DE69812773D1 - Methode zur de novo Peptidsequenz-Bestimmung - Google Patents

Methode zur de novo Peptidsequenz-Bestimmung

Info

Publication number
DE69812773D1
DE69812773D1 DE69812773T DE69812773T DE69812773D1 DE 69812773 D1 DE69812773 D1 DE 69812773D1 DE 69812773 T DE69812773 T DE 69812773T DE 69812773 T DE69812773 T DE 69812773T DE 69812773 D1 DE69812773 D1 DE 69812773D1
Authority
DE
Germany
Prior art keywords
peptide sequence
sequence determination
novo peptide
novo
determination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69812773T
Other languages
English (en)
Inventor
Rajesh Bhikhu Parekh
Sally Barbara Prime
Nick Sinclair Wedd
Robert Reid Townsend
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford Glycosciences UK Ltd
Original Assignee
Oxford Glycosciences UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford Glycosciences UK Ltd filed Critical Oxford Glycosciences UK Ltd
Application granted granted Critical
Publication of DE69812773D1 publication Critical patent/DE69812773D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
DE69812773T 1997-05-22 1998-05-22 Methode zur de novo Peptidsequenz-Bestimmung Expired - Lifetime DE69812773D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9710582.9A GB9710582D0 (en) 1997-05-22 1997-05-22 A method for de novo peptide sequence determination

Publications (1)

Publication Number Publication Date
DE69812773D1 true DE69812773D1 (de) 2003-05-08

Family

ID=10812887

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69812773T Expired - Lifetime DE69812773D1 (de) 1997-05-22 1998-05-22 Methode zur de novo Peptidsequenz-Bestimmung

Country Status (8)

Country Link
US (1) US6582965B1 (de)
EP (1) EP0887646B1 (de)
JP (1) JP2002505740A (de)
AU (1) AU7540398A (de)
CA (1) CA2290591A1 (de)
DE (1) DE69812773D1 (de)
GB (2) GB9710582D0 (de)
WO (1) WO1998053323A2 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6489121B1 (en) 1999-04-06 2002-12-03 Micromass Limited Methods of identifying peptides and proteins by mass spectrometry
US6489608B1 (en) 1999-04-06 2002-12-03 Micromass Limited Method of determining peptide sequences by mass spectrometry
AU2001269058A1 (en) * 2000-06-07 2001-12-17 Basf Aktiengesellschaft Method for the qualitative and quantitative analysis of complex mixtures of chemical compounds, using maldi-tof mass spectrometry
WO2002066952A2 (en) * 2000-10-19 2002-08-29 Target Discovery, Inc Mass defect labeling for the determination of oligomer sequences
US6829539B2 (en) 2001-04-13 2004-12-07 The Institute For Systems Biology Methods for quantification and de novo polypeptide sequencing by mass spectrometry
US7409296B2 (en) * 2002-07-29 2008-08-05 Geneva Bioinformatics (Genebio), S.A. System and method for scoring peptide matches
US6891154B2 (en) * 2002-08-30 2005-05-10 Syn X Pharma, Inc. Amino acid sequence pattern matching
CN102297798B (zh) * 2002-12-03 2015-11-18 病原体切除与诊断科技公司 朊病毒蛋白配基和使用方法
JP3534191B1 (ja) 2002-12-26 2004-06-07 日本電気株式会社 質量分析法を利用するペプチドｃ末端アミノ酸配列解析方法
US6906320B2 (en) * 2003-04-02 2005-06-14 Merck & Co., Inc. Mass spectrometry data analysis techniques
DE602004002856T2 (de) * 2003-04-09 2007-05-16 MDS Inc. doing business through its MDS Sciex Division, Concord Dynamische signalauswahl in einem chromatographie-/massenspektometrie-/massenspektrometriesystem
WO2004108742A1 (en) * 2003-06-11 2004-12-16 Proteome Systems Intellectual Property Pty Ltd Method of identifying glycan structures using mass spectrometer data
WO2005057208A1 (en) * 2003-12-03 2005-06-23 Prolexys Pharmaceuticals, Inc. Methods of identifying peptides and proteins
JP4541122B2 (ja) * 2004-12-10 2010-09-08 株式会社メディカル・プロテオスコープ 質量分析法を用いたアミノ酸配列同定方法
JP4543929B2 (ja) * 2005-01-04 2010-09-15 日本電気株式会社 タンパク質の解析方法
US7783429B2 (en) * 2005-02-18 2010-08-24 Charite'-Universitatsmedizin Berlin Peptide sequencing from peptide fragmentation mass spectra
US7297940B2 (en) * 2005-05-03 2007-11-20 Palo Alto Research Center Incorporated Method, apparatus, and program product for classifying ionized molecular fragments
US7429727B2 (en) * 2005-12-13 2008-09-30 Palo Alto Research Center Incorporated Method, apparatus, and program product for quickly selecting complex molecules from a data base of molecules
US8108153B2 (en) * 2005-12-13 2012-01-31 Palo Alto Research Center Incorporated Method, apparatus, and program product for creating an index into a database of complex molecules
CA2636822C (en) 2006-01-11 2015-03-03 Mds Inc., Doing Business Through Its Mds Sciex Division Fragmenting ions in mass spectrometry
JP2007287531A (ja) * 2006-04-18 2007-11-01 Shimadzu Corp 質量分析データ解析方法
GB0611116D0 (en) 2006-06-06 2006-07-19 Oxford Genome Sciences Uk Ltd Proteins
JP2008039608A (ja) * 2006-08-07 2008-02-21 Hitachi High-Technologies Corp 質量分析システム
US8735806B2 (en) * 2006-11-15 2014-05-27 Shimadzu Corporation Mass-analyzing method and mass spectrometer
JP4841414B2 (ja) * 2006-12-08 2011-12-21 株式会社島津製作所 質量分析を用いたアミノ酸配列解析方法、アミノ酸配列解析装置、アミノ酸配列解析用プログラム、及びアミノ酸配列解析用プログラムを記録した記録媒体
WO2008093762A1 (ja) * 2007-01-31 2008-08-07 Chugai Seiyaku Kabushiki Kaisha 低分子量ペプチドの高感度定量方法
WO2008104803A2 (en) 2007-02-26 2008-09-04 Oxford Genome Sciences (Uk) Limited Proteins
EP2447719B1 (de) 2007-02-26 2016-08-24 Oxford BioTherapeutics Ltd Proteine
US7555393B2 (en) * 2007-06-01 2009-06-30 Thermo Finnigan Llc Evaluating the probability that MS/MS spectral data matches candidate sequence data
US20120282177A1 (en) 2009-11-02 2012-11-08 Christian Rohlff ROR1 as Therapeutic and Diagnostic Target
CA2811470C (en) * 2010-11-08 2018-03-20 Dh Technologies Development Pte. Ltd. Systems and methods for rapidly screening samples by mass spectrometry
WO2014076529A1 (en) * 2012-11-15 2014-05-22 Dh Technologies Development Pte. Ltd. Systems and methods for identifying compounds from ms/ms data without precursor ion information
WO2017114943A1 (en) * 2015-12-30 2017-07-06 Vito Nv Methods for mass spectrometry-based structure determination of biomacromolecules
US20210020270A1 (en) * 2018-03-08 2021-01-21 The Trustees Of Indiana University Constrained de novo sequencing of neo-epitope peptides using tandem mass spectrometry

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4224031A (en) 1977-11-15 1980-09-23 Mee John M L CI Mass spectrometric analysis of physiologically active compounds
GB2168478A (en) 1984-11-26 1986-06-18 Scan Limited M Analysis of protein etc using mass spectrometry
US5221518A (en) 1984-12-14 1993-06-22 Mills Randell L DNA sequencing apparatus
US4820648A (en) 1985-08-21 1989-04-11 Spectros Limited Methods for use in the mass analysis of chemical samples
JP2834136B2 (ja) 1988-04-27 1998-12-09 株式会社日立製作所 質量分析計
US5010175A (en) * 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5003059A (en) 1988-06-20 1991-03-26 Genomyx, Inc. Determining DNA sequences by mass spectrometry
US5045694A (en) 1989-09-27 1991-09-03 The Rockefeller University Instrument and method for the laser desorption of ions in mass spectrometry
US5288644A (en) 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
US5135870A (en) 1990-06-01 1992-08-04 Arizona Board Of Regents Laser ablation/ionizaton and mass spectrometric analysis of massive polymers
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
WO1992013629A1 (en) 1991-01-31 1992-08-20 Wayne State University A method for analyzing an organic sample
US5240859A (en) 1991-02-22 1993-08-31 B.R. Centre Limited Methods for amino acid sequencing of a polypeptide
US5534440A (en) 1991-02-22 1996-07-09 Biomedical Research Centre Limited Compounds and methods for sequencing amino acids
GB9109842D0 (en) 1991-05-07 1991-06-26 Oxford Glycosystems Ltd Sequencing of oligosaccharides
US5521097A (en) 1991-08-28 1996-05-28 Seiko Instruments Inc. Method of determining amino acid sequence of protein or peptide from carboxy-terminal
US5246865A (en) 1992-07-24 1993-09-21 California Institute Of Technology Thiobenzoylation method of peptide sequencing with gas chromatography and mass spectrometric detection
US5470753A (en) 1992-09-03 1995-11-28 Selectide Corporation Peptide sequencing using mass spectrometry
US5432093A (en) 1992-11-23 1995-07-11 City Of Hope Sequential degradation of proteins and peptides from the N-terminus
EP1262564A3 (de) 1993-01-07 2004-03-31 Sequenom, Inc. Dns-Sequenzierung durch Massenspektrometrie
US5565171A (en) 1993-05-28 1996-10-15 Governors Of The University Of Alberta Continuous biochemical reactor for analysis of sub-picomole quantities of complex organic molecules
US5527675A (en) 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
US5538897A (en) 1994-03-14 1996-07-23 University Of Washington Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases
ES2151057T3 (es) * 1994-03-23 2000-12-16 Penn State Res Found Procedimiento para la identificacion de elementos de bibliotecas combinatorias.
US5672869A (en) * 1996-04-03 1997-09-30 Eastman Kodak Company Noise and background reduction method for component detection in chromatography/spectrometry
US5668373A (en) * 1996-04-26 1997-09-16 Trustees Of Tufts College Methods and apparatus for analysis of complex mixtures
AUPO680897A0 (en) 1997-05-15 1997-06-05 Macquarie Research Limited Constitutional analysis of protein domains

Also Published As

Publication number Publication date
GB9710582D0 (en) 1997-07-16
US6582965B1 (en) 2003-06-24
EP0887646A1 (de) 1998-12-30
WO1998053323A3 (en) 1999-03-11
EP0887646B1 (de) 2003-04-02
WO1998053323A2 (en) 1998-11-26
AU7540398A (en) 1998-12-11
JP2002505740A (ja) 2002-02-19
GB9811196D0 (en) 1998-07-22
GB2325465A (en) 1998-11-25
CA2290591A1 (en) 1998-11-26

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