DE69316240D1 - Durch eine tropon gruppe substituierte phenyloxazolidinone-derivate als antibakterielles mittel - Google Patents

Durch eine tropon gruppe substituierte phenyloxazolidinone-derivate als antibakterielles mittel

Info

Publication number
DE69316240D1
DE69316240D1 DE69316240T DE69316240T DE69316240D1 DE 69316240 D1 DE69316240 D1 DE 69316240D1 DE 69316240 T DE69316240 T DE 69316240T DE 69316240 T DE69316240 T DE 69316240T DE 69316240 D1 DE69316240 D1 DE 69316240D1
Authority
DE
Germany
Prior art keywords
tropon
group
antibacterial agent
derivatives substituted
phenyloxazolidinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69316240T
Other languages
English (en)
Other versions
DE69316240T2 (de
Inventor
Michael Barbachyn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co filed Critical Pharmacia and Upjohn Co
Publication of DE69316240D1 publication Critical patent/DE69316240D1/de
Application granted granted Critical
Publication of DE69316240T2 publication Critical patent/DE69316240T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
DE69316240T 1992-12-08 1993-10-14 Durch eine tropon gruppe substituierte phenyloxazolidinone-derivate als antibakterielles mittel Expired - Fee Related DE69316240T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US98858992A 1992-12-08 1992-12-08
US377893A 1993-01-13 1993-01-13
US6635693A 1993-05-21 1993-05-21
PCT/US1993/009589 WO1994013649A1 (en) 1992-12-08 1993-10-14 Tropone-substituted phenyloxazolidinone antibacterial agents

Publications (2)

Publication Number Publication Date
DE69316240D1 true DE69316240D1 (de) 1998-02-12
DE69316240T2 DE69316240T2 (de) 1998-05-20

Family

ID=27357482

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69316240T Expired - Fee Related DE69316240T2 (de) 1992-12-08 1993-10-14 Durch eine tropon gruppe substituierte phenyloxazolidinone-derivate als antibakterielles mittel

Country Status (20)

Country Link
US (1) US5523403A (de)
EP (1) EP0673370B1 (de)
JP (1) JP3558088B2 (de)
KR (1) KR100276382B1 (de)
AT (1) ATE161833T1 (de)
AU (1) AU670842B2 (de)
CA (1) CA2147753C (de)
CZ (1) CZ288788B6 (de)
DE (1) DE69316240T2 (de)
DK (1) DK0673370T3 (de)
ES (1) ES2111188T3 (de)
FI (1) FI952798A0 (de)
GR (1) GR3026228T3 (de)
HU (1) HUT74099A (de)
NO (1) NO952253L (de)
NZ (1) NZ257031A (de)
PL (1) PL175782B1 (de)
RU (1) RU2119484C1 (de)
SK (1) SK282453B6 (de)
WO (1) WO1994013649A1 (de)

