DE602006019870D1 - Verfahren zur synthese von triazolen - Google Patents
Verfahren zur synthese von triazolenInfo
- Publication number
- DE602006019870D1 DE602006019870D1 DE602006019870T DE602006019870T DE602006019870D1 DE 602006019870 D1 DE602006019870 D1 DE 602006019870D1 DE 602006019870 T DE602006019870 T DE 602006019870T DE 602006019870 T DE602006019870 T DE 602006019870T DE 602006019870 D1 DE602006019870 D1 DE 602006019870D1
- Authority
- DE
- Germany
- Prior art keywords
- triazolene
- synthesis
- triazoles
- infective
- proliferative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68899005P | 2005-06-08 | 2005-06-08 | |
PCT/US2006/022424 WO2006133397A2 (en) | 2005-06-08 | 2006-06-08 | Process for the synthesis of triazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006019870D1 true DE602006019870D1 (de) | 2011-03-10 |
Family
ID=37450902
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006019870T Active DE602006019870D1 (de) | 2005-06-08 | 2006-06-08 | Verfahren zur synthese von triazolen |
Country Status (7)
Country | Link |
---|---|
US (3) | US8399660B2 (de) |
EP (1) | EP1904489B1 (de) |
JP (2) | JP5534497B2 (de) |
KR (1) | KR101394307B1 (de) |
AT (1) | ATE496914T1 (de) |
DE (1) | DE602006019870D1 (de) |
WO (1) | WO2006133397A2 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
JP5534497B2 (ja) * | 2005-06-08 | 2014-07-02 | メリンタ セラピューティクス,インコーポレイテッド | トリアゾール類の合成方法 |
WO2007133803A2 (en) * | 2006-05-15 | 2007-11-22 | Rib-X Pharmaceuticals, Inc. | Treatment of mycobacterial infections |
JP5643197B2 (ja) * | 2008-07-09 | 2014-12-17 | ポステック アカデミー−インダストリー ファンデーション | 不均一銅ナノ触媒およびその製造方法 |
US20100069441A1 (en) | 2008-09-02 | 2010-03-18 | Mikhail Fedorovich Gordeev | Antimicrobial indoline compounds for treatment of bacterial infections |
EP2635307B1 (de) * | 2010-11-01 | 2020-07-29 | Melinta Subsidiary Corp. | Pharmazeutische zusammensetzungen |
US9126991B2 (en) | 2012-10-04 | 2015-09-08 | Hui-Yin Li | Radezolid salts and polymorphic forms thereof |
US10471046B2 (en) | 2014-11-14 | 2019-11-12 | Melinta Subsidary Corp. | Method for treating, preventing, or reducing the risk of skin infection |
WO2016088103A1 (en) * | 2014-12-05 | 2016-06-09 | Sun Pharmaceutical Industries Limited | A process for the preparation of tedizolid phosphate |
US20170333400A1 (en) * | 2016-05-17 | 2017-11-23 | Melinta Therapeutics, Inc. | Topical formulations of biaryl heterocyclic compounds and methods of use thereof |
CN106749074A (zh) * | 2016-11-14 | 2017-05-31 | 沈阳药科大学 | 一种联芳基噁唑烷酮中间体的制备方法 |
Family Cites Families (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4348393A (en) | 1978-06-09 | 1982-09-07 | Delalande S.A. | N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones |
US4948801A (en) | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
US5130316A (en) | 1988-07-29 | 1992-07-14 | Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazlidinyl arylbenzene derivatives useful as antibacterial agents |
US5043443A (en) | 1988-07-29 | 1991-08-27 | Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives |
US5254577A (en) | 1988-07-29 | 1993-10-19 | The Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
AU667198B2 (en) | 1991-11-01 | 1996-03-14 | Pharmacia & Upjohn Company | Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents |
AU670842B2 (en) | 1992-12-08 | 1996-08-01 | Pharmacia & Upjohn Company | Tropone-substituted phenyloxazolidinone antibacterial agents |
DE4425609A1 (de) | 1994-07-20 | 1996-01-25 | Bayer Ag | Benzofuranyl- und Benzothienyloxazolidinone |
DE4425612A1 (de) | 1994-07-20 | 1996-04-04 | Bayer Ag | 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone |
JPH08151577A (ja) | 1994-11-30 | 1996-06-11 | Canon Inc | 光学活性化合物、それを含有する液晶組成物、それを有する液晶素子、それらを用いた液晶装置及び表示方法 |
JPH08151578A (ja) | 1994-11-30 | 1996-06-11 | Canon Inc | 光学活性化合物、それを含有する液晶組成物、それを有する液晶素子及びそれらを用いた表示方法、液晶装置 |
HRP970049A2 (en) | 1996-02-06 | 1998-04-30 | Bayer Ag | New heteroaryl oxazolidinones |
GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
WO1998054161A1 (en) | 1997-05-30 | 1998-12-03 | Pharmacia & Upjohn Company | Oxazolidinone antibacterial agents having a thiocarbonyl functionality |
GB9717807D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
