CA2373362A1 - Lubricious coating for medical devices comprising an antiblock agent - Google Patents

Lubricious coating for medical devices comprising an antiblock agent Download PDF

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Publication number
CA2373362A1
CA2373362A1 CA002373362A CA2373362A CA2373362A1 CA 2373362 A1 CA2373362 A1 CA 2373362A1 CA 002373362 A CA002373362 A CA 002373362A CA 2373362 A CA2373362 A CA 2373362A CA 2373362 A1 CA2373362 A1 CA 2373362A1
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CA
Canada
Prior art keywords
medical device
group
poly
fatty
hydrophilic coating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002373362A
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French (fr)
Other versions
CA2373362C (en
Inventor
Lixiao Wang
Irina Nazarova
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Boston Scientific Ltd Barbados
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2373362A1 publication Critical patent/CA2373362A1/en
Application granted granted Critical
Publication of CA2373362C publication Critical patent/CA2373362C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/145—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials

Abstract

The present invention relates to a medical device for insertion into the bod y wherein said device has at least one surface which periodically comes into contact with a second surface, the first surface comprising a lubricious hydrophilic coating disposed thereon, said hydrophilic coating further comprising at least one antiblock agent.

Claims (20)

1. A medical device for insertion into the body, said device having at least one surface which periodically comes into contact with a second surface, said first surface comprising a lubricious hydrophilic coating disposed on said first surface wherein said hydrophilic coating comprises at least one antiblock agent.
2. The medical device of Claim 1 wherein said hydrophilic coating comprises at least one polymeric material selected from the group consisting of polyalkylene glycols, alkoxy polyalkylene glycols, copolymers of methylvinyl ether and maleic acid, poly(vinylpyrrolidone), poly(N-alkylacrylamide), poly(acrylic acid), poly(vinyl alcohol), poly(ethyleneimine), methyl cellulose, carboxymethyl cellulose, polyvinyl sulfonic acid, heparin, dextran, modified dextran and chondroitin sulphate.
3. The medical device of Claim 1 wherein said hydrophilic coating comprises at least one copolymer of maleic anhydride.
4. The medical device of Claim 1 wherein said hydrophilic coating comprises at least one polycarboxylic acid.
5. The medical device of Claim 1 wherein said antiblock agent is selected from the group consisting of long chain alkyl derivatives of fatty esters, fatty amides, fatty acid amides, fatty acids, fatty amines, alcohols, fatty acid alcohols, polyalkylene waxes, oxidized polyalkylene waxes, silicone waxes, silicone oils, alphaolefin sulfonates, phosphate ester of fatty alcohols, and mixtures thereof.
6. The medical device of Claim 5 wherein said oxidized polyakylene wax is an alkane hydrocarbon capped with at least one functional group selected from the group consisting of ester, carboxylic and hydroxy.
7. The medical device of Claim 1 wherein said antiblock agent blooms to the surface of said hydrophilic coating.
8. The medical device of Claim 1 wherein said antiblock agent prevents premature absorption of water by said hydrophilic coating.
9. The medical device of Claim 1 wherein said hydrophilic coating and said antiblock agent are disposed on said surface in a solvent selected from the group consisting of alcohols, chlorinated solvents, esters, glycols, glycol ethers, ketones, aliphatic hydrocarbons, aromatic hydrocarbons and mixtures thereof.
10. The medical device of Claim 1 wherein said device is a dilatation balloon.
11. The medical device of Claim 1 wherein said device is a guide wire.
12. The medical device of Claim 10 wherein said balloon comprises a polymeric material selected from the group consisting of polyether block amides, polyester block ethers, polyethylene terephthalate and nylon.
13. A method for producing a medical device as in Claim 1 comprising coating said device with a lubricious hydrophilic polymeric material wherein said coating further comprises at least one antiblock agent.
14. The method of Claim 13 wherein said antiblock agent is selected from the group consisting of long chain alkyl derivatives of fatty esters, fatty amides, fatty acid amides, fatty acids, fatty amines, alcohols, fatty acid alcohols, polyalkylene waxes, oxidized polyalkylene waxes, and mixtures thereof.
15. The method of Claim 13 wherein said medical device is a dilatation balloon.
16. The method of Claim 13 wherein said medical device is a guide wire.
17. The method of Claim 13 wherein said hydrophilic coating is a polymeric material selected from the group consisting of polyalkylene glycols, alkoxy polyalkylene glycols, copolymers of methylvinyl ether and maleic acid, poly(vinylpyrrolidone), poly(N-alkylacrylamide), poly(acrylic acid), poly(vinyl alcohol), poly(ethyleneimine), methyl cellulose, carboxymethyl cellulose, polyvinyl sulfonic acid, heparin, dextran, modified dextran and chondroitin sulphate.
18. The method of Claim 17 wherein said hydrophilic coating comprises at least one polymer selected from the group consisting of copolymers of maleic anhydride and polycarboxylic acids.
19. The method of Claim 13 wherein said method is selected from the group consisting of dipping, spraying, brushing and mixtures thereof.
20. The method of Claim 19 wherein said method is accomplished out of a solvent selected from the group consisting of alcohols, chlorinated solvents, esters, glycols, glycol ethers, ketones, aliphatic hydrocarbons, aromatic hydrocarbons, and mixtures thereof.
CA002373362A 1999-05-07 2000-02-09 Lubricious coating for medical devices comprising an antiblock agent Expired - Fee Related CA2373362C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/307,309 1999-05-07
US09/307,309 US6673053B2 (en) 1999-05-07 1999-05-07 Hydrophilic lubricity coating for medical devices comprising an antiblock agent
PCT/US2000/003329 WO2000067816A1 (en) 1999-05-07 2000-02-09 Lubricious coating for medical devices comprising an antiblock agent

Publications (2)

Publication Number Publication Date
CA2373362A1 true CA2373362A1 (en) 2000-11-16
CA2373362C CA2373362C (en) 2009-12-22

Family

ID=23189161

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002373362A Expired - Fee Related CA2373362C (en) 1999-05-07 2000-02-09 Lubricious coating for medical devices comprising an antiblock agent

Country Status (5)

Country Link
US (1) US6673053B2 (en)
EP (1) EP1176996A1 (en)
JP (1) JP2002543885A (en)
CA (1) CA2373362C (en)
WO (1) WO2000067816A1 (en)

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Also Published As

Publication number Publication date
JP2002543885A (en) 2002-12-24
EP1176996A1 (en) 2002-02-06
CA2373362C (en) 2009-12-22
US20020016574A1 (en) 2002-02-07
WO2000067816A1 (en) 2000-11-16
US6673053B2 (en) 2004-01-06

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