DE60205030D1 - Oxazolidinon- und/oder isoxazolinderivate als antibakterielle mittel - Google Patents

Oxazolidinon- und/oder isoxazolinderivate als antibakterielle mittel

Info

Publication number
DE60205030D1
DE60205030D1 DE60205030T DE60205030T DE60205030D1 DE 60205030 D1 DE60205030 D1 DE 60205030D1 DE 60205030 T DE60205030 T DE 60205030T DE 60205030 T DE60205030 T DE 60205030T DE 60205030 D1 DE60205030 D1 DE 60205030D1
Authority
DE
Germany
Prior art keywords
oxazolidinone
antibacterial agents
isoxazoline derivatives
isoxazoline
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60205030T
Other languages
English (en)
Other versions
DE60205030T2 (de
Inventor
Barry Gravestock
James Hales
Lingard Swain
Irene Hauck
Dennett Mills
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0121942A external-priority patent/GB0121942D0/en
Priority claimed from GB0215420A external-priority patent/GB0215420D0/en
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE60205030D1 publication Critical patent/DE60205030D1/de
Application granted granted Critical
Publication of DE60205030T2 publication Critical patent/DE60205030T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
DE60205030T 2001-09-11 2002-09-09 Oxazolidinon- und/oder isoxazolinderivate als antibakterielle mittel Expired - Fee Related DE60205030T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0121942A GB0121942D0 (en) 2001-09-11 2001-09-11 Chemical compounds
GB0121942 2001-09-11
GB0215420A GB0215420D0 (en) 2002-07-04 2002-07-04 Chemical compounds
GB0215420 2002-07-04
PCT/GB2002/004120 WO2003022824A1 (en) 2001-09-11 2002-09-09 Oxazolidinone and/or isoxazoline as antibacterial agents

Publications (2)

Publication Number Publication Date
DE60205030D1 true DE60205030D1 (de) 2005-08-18
DE60205030T2 DE60205030T2 (de) 2006-04-20

Family

ID=26246531

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60205030T Expired - Fee Related DE60205030T2 (de) 2001-09-11 2002-09-09 Oxazolidinon- und/oder isoxazolinderivate als antibakterielle mittel

Country Status (26)

Country Link
US (2) US7396847B2 (de)
EP (1) EP1427711B1 (de)
JP (1) JP2005507386A (de)
KR (1) KR20040044886A (de)
CN (1) CN1639136A (de)
AR (1) AR036778A1 (de)
AT (1) ATE299502T1 (de)
AU (1) AU2002329393B2 (de)
BR (1) BR0212458A (de)
CA (1) CA2459766A1 (de)
CO (1) CO5560609A2 (de)
DE (1) DE60205030T2 (de)
DK (1) DK1427711T3 (de)
ES (1) ES2244802T3 (de)
HK (1) HK1065789A1 (de)
HU (1) HUP0401005A3 (de)
IL (1) IL160739A0 (de)
IS (1) IS7175A (de)
MX (1) MXPA04002303A (de)
NO (1) NO327010B1 (de)
NZ (1) NZ531621A (de)
PL (1) PL369183A1 (de)
PT (1) PT1427711E (de)
RU (1) RU2004111285A (de)
SI (1) SI1427711T1 (de)
WO (1) WO2003022824A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6667299B1 (en) * 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
US7022705B2 (en) 2001-10-25 2006-04-04 Astrazeneca Ab Isoxazoline derivatives useful as antimicrobials
JP2005524661A (ja) * 2002-02-28 2005-08-18 アストラゼネカ アクチボラグ ３−シクリル−５−（窒素含有５員環）メチル−オキサゾリジノン誘導体と抗菌剤としてのその使用
EP1480975A2 (de) 2002-02-28 2004-12-01 Astrazeneca AB Chemische verbindungen
JP4651945B2 (ja) * 2002-04-25 2011-03-16 ビーエーエスエフ ソシエタス・ヨーロピア ３−ヘテロアリール置換イソキサゾリン
US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
JP2006508192A (ja) * 2002-11-28 2006-03-09 アストラゼネカ アクチボラグ 抗細菌薬としてのオキサゾリジノンおよび／またはイソオキサゾリン誘導体
MXPA05005522A (es) * 2002-11-28 2005-07-25 Astrazeneca Ab Oxazolidinonas como agentes antibacterianos.
GB0227701D0 (en) * 2002-11-28 2003-01-08 Astrazeneca Ab Chemical compounds
GB0229522D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
GB0229521D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
GB0229526D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
TW200500360A (en) * 2003-03-01 2005-01-01 Astrazeneca Ab Hydroxymethyl compounds
GB0304723D0 (en) * 2003-03-01 2003-04-02 Astrazeneca Ab Chemical compounds
CA2528089C (en) 2003-06-03 2015-11-24 Rib-X Pharmaceuticals, Inc. Biaryl heterocyclic compounds and methods of making and using the same
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
EP1660465B1 (de) * 2003-07-29 2014-12-17 Melinta Therapeutics, Inc. Verfahren zur synthese von biaryloxazolidinonen
JP4777246B2 (ja) * 2003-07-29 2011-09-21 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ビアリールオキサゾリジノンの合成方法
AR046782A1 (es) 2003-12-17 2005-12-21 Rib X Pharmaceuticals Inc Compuestos heterociclicos de biarilo halogenados, composiciones farmaceuticas que los contienen, metodos para su elaboracion y su uso como medicamentos.
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
WO2005085266A2 (en) 2004-02-27 2005-09-15 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
US20080064689A1 (en) * 2004-05-25 2008-03-13 Astrazeneca Ab 3-[4-(6-Pyridin-3-Yl)-3-Phenyl] -5-(1H-1,2,3-Triazol-1-Ylmethyl)-1,3-Oxazolidin-2-Ones as Antibacterial Agents
GB0411596D0 (en) * 2004-05-25 2004-06-30 Astrazeneca Ab Chemical process
BRPI0511535A (pt) * 2004-05-25 2008-01-02 Astrazeneca Ab composto ou um sal farmaceuticamente aceitável do mesmo, ou pró-droga do mesmo, pró-droga, método para a produção de um efeito antibacteriano em um animal de sangue quente, uso de um composto ou um sal farmaceuticamente aceitável, ou éster hidrolisável in-vivo do mesmo, ou de um seu éster hidrolisável in vivo, composição farmacêutica, e, processo para a preparação de um composto ou sais farmaceuticamente aceitáveis ou ésteres hidrolisáveis in-vivo do mesmo
DOP2005000123A (es) 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
EP1799677A1 (de) * 2004-10-08 2007-06-27 Ranbaxy Laboratories Limited Oxazolidinon-derivate mit antimikrobieller funktion
WO2006109156A1 (en) 2005-04-15 2006-10-19 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
KR101394307B1 (ko) 2005-06-08 2014-05-13 멜린타 테라퓨틱스, 인크. 트리아졸의 합성 방법
WO2007025089A2 (en) 2005-08-24 2007-03-01 Rib-X Pharmaceutical, Inc. Triazole compounds and methods of making and using the same
ES2638427T3 (es) 2005-08-24 2017-10-20 Melinta Therapeutics, Inc. Compuestos de triazol y procedimientos de preparación y uso del mismo
MX366793B (es) 2008-10-10 2019-07-24 Merck Sharp & Dohme Corp Star Metodos para preparar oxazolidinonas y composiciones que las contienen.
NZ620458A (en) 2009-02-03 2015-10-30 Merck Sharp & Dohme Crystalline form of r)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate
US8580767B2 (en) 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
KR101561964B1 (ko) 2013-11-15 2015-10-20 한국과학기술연구원 옥사졸리디논 화합물 및 이를 포함하는 c형 간염 예방 또는 치료용 약학 조성물
CN114835596A (zh) * 2015-02-27 2022-08-02 海洋规划生物工厂株式会社 Kakeromycin及其衍生物的制造方法
CN106083994B (zh) * 2016-04-18 2019-12-06 南京曼杰生物科技有限公司 取代的噁唑烷酮水溶性衍生物及其应用
US20170333305A1 (en) * 2016-05-23 2017-11-23 Microban Products Company Topical skin product having retention property
EP3723758A4 (de) 2017-12-13 2021-06-23 Merck Sharp & Dohme Corp. Pharmazeutische zusammensetzungen von tedizolidphosphat
CN113149924B (zh) * 2021-03-29 2023-11-03 苏州大学 一种异噁唑啉的简单制备方法
CN113831517A (zh) * 2021-09-09 2021-12-24 万凯新材料股份有限公司 抗菌及抗紫外聚酯的制备方法

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5043443A (en) * 1988-07-29 1991-08-27 Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
GB9521508D0 (en) 1995-10-20 1995-12-20 Zeneca Ltd Chemical compounds
GB9601666D0 (en) 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9604301D0 (en) 1996-02-29 1996-05-01 Zeneca Ltd Chemical compounds
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9614238D0 (en) 1996-07-06 1996-09-04 Zeneca Ltd Chemical compounds
GB9614236D0 (en) 1996-07-06 1996-09-04 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
AU8872198A (en) 1997-08-29 1999-03-22 Zeneca Limited Aminometyl oxooxazolidinyl benzene derivatives
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
AU1694099A (en) 1997-12-26 1999-07-19 Cheil Jedang Corporation Cephem derivatives and a method for producing the compounds and an antibacterialcomposition containing the compounds
GB9812019D0 (en) 1998-06-05 1998-07-29 Zeneca Ltd Chemical compounds
CA2333332A1 (en) 1998-06-05 1999-12-16 Astrazeneca Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
EP1085846A2 (de) 1998-06-08 2001-03-28 Advanced Medicine, Inc. Mehrfachbindende inhibitoren des microsomalen triglyceridtransferase-proteins
GB9821938D0 (en) 1998-10-09 1998-12-02 Zeneca Ltd Chemical compounds
GB9928499D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical processes and intermediates
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
MXPA02012045A (es) * 2000-06-05 2003-10-15 Dong A Pharm Co Ltd Nuevos derivados de oxazolidinona y proceso para su preparacion.
DE10034624A1 (de) 2000-07-17 2002-01-31 Bayer Ag Aryl-substituierte Thienyl-1,3-oxazolidin-2-one als Cytokin-Inhibitoren
DE10034625A1 (de) 2000-07-17 2002-01-31 Bayer Ag Heterocyclisch substituierte Thienyl-Phenyl-Oxazolidinone
US20020115669A1 (en) * 2000-08-31 2002-08-22 Wiedeman Paul E. Oxazolidinone chemotherapeutic agents
YU52403A (sh) 2000-12-26 2006-03-03 Dr.Reddy's Research Foundation Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže
DE60212959T2 (de) 2001-04-07 2007-02-15 Astrazeneca Ab Eine sulfonimid-gruppe enthaltende oxazolidinone als antibiotika
GB0108794D0 (en) 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compound
GB0108793D0 (en) 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
GB0108764D0 (en) 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
GB0113299D0 (en) 2001-06-01 2001-07-25 Astrazeneca Ab Chemical process & intermediates
GB0113297D0 (en) 2001-06-01 2001-07-25 Astrazeneca Ab Chemical Process
GB0113300D0 (en) 2001-06-01 2001-07-25 Astrazeneca Ab Purification process
GB0113298D0 (en) 2001-06-01 2001-07-25 Astrazeneca Ab Purification process and intermediates
EP1451164A2 (de) 2001-07-12 2004-09-01 PHARMACIA & UPJOHN COMPANY Amide derivate mit verbesserten löslichkeit
GB0118407D0 (en) 2001-07-27 2001-09-19 Cipla Ltd Oxazolidinone derivatives as antibacterial agents
WO2003031441A1 (en) 2001-10-04 2003-04-17 Morphochen Aktiengesellschaft Für Kombinatorische Chemie Multiple action compounds
WO2003031443A1 (de) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual action antibiotics
US7022705B2 (en) 2001-10-25 2006-04-04 Astrazeneca Ab Isoxazoline derivatives useful as antimicrobials
JP2005519870A (ja) 2001-10-25 2005-07-07 アストラゼネカ アクチボラグ 抗菌活性をもつアリール置換オキサゾリジノン類
JP2005524661A (ja) 2002-02-28 2005-08-18 アストラゼネカ アクチボラグ ３−シクリル−５−（窒素含有５員環）メチル−オキサゾリジノン誘導体と抗菌剤としてのその使用
EP1480975A2 (de) 2002-02-28 2004-12-01 Astrazeneca AB Chemische verbindungen
JP2003335762A (ja) 2002-05-20 2003-11-28 Meiji Seika Kaisha Ltd 新規ビフェニル誘導体
US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
JP2006508192A (ja) * 2002-11-28 2006-03-09 アストラゼネカ アクチボラグ 抗細菌薬としてのオキサゾリジノンおよび／またはイソオキサゾリン誘導体

Also Published As

Publication number Publication date
PT1427711E (pt) 2005-11-30
WO2003022824A1 (en) 2003-03-20
CO5560609A2 (es) 2005-09-30
AU2002329393B2 (en) 2008-06-12
SI1427711T1 (sl) 2005-12-31
AR036778A1 (es) 2004-10-06
US20050107435A1 (en) 2005-05-19
US7396847B2 (en) 2008-07-08
HK1065789A1 (en) 2005-03-04
JP2005507386A (ja) 2005-03-17
IL160739A0 (en) 2004-08-31
EP1427711A1 (de) 2004-06-16
BR0212458A (pt) 2004-10-19
NO20041428L (no) 2004-06-08
HUP0401005A2 (hu) 2004-08-30
US20100137243A1 (en) 2010-06-03
NO327010B1 (no) 2009-04-06
MXPA04002303A (es) 2004-06-29
EP1427711B1 (de) 2005-07-13
ATE299502T1 (de) 2005-07-15
DK1427711T3 (da) 2005-10-17
KR20040044886A (ko) 2004-05-31
HUP0401005A3 (en) 2007-11-28
DE60205030T2 (de) 2006-04-20
IS7175A (is) 2004-03-10
CA2459766A1 (en) 2003-03-20
NZ531621A (en) 2005-06-24
CN1639136A (zh) 2005-07-13
PL369183A1 (en) 2005-04-18
ES2244802T3 (es) 2005-12-16
RU2004111285A (ru) 2005-10-10

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