WO1999033839A1 (en) | 1997-12-26 | 1999-07-08 | Cheil Jedang Corporation | Cephem derivatives and a method for producing the compounds and an antibacterial composition containing the compounds |
US6562844B2 (en) | 1998-01-23 | 2003-05-13 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
KR20010015910A (ko) | 1998-01-23 | 2001-02-26 | 로렌스 티. 마이젠헬더 | 옥사졸리디논 조합 라이브러리, 조성물 및 제조 방법 |
HUP0103082A3 (en) | 1998-06-05 | 2002-12-28 | Astrazeneca Ab | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them |
GB9812019D0 (en) | 1998-06-05 | 1998-07-29 | Zeneca Ltd | Chemical compounds |
TW572757B (en) | 1998-08-24 | 2004-01-21 | Bristol Myers Squibb Co | Novel isoxazolinone antibacterial agents |
GB9821938D0 (en) | 1998-10-09 | 1998-12-02 | Zeneca Ltd | Chemical compounds |
AU1379900A (en) | 1998-11-17 | 2000-06-05 | Bayer Aktiengesellschaft | Novel substituted phenyloxazolidone derivatives |
EP1200416A1 (de) | 1999-07-28 | 2002-05-02 | Pharmacia & Upjohn Company | Oxazolidinone und ihre verwendung als antiinfektiva |
US6297242B1 (en) | 1999-08-12 | 2001-10-02 | Ortho-Mcneil Pharmaceutical, Inc. | N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof |
AU769644B2 (en) | 1999-11-04 | 2004-01-29 | Basilea Pharmaceutica Ag | Substituted 5-benzyl-2,4-diaminopyrimidines |
GB9928499D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical processes and intermediates |
GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
NZ522990A (en) | 2000-06-05 | 2003-08-29 | Dong A Pharm | Novel oxazolidinone derivatives and a process for the preparation thereof |
DE10034627A1 (de) | 2000-07-17 | 2002-01-31 | Bayer Ag | Aryl-substituierte Oxazolidinone mit Cytokin inhibitorischer Wirkung |
GB0100102D0 (en) | 2001-01-03 | 2001-02-14 | Syngenta Participations Ag | Organic compounds |
GB0108793D0 (en) | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compounds |
GB0108794D0 (en) | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compound |
GB0108764D0 (en) | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compounds |
WO2002081470A1 (en) | 2001-04-07 | 2002-10-17 | Astrazeneca Ab | Oxazolidinones containing a sulfonimid group as antibiotics |
GB0113297D0 (en) | 2001-06-01 | 2001-07-25 | Astrazeneca Ab | Chemical Process |
GB0113299D0 (en) | 2001-06-01 | 2001-07-25 | Astrazeneca Ab | Chemical process & intermediates |
DK1427711T3 (da) | 2001-09-11 | 2005-10-17 | Astrazeneca Ab | Oxazolidinon og/eller isoxazolinderivater som antibakterielle midler |
EP1446403B1 (de) | 2001-10-25 | 2006-04-12 | AstraZeneca AB | Aryl substituierte oxazolidinone mit antibacterieller activität |
AR038536A1 (es) | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
US7473699B2 (en) | 2002-02-28 | 2009-01-06 | Astrazeneca Ab | 3-cyclyl-5-(nitrogen-containing 5-membered ring)methyl-oxazolidinone derivatives and their use as antibacterial agents |
EP1490059A1 (de) | 2002-03-29 | 2004-12-29 | Pharmacia & Upjohn Company LLC | Parenterale, intravenöse und orale verabreichung von oxazolidinonen zur behandlung von diabetischem fuss-syndrom |
AR043050A1 (es) | 2002-09-26 | 2005-07-13 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos |
US20040132764A1 (en) | 2002-10-23 | 2004-07-08 | Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie | Antibiotics for the treatment of infections in acidic environments |
AU2003302404B2 (en) | 2002-11-28 | 2008-06-19 | Astrazeneca Ab | Oxazolidinone and / or isoxazoline derivatives as antibacterial agents |
GB0229521D0 (en) | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
GB0229518D0 (en) | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
GB0229526D0 (en) | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
TW200500360A (en) | 2003-03-01 | 2005-01-01 | Astrazeneca Ab | Hydroxymethyl compounds |
WO2004089943A1 (en) | 2003-04-09 | 2004-10-21 | Pharmacia & Upjohn Company Llc | Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues |
WO2005012271A2 (en) | 2003-07-29 | 2005-02-10 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
CN101429170B (zh) | 2003-06-03 | 2015-05-13 | 梅林塔医疗有限公司 | 联芳基杂环化合物的制备和用途 |
WO2005019211A2 (en) * | 2003-06-03 | 2005-03-03 | Rib-X Pharmaceuticals, Inc. | Biaryl heterocyclic compounds and methods of making and using the same |
WO2005003087A2 (en) | 2003-07-01 | 2005-01-13 | Orchid Chemicals And Pharmaceuticals Ltd. | Oxazole derivatives as antibacterial agents |
EP1646629B1 (de) | 2003-07-02 | 2010-06-23 | Merck Sharp & Dohme Corp. | Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon |
JP2007500707A (ja) | 2003-07-29 | 2007-01-18 | リブ−エックス ファーマシューティカルズ,インコーポレイテッド | ビアリールヘテロ環状のアミン、アミドおよび硫黄−含有化合物、並びに該化合物の製造方法および使用方法 |
US7129259B2 (en) * | 2003-12-17 | 2006-10-31 | Rib-X Pharmaceuticals, Inc. | Halogenated biaryl heterocyclic compounds and methods of making and using the same |
KR100854211B1 (ko) | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
JP5534497B2 (ja) * | 2005-06-08 | 2014-07-02 | メリンタ セラピューティクス,インコーポレイテッド | トリアゾール類の合成方法 |
-
2006
- 2006-06-08 JP JP2008515957A patent/JP5534497B2/ja not_active Expired - Fee Related
- 2006-06-08 EP EP06784685A patent/EP1904489B1/de active Active
- 2006-06-08 DE DE602006019870T patent/DE602006019870D1/de active Active
- 2006-06-08 AT AT06784685T patent/ATE496914T1/de not_active IP Right Cessation
- 2006-06-08 KR KR1020087000377A patent/KR101394307B1/ko active IP Right Grant
- 2006-06-08 WO PCT/US2006/022424 patent/WO2006133397A2/en active Application Filing
- 2006-06-08 US US11/921,838 patent/US8399660B2/en active Active
-
2013
- 2013-03-18 US US13/845,759 patent/US8796465B2/en active Active
- 2013-04-03 JP JP2013077419A patent/JP5923457B2/ja active Active
-
2014
- 2014-07-07 US US14/325,248 patent/US9376400B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US9376400B2 (en) | 2016-06-28 |
JP5534497B2 (ja) | 2014-07-02 |
WO2006133397A2 (en) | 2006-12-14 |
JP2008545798A (ja) | 2008-12-18 |
US20140031402A1 (en) | 2014-01-30 |
US20100234615A1 (en) | 2010-09-16 |
ATE496914T1 (de) | 2011-02-15 |
KR101394307B1 (ko) | 2014-05-13 |
US8796465B2 (en) | 2014-08-05 |
US20150158827A1 (en) | 2015-06-11 |
KR20080020669A (ko) | 2008-03-05 |
JP2013129680A (ja) | 2013-07-04 |
EP1904489A2 (de) | 2008-04-02 |
US8399660B2 (en) | 2013-03-19 |
WO2006133397A3 (en) | 2007-05-24 |
EP1904489B1 (de) | 2011-01-26 |
JP5923457B2 (ja) | 2016-05-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE602006019870D1 (de) | Verfahren zur synthese von triazolen | |
DK1853602T3 (da) | Kemiske forbindelser | |
DK1853588T3 (da) | Kemiske forbindelser | |
ATE543910T1 (de) | Verfahren und materialien zur herstellung von simvastatin und verwandten verbindungen | |
EA201100094A1 (ru) | Тиадиазолилоксифениламидины и их применение в качестве фунгицидов | |
MY148253A (en) | Azaadamantane derivatives and methods of use | |
EA201190144A1 (ru) | Изотиазолилоксифениламидины и их применение в качестве фунгицидов | |
NO20076371L (no) | Fremgangsmate for fremstilling av fenoliske 4-bifenylylazetidin-2-oner | |
DE602006017995D1 (de) | Verfahren zur herstellung von pregabalin und salzen daraus | |
DE602006010302D1 (de) | Verfahren zur Herstellung von 5-methyl-2-furfural | |
DE602006012585D1 (de) | Verfahren zur Förderung von Michael-additionsreaktionen | |
EA200900090A1 (ru) | Бензиламины, способ их получения и их применение в качестве противовоспалительных средств | |
DE602006009562D1 (de) | Verfahren zur herstellung von ferrisuccinylcasein | |
ATE540032T1 (de) | Wege zur synthese von 2(s),4(s),5(s),7(s)-2,7- | |
ATE410166T1 (de) | 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydrochinolin- derivate zur behandlung von unfruchtbarkeit | |
DE602005020185D1 (de) | Verfahren zur herstellung von 17-hydroxy-6 beta, 7 beta, 15 beta,16 beta-bismethylen-17alpha-pregn-4henprodukte für dieses verfahren | |
DE112006000985A5 (de) | Verfahren zur Herstellung von Tetrahydropyranen aus Tetrahydropyran-3-onen | |
TNSN06260A1 (en) | Process for the preparation of tryptase inhibitors | |
ATE465152T1 (de) | Verfahren zum herstellen von alkylaniliden aus halogenbenzolderivaten | |
ATE529413T1 (de) | Verfahren zur synthese von aryloxydiaminopyrimidinen | |
WO2005012271A3 (en) | Process for the synthesis of biaryl oxazolidinones | |
DE102006042191A8 (de) | Verfahren zur Reinigung von Radium aus verschiedenen Quellen | |
ATE544455T1 (de) | Zusammensetzungen und verfahren für die krebsbehandlung | |
DE602005026366D1 (de) | Verfahren zur Herstellung von Synthesegas | |
DE602006008022D1 (de) | Verfahren zur herstellung von duloxetin |