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DK0920421T3 (da) * 1996-08-21 2003-03-10 Upjohn Co Isoxazolinderivater anvendelige som antimikrobielle midler
US5998414A (en) * 1996-08-22 1999-12-07 Hoechst Marion Roussel, Inc. Troponyl piperazines as dopamine D4 receptor ligands
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
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ES2284216T3 (es) * 1997-11-07 2007-11-01 PHARMACIA & UPJOHN COMPANY LLC Procedeimiento para producir oxazolidinonas.
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
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CN1288462A (zh) * 1998-01-23 2001-03-21 法玛西雅厄普约翰美国公司 噁唑烷酮组合库、组合物和制备方法
WO1999064417A2 (en) * 1998-06-05 1999-12-16 Astrazeneca Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
US6420349B1 (en) 1998-08-24 2002-07-16 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
TW572757B (en) * 1998-08-24 2004-01-21 Bristol Myers Squibb Co Novel isoxazolinone antibacterial agents
AU4224699A (en) 1999-01-27 2000-08-18 Pharmacia & Upjohn Company Assays for modulators of elongation factor p activity
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
US6465456B2 (en) 2000-06-29 2002-10-15 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
CA2424402A1 (en) 2000-12-21 2002-08-01 Pharmacia & Upjohn Company Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
WO2003027083A1 (en) * 2001-04-17 2003-04-03 Merck & Co., Inc. Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof
TW200302095A (en) * 2002-01-25 2003-08-01 Upjohn Co Oxazolidinone cotherapy
WO2003066631A1 (en) * 2002-02-05 2003-08-14 Pharmacia & Upjohn Company Antimicrobial thiadiazinone derivatives useful in treatment of bacterial infections
AR038536A1 (es) * 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
US7141588B2 (en) * 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
BR0308806A (pt) * 2002-03-29 2005-01-04 Upjohn Co Uso de oxazolidinonas para tratar infecções do tipo pé diabético
AU2003259159A1 (en) * 2002-08-12 2004-02-25 Pharmacia & Upjohn Company Llc N-aryl-2-oxazolidinones and their derivatives
CA2502017A1 (en) * 2002-11-21 2004-06-03 Pharmacia & Upjohn Company Llc N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinone-5-carboxamide derivates and related compounds as antibacterial agents
US7474742B2 (en) * 2003-01-31 2009-01-06 Qwest Communications International Inc. Environmentally-controlled network interface device and methods
US8813142B2 (en) * 2003-01-31 2014-08-19 Qwest Communications International Inc. Methods, systems and apparatus for providing video transmissions over multiple media
US8050281B2 (en) * 2003-01-31 2011-11-01 Qwest Communications International Inc. Alert gateway, systems and methods
EP1594865A2 (de) * 2003-02-07 2005-11-16 Warner-Lambert Company LLC Antibakterielle mittel
US20040204463A1 (en) * 2003-04-01 2004-10-14 Harris Christina Renee N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
SG2009082793A (en) 2003-06-03 2015-03-30 Rib X Pharmaceuticals Inc Biaryl heterocyclic compounds and methods of making and using the same
RU2348628C2 (ru) 2003-07-02 2009-03-10 Мерк Энд Ко., Инк. Замещенные циклопропильной группой оксазолидиноновые антибиотики и их производные
CA2529293A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
WO2005005399A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
JP2007521284A (ja) * 2003-07-02 2007-08-02 メルク アンド カンパニー インコーポレーテッド オキサゾリジノン系抗生物質及びその誘導体
BRPI0413838A (pt) * 2003-08-25 2006-10-24 Warner Lambert Co compostos de ariloxazolidinona antimicrobianos
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
AR046782A1 (es) * 2003-12-17 2005-12-21 Rib X Pharmaceuticals Inc Compuestos heterociclicos de biarilo halogenados, composiciones farmaceuticas que los contienen, metodos para su elaboracion y su uso como medicamentos.
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
EP1904489B1 (de) 2005-06-08 2011-01-26 Rib-X Pharmaceuticals, Inc. Verfahren zur synthese von triazolen
KR20080110877A (ko) 2006-03-31 2008-12-19 재단법인 이쯔우 연구소 헤테로환을 갖는 신규 화합물
WO2007116960A1 (ja) * 2006-04-06 2007-10-18 Research Foundation Itsuu Laboratory 炭素環を有するオキサゾリジノン誘導体
US8530646B2 (en) * 2007-10-02 2013-09-10 Research Foundation Itsuu Laboratory Oxazolidinone derivative having 7-membered hetero ring
CN106220621B (zh) 2008-10-10 2019-06-11 默沙东公司 制备噁唑烷酮类的方法及含有噁唑烷酮类的组合物
MY156354A (en) 2009-02-03 2016-02-15 Merck Sharp & Dohme Crystalline form of r)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate
US8580767B2 (en) * 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use

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USRE29607E (en) * 1969-03-18 1978-04-11 Delalande S. A. Derivatives of 5-hydroxymethyl-3-substituted-2-oxazolidinones, process of preparation thereof and therapeutic application
LU80081A1 (fr) * 1977-08-26 1979-05-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique
US4128654A (en) * 1978-02-10 1978-12-05 E. I. Du Pont De Nemours And Company 5-Halomethyl-3-phenyl-2-oxazolidinones
US4340606A (en) * 1980-10-23 1982-07-20 E. I. Du Pont De Nemours And Company 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents
FR2500450A1 (fr) * 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
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US4461773A (en) * 1982-09-15 1984-07-24 E. I. Dupont De Nemours And Company P-Oxooxazolidinylbenzene compounds as antibacterial agents
ES8506659A1 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
US4705799A (en) * 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4921869A (en) * 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
CA1320730C (en) * 1987-10-16 1993-07-27 The Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
ATE95176T1 (de) * 1987-10-21 1993-10-15 Du Pont Merck Pharma Aminomethyl-oxo-oxazolidinyl-ethenylbenzenderivate, nuetzlich als antibakterielles mittel.
US4977173A (en) * 1987-10-21 1990-12-11 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5164510A (en) * 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones

Also Published As

Publication number Publication date
RU95114378A (ru) 1997-06-10
NO952253L (no) 1995-08-08
EP0673370B1 (de) 1998-01-07
DE69316240T2 (de) 1998-05-20
AU5323994A (en) 1994-07-04
DK0673370T3 (da) 1998-09-07
RU2119484C1 (ru) 1998-09-27
JP3558088B2 (ja) 2004-08-25
HUT74099A (en) 1996-11-28
GR3026228T3 (en) 1998-05-29
SK282453B6 (sk) 2002-02-05
US5523403A (en) 1996-06-04
CZ288788B6 (cs) 2001-09-12
ATE161833T1 (de) 1998-01-15
SK74695A3 (en) 1995-10-11
PL175782B1 (pl) 1999-02-26
CZ136695A3 (en) 1995-10-18
FI952798A (fi) 1995-06-07
FI952798A0 (fi) 1995-06-07
ES2111188T3 (es) 1998-03-01
JPH08504205A (ja) 1996-05-07
AU670842B2 (en) 1996-08-01
PL309283A1 (en) 1995-10-02
EP0673370A1 (de) 1995-09-27
NZ257031A (en) 1996-07-26
CA2147753A1 (en) 1994-06-23
NO952253D0 (no) 1995-06-07
CA2147753C (en) 2004-08-03
HU9501670D0 (en) 1995-08-28
WO1994013649A1 (en) 1994-06-23
KR100276382B1 (ko) 2000-12-15

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee