DE69502733T2 - Elektrophoretische gen- und medikamenttherapie mittels eines induzierten elektrischen feldes - Google Patents

Elektrophoretische gen- und medikamenttherapie mittels eines induzierten elektrischen feldes

Info

Publication number
DE69502733T2
DE69502733T2 DE69502733T DE69502733T DE69502733T2 DE 69502733 T2 DE69502733 T2 DE 69502733T2 DE 69502733 T DE69502733 T DE 69502733T DE 69502733 T DE69502733 T DE 69502733T DE 69502733 T2 DE69502733 T2 DE 69502733T2
Authority
DE
Germany
Prior art keywords
preselected
blood vessel
cells
molecules
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69502733T
Other languages
English (en)
Other versions
DE69502733D1 (de
Inventor
Gunter Hofmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetronics Inc
Original Assignee
Genetronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetronics Inc filed Critical Genetronics Inc
Application granted granted Critical
Publication of DE69502733D1 publication Critical patent/DE69502733D1/de
Publication of DE69502733T2 publication Critical patent/DE69502733T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
DE69502733T 1994-10-25 1995-06-27 Elektrophoretische gen- und medikamenttherapie mittels eines induzierten elektrischen feldes Expired - Lifetime DE69502733T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/328,895 US6132419A (en) 1992-05-22 1994-10-25 Electroporetic gene and drug therapy
PCT/US1995/008138 WO1996012520A1 (en) 1994-10-25 1995-06-27 Electroporetic gene and drug therapy by induced electric fields

Publications (2)

Publication Number Publication Date
DE69502733D1 DE69502733D1 (de) 1998-07-02
DE69502733T2 true DE69502733T2 (de) 1998-09-24

Family

ID=23282925

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69502733T Expired - Lifetime DE69502733T2 (de) 1994-10-25 1995-06-27 Elektrophoretische gen- und medikamenttherapie mittels eines induzierten elektrischen feldes

Country Status (8)

Country Link
US (1) US6132419A (de)
EP (1) EP0788392B1 (de)
AT (1) ATE166585T1 (de)
AU (1) AU2951595A (de)
DE (1) DE69502733T2 (de)
DK (1) DK0788392T3 (de)
ES (1) ES2117871T3 (de)
WO (1) WO1996012520A1 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005031427B4 (de) * 2004-12-28 2008-05-29 National Cancer Centre Of Singapore Pte Ltd. Programmierbare Vorrichtung und Verfahren zur Optimierung und Echtzeit-Überwachung der Gen-Transfektion auf der Basis einer benutzerkonfigurierten willkürlichen Wellenformimpulsfolge
DE102012000354A1 (de) * 2012-01-11 2013-07-11 Udo Tartler Vorrichtung für eine Angussöffnung einer Gussform

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6585763B1 (en) * 1997-10-14 2003-07-01 Vascusense, Inc. Implantable therapeutic device and method
US6775574B1 (en) * 1997-11-07 2004-08-10 Medtronic, Inc. Method and system for myocardial infarction repair
EP1056501B1 (de) 1998-02-24 2005-11-16 Boston Scientific Limited Dialysekatheter mit hohem durchfluss und verfahren dazu
EP1079890A4 (de) 1998-05-08 2008-12-03 Genetronics Inc Elektrisch induzierte gefässdilation
US6300108B1 (en) * 1999-07-21 2001-10-09 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
US20060127466A1 (en) * 2000-02-25 2006-06-15 Arindam Sen Method for transdermal or intradermal delivery of molecules
WO2001065911A2 (en) * 2000-03-03 2001-09-13 Valentis, Inc. Improved poloxamer and poloxamine compositions for nucleic acid delivery
US6697670B2 (en) 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US8251986B2 (en) 2000-08-17 2012-08-28 Angiodynamics, Inc. Method of destroying tissue cells by eletroporation
US6795728B2 (en) 2001-08-17 2004-09-21 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation
US6892099B2 (en) 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
USRE42016E1 (en) 2001-08-13 2010-12-28 Angiodynamics, Inc. Apparatus and method for the treatment of benign prostatic hyperplasia
AR037038A1 (es) 2001-10-26 2004-10-20 Baylor College Medicine Una composicion y metodo para alterar la masa corporal magra y las propiedades oseas en un sujeto
US6733518B2 (en) * 2001-10-31 2004-05-11 Seacoast Technologies, Inc. Method and apparatus for thermal therapy
US7211083B2 (en) * 2003-03-17 2007-05-01 Minnesota Medical Physics, Llc Apparatus and method for hair removal by electroporation
US7261882B2 (en) 2003-06-23 2007-08-28 Reagents Of The University Of Colorado Methods for treating neuropathic pain by administering IL-10 polypeptides
US7361642B2 (en) 2003-08-04 2008-04-22 Vgx Pharmaceuticals, Inc. Canine specific growth hormone releasing hormone
US8298222B2 (en) 2003-12-24 2012-10-30 The Regents Of The University Of California Electroporation to deliver chemotherapeutics and enhance tumor regression
US8048067B2 (en) 2003-12-24 2011-11-01 The Regents Of The University Of California Tissue ablation with irreversible electroporation
WO2005065722A2 (en) 2003-12-31 2005-07-21 Advisys, Inc. Reducing arthritis and lameness in subjects by growth hormone releasing hormone (ghrh) supplementation
ATE507239T1 (de) 2004-01-20 2011-05-15 VGX Pharmaceuticals LLC Erhöhte sekretion/retention von wachstumshormonfreisetzendem hormon (ghrh) aus muskelzellen durch speziesspezifisches signalpeptid
US7840263B2 (en) 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
US7764995B2 (en) 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
US7729761B2 (en) * 2004-07-14 2010-06-01 Cardiac Pacemakers, Inc. Method and apparatus for controlled gene or protein delivery
LT2816118T (lt) 2005-05-31 2018-12-10 The Regents Of The University Of Colorado, A Body Corporate Genų pristatymo būdai
US20060293730A1 (en) 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating restenosis sites using electroporation
US8114070B2 (en) * 2005-06-24 2012-02-14 Angiodynamics, Inc. Methods and systems for treating BPH using electroporation
EP1997234A1 (de) * 2006-03-13 2008-12-03 Novo Nordisk A/S Medizinisches system mit zweifach verwendbaren kommunikationsmitteln
CN101401313B (zh) 2006-03-13 2014-06-11 诺沃—诺迪斯克有限公司 用于使用成双通信装置的电子设备的安全配对的系统
US8058253B2 (en) 2006-07-06 2011-11-15 Vgx Pharmaceuticals, Inc. Growth hormone releasing hormone treatment to decrease cholesterol levels
JP2010506657A (ja) * 2006-10-16 2010-03-04 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 組織の不可逆的エレクトロポレーションに使用される、所定の導電率を有するゲル
WO2009121017A1 (en) 2008-03-27 2009-10-01 The Regents Of The University Of California Balloon catheter for reducing restenosis via irreversible electroporation
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
US10117707B2 (en) 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US10448989B2 (en) 2009-04-09 2019-10-22 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US8926606B2 (en) 2009-04-09 2015-01-06 Virginia Tech Intellectual Properties, Inc. Integration of very short electric pulses for minimally to noninvasive electroporation
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US9198733B2 (en) * 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
WO2009134876A1 (en) 2008-04-29 2009-11-05 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
US20090281477A1 (en) 2008-05-09 2009-11-12 Angiodynamics, Inc. Electroporation device and method
US8849395B2 (en) 2008-05-30 2014-09-30 Boston Scientific Scimed, Inc. Guide catheter having vasomodulating electrodes
US9173704B2 (en) 2008-06-20 2015-11-03 Angiodynamics, Inc. Device and method for the ablation of fibrin sheath formation on a venous catheter
WO2010008834A2 (en) 2008-06-23 2010-01-21 Angiodynamics, Inc. Treatment devices and methods
WO2010085765A2 (en) 2009-01-23 2010-07-29 Moshe Meir H Therapeutic energy delivery device with rotational mechanism
US8231603B2 (en) 2009-02-10 2012-07-31 Angiodynamics, Inc. Irreversible electroporation and tissue regeneration
US20100249488A1 (en) * 2009-03-30 2010-09-30 MagneGene, Inc. Method of contactless magnetic electroporation
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
USD630321S1 (en) 2009-05-08 2011-01-04 Angio Dynamics, Inc. Probe handle
US20120078163A1 (en) 2009-05-27 2012-03-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of generating connective tissue
US8903488B2 (en) 2009-05-28 2014-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
US20110118732A1 (en) 2009-11-19 2011-05-19 The Regents Of The University Of California Controlled irreversible electroporation
AU2010332400B2 (en) 2009-12-16 2016-08-04 Chrontech Pharma Ab Injection Needle and Device
US8822663B2 (en) 2010-08-06 2014-09-02 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
NZ608972A (en) 2010-10-01 2015-09-25 Moderna Therapeutics Inc Engineered nucleic acids and methods of use thereof
WO2012051433A2 (en) 2010-10-13 2012-04-19 Angiodynamics, Inc. System and method for electrically ablating tissue of a patient
WO2012106281A2 (en) 2011-01-31 2012-08-09 The General Hospital Corporation Multimodal trail molecules and uses in cellular therapies
AU2012236099A1 (en) 2011-03-31 2013-10-03 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
WO2012172424A1 (en) 2011-06-15 2012-12-20 Crontech Pharma Ab Injection needle and device
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
DE19216461T1 (de) 2011-10-03 2021-10-07 Modernatx, Inc. Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon
WO2013090648A1 (en) 2011-12-16 2013-06-20 modeRNA Therapeutics Modified nucleoside, nucleotide, and nucleic acid compositions
US9414881B2 (en) 2012-02-08 2016-08-16 Angiodynamics, Inc. System and method for increasing a target zone for electrical ablation
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
AU2013243948A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins associated with human disease
EP2890720B1 (de) 2012-08-30 2019-07-17 The General Hospital Corporation Zusammensetzungen und verfahren zur behandlung von krebs
WO2014064534A2 (en) 2012-10-05 2014-05-01 Chrontech Pharma Ab Injection needle, device, immunogenic compositions and method of use
ES2921623T3 (es) 2012-11-26 2022-08-30 Modernatx Inc ARN modificado terminalmente
US9888956B2 (en) 2013-01-22 2018-02-13 Angiodynamics, Inc. Integrated pump and generator device and method of use
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
WO2014145042A1 (en) 2013-03-15 2014-09-18 Loma Linda University Treatment of autoimmune diseases
CA2913155A1 (en) 2013-05-21 2014-11-27 President And Fellows Of Harvard College Engineered heme-binding compositions and uses thereof
EA201690675A1 (ru) 2013-10-03 2016-08-31 Модерна Терапьютикс, Инк. Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности
US10166321B2 (en) 2014-01-09 2019-01-01 Angiodynamics, Inc. High-flow port and infusion needle systems
AU2015259303B2 (en) 2014-05-12 2021-10-28 Arena, Christopher B. Selective modulation of intracellular effects of cells using pulsed electric fields
WO2016100325A1 (en) 2014-12-15 2016-06-23 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
US20180112006A1 (en) 2015-04-17 2018-04-26 The General Hospital Corporation Agents, systems and methods for treating cancer
US10660691B2 (en) 2015-10-07 2020-05-26 Angiodynamics, Inc. Multiple use subassembly with integrated fluid delivery system for use with single or dual-lumen peristaltic tubing
US10233419B2 (en) 2016-06-30 2019-03-19 Zymergen Inc. Apparatuses and methods for electroporation
EP3559228A4 (de) 2016-11-09 2021-01-27 Sigma Genetics, Inc. Systeme, vorrichtungen und verfahren zur durch magnetfelder induzierten elektroporation
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
JP2023520370A (ja) 2020-03-27 2023-05-17 スヴェンスカ ヴァクチンファブリケン プロダクション アーベー コロナウイルスの治療および予防のための組成物および方法
US20230295244A1 (en) 2021-09-29 2023-09-21 Svenska Vaccinfabriken Produktion Ab Compositions and methods for treating and preventing coronaviruses

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2320462A (en) * 1940-09-27 1943-06-01 Nawells Frank Clock operated switch
US3978864A (en) * 1965-10-11 1976-09-07 L. B. Smith Estates, Inc. Electrotherapeutic treatment head
US4374669A (en) * 1975-05-09 1983-02-22 Mac Gregor David C Cardiovascular prosthetic devices and implants with porous systems
SU624640A1 (ru) * 1977-03-28 1978-09-25 Каунасский Медицинский Институт Способ электрофореза
EP0054781B1 (de) * 1980-12-23 1984-10-10 Kontron Ag Implantierbare Elektrode
US4501265A (en) * 1982-12-23 1985-02-26 Electro-Biology, Inc. Applicator head for electromagnetic treatment of an afflicted body region
US4639244A (en) * 1983-05-03 1987-01-27 Nabil I. Rizk Implantable electrophoretic pump for ionic drugs and associated methods
US4842598A (en) * 1984-12-06 1989-06-27 Controlled Release Technologies, Inc. Therapeutic agent delivery system and method
US4690130A (en) * 1985-12-19 1987-09-01 Mirell Stuart G Electromagnetic therapy control system
US4906576A (en) * 1986-05-09 1990-03-06 Electropore, Inc. High speed, high power apparatus for vesicle prealignment, poration, loading and fusion in uniform electric fields and method therefor
US5042975A (en) * 1986-07-25 1991-08-27 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
US4801459A (en) * 1986-08-05 1989-01-31 Liburdy Robert P Technique for drug and chemical delivery
US5290409A (en) * 1986-10-27 1994-03-01 Life Resonances, Inc. Methods and apparatus for regulating transmembrane ion movement utilizing selective harmonic frequencies and simultaneous multiple ion regulation
US4818697A (en) * 1986-10-27 1989-04-04 Life Resonances, Inc. Techniques for enhancing the permeability of ions through membranes
US5098843A (en) * 1987-06-04 1992-03-24 Calvin Noel M Apparatus for the high efficiency transformation of living cells
US5128257A (en) * 1987-08-31 1992-07-07 Baer Bradford W Electroporation apparatus and process
US4970154A (en) * 1987-10-09 1990-11-13 Baylor College Of Medicine Method for inserting foreign genes into cells using pulsed radiofrequency
US5389069A (en) * 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
DE68925030T2 (de) * 1988-01-21 1996-07-25 Massachusetts Inst Technology Molekültransport durch gewebe mit der verwendung von elektroporation.
WO1989010690A1 (en) * 1988-05-02 1989-11-16 University Of South Florida Method for electrofusing biological particles to tissues
US5224922A (en) * 1988-05-19 1993-07-06 Kurtz Warren H Quasistatic biological cell and tissue modifier
US5183456A (en) * 1989-11-15 1993-02-02 Life Resonances, Inc. Method and apparatus for the treatment of cancer
US5016615A (en) * 1990-02-20 1991-05-21 Riverside Research Institute Local application of medication with ultrasound
US5236413B1 (en) * 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
ATE123658T1 (de) * 1990-06-15 1995-06-15 Cortrak Medical Inc Vorrichtung zur abgabe von medikamenten.
US5087243A (en) * 1990-06-18 1992-02-11 Boaz Avitall Myocardial iontophoresis
US5246437A (en) * 1992-04-10 1993-09-21 Abela George S Cell treatment apparatus and method
US5501662A (en) * 1992-05-22 1996-03-26 Genetronics, Inc. Implantable electroporation method and apparatus for drug and gene delivery
US5304120A (en) * 1992-07-01 1994-04-19 Btx Inc. Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
US5273525A (en) * 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US5318514A (en) * 1992-08-17 1994-06-07 Btx, Inc. Applicator for the electroporation of drugs and genes into surface cells
US5439440A (en) * 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5419763B1 (en) * 1994-01-04 1997-07-15 Cor Trak Medical Inc Prostatic drug-delivery catheter

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005031427B4 (de) * 2004-12-28 2008-05-29 National Cancer Centre Of Singapore Pte Ltd. Programmierbare Vorrichtung und Verfahren zur Optimierung und Echtzeit-Überwachung der Gen-Transfektion auf der Basis einer benutzerkonfigurierten willkürlichen Wellenformimpulsfolge
DE102012000354A1 (de) * 2012-01-11 2013-07-11 Udo Tartler Vorrichtung für eine Angussöffnung einer Gussform

Also Published As

Publication number Publication date
DK0788392T3 (da) 1999-03-01
ATE166585T1 (de) 1998-06-15
DE69502733D1 (de) 1998-07-02
US6132419A (en) 2000-10-17
WO1996012520A1 (en) 1996-05-02
AU2951595A (en) 1996-05-15
ES2117871T3 (es) 1998-08-16
EP0788392B1 (de) 1998-05-27
EP0788392A1 (de) 1997-08-13

Similar Documents

Publication Publication Date Title
DE69502733T2 (de) Elektrophoretische gen- und medikamenttherapie mittels eines induzierten elektrischen feldes
RU2141853C1 (ru) Система для клинического применения электропорации с обратной связью, управляющей напряжением
Jaroszeski et al. In vivo antitumor effects of electrochemotherapy in a hepatoma model
ES2387536T3 (es) Aparato de mejora de agentes farmacológicos, químicos y tópicos
US6564093B1 (en) Transdermal active drug delivery system and method
EP0625360B1 (de) Gerät und einheit zur dosierung von medikamenten und zur sammlung von körperflüssigkeiten
US4953565A (en) Endermic application kits for external medicines
SR et al. Effect of light on calcium uptake by macrophages
US6366808B1 (en) Implantable device and method for the electrical treatment of cancer
CN1980610B (zh) 电磁治疗装置
US20070078292A1 (en) Electromagnetic fields for systemic effect in therapy
FI59203B (fi) Elektromedicinsk apparat foer terapeutisk behandling av celler och/eller levande vaevnad
US20050052630A1 (en) Constant current electroporation device and methods of use
DE69332033T2 (de) Magnetotherapeutische vorrichtung
ITUB20159823A1 (it) Apparecchiatura elettromedicale per il trattamento del corpo umano e procedimento di trattamento mediante detta apparecchiatura
ATE183231T1 (de) Durchflussvorrichtung und verfahren zur elektroporation
Gehl Electroporation for drug and gene delivery in the clinic: doctors go electric
ATE236681T1 (de) Elektroporation und iontophorese vorrichtung für die abgabe von medikamenten und genen in zellen
EP1131131A1 (de) System und verfahren zum aktiven transdermalen verabreichen einer arznei
CA2112131C (en) Device for causing protons to migrate out of electrolytical internal body fluids
JPH0623060A (ja) 電子薬物投与器
WO2008051521A2 (en) Excessive fibrous capsule formation and capsular contracture apparatus and method for using same
JPH02111378A (ja) 電磁生体刺激装置
MX2008004415A (en) Electromagnetic fields for systemic effect in therapy
KR20070015908A (ko) 전자기적 치료 장치 및 방법

Legal Events

Date Code Title Description
8364 No opposition during term of opposition