DE69316240T2 - Durch eine tropon gruppe substituierte phenyloxazolidinone-derivate als antibakterielles mittel - Google Patents

Durch eine tropon gruppe substituierte phenyloxazolidinone-derivate als antibakterielles mittel

Info

Publication number
DE69316240T2
DE69316240T2 DE69316240T DE69316240T DE69316240T2 DE 69316240 T2 DE69316240 T2 DE 69316240T2 DE 69316240 T DE69316240 T DE 69316240T DE 69316240 T DE69316240 T DE 69316240T DE 69316240 T2 DE69316240 T2 DE 69316240T2
Authority
DE
Germany
Prior art keywords
tropon
group
antibacterial agent
derivatives substituted
phenyloxazolidinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69316240T
Other languages
English (en)
Other versions
DE69316240D1 (de
Inventor
Michael Barbachyn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Application granted granted Critical
Publication of DE69316240D1 publication Critical patent/DE69316240D1/de
Publication of DE69316240T2 publication Critical patent/DE69316240T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
DE69316240T 1992-12-08 1993-10-14 Durch eine tropon gruppe substituierte phenyloxazolidinone-derivate als antibakterielles mittel Expired - Fee Related DE69316240T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US98858992A 1992-12-08 1992-12-08
US377893A 1993-01-13 1993-01-13
US6635693A 1993-05-21 1993-05-21
PCT/US1993/009589 WO1994013649A1 (en) 1992-12-08 1993-10-14 Tropone-substituted phenyloxazolidinone antibacterial agents

Publications (2)

Publication Number Publication Date
DE69316240D1 DE69316240D1 (de) 1998-02-12
DE69316240T2 true DE69316240T2 (de) 1998-05-20

Family

ID=27357482

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69316240T Expired - Fee Related DE69316240T2 (de) 1992-12-08 1993-10-14 Durch eine tropon gruppe substituierte phenyloxazolidinone-derivate als antibakterielles mittel

Country Status (20)

Country Link
US (1) US5523403A (de)
EP (1) EP0673370B1 (de)
JP (1) JP3558088B2 (de)
KR (1) KR100276382B1 (de)
AT (1) ATE161833T1 (de)
AU (1) AU670842B2 (de)
CA (1) CA2147753C (de)
CZ (1) CZ288788B6 (de)
DE (1) DE69316240T2 (de)
DK (1) DK0673370T3 (de)
ES (1) ES2111188T3 (de)
FI (1) FI952798A0 (de)
GR (1) GR3026228T3 (de)
HU (1) HUT74099A (de)
NO (1) NO952253L (de)
NZ (1) NZ257031A (de)
PL (1) PL175782B1 (de)
RU (1) RU2119484C1 (de)
SK (1) SK282453B6 (de)
WO (1) WO1994013649A1 (de)

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GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
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EE200000707A (et) 1998-06-05 2002-04-15 Astrazeneca Ab Oksasolidinooni derivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
US6420349B1 (en) 1998-08-24 2002-07-16 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
TW572757B (en) * 1998-08-24 2004-01-21 Bristol Myers Squibb Co Novel isoxazolinone antibacterial agents
JP2002535680A (ja) 1999-01-27 2002-10-22 ファルマシア・アンド・アップジョン・カンパニー 延長因子ｐ活性モジュレーターのアッセイ方法
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
US6465456B2 (en) 2000-06-29 2002-10-15 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
ES2256331T3 (es) 2000-12-21 2006-07-16 PHARMACIA & UPJOHN COMPANY LLC Derivados de quinolina antimicrobianos y uso de los mismos para tratar infecciones bacterianas.
US6897230B2 (en) * 2001-04-17 2005-05-24 Kyorin Pharmaceutical Co., Ltd. Bicyclo[3/1/0] hexane containing oxazolidinone antibiotics and derivatives thereof
TW200302095A (en) * 2002-01-25 2003-08-01 Upjohn Co Oxazolidinone cotherapy
JP2005519931A (ja) * 2002-02-05 2005-07-07 ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー 細菌感染症治療に有用な抗微生物性チアジアジノン誘導体
AR038536A1 (es) * 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
US7141588B2 (en) * 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
RU2354372C2 (ru) * 2002-03-29 2009-05-10 Фармация Энд Апджон Компани Ллс Парентеральное, внутривенное и пероральное введение оксазолидинонов для лечения инфекционных поражений стопы при диабете
EP1539745B1 (de) * 2002-08-12 2006-03-29 Pharmacia & Upjohn Company LLC N-aryl-2-oxazolidinone und deren derivate
AU2003280143A1 (en) * 2002-11-21 2004-06-15 Pharmacia & Upjohn Company Llc N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinone-5-carboxamide derivates and related compounds as antibacterial agents
US7474742B2 (en) * 2003-01-31 2009-01-06 Qwest Communications International Inc. Environmentally-controlled network interface device and methods
US8050281B2 (en) * 2003-01-31 2011-11-01 Qwest Communications International Inc. Alert gateway, systems and methods
US8813142B2 (en) * 2003-01-31 2014-08-19 Qwest Communications International Inc. Methods, systems and apparatus for providing video transmissions over multiple media
BRPI0407252A (pt) * 2003-02-07 2006-01-31 Warner Lambert Co Agentes antibacterianos.
US20040204463A1 (en) * 2003-04-01 2004-10-14 Harris Christina Renee N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
CA2528089C (en) 2003-06-03 2015-11-24 Rib-X Pharmaceuticals, Inc. Biaryl heterocyclic compounds and methods of making and using the same
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WO2005005399A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
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JP4607107B2 (ja) 2003-07-02 2011-01-05 メルク・シャープ・エンド・ドーム・コーポレイション シクロプロピル基置換されたオキサゾリジノン抗生物質およびこれらの誘導体
WO2005005422A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
BRPI0413838A (pt) * 2003-08-25 2006-10-24 Warner Lambert Co compostos de ariloxazolidinona antimicrobianos
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
TW200526649A (en) 2003-12-17 2005-08-16 Rib X Pharmaceuticals Inc Halogenated biaryl heterocyclic compounds and methods of making and using the same
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
US8399660B2 (en) 2005-06-08 2013-03-19 Rib-X Pharmaceuticals, Inc. Process for the synthesis of triazoles
TW200804358A (en) 2006-03-31 2008-01-16 Res Found Itsuu Lab Novel compound having heterocycle
JPWO2007116960A1 (ja) * 2006-04-06 2009-08-20 財団法人乙卯研究所 炭素環を有するオキサゾリジノン誘導体
JPWO2009044777A1 (ja) 2007-10-02 2011-02-10 財団法人乙卯研究所 ７員ヘテロ環を有するオキサゾリジノン誘導体
EP2757104B1 (de) * 2008-10-10 2019-08-14 Merck Sharp & Dohme Corp. In der synthese von oxazolidinonen verwendete verbindungen
CU24089B1 (es) 2009-02-03 2015-04-29 Trius Therapeutics Forma cristalina del fosfato de dihidrógeno r)-3-(4-(2-(2-metiltretazol-5-il)-3-fluorofenil)-5-hidroximetil oxazolidin-2-ona
US8580767B2 (en) * 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use

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LU80081A1 (fr) * 1977-08-26 1979-05-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique
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US4340606A (en) * 1980-10-23 1982-07-20 E. I. Du Pont De Nemours And Company 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents
FR2500450A1 (fr) * 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
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US4461773A (en) * 1982-09-15 1984-07-24 E. I. Dupont De Nemours And Company P-Oxooxazolidinylbenzene compounds as antibacterial agents
US4705799A (en) * 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
ES8506659A1 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4921869A (en) * 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
CA1320730C (en) * 1987-10-16 1993-07-27 The Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
US4977173A (en) * 1987-10-21 1990-12-11 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
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US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
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Also Published As

Publication number Publication date
PL175782B1 (pl) 1999-02-26
HUT74099A (en) 1996-11-28
US5523403A (en) 1996-06-04
WO1994013649A1 (en) 1994-06-23
FI952798A (fi) 1995-06-07
HU9501670D0 (en) 1995-08-28
CZ288788B6 (cs) 2001-09-12
NO952253D0 (no) 1995-06-07
ES2111188T3 (es) 1998-03-01
AU5323994A (en) 1994-07-04
EP0673370B1 (de) 1998-01-07
EP0673370A1 (de) 1995-09-27
CZ136695A3 (en) 1995-10-18
DK0673370T3 (da) 1998-09-07
NO952253L (no) 1995-08-08
SK282453B6 (sk) 2002-02-05
RU95114378A (ru) 1997-06-10
DE69316240D1 (de) 1998-02-12
NZ257031A (en) 1996-07-26
GR3026228T3 (en) 1998-05-29
CA2147753A1 (en) 1994-06-23
JPH08504205A (ja) 1996-05-07
JP3558088B2 (ja) 2004-08-25
AU670842B2 (en) 1996-08-01
SK74695A3 (en) 1995-10-11
CA2147753C (en) 2004-08-03
ATE161833T1 (de) 1998-01-15
PL309283A1 (en) 1995-10-02
KR100276382B1 (ko) 2000-12-15
FI952798A0 (fi) 1995-06-07
RU2119484C1 (ru) 1998-09-27

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee