DE60103754D1 - Oxazolidinonderivate mit antibiotischer aktivität - Google Patents
Oxazolidinonderivate mit antibiotischer aktivitätInfo
- Publication number
- DE60103754D1 DE60103754D1 DE60103754T DE60103754T DE60103754D1 DE 60103754 D1 DE60103754 D1 DE 60103754D1 DE 60103754 T DE60103754 T DE 60103754T DE 60103754 T DE60103754 T DE 60103754T DE 60103754 D1 DE60103754 D1 DE 60103754D1
- Authority
- DE
- Germany
- Prior art keywords
- sup
- alkyl
- optionally substituted
- atom
- het
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0009803.8A GB0009803D0 (en) | 2000-04-25 | 2000-04-25 | Chemical compounds |
GB0009803 | 2000-04-25 | ||
PCT/GB2001/001815 WO2001081350A1 (en) | 2000-04-25 | 2001-04-23 | Oxazolidinone derivatives with antibiotic activity |
Publications (3)
Publication Number | Publication Date |
---|---|
DE60103754D1 true DE60103754D1 (de) | 2004-07-15 |
DE60103754T2 DE60103754T2 (de) | 2005-06-16 |
DE60103754T3 DE60103754T3 (de) | 2008-06-05 |
Family
ID=9890314
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60103754T Expired - Lifetime DE60103754T3 (de) | 2000-04-25 | 2001-04-23 | Oxazolidinonderivate mit antibiotischer aktivität |
Country Status (29)
Country | Link |
---|---|
US (1) | US7141583B2 (de) |
EP (1) | EP1286998B2 (de) |
JP (1) | JP2003531211A (de) |
KR (1) | KR100858771B1 (de) |
CN (1) | CN1277829C (de) |
AT (1) | ATE268778T1 (de) |
AU (1) | AU781784B2 (de) |
BR (1) | BR0110240A (de) |
CA (1) | CA2405349C (de) |
CZ (1) | CZ20023527A3 (de) |
DE (1) | DE60103754T3 (de) |
DK (1) | DK1286998T4 (de) |
EE (1) | EE200200598A (de) |
ES (1) | ES2220759T5 (de) |
GB (1) | GB0009803D0 (de) |
HK (1) | HK1053114A1 (de) |
HU (1) | HUP0300416A2 (de) |
IL (2) | IL152284A0 (de) |
IS (1) | IS6583A (de) |
MX (1) | MXPA02010453A (de) |
NO (1) | NO328549B1 (de) |
NZ (1) | NZ521765A (de) |
PL (1) | PL358326A1 (de) |
PT (1) | PT1286998E (de) |
RU (1) | RU2002131455A (de) |
SI (1) | SI1286998T2 (de) |
TR (1) | TR200402261T4 (de) |
WO (1) | WO2001081350A1 (de) |
ZA (1) | ZA200208187B (de) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0113299D0 (en) * | 2001-06-01 | 2001-07-25 | Astrazeneca Ab | Chemical process & intermediates |
SI1427711T1 (sl) | 2001-09-11 | 2005-12-31 | Astrazeneca Ab | Oksazolidinonski in/ali izoksazolinski derivati kot antibakterijska sredstva |
EP1443930A1 (de) | 2001-10-25 | 2004-08-11 | AstraZeneca AB | Isoxazolinderivative verwendbar als antimikrobielle agenzien |
KR100445437B1 (ko) * | 2002-02-08 | 2004-08-21 | 한국과학기술연구원 | 네오마이신-옥사졸리디논 헤테로 이합체, 그의 제조방법및 그의 용도 |
US7141588B2 (en) | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
AR038536A1 (es) | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
BR0308018A (pt) | 2002-02-28 | 2005-01-04 | Astrazeneca Ab | Composto ou um seu sal farmaceuticamente aceitável ou um seu éster hidrolisável in vivo, pró-droga, método para produzir um efeito antibacteriano em um animal de sangue quente, uso de um composto ou um seu sal farmaceuticamente aceitável ou um seu éster hirolisável in vivo, composição farmacêutica, e, processo para a preparação de um composto ou um seu sal farmaceuticamente aceitável ou um seu éster hidrolisável in vivo |
PL372191A1 (en) * | 2002-02-28 | 2005-07-11 | Astrazeneca Ab | 3-cyclyl-5-(nitrogen-containing 5-membered ring) methyl-oxazolidinone derivatives and their use as antibacterial agents |
EP1539745B1 (de) | 2002-08-12 | 2006-03-29 | Pharmacia & Upjohn Company LLC | N-aryl-2-oxazolidinone und deren derivate |
AR043050A1 (es) * | 2002-09-26 | 2005-07-13 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos |
US6875784B2 (en) | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
AU2003280143A1 (en) | 2002-11-21 | 2004-06-15 | Pharmacia & Upjohn Company Llc | N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinone-5-carboxamide derivates and related compounds as antibacterial agents |
GB0227701D0 (en) * | 2002-11-28 | 2003-01-08 | Astrazeneca Ab | Chemical compounds |
US7498350B2 (en) | 2002-11-28 | 2009-03-03 | Astrazeneca Ab | Oxazolidinones as antibacterial agents |
GB0229522D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
US7012088B2 (en) | 2003-02-24 | 2006-03-14 | Pharmacia & Upjohn Company | Indolone oxazolidinones and derivatives thereof |
GB0304723D0 (en) * | 2003-03-01 | 2003-04-02 | Astrazeneca Ab | Chemical compounds |
GB0306357D0 (en) * | 2003-03-20 | 2003-04-23 | Astrazeneca Ab | Chemical compounds |
GB0306358D0 (en) * | 2003-03-20 | 2003-04-23 | Astrazeneca Ab | Chemical compounds |
WO2004089943A1 (en) | 2003-04-09 | 2004-10-21 | Pharmacia & Upjohn Company Llc | Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues |
US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
CN101429170B (zh) * | 2003-06-03 | 2015-05-13 | 梅林塔医疗有限公司 | 联芳基杂环化合物的制备和用途 |
CA2528089C (en) | 2003-06-03 | 2015-11-24 | Rib-X Pharmaceuticals, Inc. | Biaryl heterocyclic compounds and methods of making and using the same |
JP4607107B2 (ja) | 2003-07-02 | 2011-01-05 | メルク・シャープ・エンド・ドーム・コーポレイション | シクロプロピル基置換されたオキサゾリジノン抗生物質およびこれらの誘導体 |
WO2005005422A1 (en) * | 2003-07-02 | 2005-01-20 | Merck & Co., Inc. | Oxazolidinone antibiotics and derivatives thereof |
WO2005012270A2 (en) * | 2003-07-29 | 2005-02-10 | Rib-X Pharmaceuticals, Inc. | Biaryl heterocyclic amines, amides, and sulfur-containing compounds and methods of making and using the same |
BRPI0413838A (pt) * | 2003-08-25 | 2006-10-24 | Warner Lambert Co | compostos de ariloxazolidinona antimicrobianos |
US7687627B2 (en) | 2003-09-08 | 2010-03-30 | Wockhardt Limited | Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy |
US7304050B2 (en) | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
WO2005042523A1 (en) * | 2003-11-03 | 2005-05-12 | Il-Dong Pharm. Co., Ltd. | A novel oxazolidinone derivative and manufacturing process thereof |
TW200526649A (en) | 2003-12-17 | 2005-08-16 | Rib X Pharmaceuticals Inc | Halogenated biaryl heterocyclic compounds and methods of making and using the same |
KR100854211B1 (ko) | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
US8202843B2 (en) | 2004-02-27 | 2012-06-19 | Rib-X Pharmaceuticals, Inc. | Macrocyclic compounds and methods of making and using the same |
US20080021071A1 (en) * | 2004-05-25 | 2008-01-24 | Astrazeneca Ab | 3-{4-(Pyridin-3-Yl) Phenyl}-5-(1H-1,2,3-Triazol-1-Ylmethyl)-1,3-Oxazolidin-2-Ones as Antibacterial Agents |
CA2566963A1 (en) * | 2004-05-25 | 2005-12-08 | Astrazeneca Ab | 3-[4-{6-substituted alkanoyl pyridin-3-yl}-3-phenyl]-5-(1h-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-ones as antibacterial agents |
CN100360525C (zh) * | 2004-09-16 | 2008-01-09 | 中国科学院上海药物研究所 | 一类新的噁唑烷酮衍生物、其制备方法和用途 |
KR100629327B1 (ko) | 2004-10-20 | 2006-09-29 | 한국과학기술연구원 | 신규 트리아졸릴메틸옥사졸리디논 유도체 |
US8399660B2 (en) | 2005-06-08 | 2013-03-19 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of triazoles |
US8470985B2 (en) | 2005-08-24 | 2013-06-25 | Rib-X Pharmaceuticals, Inc. | Triazole compounds and methods of making and using the same |
WO2007025098A2 (en) | 2005-08-24 | 2007-03-01 | Rib-X Pharmaceuticals, Inc. | Triazole compounds and methods of making and using the same |
JP2009526036A (ja) * | 2006-02-08 | 2009-07-16 | ファイザー・プロダクツ・インク | 抗菌剤としてのオキシインドールを含有するオキサゾリジノン |
CN100406455C (zh) * | 2006-02-20 | 2008-07-30 | 中国科学院上海药物研究所 | 含三氮唑基的噁唑烷酮类化合物及其制备方法和用途 |
TW200815428A (en) * | 2006-08-15 | 2008-04-01 | Wyeth Corp | Oxazolidone derivatives as PR modulators |
US7618989B2 (en) * | 2006-08-15 | 2009-11-17 | Wyeth | Tricyclic oxazolidone derivatives useful as PR modulators |
CN102131811A (zh) | 2008-06-24 | 2011-07-20 | 财团法人乙卯研究所 | 具有稠合环的*唑烷酮衍生物 |
EP2757104B1 (de) * | 2008-10-10 | 2019-08-14 | Merck Sharp & Dohme Corp. | In der synthese von oxazolidinonen verwendete verbindungen |
CU24089B1 (es) | 2009-02-03 | 2015-04-29 | Trius Therapeutics | Forma cristalina del fosfato de dihidrógeno r)-3-(4-(2-(2-metiltretazol-5-il)-3-fluorofenil)-5-hidroximetil oxazolidin-2-ona |
US8580767B2 (en) * | 2009-05-28 | 2013-11-12 | Trius Therapeutics, Inc. | Oxazolidinone containing dimer compounds, compositions and methods to make and use |
CN101792437B (zh) * | 2010-03-10 | 2012-01-25 | 天津药物研究院 | 一类三氮唑的衍生物、其制备方法和用途 |
WO2014085413A1 (en) * | 2012-11-28 | 2014-06-05 | Temple University - Of The Commonwealth System Of Higher Education | Disubstituted oxazolidin-2-ones 5-hydroxytryptamine receptor 2b activity modulators |
WO2017013498A2 (en) * | 2015-07-22 | 2017-01-26 | Anavex Life Sciences Corp. | Crystal forms of tetra-hydro-n, n-dimethyl-2, 2-diphenyl-3-furanmethanamine hydrochloride, processes for making such forms, and their pharmaceutical compositions |
WO2020147504A1 (en) * | 2019-01-18 | 2020-07-23 | Merck Sharp & Dohme Corp. | Oxazolidinone compounds and methods of use thereof as antibacterial agents |
WO2020234636A1 (en) * | 2019-05-17 | 2020-11-26 | Cadila Healthcare Limited | Novel compounds for the treatment of mammalian infections |
CN111560014A (zh) * | 2020-05-13 | 2020-08-21 | 河南科技大学第一附属医院 | 一种杀菌消毒所用噁唑链接三唑类药物分子及其制备方法和应用 |
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DE4425612A1 (de) | 1994-07-20 | 1996-04-04 | Bayer Ag | 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone |
DE4425609A1 (de) | 1994-07-20 | 1996-01-25 | Bayer Ag | Benzofuranyl- und Benzothienyloxazolidinone |
DE4425613A1 (de) | 1994-07-20 | 1996-01-25 | Bayer Ag | 5-gliedrige Heteroaryl-oxazolidinone |
DE19514313A1 (de) | 1994-08-03 | 1996-02-08 | Bayer Ag | Benzoxazolyl- und Benzothiazolyloxazolidinone |
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