DE69614847T2 - Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone - Google Patents

Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone

Info

Publication number
DE69614847T2
DE69614847T2 DE69614847T DE69614847T DE69614847T2 DE 69614847 T2 DE69614847 T2 DE 69614847T2 DE 69614847 T DE69614847 T DE 69614847T DE 69614847 T DE69614847 T DE 69614847T DE 69614847 T2 DE69614847 T2 DE 69614847T2
Authority
DE
Germany
Prior art keywords
pct
carbazinyloxazolidinone
spirocyclic
date nov
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69614847T
Other languages
English (en)
Other versions
DE69614847D1 (de
Inventor
Robert Barbachyn
J Brickner
K Hutchinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Publication of DE69614847D1 publication Critical patent/DE69614847D1/de
Application granted granted Critical
Publication of DE69614847T2 publication Critical patent/DE69614847T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
DE69614847T 1995-05-11 1996-04-18 Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone Expired - Fee Related DE69614847T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43870595A 1995-05-11 1995-05-11
PCT/US1996/005202 WO1996035691A1 (en) 1995-05-11 1996-04-18 Spirocyclic and bicyclic diazinyl and carbazinyl oxazolidinones

Publications (2)

Publication Number Publication Date
DE69614847D1 DE69614847D1 (de) 2001-10-04
DE69614847T2 true DE69614847T2 (de) 2002-04-04

Family

ID=23741700

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69614847T Expired - Fee Related DE69614847T2 (de) 1995-05-11 1996-04-18 Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone

Country Status (18)

Country Link
US (1) US6090820A (de)
EP (1) EP0828741B1 (de)
JP (1) JPH11506430A (de)
KR (1) KR100463771B1 (de)
CN (2) CN1068328C (de)
AT (1) ATE204874T1 (de)
AU (1) AU702752B2 (de)
CA (1) CA2218088A1 (de)
DE (1) DE69614847T2 (de)
DK (1) DK0828741T3 (de)
ES (1) ES2162047T3 (de)
FI (1) FI974180A (de)
HK (2) HK1009449A1 (de)
MX (1) MX9708627A (de)
NO (1) NO311298B1 (de)
NZ (1) NZ306310A (de)
PT (1) PT828741E (de)
WO (1) WO1996035691A1 (de)

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JPH11512429A (ja) * 1995-09-15 1999-10-26 ファルマシア・アンド・アップジョン・カンパニー アミノアリールオキサゾリジノン ｎ−オキシド
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
RU2176643C2 (ru) * 1996-04-11 2001-12-10 Фармация Энд Апджон Компани Способ получения 5-гидроксиметил замещенных оксазолидинонов, способ получения 5-аминометил замещенных оксазолидиноновых аминов, оксазолидинонсульфонат
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
KR100467309B1 (ko) * 1997-09-04 2005-07-18 씨제이 주식회사 옥사졸리디논유도체및그의제조방법및항균제조성물
KR100463111B1 (ko) * 1997-10-30 2005-06-13 씨제이 주식회사 신규한옥사졸리디논유도체및제조방법및그를함유하는항균제조성물
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
MXPA00011536A (es) 1998-06-05 2002-10-17 Astrazeneca Ab Derivados de oxazolidinona, proceso para su preparacion y composiciones farmaceuticas que las contienen.
US6413981B1 (en) * 1999-08-12 2002-07-02 Ortho-Mcneil Pharamceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6297242B1 (en) 1999-08-12 2001-10-02 Ortho-Mcneil Pharmaceutical, Inc. N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
US6518285B2 (en) 1999-12-21 2003-02-11 Ortho Mcneil Pharmaceutical, Inc. Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
ITVA20000023A1 (it) * 2000-07-19 2002-01-19 Lamberti Spa Composizioni di pvc stabili al calore.
SE0100326D0 (sv) 2001-02-02 2001-02-02 Astrazeneca Ab New compounds
CA2440803A1 (en) * 2001-03-07 2002-09-12 Pfizer Products Inc. Modulators of chemokine receptor activity
CA2463794A1 (en) * 2001-11-29 2003-06-12 Merck & Co., Inc. Cyclopropyl hexane containing oxazolidinone antibiotics and derivatives thereof
AR038536A1 (es) 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
US7141588B2 (en) 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
AU2003259159A1 (en) 2002-08-12 2004-02-25 Pharmacia & Upjohn Company Llc N-aryl-2-oxazolidinones and their derivatives
KR100454099B1 (ko) * 2002-08-22 2004-10-26 한국화학연구원 제초활성을 갖는9-(5-이속사졸린메톡시페닐)이미노-8-치아-1,6-디아자비시클로[4.3.0]노난-7-온 유도체
US7141570B2 (en) 2002-11-21 2006-11-28 Pharmacia & Upjohn Company N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
RU2348628C2 (ru) 2003-07-02 2009-03-10 Мерк Энд Ко., Инк. Замещенные циклопропильной группой оксазолидиноновые антибиотики и их производные
US7304050B2 (en) 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
EP1671972A1 (de) * 2004-11-24 2006-06-21 Pfizer Limited Octahydropyrrolo[3,4-c]pyrrol-Derivate
JP2008520644A (ja) * 2004-11-24 2008-06-19 ファイザー・インク オクタヒドロピロロ［３，４−ｃ］ピロール誘導体
KR100729344B1 (ko) * 2006-02-16 2007-06-15 스마텍(주) 차량용 사방 감지 카메라의 보호 및 작동 구조
US7728031B2 (en) 2006-02-24 2010-06-01 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole derivatives
WO2009036132A1 (en) 2007-09-11 2009-03-19 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole n-oxides
JP5662940B2 (ja) 2008-11-20 2015-02-04 パナセア バイオテック リミテッド 新規な抗微生物薬
US8906913B2 (en) 2009-06-26 2014-12-09 Panacea Biotec Limited Azabicyclohexanes
EP2635589A1 (de) 2010-11-03 2013-09-11 Wockhardt Limited Verfahren zur herstellung von phosphorsäure-mono- l- {[4- (s) -5- (acetylaminomethyl) - 2 - oxo - oxazolidin- - 3 yl] - 2, 6 -} difluorphenyl - 4 - methoxymethylpiperidin- 4 - yl)-ester
KR101271224B1 (ko) 2011-07-05 2013-06-10 한국과학기술연구원 항균활성을 갖는 신규 이중고리를 포함하는 옥사졸리디논 유도체 및 이의 제조방법
EP2762480A4 (de) * 2011-09-30 2015-03-18 Xuanzhu Pharma Co Ltd Oxazolidinonantibiotika mit kondensierten ringen
WO2015173664A1 (en) 2014-05-14 2015-11-19 Wockhardt Limited Process for the preparation of (5s)-n-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
US10364232B2 (en) 2015-07-02 2019-07-30 Janssen Sciences Ireland Uc Antibacterial compounds
CN108348507B (zh) * 2015-07-17 2021-10-08 结核病药物开发全球联盟公司 用于抗微生物治疗的经取代苯基噁唑烷酮
CN107400126A (zh) * 2016-05-19 2017-11-28 陕西合成药业股份有限公司 新型噁唑烷酮类化合物及其制备方法和在医学上的应用
EA201990043A1 (ru) 2016-06-16 2019-05-31 Янссен Сайенсиз Айрлэнд Анлимитед Компани Антибактериальные соединения
KR20190121315A (ko) 2017-03-01 2019-10-25 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 병용 요법
CN108727406B (zh) 2017-03-28 2021-12-07 北京协和制药二厂 含氮杂环取代的苯并噁嗪噁唑烷酮类化合物及其制备方法和用途
WO2020234636A1 (en) 2019-05-17 2020-11-26 Cadila Healthcare Limited Novel compounds for the treatment of mammalian infections

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921869A (en) * 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
CA1320730C (en) * 1987-10-16 1993-07-27 The Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
ATE95176T1 (de) * 1987-10-21 1993-10-15 Du Pont Merck Pharma Aminomethyl-oxo-oxazolidinyl-ethenylbenzenderivate, nuetzlich als antibakterielles mittel.
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
DE68929303T2 (de) * 1988-09-15 2002-05-02 Upjohn Co 3-(Stickstoff substituierte)phenyl-5-beta-amidomethyloxazoliden-2-one
KR100257418B1 (ko) * 1991-11-01 2000-05-15 로렌스 티. 마이젠헬더 치환된 아릴-및 헤테로아릴-페닐옥사졸리디논
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
JPH0873455A (ja) * 1994-03-15 1996-03-19 Upjohn Co:The オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物

Also Published As

Publication number Publication date
CN1336375A (zh) 2002-02-20
US6090820A (en) 2000-07-18
KR100463771B1 (ko) 2005-05-16
ES2162047T3 (es) 2001-12-16
CA2218088A1 (en) 1996-11-14
AU702752B2 (en) 1999-03-04
KR19990008399A (ko) 1999-01-25
EP0828741B1 (de) 2001-08-29
EP0828741A1 (de) 1998-03-18
FI974180A0 (fi) 1997-11-10
MX9708627A (es) 1998-02-28
CN1068328C (zh) 2001-07-11
DE69614847D1 (de) 2001-10-04
WO1996035691A1 (en) 1996-11-14
NO975158D0 (no) 1997-11-10
NO975158L (no) 1998-01-09
NO311298B1 (no) 2001-11-12
ATE204874T1 (de) 2001-09-15
PT828741E (pt) 2002-02-28
FI974180A (fi) 1997-11-10
JPH11506430A (ja) 1999-06-08
AU5484996A (en) 1996-11-29
CN1184481A (zh) 1998-06-10
DK0828741T3 (da) 2001-11-26
NZ306310A (en) 2001-05-25
HK1009449A1 (en) 1999-09-10
HK1042093A1 (zh) 2002-08-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee