DE69419523D1 - Substituierte hydroxyacetyl piperazine phenyl oxazolidinonsäureester - Google Patents
Substituierte hydroxyacetyl piperazine phenyl oxazolidinonsäureesterInfo
- Publication number
- DE69419523D1 DE69419523D1 DE69419523T DE69419523T DE69419523D1 DE 69419523 D1 DE69419523 D1 DE 69419523D1 DE 69419523 T DE69419523 T DE 69419523T DE 69419523 T DE69419523 T DE 69419523T DE 69419523 D1 DE69419523 D1 DE 69419523D1
- Authority
- DE
- Germany
- Prior art keywords
- 6alkyl
- pct
- date
- phenyl
- 3alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15598893A | 1993-11-22 | 1993-11-22 | |
PCT/US1994/010582 WO1995014684A1 (en) | 1993-11-22 | 1994-09-27 | Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69419523D1 true DE69419523D1 (en) | 1999-08-19 |
DE69419523T2 DE69419523T2 (de) | 1999-11-25 |
Family
ID=22557606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69419523T Expired - Fee Related DE69419523T2 (de) | 1993-11-22 | 1994-09-27 | Substituierte hydroxyacetyl piperazine phenyl oxazolidinonsäureester |
Country Status (20)
Country | Link |
---|---|
US (1) | US5652238A (de) |
EP (1) | EP0730591B1 (de) |
JP (1) | JP3698724B2 (de) |
KR (1) | KR100312903B1 (de) |
CN (1) | CN1046276C (de) |
AT (1) | ATE182142T1 (de) |
AU (1) | AU698699B2 (de) |
CA (1) | CA2174107C (de) |
CO (1) | CO4290433A1 (de) |
DE (1) | DE69419523T2 (de) |
DK (1) | DK0730591T3 (de) |
ES (1) | ES2133588T3 (de) |
GR (1) | GR3031420T3 (de) |
IL (1) | IL111215A0 (de) |
LV (1) | LV12538B (de) |
NZ (1) | NZ274966A (de) |
PE (1) | PE22896A1 (de) |
TW (1) | TW427987B (de) |
WO (1) | WO1995014684A1 (de) |
ZA (1) | ZA947885B (de) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9509673A (pt) * | 1994-11-15 | 1997-09-30 | Upjohn Co | Compostos e uso dos mesmos |
AU6964096A (en) * | 1995-09-15 | 1997-04-01 | Pharmacia & Upjohn Company | Aminoaryl oxazolidinone n-oxides |
ZA969622B (en) * | 1995-12-13 | 1998-05-15 | Upjohn Co | Oxazolidinone antibacterial agents having a six-membered heteroaromatic ring. |
GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
GB9702213D0 (en) * | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
MY116093A (en) * | 1996-02-26 | 2003-11-28 | Upjohn Co | Azolyl piperazinyl phenyl oxazolidinone antimicrobials |
GB9609919D0 (en) * | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
GB9614236D0 (en) * | 1996-07-06 | 1996-09-04 | Zeneca Ltd | Chemical compounds |
GB9614238D0 (en) * | 1996-07-06 | 1996-09-04 | Zeneca Ltd | Chemical compounds |
GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
GB9717807D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
CA2303959A1 (en) * | 1997-11-12 | 1999-05-20 | Pharmacia & Upjohn Company | Oxazolidinone derivatives and pharmaceutical compositions |
ES2193592T3 (es) * | 1997-11-18 | 2003-11-01 | Upjohn Co | Uso de derivados de la oxazolidinona para el tratamiento de la artritis. |
ES2243650T3 (es) * | 1997-11-18 | 2005-12-01 | PHARMACIA & UPJOHN COMPANY LLC | Uso de derivados de oxazolidinonas para el tratamiento de la psoriasis. |
US6040306A (en) * | 1997-11-18 | 2000-03-21 | Pharmacia & Upjohn Company | Method of treating psoriasis, arthritis and reducing the toxicity of cancer chemotherapy |
AU780197B2 (en) * | 1997-11-18 | 2005-03-10 | Pharmacia & Upjohn Company | Method of treating psoriasis, arthritis and reducing the toxicity of cancer chemotherapy |
GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
CA2318969A1 (en) | 1998-01-23 | 1999-07-29 | Mikhail F. Gordeev | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
US6562844B2 (en) | 1998-01-23 | 2003-05-13 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
US7002020B1 (en) | 1998-01-23 | 2006-02-21 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
NZ506292A (en) * | 1998-02-13 | 2003-05-30 | Upjohn Co | Substituted aminophenyl isoxazoline methylamide derivatives useful as antimicrobials |
MY122454A (en) | 1998-06-05 | 2006-04-29 | Upjohn Co | Use of oxazolidinones for the preparation of a medicament for transdermal delivery |
EE200000707A (et) | 1998-06-05 | 2002-04-15 | Astrazeneca Ab | Oksasolidinooni derivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid |
KR20010079530A (ko) * | 1998-07-14 | 2001-08-22 | 로렌스 티. 마이젠헬더 | 안 감염증 치료용 옥사졸리디논 |
AR020660A1 (es) * | 1998-09-30 | 2002-05-22 | Alcon Lab Inc | Composiciones antibioticas para el tratamiento de ojos, oidos y nariz |
JP2002535680A (ja) | 1999-01-27 | 2002-10-22 | ファルマシア・アンド・アップジョン・カンパニー | 延長因子p活性モジュレーターのアッセイ方法 |
GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
PE20010851A1 (es) * | 1999-12-14 | 2001-08-17 | Upjohn Co | Esteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina |
US6642238B2 (en) | 2000-02-10 | 2003-11-04 | Pharmacia And Upjohn Company | Oxazolidinone thioamides with piperazine amide substituents |
GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
AU5889701A (en) * | 2000-06-05 | 2001-12-17 | Dong A Pharm Co Ltd | Novel oxazolidinone derivatives and a process for the preparation thereof |
WO2003008389A1 (en) * | 2001-07-16 | 2003-01-30 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as potential antimicrobials |
JP2004504321A (ja) * | 2000-07-17 | 2004-02-12 | ランバクシー ラボラトリーズ リミテッド | 抗微生物剤としてのオキサゾリジノン誘導体 |
PE20020300A1 (es) * | 2000-08-22 | 2002-05-10 | Pharmacia Corp | Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco |
PE20020578A1 (es) | 2000-10-10 | 2002-08-14 | Upjohn Co | Una composicion de antibiotico topico para el tratamiento de infecciones oculares |
US6861433B2 (en) * | 2000-12-15 | 2005-03-01 | Pharmacia & Upjohn Company | Oxazolidinone photoaffinity probes |
US6956040B2 (en) | 2001-07-16 | 2005-10-18 | Ranbaxy Laboratories Limited | Oxazolidinone piperazinyl derivatives as potential antimicrobials |
TW200302095A (en) * | 2002-01-25 | 2003-08-01 | Upjohn Co | Oxazolidinone cotherapy |
MXPA04008173A (es) * | 2002-02-22 | 2004-11-26 | Pharmacia Corp | Formulaciones de farmaco antibiotico oftalmico que contienen un compuesto de ciclodextrina y cloruro de cetil piridinio. |
US7141588B2 (en) * | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
AR038536A1 (es) * | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
RU2354372C2 (ru) * | 2002-03-29 | 2009-05-10 | Фармация Энд Апджон Компани Ллс | Парентеральное, внутривенное и пероральное введение оксазолидинонов для лечения инфекционных поражений стопы при диабете |
EP1539745B1 (de) * | 2002-08-12 | 2006-03-29 | Pharmacia & Upjohn Company LLC | N-aryl-2-oxazolidinone und deren derivate |
EP1578734A1 (de) * | 2002-08-22 | 2005-09-28 | Orchid Chemicals and Pharmaceuticals Ltd | Neue antibakterielle wirkstoffe |
WO2004026848A1 (en) * | 2002-09-20 | 2004-04-01 | Lupin Limited | Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents |
AU2003280143A1 (en) * | 2002-11-21 | 2004-06-15 | Pharmacia & Upjohn Company Llc | N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinone-5-carboxamide derivates and related compounds as antibacterial agents |
AU2002357561A1 (en) * | 2002-12-30 | 2004-07-22 | Nanjing Chang'ao Pharmaceutical Science And Technology Limited Company | Oxazolidine derivative, methods of preparation and uses |
US20040170686A1 (en) * | 2003-01-31 | 2004-09-02 | Fredrickson Jennifer K. | Suspension vehicle for coated drug particles |
BRPI0407252A (pt) * | 2003-02-07 | 2006-01-31 | Warner Lambert Co | Agentes antibacterianos. |
BRPI0407304A (pt) * | 2003-02-07 | 2006-01-10 | Warner Lambert Co | Agentes antibacterianos |
US20040191326A1 (en) * | 2003-03-31 | 2004-09-30 | Reo Joseph P. | Taste-masking vehicle for coated oxazolidinone particles |
US20040204463A1 (en) * | 2003-04-01 | 2004-10-14 | Harris Christina Renee | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
BRPI0413838A (pt) * | 2003-08-25 | 2006-10-24 | Warner Lambert Co | compostos de ariloxazolidinona antimicrobianos |
US7304050B2 (en) * | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
KR100854211B1 (ko) | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
EP1925609A1 (de) * | 2006-11-23 | 2008-05-28 | Agfa Graphics N.V. | Neue Coinitiatoren |
WO2008061954A1 (en) * | 2006-11-23 | 2008-05-29 | Agfa Graphics Nv | Novel co-initiators |
KR101023174B1 (ko) * | 2008-09-24 | 2011-03-18 | 주식회사 레고켐 바이오사이언스 | 사이클릭 아미독심 또는 사이클릭 아미드라존 기를 가지는 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물 |
EP2757104B1 (de) | 2008-10-10 | 2019-08-14 | Merck Sharp & Dohme Corp. | In der synthese von oxazolidinonen verwendete verbindungen |
CU24089B1 (es) | 2009-02-03 | 2015-04-29 | Trius Therapeutics | Forma cristalina del fosfato de dihidrógeno r)-3-(4-(2-(2-metiltretazol-5-il)-3-fluorofenil)-5-hidroximetil oxazolidin-2-ona |
CA2754712A1 (en) * | 2009-03-13 | 2010-09-16 | Sun Chemical B.V. | Cyclic carbamate compounds useful in energy-curable compositions |
US8580767B2 (en) * | 2009-05-28 | 2013-11-12 | Trius Therapeutics, Inc. | Oxazolidinone containing dimer compounds, compositions and methods to make and use |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4921869A (en) * | 1987-10-09 | 1990-05-01 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US4801600A (en) * | 1987-10-09 | 1989-01-31 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
CA1320730C (en) * | 1987-10-16 | 1993-07-27 | The Du Pont Merck Pharmaceutical Company | Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents |
DE3884563T2 (de) * | 1987-10-21 | 1994-02-17 | Du Pont Merck Pharma | Aminomethyl-oxo-oxazolidinyl-ethenylbenzen-Derivate, nützlich als antibakterielles Mittel. |
US4948801A (en) * | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
US5164510A (en) * | 1988-09-15 | 1992-11-17 | The Upjohn Company | 5'Indolinyl-5β-amidomethyloxazolidin-2-ones |
US5225565A (en) * | 1988-09-15 | 1993-07-06 | The Upjohn Company | Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones |
US5182403A (en) * | 1988-09-15 | 1993-01-26 | The Upjohn Company | Substituted 3(5'indazolyl) oxazolidin-2-ones |
WO1993009103A1 (en) * | 1991-11-01 | 1993-05-13 | The Upjohn Company | Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents |
SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
-
1994
- 1994-09-27 AU AU80103/94A patent/AU698699B2/en not_active Ceased
- 1994-09-27 KR KR1019960702714A patent/KR100312903B1/ko not_active IP Right Cessation
- 1994-09-27 DK DK94931278T patent/DK0730591T3/da active
- 1994-09-27 EP EP94931278A patent/EP0730591B1/de not_active Expired - Lifetime
- 1994-09-27 US US08/640,899 patent/US5652238A/en not_active Expired - Fee Related
- 1994-09-27 CA CA002174107A patent/CA2174107C/en not_active Expired - Fee Related
- 1994-09-27 CN CN94194241A patent/CN1046276C/zh not_active Expired - Fee Related
- 1994-09-27 ES ES94931278T patent/ES2133588T3/es not_active Expired - Lifetime
- 1994-09-27 AT AT94931278T patent/ATE182142T1/de not_active IP Right Cessation
- 1994-09-27 NZ NZ274966A patent/NZ274966A/en unknown
- 1994-09-27 WO PCT/US1994/010582 patent/WO1995014684A1/en active IP Right Grant
- 1994-09-27 DE DE69419523T patent/DE69419523T2/de not_active Expired - Fee Related
- 1994-09-27 JP JP51504895A patent/JP3698724B2/ja not_active Expired - Fee Related
- 1994-10-07 ZA ZA947885A patent/ZA947885B/xx unknown
- 1994-10-10 IL IL11121594A patent/IL111215A0/xx unknown
- 1994-10-13 TW TW083109509A patent/TW427987B/zh not_active IP Right Cessation
- 1994-11-17 CO CO94052446A patent/CO4290433A1/es unknown
- 1994-11-17 PE PE1994254930A patent/PE22896A1/es not_active Application Discontinuation
-
1999
- 1999-10-07 GR GR990402509T patent/GR3031420T3/el unknown
-
2000
- 2000-07-14 LV LVP-00-91A patent/LV12538B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP0730591A1 (de) | 1996-09-11 |
WO1995014684A1 (en) | 1995-06-01 |
TW427987B (en) | 2001-04-01 |
ES2133588T3 (es) | 1999-09-16 |
NZ274966A (en) | 1998-01-26 |
JPH09505582A (ja) | 1997-06-03 |
US5652238A (en) | 1997-07-29 |
PE22896A1 (es) | 1996-06-07 |
CO4290433A1 (es) | 1996-04-17 |
GR3031420T3 (en) | 2000-01-31 |
CA2174107A1 (en) | 1995-06-01 |
EP0730591B1 (de) | 1999-07-14 |
ZA947885B (en) | 1996-04-09 |
JP3698724B2 (ja) | 2005-09-21 |
IL111215A0 (en) | 1994-12-29 |
AU8010394A (en) | 1995-06-13 |
ATE182142T1 (de) | 1999-07-15 |
CN1046276C (zh) | 1999-11-10 |
KR100312903B1 (ko) | 2002-02-28 |
CA2174107C (en) | 2005-04-12 |
LV12538B (en) | 2000-12-20 |
AU698699B2 (en) | 1998-11-05 |
CN1135752A (zh) | 1996-11-13 |
DE69419523T2 (de) | 1999-11-25 |
DK0730591T3 (da) | 2000-01-31 |
LV12538A (en) | 2000-10-20 |
KR960705818A (ko) | 1996-11-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |