DE69216251D1 - Substituierte aryl- und heteroaryl-phenyloxazolidinone - Google Patents

Substituierte aryl- und heteroaryl-phenyloxazolidinone

Info

Publication number
DE69216251D1
DE69216251D1 DE69216251T DE69216251T DE69216251D1 DE 69216251 D1 DE69216251 D1 DE 69216251D1 DE 69216251 T DE69216251 T DE 69216251T DE 69216251 T DE69216251 T DE 69216251T DE 69216251 D1 DE69216251 D1 DE 69216251D1
Authority
DE
Germany
Prior art keywords
phenyloxazolidinone
aryl
und heteroaryl
heteroarylphenyloxazolidinones
oxazolidinones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69216251T
Other languages
English (en)
Other versions
DE69216251T2 (de
Inventor
Michael Barbachyn
Steven Brickner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Publication of DE69216251D1 publication Critical patent/DE69216251D1/de
Application granted granted Critical
Publication of DE69216251T2 publication Critical patent/DE69216251T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
DE69216251T 1991-11-01 1992-10-05 Substituierte aryl- und heteroaryl-phenyloxazolidinone Expired - Fee Related DE69216251T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78610791A 1991-11-01 1991-11-01
US83121392A 1992-02-07 1992-02-07
PCT/US1992/008267 WO1993009103A1 (en) 1991-11-01 1992-10-05 Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents

Publications (2)

Publication Number Publication Date
DE69216251D1 true DE69216251D1 (en) 1997-02-06
DE69216251T2 DE69216251T2 (de) 1997-05-15

Family

ID=27120493

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69216251T Expired - Fee Related DE69216251T2 (de) 1991-11-01 1992-10-05 Substituierte aryl- und heteroaryl-phenyloxazolidinone

Country Status (11)

Country Link
US (6) US5565571A (de)
EP (1) EP0610265B1 (de)
JP (1) JP3176626B2 (de)
KR (1) KR100257418B1 (de)
AT (1) ATE146783T1 (de)
AU (1) AU667198B2 (de)
CA (1) CA2119556C (de)
DE (1) DE69216251T2 (de)
DK (1) DK0610265T3 (de)
GR (1) GR3022340T3 (de)
WO (1) WO1993009103A1 (de)

Families Citing this family (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2119556C (en) * 1991-11-01 2004-07-06 Michael Robert Barbachyn Substituted aryl- and heteroaryl-phenyloxazolidinones
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
DK0730591T3 (da) * 1993-11-22 2000-01-31 Upjohn Co Estere af substituerede hydroxyacetyl-piperazin-phenyl-oxazolidinoner
JPH0873455A (ja) * 1994-03-15 1996-03-19 Upjohn Co:The オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物
US5668286A (en) * 1994-03-15 1997-09-16 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions containing them
DE4425612A1 (de) * 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
DE4425613A1 (de) * 1994-07-20 1996-01-25 Bayer Ag 5-gliedrige Heteroaryl-oxazolidinone
DE19514313A1 (de) * 1994-08-03 1996-02-08 Bayer Ag Benzoxazolyl- und Benzothiazolyloxazolidinone
ES2162941T3 (es) * 1994-10-26 2002-01-16 Upjohn Co Compuestos antimicrobianos de feniloxazolidinona.
US5952324A (en) * 1994-11-15 1999-09-14 Pharmacia & Upjohn Company Bicyclic oxazine and thiazine oxazolidinone antibacterials
ATE205205T1 (de) * 1995-02-03 2001-09-15 Upjohn Co Durch hetero-aromatische ring substituierte phenyloxazolidinone als antimikrobielles mittel
DE69614847T2 (de) * 1995-05-11 2002-04-04 Upjohn Co Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone
HUP9901979A3 (en) * 1995-09-01 2000-03-28 Upjohn Co Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings and pharmaceutical compositions containing the same
US5883093A (en) * 1995-09-12 1999-03-16 Pharmacia & Upjohn Company Phenyloxazolidinone antimicrobials
GB9521508D0 (en) * 1995-10-20 1995-12-20 Zeneca Ltd Chemical compounds
ZA969622B (en) * 1995-12-13 1998-05-15 Upjohn Co Oxazolidinone antibacterial agents having a six-membered heteroaromatic ring.
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
HRP970049A2 (en) * 1996-02-06 1998-04-30 Bayer Ag New heteroaryl oxazolidinones
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9604301D0 (en) * 1996-02-29 1996-05-01 Zeneca Ltd Chemical compounds
CA2248143C (en) * 1996-04-11 2008-10-07 Bruce A. Pearlman Process to prepare oxazolidinones
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9614236D0 (en) * 1996-07-06 1996-09-04 Zeneca Ltd Chemical compounds
GB9614238D0 (en) * 1996-07-06 1996-09-04 Zeneca Ltd Chemical compounds
US6037354A (en) * 1997-06-18 2000-03-14 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
KR20010021645A (ko) * 1997-07-11 2001-03-15 로렌스 티. 마이젠헬더 티아디아졸릴 및 옥사디아졸릴 페닐 옥사졸리디논 항균제
DE19730847A1 (de) * 1997-07-18 1999-01-28 Bayer Ag Tricyclisch substituierte Oxazolidinone
GB9717807D0 (en) * 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) * 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
HUP0004388A3 (en) 1997-11-07 2001-10-29 Upjohn Co Process for the preparation of oxazolidinones, intermediates and preparation thereof
SK284577B6 (sk) * 1997-11-12 2005-07-01 Pharmacia & Upjohn Company Deriváty oxazolidinónu, ich použitie a farmaceutické kompozície
US6040306A (en) * 1997-11-18 2000-03-21 Pharmacia & Upjohn Company Method of treating psoriasis, arthritis and reducing the toxicity of cancer chemotherapy
DK1304107T3 (da) * 1997-11-18 2005-08-22 Pharmacia & Upjohn Co Llc Anvendelse af oxozolidinonderivater til behandling af psoriasis
JP2001522886A (ja) * 1997-11-18 2001-11-20 ファルマシア・アンド・アップジョン・カンパニー 乾癬、関節炎を治療し、癌化学療法の毒性を低減するためのオキサゾリジノン誘導体の使用
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
US6083967A (en) * 1997-12-05 2000-07-04 Pharmacia & Upjohn Company S-oxide and S,S-dioxide tetrahydrothiopyran phenyloxazolidinones
WO1999033839A1 (en) * 1997-12-26 1999-07-08 Cheil Jedang Corporation Cephem derivatives and a method for producing the compounds and an antibacterial composition containing the compounds
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
CA2318969A1 (en) * 1998-01-23 1999-07-29 Mikhail F. Gordeev Oxazolidinone combinatorial libraries, compositions and methods of preparation
EE200000707A (et) 1998-06-05 2002-04-15 Astrazeneca Ab Oksasolidinooni derivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
MY122454A (en) * 1998-06-05 2006-04-29 Upjohn Co Use of oxazolidinones for the preparation of a medicament for transdermal delivery
IL140769A0 (en) 1998-07-14 2002-02-10 Upjohn Co Oxazolidinones to treat eye infections
WO2000029396A1 (de) * 1998-11-17 2000-05-25 Bayer Aktiengesellschaft Neue substituierte phenyloxazolidon-derivate
JP2002535680A (ja) 1999-01-27 2002-10-22 ファルマシア・アンド・アップジョン・カンパニー 延長因子ｐ活性モジュレーターのアッセイ方法
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6413981B1 (en) 1999-08-12 2002-07-02 Ortho-Mcneil Pharamceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6297242B1 (en) 1999-08-12 2001-10-02 Ortho-Mcneil Pharmaceutical, Inc. N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
KR100638288B1 (ko) * 1999-12-15 2006-10-25 동아제약주식회사 옥사졸리디논 유도체 및 그 제조방법
US6518285B2 (en) 1999-12-21 2003-02-11 Ortho Mcneil Pharmaceutical, Inc. Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
KR100713170B1 (ko) * 2001-03-07 2007-05-02 동아제약주식회사 헤테로고리 또는 헤테로아로마틱 고리가 치환된 피리딘고리를 포함하는 옥사졸리디논 유도체 및 그의 제조방법
KR100674096B1 (ko) * 2000-06-05 2007-01-26 동아제약주식회사 피리미딘 고리를 포함하는 신규 옥사졸리디논 유도체와그의 제조방법
KR100731469B1 (ko) * 2000-06-05 2007-06-21 동아제약주식회사 피리딘 고리를 포함하는 옥사졸리디논 유도체 및 그의제조방법
AU5889701A (en) 2000-06-05 2001-12-17 Dong A Pharm Co Ltd Novel oxazolidinone derivatives and a process for the preparation thereof
JP2004504321A (ja) 2000-07-17 2004-02-12 ランバクシー　ラボラトリーズ　リミテッド 抗微生物剤としてのオキサゾリジノン誘導体
PE20020300A1 (es) * 2000-08-22 2002-05-10 Pharmacia Corp Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco
US6277868B1 (en) * 2000-08-31 2001-08-21 Abbott Laboratories Oxazolidinone chemotherapeutic agents
US6410728B1 (en) * 2000-08-31 2002-06-25 Abbott Laboratories Oxazolidinone chemotherapeutic agents
WO2002020515A1 (en) * 2000-09-08 2002-03-14 Abbott Laboratories Oxazolidinone antibacterial agents
PE20020578A1 (es) 2000-10-10 2002-08-14 Upjohn Co Una composicion de antibiotico topico para el tratamiento de infecciones oculares
EP1328509B1 (de) 2000-10-17 2006-03-22 Pharmacia & Upjohn Company LLC Verfahren zur herstellung von oxazolidinonverbindungen
US6861433B2 (en) 2000-12-15 2005-03-01 Pharmacia & Upjohn Company Oxazolidinone photoaffinity probes
US6689769B2 (en) 2000-12-21 2004-02-10 Pharmacia & Upjohn Company Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
CA2405532A1 (en) 2001-02-07 2002-08-22 Ortho-Mcneil Pharmaceutical, Inc. Pyridoarylphenyl oxazolidinone antibacterials, and related compositions and methods
WO2003027083A1 (en) * 2001-04-17 2003-04-03 Merck & Co., Inc. Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof
DE10129725A1 (de) 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
US6956040B2 (en) 2001-07-16 2005-10-18 Ranbaxy Laboratories Limited Oxazolidinone piperazinyl derivatives as potential antimicrobials
US7125568B2 (en) 2001-08-23 2006-10-24 Sung Michael T Lipophilic drug compositions
WO2003031441A1 (en) * 2001-10-04 2003-04-17 Morphochen Aktiengesellschaft Für Kombinatorische Chemie Multiple action compounds
WO2003031443A1 (de) * 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual action antibiotics
JP2003192773A (ja) * 2001-12-26 2003-07-09 Mitsui Chemicals Inc 生体吸収性ポリヒドロキシカルボン酸及びその製造法
TW200302095A (en) * 2002-01-25 2003-08-01 Upjohn Co Oxazolidinone cotherapy
MXPA04007468A (es) * 2002-02-05 2004-11-10 Upjohn Co Derivados de tiadiazinona antimicrobianos y su aplicacion para el tratamiento de infecciones bacterianas.
BR0307898A (pt) * 2002-02-22 2004-12-07 Pharmacia Corp Formulações de droga antibiótica oftálmica contendo um composto de ciclodextrina e cloreto de cetil piridìnio
US7141588B2 (en) * 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
AR038536A1 (es) * 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
BR0308806A (pt) * 2002-03-29 2005-01-04 Upjohn Co Uso de oxazolidinonas para tratar infecções do tipo pé diabético
ATE321760T1 (de) * 2002-08-12 2006-04-15 Pharmacia & Upjohn Co Llc N-aryl-2-oxazolidinone und deren derivate
AU2002339721A1 (en) * 2002-09-20 2004-04-08 Lupin Limited Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents
ES2271660T3 (es) * 2002-11-21 2007-04-16 PHARMACIA & UPJOHN COMPANY LLC Derivados de n-(4-piperazin-1-il)-fenil-2-oxazolidinona-5-carboxamida y compuestos relacionados como agentes antibacterianos.
GB0229526D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
GB0229521D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
DE10300111A1 (de) * 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
US20040170686A1 (en) * 2003-01-31 2004-09-02 Fredrickson Jennifer K. Suspension vehicle for coated drug particles
WO2004069832A2 (en) * 2003-02-07 2004-08-19 Warner-Lambert Company Llc Antibacterial agents
TW200500360A (en) * 2003-03-01 2005-01-01 Astrazeneca Ab Hydroxymethyl compounds
US20040191326A1 (en) * 2003-03-31 2004-09-30 Reo Joseph P. Taste-masking vehicle for coated oxazolidinone particles
US20040204463A1 (en) * 2003-04-01 2004-10-14 Harris Christina Renee N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
US20070155714A1 (en) 2003-04-30 2007-07-05 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
US6969726B2 (en) * 2003-06-03 2005-11-29 Rib X Pharmaceuticals Inc Biaryl heterocyclic compounds and methods of making and using the same
ATE471937T1 (de) * 2003-07-02 2010-07-15 Merck Sharp & Dohme Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon
JP2007521282A (ja) * 2003-07-02 2007-08-02 メルク アンド カンパニー インコーポレーテッド オキサゾリジノン抗生物質およびその誘導体
WO2005005422A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
WO2005005420A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Cyclopropyl group substituted oyazolidinone antibiotics and derivatives thereof
EP1660488A1 (de) * 2003-08-25 2006-05-31 Warner-Lambert Company LLC Neue antibakterielle aryloxazolidinone
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
EP1713785A1 (de) * 2003-12-17 2006-10-25 Rib-X Pharmaceuticals, Inc. Halogenierte heterocyclische biarylverbindungen und verfahren zu deren herstellung und verwendung
ES2310299T5 (es) 2003-12-18 2014-02-10 Morphochem Aktiengesellschaft für kombinatorische Chemie Antibióticos híbridos a base de oxazolidinona-quinolona
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
EP1778653A1 (de) * 2004-07-28 2007-05-02 Rib-X Pharmaceuticals, Inc. Heterocyclische biarylverbindungen und verfahren zu deren herstellung und anwendung
WO2006018682A2 (en) * 2004-08-11 2006-02-23 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
EP1796673A2 (de) * 2004-09-23 2007-06-20 Reddy US Therapeutics, Inc. Neue pyrimidin-verbindungen, verfahren zu ihrer herstellung und diese enthaltende zusammensetzungen
US8088891B2 (en) 2004-09-28 2012-01-03 Janssen Pharmaceutica N.V. Bacterial ATP synthase binding domain
US20100286211A1 (en) * 2004-10-08 2010-11-11 Biswajit Das Oxazolidinone derivatives as antimicrobials
DE102004062475A1 (de) * 2004-12-24 2006-07-06 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
EP1685841A1 (de) 2005-01-31 2006-08-02 Bayer Health Care Aktiengesellschaft Prophylaxe und Behandlung von thrombolischen Erkrankungen
US7291614B2 (en) * 2005-02-24 2007-11-06 Teva Pharmaceutical Industries Ltd. Processes for the preparation of linezolid intermediate
WO2006109156A1 (en) 2005-04-15 2006-10-19 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
DE602006019870D1 (de) 2005-06-08 2011-03-10 Rib X Pharmaceuticals Inc Verfahren zur synthese von triazolen
DE102005045518A1 (de) 2005-09-23 2007-03-29 Bayer Healthcare Ag 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung
WO2007039132A1 (de) 2005-10-04 2007-04-12 Bayer Healthcare Ag Neue polymorphe form und die amorphe form von 5-chlor-n- ( { ( 5s ) -2-0x0-3-[4-( 3-oxo-4-morpholinyl) - phenyl] -1,3-oxazolidin-5-yl} -methyl) -2- thiophencarboxamid
DE102005047558A1 (de) * 2005-10-04 2008-02-07 Bayer Healthcare Ag Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen
DE102005047561A1 (de) 2005-10-04 2007-04-05 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
DE102005048824A1 (de) * 2005-10-10 2007-04-12 Bayer Healthcare Ag Behandlung und Prophylaxe von Mikroangiopathien
WO2007133803A2 (en) * 2006-05-15 2007-11-22 Rib-X Pharmaceuticals, Inc. Treatment of mycobacterial infections
DE102006051625A1 (de) * 2006-11-02 2008-05-08 Bayer Materialscience Ag Kombinationstherapie substituierter Oxazolidinone
DE102007018662A1 (de) 2007-04-20 2008-10-23 Bayer Healthcare Ag Oxazolidinone zur Behandlung und Prophylaxe von pulmonaler Hypertonie
DE102007028318A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Oxazolidinone zur Behandlung und Prophylaxe von Sepsis
JP2011506363A (ja) * 2007-12-11 2011-03-03 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト 心不全の処置および／または予防用のオキサゾリジノン類
JPWO2009157423A1 (ja) 2008-06-24 2011-12-15 財団法人乙卯研究所 縮合環を有するオキサゾリジノン誘導体
EP2138178A1 (de) 2008-06-28 2009-12-30 Bayer Schering Pharma Aktiengesellschaft Oxazolidninone zur Behandlung der chronisch obstruktiven Lungenerkrankung (COPD) und/oder Asthma
EP2140866A1 (de) 2008-07-04 2010-01-06 Bayer Schering Pharma Aktiengesellschaft Oxazolidinone zur Behandlung von Entzündungserkrankungen des Magen-Darm-Trakts
WO2010042887A2 (en) 2008-10-10 2010-04-15 Trius Therapeutics Methods for preparing oxazolidinones and compositions containing them
JP5662940B2 (ja) 2008-11-20 2015-02-04 パナセア バイオテック リミテッド 新規な抗微生物薬
NZ594408A (en) 2009-02-03 2014-03-28 Trius Therapeutics Crystalline form of r)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate
US8580767B2 (en) 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
RU2012102094A (ru) 2009-06-26 2013-08-10 Панацеа Биотек Лтд. Новые азабициклогексаны
BR112012010635A2 (pt) * 2009-11-04 2018-03-20 Sichuan Beilike Biotechnology Llc hidratos cristalinos, composições farmaceuticas e seus métodos de preparação e métodos para uso dos mesmos
CN102153547A (zh) * 2010-02-11 2011-08-17 山东轩竹医药科技有限公司 含有并环的噁唑烷酮抗菌素
CN102276595A (zh) * 2010-04-16 2011-12-14 山东轩竹医药科技有限公司 含有五元杂环的噁唑烷酮抗菌素
CN104356124A (zh) * 2014-10-30 2015-02-18 广东东阳光药业有限公司 噁唑烷酮类化合物及其组合物和用途
CA2967825A1 (en) 2014-11-14 2016-05-19 Melinta Therapeutics, Inc. Method for treating, preventing, or reducing the risk of skin infection
CN104447730B (zh) * 2014-12-05 2017-11-07 广东东阳光药业有限公司 噁唑烷酮类化合物及其在药物中的应用
KR101660874B1 (ko) 2015-09-04 2016-09-30 주식회사 알에스텍 리네졸리드의 제조방법 및 그 중간체
WO2017066964A1 (en) 2015-10-22 2017-04-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US29607A (en) * 1860-08-14 Portable scaffold
USRE29607E (en) * 1969-03-18 1978-04-11 Delalande S. A. Derivatives of 5-hydroxymethyl-3-substituted-2-oxazolidinones, process of preparation thereof and therapeutic application
LU80081A1 (fr) * 1977-08-26 1979-05-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique
US4128654A (en) * 1978-02-10 1978-12-05 E. I. Du Pont De Nemours And Company 5-Halomethyl-3-phenyl-2-oxazolidinones
US4340606A (en) * 1980-10-23 1982-07-20 E. I. Du Pont De Nemours And Company 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents
FR2500450A1 (fr) * 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
US4461773A (en) * 1982-09-15 1984-07-24 E. I. Dupont De Nemours And Company P-Oxooxazolidinylbenzene compounds as antibacterial agents
JPS59224600A (ja) * 1983-06-03 1984-12-17 富士写真フイルム株式会社 放射線像変換パネル
US4705799A (en) * 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
ES533097A0 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
US4921869A (en) * 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
CA1320730C (en) * 1987-10-16 1993-07-27 The Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
DE3884563T2 (de) * 1987-10-21 1994-02-17 Du Pont Merck Pharma Aminomethyl-oxo-oxazolidinyl-ethenylbenzen-Derivate, nützlich als antibakterielles Mittel.
US4977173A (en) * 1987-10-21 1990-12-11 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5254577A (en) * 1988-07-29 1993-10-19 The Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5164510A (en) * 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones
CA2066191C (en) * 1989-11-17 2001-07-24 Pharmacia & Upjohn Company Llc Tricyclic ¬6,5,5|/¬6,6,5|-fused oxazolidinone antibacterial agents
CA2119556C (en) * 1991-11-01 2004-07-06 Michael Robert Barbachyn Substituted aryl- and heteroaryl-phenyloxazolidinones

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JP3176626B2 (ja) 2001-06-18
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US5654428A (en) 1997-08-05
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AU667198B2 (en) 1996-03-14
US5801246A (en) 1998-09-01
EP0610265A1 (de) 1994-08-17
KR100257418B1 (ko) 2000-05-15
DK0610265T3 (da) 1997-06-09
GR3022340T3 (en) 1997-04-30
WO1993009103A1 (en) 1993-05-13
EP0610265B1 (de) 1996-12-27
US5565571A (en) 1996-10-15
DE69216251T2 (de) 1997-05-15
ATE146783T1 (de) 1997-01-15
JPH07500603A (ja) 1995-01-19
US5929248A (en) 1999-07-27
US5756732A (en) 1998-05-26
US5654435A (en) 1997-08-05

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