DE69419523T2 - Substituierte hydroxyacetyl piperazine phenyl oxazolidinonsäureester - Google Patents

Substituierte hydroxyacetyl piperazine phenyl oxazolidinonsäureester

Info

Publication number
DE69419523T2
DE69419523T2 DE69419523T DE69419523T DE69419523T2 DE 69419523 T2 DE69419523 T2 DE 69419523T2 DE 69419523 T DE69419523 T DE 69419523T DE 69419523 T DE69419523 T DE 69419523T DE 69419523 T2 DE69419523 T2 DE 69419523T2
Authority
DE
Germany
Prior art keywords
6alkyl
pct
date
phenyl
oxazolidinonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69419523T
Other languages
English (en)
Other versions
DE69419523D1 (en
Inventor
Steven Brickner
Michel Barbachyn
Douglas HUTCHINSON
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Publication of DE69419523D1 publication Critical patent/DE69419523D1/de
Application granted granted Critical
Publication of DE69419523T2 publication Critical patent/DE69419523T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
DE69419523T 1993-11-22 1994-09-27 Substituierte hydroxyacetyl piperazine phenyl oxazolidinonsäureester Expired - Fee Related DE69419523T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15598893A 1993-11-22 1993-11-22
PCT/US1994/010582 WO1995014684A1 (en) 1993-11-22 1994-09-27 Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones

Publications (2)

Publication Number Publication Date
DE69419523D1 DE69419523D1 (en) 1999-08-19
DE69419523T2 true DE69419523T2 (de) 1999-11-25

Family

ID=22557606

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69419523T Expired - Fee Related DE69419523T2 (de) 1993-11-22 1994-09-27 Substituierte hydroxyacetyl piperazine phenyl oxazolidinonsäureester

Country Status (20)

Country Link
US (1) US5652238A (de)
EP (1) EP0730591B1 (de)
JP (1) JP3698724B2 (de)
KR (1) KR100312903B1 (de)
CN (1) CN1046276C (de)
AT (1) ATE182142T1 (de)
AU (1) AU698699B2 (de)
CA (1) CA2174107C (de)
CO (1) CO4290433A1 (de)
DE (1) DE69419523T2 (de)
DK (1) DK0730591T3 (de)
ES (1) ES2133588T3 (de)
GR (1) GR3031420T3 (de)
IL (1) IL111215A0 (de)
LV (1) LV12538B (de)
NZ (1) NZ274966A (de)
PE (1) PE22896A1 (de)
TW (1) TW427987B (de)
WO (1) WO1995014684A1 (de)
ZA (1) ZA947885B (de)

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ZA969622B (en) * 1995-12-13 1998-05-15 Upjohn Co Oxazolidinone antibacterial agents having a six-membered heteroaromatic ring.
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
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MY116093A (en) * 1996-02-26 2003-11-28 Upjohn Co Azolyl piperazinyl phenyl oxazolidinone antimicrobials
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9614236D0 (en) * 1996-07-06 1996-09-04 Zeneca Ltd Chemical compounds
GB9614238D0 (en) * 1996-07-06 1996-09-04 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717807D0 (en) * 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
WO1999024428A1 (en) * 1997-11-12 1999-05-20 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions
US6040306A (en) * 1997-11-18 2000-03-21 Pharmacia & Upjohn Company Method of treating psoriasis, arthritis and reducing the toxicity of cancer chemotherapy
NZ504612A (en) * 1997-11-18 2002-08-28 Upjohn Co Use of oxazolidinone derivatives for treating psoriasis, arthritis and reducing the toxicity of cancer chemotherapy
ES2243650T3 (es) * 1997-11-18 2005-12-01 PHARMACIA & UPJOHN COMPANY LLC Uso de derivados de oxazolidinonas para el tratamiento de la psoriasis.
AU780197B2 (en) * 1997-11-18 2005-03-10 Pharmacia & Upjohn Company Method of treating psoriasis, arthritis and reducing the toxicity of cancer chemotherapy
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
KR20010015910A (ko) * 1998-01-23 2001-02-26 로렌스 티. 마이젠헬더 옥사졸리디논 조합 라이브러리, 조성물 및 제조 방법
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
JP2002503655A (ja) * 1998-02-13 2002-02-05 ファルマシア・アンド・アップジョン・カンパニー 抗菌剤として有用な置換アミノフェニルイソオキサゾリン誘導体
HUP0103082A3 (en) 1998-06-05 2002-12-28 Astrazeneca Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
MY122454A (en) 1998-06-05 2006-04-29 Upjohn Co Use of oxazolidinones for the preparation of a medicament for transdermal delivery
BR9912004A (pt) 1998-07-14 2001-04-10 Upjohn Co Oxazolidinonas para tratar infecções dos olhos
AR020660A1 (es) * 1998-09-30 2002-05-22 Alcon Lab Inc Composiciones antibioticas para el tratamiento de ojos, oidos y nariz
JP2002535680A (ja) 1999-01-27 2002-10-22 ファルマシア・アンド・アップジョン・カンパニー 延長因子ｐ活性モジュレーターのアッセイ方法
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
PE20010851A1 (es) * 1999-12-14 2001-08-17 Upjohn Co Esteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina
US6642238B2 (en) 2000-02-10 2003-11-04 Pharmacia And Upjohn Company Oxazolidinone thioamides with piperazine amide substituents
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
NZ522990A (en) 2000-06-05 2003-08-29 Dong A Pharm Novel oxazolidinone derivatives and a process for the preparation thereof
BR0112826A (pt) 2000-07-17 2003-06-24 Ranbaxy Lab Ltd Derivados da oxazolidinona como antimicrobianos
PE20020300A1 (es) * 2000-08-22 2002-05-10 Pharmacia Corp Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco
PE20020578A1 (es) 2000-10-10 2002-08-14 Upjohn Co Una composicion de antibiotico topico para el tratamiento de infecciones oculares
US6861433B2 (en) 2000-12-15 2005-03-01 Pharmacia & Upjohn Company Oxazolidinone photoaffinity probes
US6956040B2 (en) 2001-07-16 2005-10-18 Ranbaxy Laboratories Limited Oxazolidinone piperazinyl derivatives as potential antimicrobials
EP1409464A4 (de) * 2001-07-16 2005-11-02 Ranbaxy Lab Ltd Oxazolidinonderivate als potentielle antimikrobielle mittel
TW200302095A (en) * 2002-01-25 2003-08-01 Upjohn Co Oxazolidinone cotherapy
EP1478404A1 (de) * 2002-02-22 2004-11-24 Pharmacia Corporation Ophthalmische antibiotische arzneimittel formulierungen enthaltend eine cyclodextrin verbindung und cetylpyridiniumchlorid
AR038536A1 (es) * 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
US7141588B2 (en) * 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
EP1490059A1 (de) * 2002-03-29 2004-12-29 Pharmacia & Upjohn Company LLC Parenterale, intravenöse und orale verabreichung von oxazolidinonen zur behandlung von diabetischem fuss-syndrom
WO2004014897A1 (en) * 2002-08-12 2004-02-19 Pharmacia & Upjohn Company Llc N-aryl-2-oxazolidinones and their derivatives
US7217726B2 (en) * 2002-08-22 2007-05-15 Orchid Chemicals & Pharmaceuticals Limited Antibacterial agents
WO2004026848A1 (en) * 2002-09-20 2004-04-01 Lupin Limited Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents
JP2006509035A (ja) * 2002-11-21 2006-03-16 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗菌剤としてのｎ−（４−（ピペラジン−１−イル）−フェニル−２−オキサゾリジノン−５−カルボキサミド誘導体および関連化合物
AU2002357561A1 (en) * 2002-12-30 2004-07-22 Nanjing Chang'ao Pharmaceutical Science And Technology Limited Company Oxazolidine derivative, methods of preparation and uses
US20040170686A1 (en) * 2003-01-31 2004-09-02 Fredrickson Jennifer K. Suspension vehicle for coated drug particles
WO2004069244A1 (en) * 2003-02-07 2004-08-19 Warner-Lambert Company Llc Oxazolidinone derivatives n-substituted by a bicyclic ring, for use as antibacterial agents
BRPI0407252A (pt) * 2003-02-07 2006-01-31 Warner Lambert Co Agentes antibacterianos.
US20040191326A1 (en) * 2003-03-31 2004-09-30 Reo Joseph P. Taste-masking vehicle for coated oxazolidinone particles
US20040204463A1 (en) * 2003-04-01 2004-10-14 Harris Christina Renee N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
WO2005019214A1 (en) * 2003-08-25 2005-03-03 Warner-Lambert Company Llc Novel antimicrobial aryloxazolidinone compounds
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
EP1925609A1 (de) * 2006-11-23 2008-05-28 Agfa Graphics N.V. Neue Coinitiatoren
WO2008061954A1 (en) * 2006-11-23 2008-05-29 Agfa Graphics Nv Novel co-initiators
KR101023174B1 (ko) * 2008-09-24 2011-03-18 주식회사 레고켐 바이오사이언스 사이클릭 아미독심 또는 사이클릭 아미드라존 기를 가지는 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
US8604209B2 (en) 2008-10-10 2013-12-10 Trius Therapeutics, Inc. Methods for preparing oxazolidinones and compositions containing them
KR101739923B1 (ko) 2009-02-03 2017-05-25 머크 샤프 앤드 돔 코포레이션 Ｒ)-3-(4-(2-(2-메틸테트라졸-5-일)피리딘-5-일)-3-플루오로페닐)-5-히드록시메틸 옥사졸리딘-2-온 디히드로겐 포스페이트의 결정형
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US4921869A (en) * 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
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Also Published As

Publication number Publication date
EP0730591B1 (de) 1999-07-14
JP3698724B2 (ja) 2005-09-21
DE69419523D1 (en) 1999-08-19
WO1995014684A1 (en) 1995-06-01
GR3031420T3 (en) 2000-01-31
KR960705818A (ko) 1996-11-08
AU8010394A (en) 1995-06-13
IL111215A0 (en) 1994-12-29
US5652238A (en) 1997-07-29
CA2174107C (en) 2005-04-12
NZ274966A (en) 1998-01-26
EP0730591A1 (de) 1996-09-11
CO4290433A1 (es) 1996-04-17
TW427987B (en) 2001-04-01
LV12538A (en) 2000-10-20
DK0730591T3 (da) 2000-01-31
CA2174107A1 (en) 1995-06-01
ATE182142T1 (de) 1999-07-15
KR100312903B1 (ko) 2002-02-28
JPH09505582A (ja) 1997-06-03
CN1135752A (zh) 1996-11-13
PE22896A1 (es) 1996-06-07
ZA947885B (en) 1996-04-09
AU698699B2 (en) 1998-11-05
CN1046276C (zh) 1999-11-10
ES2133588T3 (es) 1999-09-16
LV12538B (en) 2000-12-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee