DE602004014107D1 - Hydroxymethylsubstituierte dihydroisoxazolderivate, die sich als antibiotika eignen - Google Patents

Hydroxymethylsubstituierte dihydroisoxazolderivate, die sich als antibiotika eignen

Info

Publication number
DE602004014107D1
DE602004014107D1 DE602004014107T DE602004014107T DE602004014107D1 DE 602004014107 D1 DE602004014107 D1 DE 602004014107D1 DE 602004014107 T DE602004014107 T DE 602004014107T DE 602004014107 T DE602004014107 T DE 602004014107T DE 602004014107 D1 DE602004014107 D1 DE 602004014107D1
Authority
DE
Germany
Prior art keywords
sub
antibiotics
suffering
hydrogen
hydroxymethyl substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE602004014107T
Other languages
English (en)
Inventor
Michael B Gravestock
Neil J Hales
Daniel R Carcanague
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0304723A external-priority patent/GB0304723D0/en
Priority claimed from GB0318607A external-priority patent/GB0318607D0/en
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE602004014107D1 publication Critical patent/DE602004014107D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE602004014107T 2003-03-01 2004-02-24 Hydroxymethylsubstituierte dihydroisoxazolderivate, die sich als antibiotika eignen Expired - Fee Related DE602004014107D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0304723A GB0304723D0 (en) 2003-03-01 2003-03-01 Chemical compounds
GB0318607A GB0318607D0 (en) 2003-08-08 2003-08-08 Chemical compounds
PCT/GB2004/000730 WO2004078753A1 (en) 2003-03-01 2004-02-24 Hydroxymethyl substituted dihydroisoxazole derivatives useful as antibiotic agents

Publications (1)

Publication Number Publication Date
DE602004014107D1 true DE602004014107D1 (de) 2008-07-10

Family

ID=32964061

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004014107T Expired - Fee Related DE602004014107D1 (de) 2003-03-01 2004-02-24 Hydroxymethylsubstituierte dihydroisoxazolderivate, die sich als antibiotika eignen

Country Status (17)

Country Link
US (1) US7192974B2 (de)
EP (1) EP1599471B1 (de)
JP (1) JP2006519247A (de)
KR (1) KR20050106064A (de)
AT (1) ATE396991T1 (de)
AU (1) AU2004218206A1 (de)
BR (1) BRPI0407835A (de)
CA (1) CA2517706A1 (de)
CL (1) CL2004000400A1 (de)
DE (1) DE602004014107D1 (de)
ES (1) ES2305732T3 (de)
HK (1) HK1083097A1 (de)
MX (1) MXPA05009205A (de)
NO (1) NO20054523L (de)
TW (1) TW200500360A (de)
UY (1) UY28211A1 (de)
WO (1) WO2004078753A1 (de)

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BR0308018A (pt) 2002-02-28 2005-01-04 Astrazeneca Ab Composto ou um seu sal farmaceuticamente aceitável ou um seu éster hidrolisável in vivo, pró-droga, método para produzir um efeito antibacteriano em um animal de sangue quente, uso de um composto ou um seu sal farmaceuticamente aceitável ou um seu éster hirolisável in vivo, composição farmacêutica, e, processo para a preparação de um composto ou um seu sal farmaceuticamente aceitável ou um seu éster hidrolisável in vivo
CA2528089C (en) 2003-06-03 2015-11-24 Rib-X Pharmaceuticals, Inc. Biaryl heterocyclic compounds and methods of making and using the same
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
JP2007521283A (ja) * 2003-07-02 2007-08-02 メルク アンド カンパニー インコーポレーテッド シクロプロピル基で置換されたオキサゾリジノン系抗生物質およびその誘導体
WO2005005399A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
JP4607107B2 (ja) * 2003-07-02 2011-01-05 メルク・シャープ・エンド・ドーム・コーポレイション シクロプロピル基置換されたオキサゾリジノン抗生物質およびこれらの誘導体
WO2005005422A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
EP1660465B1 (de) * 2003-07-29 2014-12-17 Melinta Therapeutics, Inc. Verfahren zur synthese von biaryloxazolidinonen
ES2536001T3 (es) * 2003-07-29 2015-05-19 Melinta Therapeutics, Inc. Procedimiento para la síntesis de biariloxazolidinonas
WO2005033079A1 (ja) * 2003-09-30 2005-04-14 Eisai Co., Ltd. ヘテロ環化合物を含有する新規な抗真菌剤
TW200526649A (en) 2003-12-17 2005-08-16 Rib X Pharmaceuticals Inc Halogenated biaryl heterocyclic compounds and methods of making and using the same
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
US20050241110A1 (en) * 2004-04-09 2005-11-03 Bruce Baker Ergonomic handles, especially for garden tools
GB0411596D0 (en) * 2004-05-25 2004-06-30 Astrazeneca Ab Chemical process
EP1753753A1 (de) * 2004-05-25 2007-02-21 AstraZeneca AB 3-(4-(2-dihydroisoxazol-3-ylpyridin-5-yl)phenyl)-5-triazol-1-ylmethyloxazolidin-2-onderivate als mao-inhibitoren zur behandlung von bakteriellen infektionen
US20080064689A1 (en) * 2004-05-25 2008-03-13 Astrazeneca Ab 3-[4-(6-Pyridin-3-Yl)-3-Phenyl] -5-(1H-1,2,3-Triazol-1-Ylmethyl)-1,3-Oxazolidin-2-Ones as Antibacterial Agents
US20100286211A1 (en) * 2004-10-08 2010-11-11 Biswajit Das Oxazolidinone derivatives as antimicrobials
US20100047338A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
JP4874958B2 (ja) 2005-03-30 2012-02-15 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピリジン誘導体を含有する抗真菌剤
US8399660B2 (en) 2005-06-08 2013-03-19 Rib-X Pharmaceuticals, Inc. Process for the synthesis of triazoles
TWI385169B (zh) 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
EP1946840B1 (de) * 2005-11-04 2019-08-21 NGK Insulators, Ltd. Wabenstruktur und wabenkatalysator
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
WO2008035726A1 (fr) * 2006-09-21 2008-03-27 Eisai R & D Management Co., Ltd. Dérivé de pyridine substitué par un cycle hétéroaryle, et agent antifongique le comprenant
US8258394B2 (en) * 2007-02-08 2012-09-04 Bradford G Baruh Retractable solar panel system
US20100065104A1 (en) * 2007-08-31 2010-03-18 Baruh Bradford G Retractable solar panel system
US20080190341A1 (en) * 2007-02-08 2008-08-14 Baruh Bradford G System and method of adjusting the location and position of the foresail on a sailboat
KR100848232B1 (ko) * 2007-04-12 2008-07-24 일동제약주식회사 신규 헤테로 고리 또는 알콕시아미노메틸 옥사졸리디논 및그 제조방법
TW200841879A (en) * 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
CN101622251B (zh) 2007-04-27 2012-07-04 卫材R&D管理有限公司 杂环取代吡啶衍生物的盐或其结晶
WO2008156559A2 (en) * 2007-06-01 2008-12-24 Chx Technologies, Inc. Topical dental solution of chlorhexidine in sumatra benzoin bp/ep and methods of manufacturing and evaluating same
US8513287B2 (en) 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
US20110118219A1 (en) * 2008-03-25 2011-05-19 University Of Maryland, Baltimore Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity
CA2712613C (en) 2008-03-26 2017-02-28 Global Alliance For Tb Drug Development Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones
EP2757104B1 (de) * 2008-10-10 2019-08-14 Merck Sharp & Dohme Corp. In der synthese von oxazolidinonen verwendete verbindungen
US8188119B2 (en) 2008-10-24 2012-05-29 Eisai R&D Management Co., Ltd Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
CU24089B1 (es) 2009-02-03 2015-04-29 Trius Therapeutics Forma cristalina del fosfato de dihidrógeno r)-3-(4-(2-(2-metiltretazol-5-il)-3-fluorofenil)-5-hidroximetil oxazolidin-2-ona
CA2761389A1 (en) 2009-02-05 2010-08-12 Tokai Pharmaceuticals, Inc. Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
CA2754712A1 (en) * 2009-03-13 2010-09-16 Sun Chemical B.V. Cyclic carbamate compounds useful in energy-curable compositions
US8580767B2 (en) * 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
KR101653570B1 (ko) * 2011-03-30 2016-09-02 주식회사 레고켐 바이오사이언스 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
EP2626356A1 (de) * 2012-02-08 2013-08-14 Rheinische Friedrich-Wilhelms-Universität Bonn Thiamin Analoga und ihre Verwendung als Antibiotika
AU2014236135A1 (en) 2013-03-14 2015-09-10 Thomas Jefferson University Androgen receptor down-regulating agents and uses thereof
US9808472B2 (en) 2013-08-12 2017-11-07 Tokai Pharmaceuticals, Inc. Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
CN112707779B (zh) * 2020-12-26 2023-06-30 蚌埠中实化学技术有限公司 一种乙烯基环己烷的制备方法

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US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
WO1993009103A1 (en) * 1991-11-01 1993-05-13 The Upjohn Company Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents
AU5889701A (en) * 2000-06-05 2001-12-17 Dong A Pharm Co Ltd Novel oxazolidinone derivatives and a process for the preparation thereof
US20020115669A1 (en) * 2000-08-31 2002-08-22 Wiedeman Paul E. Oxazolidinone chemotherapeutic agents
SI1427711T1 (sl) * 2001-09-11 2005-12-31 Astrazeneca Ab Oksazolidinonski in/ali izoksazolinski derivati kot antibakterijska sredstva
GB0227701D0 (en) * 2002-11-28 2003-01-08 Astrazeneca Ab Chemical compounds
WO2004048392A1 (en) * 2002-11-28 2004-06-10 Astrazeneca Ab Oxazolidinone and / or isoxazoline derivatives as antibacterial agents
GB0229526D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds

Also Published As

Publication number Publication date
ES2305732T3 (es) 2008-11-01
EP1599471B1 (de) 2008-05-28
TW200500360A (en) 2005-01-01
WO2004078753A1 (en) 2004-09-16
AU2004218206A1 (en) 2004-09-16
MXPA05009205A (es) 2005-10-18
HK1083097A1 (en) 2006-06-23
US20060270637A1 (en) 2006-11-30
NO20054523D0 (no) 2005-09-30
ATE396991T1 (de) 2008-06-15
BRPI0407835A (pt) 2006-02-14
US7192974B2 (en) 2007-03-20
CA2517706A1 (en) 2004-09-16
JP2006519247A (ja) 2006-08-24
NO20054523L (no) 2005-12-01
KR20050106064A (ko) 2005-11-08
CL2004000400A1 (es) 2005-04-22
EP1599471A1 (de) 2005-11-30
UY28211A1 (es) 2004-09-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee