en) * 2002-08-30 2005-05-10 Syn X Pharma, Inc. Amino acid sequence pattern matching
DK1953551T3 (da) * 2002-12-03 2014-05-12 Univ North Carolina State Prion-proteinligander samt fremgangsmåder til anvendelse deraf
JP3534191B1 (ja) 2002-12-26 2004-06-07 日本電気株式会社 質量分析法を利用するペプチドｃ末端アミノ酸配列解析方法
CA2521034A1 (en) * 2003-04-02 2004-10-21 Merck & Co., Inc. Mass spectrometry data analysis techniques
JP4676955B2 (ja) * 2003-04-09 2011-04-27 エムディーエス インコーポレイテッド クロマトグラフィ／質量分析／質量分析装置における動的信号選択
US20080142695A1 (en) * 2003-06-11 2008-06-19 Proteome Systems Intellectual Property Pty Ltd Characterisation of Glycans
WO2005057208A1 (en) * 2003-12-03 2005-06-23 Prolexys Pharmaceuticals, Inc. Methods of identifying peptides and proteins
JP4541122B2 (ja) * 2004-12-10 2010-09-08 株式会社メディカル・プロテオスコープ 質量分析法を用いたアミノ酸配列同定方法
JP4543929B2 (ja) * 2005-01-04 2010-09-15 日本電気株式会社 タンパク質の解析方法
US7783429B2 (en) * 2005-02-18 2010-08-24 Charite'-Universitatsmedizin Berlin Peptide sequencing from peptide fragmentation mass spectra
US7297940B2 (en) * 2005-05-03 2007-11-20 Palo Alto Research Center Incorporated Method, apparatus, and program product for classifying ionized molecular fragments
US8108153B2 (en) * 2005-12-13 2012-01-31 Palo Alto Research Center Incorporated Method, apparatus, and program product for creating an index into a database of complex molecules
US7429727B2 (en) * 2005-12-13 2008-09-30 Palo Alto Research Center Incorporated Method, apparatus, and program product for quickly selecting complex molecules from a data base of molecules
JP5107263B2 (ja) 2006-01-11 2012-12-26 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 質量分析計におけるイオンの断片化
JP2007287531A (ja) * 2006-04-18 2007-11-01 Shimadzu Corp 質量分析データ解析方法
GB0611116D0 (en) 2006-06-06 2006-07-19 Oxford Genome Sciences Uk Ltd Proteins
JP2008039608A (ja) * 2006-08-07 2008-02-21 Hitachi High-Technologies Corp 質量分析システム
WO2008059567A1 (fr) * 2006-11-15 2008-05-22 Shimadzu Corporation Procédé et dispositif de spectrométrie de masse
JP4841414B2 (ja) * 2006-12-08 2011-12-21 株式会社島津製作所 質量分析を用いたアミノ酸配列解析方法、アミノ酸配列解析装置、アミノ酸配列解析用プログラム、及びアミノ酸配列解析用プログラムを記録した記録媒体
WO2008093762A1 (ja) * 2007-01-31 2008-08-07 Chugai Seiyaku Kabushiki Kaisha 低分子量ペプチドの高感度定量方法
EP3118221B1 (de) 2007-02-26 2019-08-21 Oxford BioTherapeutics Ltd Proteine
WO2008104803A2 (en) 2007-02-26 2008-09-04 Oxford Genome Sciences (Uk) Limited Proteins
US7555393B2 (en) * 2007-06-01 2009-06-30 Thermo Finnigan Llc Evaluating the probability that MS/MS spectral data matches candidate sequence data
EP2496605A1 (de) 2009-11-02 2012-09-12 Oxford Biotherapeutics Ltd. Ror1 als therapeutisches und diagnostisches ziel
CN103109346B (zh) * 2010-11-08 2016-09-28 Dh科技发展私人贸易有限公司 用于通过质谱分析快速筛选样本的系统及方法
CN104718449B (zh) * 2012-11-15 2017-06-06 Dh科技发展私人贸易有限公司 用于在不使用前体离子信息的情况下从ms/ms数据识别化合物的系统及方法
JP2019505780A (ja) * 2015-12-30 2019-02-28 フィト エヌフェー 質量分析法に基づく生体高分子の構造決定方法
US20210020270A1 (en) * 2018-03-08 2021-01-21 The Trustees Of Indiana University Constrained de novo sequencing of neo-epitope peptides using tandem mass spectrometry

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US4224031A (en) 1977-11-15 1980-09-23 Mee John M L CI Mass spectrometric analysis of physiologically active compounds
GB2168478A (en) 1984-11-26 1986-06-18 Scan Limited M Analysis of protein etc using mass spectrometry
US5221518A (en) 1984-12-14 1993-06-22 Mills Randell L DNA sequencing apparatus
US4820648A (en) 1985-08-21 1989-04-11 Spectros Limited Methods for use in the mass analysis of chemical samples
JP2834136B2 (ja) 1988-04-27 1998-12-09 株式会社日立製作所 質量分析計
US5010175A (en) * 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5003059A (en) 1988-06-20 1991-03-26 Genomyx, Inc. Determining DNA sequences by mass spectrometry
US5045694A (en) 1989-09-27 1991-09-03 The Rockefeller University Instrument and method for the laser desorption of ions in mass spectrometry
US5288644A (en) 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
US5135870A (en) 1990-06-01 1992-08-04 Arizona Board Of Regents Laser ablation/ionizaton and mass spectrometric analysis of massive polymers
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
WO1992013629A1 (en) 1991-01-31 1992-08-20 Wayne State University A method for analyzing an organic sample
US5534440A (en) 1991-02-22 1996-07-09 Biomedical Research Centre Limited Compounds and methods for sequencing amino acids
US5240859A (en) 1991-02-22 1993-08-31 B.R. Centre Limited Methods for amino acid sequencing of a polypeptide
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US5521097A (en) 1991-08-28 1996-05-28 Seiko Instruments Inc. Method of determining amino acid sequence of protein or peptide from carboxy-terminal
US5246865A (en) 1992-07-24 1993-09-21 California Institute Of Technology Thiobenzoylation method of peptide sequencing with gas chromatography and mass spectrometric detection
US5470753A (en) 1992-09-03 1995-11-28 Selectide Corporation Peptide sequencing using mass spectrometry
US5432093A (en) 1992-11-23 1995-07-11 City Of Hope Sequential degradation of proteins and peptides from the N-terminus
EP1262564A3 (de) 1993-01-07 2004-03-31 Sequenom, Inc. Dns-Sequenzierung durch Massenspektrometrie
US5565171A (en) 1993-05-28 1996-10-15 Governors Of The University Of Alberta Continuous biochemical reactor for analysis of sub-picomole quantities of complex organic molecules
US5527675A (en) 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
US5538897A (en) 1994-03-14 1996-07-23 University Of Washington Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases
DE69519225T2 (de) * 1994-03-23 2001-03-29 Univ Penn State Res Found Verfahren zum nachweis von verbindungen einer konbinatorischen bibliothek.
US5672869A (en) * 1996-04-03 1997-09-30 Eastman Kodak Company Noise and background reduction method for component detection in chromatography/spectrometry
US5668373A (en) * 1996-04-26 1997-09-16 Trustees Of Tufts College Methods and apparatus for analysis of complex mixtures
AUPO680897A0 (en) 1997-05-15 1997-06-05 Macquarie Research Limited Constitutional analysis of protein domains

Also Published As

Publication number Publication date
GB2325465A (en) 1998-11-25
GB9710582D0 (en) 1997-07-16
EP0887646B1 (de) 2003-04-02
WO1998053323A2 (en) 1998-11-26
EP0887646A1 (de) 1998-12-30
WO1998053323A3 (en) 1999-03-11
GB9811196D0 (en) 1998-07-22
US6582965B1 (en) 2003-06-24
CA2290591A1 (en) 1998-11-26
AU7540398A (en) 1998-12-11
JP2002505740A (ja) 2002-02-19

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