CA2178541A1 - Implantable medical device - Google Patents
Implantable medical deviceInfo
- Publication number
- CA2178541A1 CA2178541A1 CA002178541A CA2178541A CA2178541A1 CA 2178541 A1 CA2178541 A1 CA 2178541A1 CA 002178541 A CA002178541 A CA 002178541A CA 2178541 A CA2178541 A CA 2178541A CA 2178541 A1 CA2178541 A1 CA 2178541A1
- Authority
- CA
- Canada
- Prior art keywords
- another
- bioactive material
- bioactive
- layer
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/10—Inorganic materials
- A61L29/106—Inorganic materials other than carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/082—Inorganic materials
- A61L31/088—Other specific inorganic materials not covered by A61L31/084 or A61L31/086
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/146—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/02—Use of inorganic materials
- A61L33/022—Metal or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
- A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1002—Intraluminal radiation therapy
Abstract
A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material posited on one surface of structure 12; and at least one porous layer 20 posited over the bioactive material layer 18 posited on one surface of structure (12) and the bioactive-material-free surface. Preferably, the structure 12 is a coronary stent. The porous layer 20 is comprised of a polymer applied preferably by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor. The invention is also directed to the method of manufacture of the device 10, as well as a method of using it in medical treatments.
Claims (111)
1. An implantable medical device (10), comprising:
a structure (12) adapted for introduction into a patient, the structure (12) being composed of a base material (14);
at least one layer (18) of a bioactive material posited on one surface of the structure (12); and at least one porous layer (20) posited over the bioactive material layer (18), composed of a polymer and being of a thickness adequate to provide a controlled release of the bioactive material.
a structure (12) adapted for introduction into a patient, the structure (12) being composed of a base material (14);
at least one layer (18) of a bioactive material posited on one surface of the structure (12); and at least one porous layer (20) posited over the bioactive material layer (18), composed of a polymer and being of a thickness adequate to provide a controlled release of the bioactive material.
2. The device (10) according to claim 1, wherein the at least one porous layer (20) is one polymerized from a catalyst-free monomer vapor.
3. The device (10) according to claim 1, wherein the polymer is selected from the group consisting essentially of a polyamide, polymers of parylene or derivatives thereof, poly(ethylene oxide), poly(ethylene glycol), poly(propylene oxide), silicone based polymers, polymers of methane, tetrafluoroethylene or tetramethyldisiloxane or a polymer derived from photopolymerizeable monomers.
4. The device (10) according to claim 3, wherein the thickness of the at least one porous layer (20) is about 5,000 to 250,000 .ANG..
5. The device (10) according to claim 1, further comprising at least one additional coating layer (16) between the structure (12) and the at least one bioactive material layer (18).
6. The device (10) according to claim 5, wherein the at least one additional coating layer (16) is less porous than, but composed of the same or different polymer as, the at least one porous layer (20).
7. The device (10) according to claim 6, wherein the polymer is selected from the group consisting essentially of polyamide, polymers of parylene or derivatives thereof, or a polymer derived from photopolymerizable monomers of bisphenol A diglycidyl ether and acrylic acid or methacrylic acid, and the at least one additional coating layer (16) is about 50,000 to 500,000 .ANG. thick.
8. The device (10) according to claim 1, wherein the structure (12) is configured as a vascular stent.
9. The device (10) according to claim 1, wherein the structure (12) is configured as at least one of: a stent, a vascular or other graft, a vascular or other graft in combination with a stent, heart valve, an orthopedic device, appliance, implant or replacement, or portion thereof; or a portion of any of these.
10. The device (10) according to claim 1, wherein the base material (14) is biocompatible.
11. The device (10) according to claim 10, wherein the base material (14) of the structure (12) includes at least one of:
stainless steel, tantalum, titanium, Nitinol, gold, platinum, inconel, iridium, silver, tungsten, or another biocompatible metal, or alloys of any of these; carbon or carbon fiber;
cellulose acetate, cellulose nitrate, silicone, polyethylene teraphthalate, polyurethane, polyamide, polyester, polyorthoester, polyanhydride, polyether sulfone, polycarbonate, polypropylene, high molecular weight polyethylene, polytetrafluoroethylene, or another biocompatible polymeric material, or mixtures or copolymers thereof; polylactic acid, polyglycolic acid or copolymers thereof, a polyanhydride, polycaprolactone, polyhydroxy-butyrate valerate or another biodegradable polymer, or mixtures or copolymers of these; a protein, an extracellular matrix component, collagen, fibrin or another biologic agent; or a mixture thereof.
stainless steel, tantalum, titanium, Nitinol, gold, platinum, inconel, iridium, silver, tungsten, or another biocompatible metal, or alloys of any of these; carbon or carbon fiber;
cellulose acetate, cellulose nitrate, silicone, polyethylene teraphthalate, polyurethane, polyamide, polyester, polyorthoester, polyanhydride, polyether sulfone, polycarbonate, polypropylene, high molecular weight polyethylene, polytetrafluoroethylene, or another biocompatible polymeric material, or mixtures or copolymers thereof; polylactic acid, polyglycolic acid or copolymers thereof, a polyanhydride, polycaprolactone, polyhydroxy-butyrate valerate or another biodegradable polymer, or mixtures or copolymers of these; a protein, an extracellular matrix component, collagen, fibrin or another biologic agent; or a mixture thereof.
12. The device (10) according to claim 1, wherein the bioactive material includes at least one of: heparin, covalent heparin, or another thrombin inhibitor, hirudin, hirulog, argatroban, D-phenylalanyl-L-poly-L-arginyl chloromethyl ketone, or another antithrombogenic agent, or mixtures thereof; urokinase, streptokinase, a tissue plasminogen activator, or another thrombolytic agent, or mixtures thereof; a fibrinolytic agent; a vasospasm inhibitor; a calcium channel blocker, a nitrate, nitric oxide, a nitric oxide promoter or another vasodilator; an antimicrobial agent or antibiotic; aspirin, ticlopidine, a glycoprotein IIb/IIIa inhibitor or another inhibitor of surface glycoprotein receptors, or another antiplatelet agent; colchicine or another antimitotic, or another microtubule inhibitor, dimethyl sulfoxide (DMSO), a retinoid or another antisecretory agent;
cytochalasin or another actin inhibitor; or a remodeling inhibitor; deoxyribonucleic acid, an antisense nucleotide or another agent for molecular genetic intervention; methotrexate or another antimetabolite or antiproliferative agent; tamoxifen citrate, Taxol? or derivatives thereof, or other anti-cancer chemotherapeutic agents; dexamethasone, dexamethasone sodium phosphate, dexamethasone acetate or another dexamethasone derivative, or another anti-inflammatory steroid or non-steroidal anti-inflammatory agent; cyclosporin or another immunosuppressive agent; trapidal (a PDGF antagonist), angiogenin, angiopeptin (a growth hormone antagonist), a growth factor or an anti-growth factor antibody, or another growth factor antagonist; dopamine, bromocriptine mesylate, pergolide mesylate or another dopamine agonist; 60Co 192Ir 32p 11lIn, soY, 99mTc or another radiotherapeutic agent; iodine-containing compounds, barium-containing compounds, gold, tantalum, platinum, tungsten or another heavy metal functioning as a radiopaque agent; a peptide, a protein, an enzyme, an extracellular matrix component, a cellular component or another biologic agent; captopril, enalapril or another angiotensin converting enzyme (ACE) inhibitor; ascorbic acid, alpha tocopherol, superoxide dismutase, deferoxamine, a 21-amino steroid (lasaroid) or another free radical scavenger, iron chelator or antioxidant; a 14C-, 3H-, 131I-, 32p- or 36S-radiolabelled form or other radiolabelled form of any of the foregoing; estrogen or another sex hormone; AZT or other antipolymerases; acyclovir, famciclovir, rimantadine hydrochloride, ganciclovir sodium or other antiviral agents; 5-aminolevulinic acid, meta-tetrahydroxyphenylchlorin, hexadecafluoro zinc phthalocyanine, tetramethyl hematoporphyrin, rhodamine 123 or other photodynamic therapy agents; an IgG2 Kappa antibody against Pseudomonas aeruginosa exotoxin A and reactive with A431 epidermoid carcinoma cells, monoclonal antibody against the noradrenergic enzyme dopamine beta-hydroxylase conjugated to saporin or other antibody targeted therapy agents; gene therapy agents; and enalapril and other prodrugs, or a mixture of any of these.
cytochalasin or another actin inhibitor; or a remodeling inhibitor; deoxyribonucleic acid, an antisense nucleotide or another agent for molecular genetic intervention; methotrexate or another antimetabolite or antiproliferative agent; tamoxifen citrate, Taxol? or derivatives thereof, or other anti-cancer chemotherapeutic agents; dexamethasone, dexamethasone sodium phosphate, dexamethasone acetate or another dexamethasone derivative, or another anti-inflammatory steroid or non-steroidal anti-inflammatory agent; cyclosporin or another immunosuppressive agent; trapidal (a PDGF antagonist), angiogenin, angiopeptin (a growth hormone antagonist), a growth factor or an anti-growth factor antibody, or another growth factor antagonist; dopamine, bromocriptine mesylate, pergolide mesylate or another dopamine agonist; 60Co 192Ir 32p 11lIn, soY, 99mTc or another radiotherapeutic agent; iodine-containing compounds, barium-containing compounds, gold, tantalum, platinum, tungsten or another heavy metal functioning as a radiopaque agent; a peptide, a protein, an enzyme, an extracellular matrix component, a cellular component or another biologic agent; captopril, enalapril or another angiotensin converting enzyme (ACE) inhibitor; ascorbic acid, alpha tocopherol, superoxide dismutase, deferoxamine, a 21-amino steroid (lasaroid) or another free radical scavenger, iron chelator or antioxidant; a 14C-, 3H-, 131I-, 32p- or 36S-radiolabelled form or other radiolabelled form of any of the foregoing; estrogen or another sex hormone; AZT or other antipolymerases; acyclovir, famciclovir, rimantadine hydrochloride, ganciclovir sodium or other antiviral agents; 5-aminolevulinic acid, meta-tetrahydroxyphenylchlorin, hexadecafluoro zinc phthalocyanine, tetramethyl hematoporphyrin, rhodamine 123 or other photodynamic therapy agents; an IgG2 Kappa antibody against Pseudomonas aeruginosa exotoxin A and reactive with A431 epidermoid carcinoma cells, monoclonal antibody against the noradrenergic enzyme dopamine beta-hydroxylase conjugated to saporin or other antibody targeted therapy agents; gene therapy agents; and enalapril and other prodrugs, or a mixture of any of these.
13. The device (10) according to claim 1, wherein the at least one layer (18) of bioactive material contains about 0.01 to 4 mg of the bioactive material per cm2 of the gross surface area of the structure (12).
14. The device (10) according to claim 1, wherein different bioactive materials are posited on the different surfaces of the structure (12).
15. The device (10) according to claim 1 wherein a bioactive material is posited on one surface of structure (12), a porous layer (20) is posited over the bioactive material (18) on the one surface of structure (12) and over the bioactive-material-free surface of structure (12), and a second bioactive material is posited on porous layer (20) and forms the outermost layer for structure (12).
16. The device according to claim 15 wherein a different and third bioactive material is posited on the bioactive-material-free side of structure (12) and further having porous layer (20) posited over the first and third bioactive materials; and wherein the second bioactive material forming the outermost layer is covalent heparin bound to porous layer (20).
17. The device according to claim 1 wherein the structure (12) comprises either a single bioactive material on one surface of said structure (12) or different bioactive materials on the different surfaces of structure (12) with a porous layer (20) over said bioactive material or materials and said second bioactive material forms the outermost layer over porous layer (12).
18. The device (10) according to claim 1 wherein plural but different bioactive materials are posited on the different surfaces of structure (12) with the proviso that the same bioactive material is not posited on the different surfaces of the structure (12) within the same layer and that the outermost layer may comprise either a porous layer or a bioactive material layer.
19. The device (10) according to claim 1 wherein said bioactive material (18) is posited on said one surface of structure (12) in a geometric pattern.
20. The device (10) according to claim 19 wherein said device is a stent and said bioactive material (18) is posited on one surface of the stent in a discontinuous geometric pattern.
21. The device (10) according to claim 20 wherein bioactive material (18) is posited on one surface of the stent in a pattern of parallel lines or wherein the bioactive material is not posited on the tips of the stent.
22. The device according to claim 1 wherein two or more different bioactive materials (18) are posited on one surface of the structure (12).
23. The device (10) according to claim 22 wherein the two or more bioactive materials (18) are posited on adjacent areas of the one surface of structure (12).
24. The device (10) according to claim 1, further comprising a connector (26) securing the at least one porous layer (20) to the base material (14) of the structure (12).
25. An implantable vascular device, comprising:
A. a stent structure adapted for introduction into a vascular system of a patient, the stent structure comprising a biocompatible metal;
B. at least one bioactive material posited on one surface of the structure of the stent; and C. a porous layer posited over the bioactive material and the bioactive-material-free stent surface, wherein said porous layer being at least about 5000 .ANG. thick adequate to provide a controlled release of the bioactive material.
A. a stent structure adapted for introduction into a vascular system of a patient, the stent structure comprising a biocompatible metal;
B. at least one bioactive material posited on one surface of the structure of the stent; and C. a porous layer posited over the bioactive material and the bioactive-material-free stent surface, wherein said porous layer being at least about 5000 .ANG. thick adequate to provide a controlled release of the bioactive material.
26. The device according to claim 25 wherein the stent surface is coated with a substantially non-porous coating layer have a thickness of about 50,000 .ANG. to about 500,000 .ANG. wherein the coating layer comprises a polymer selected from the group consisting essentially of polyamide, a polymer derived from parylene or derivatives thereof, polyalkylene oxides, polyalkylene glycols, silicon based polymers, polymers derived from methane, tetrafluoro-ethylene, tetramethyldisiloxane, or polymers derived from photopolymerizeable monomers or mixtures of such polymers or copolymers thereof.
27. The device (10) according to claim 25, wherein the bioactive material includes at least one of: heparin, covalent heparin or another thrombin inhibitor, hirudin, hirulog, argatroban, D-phenylalanyl-L-poly-L-arginyl chloromethyl ketone, or another antithrombogenic agent, or mixtures thereof; urokinase, streptokinase, a tissue plasminogen activator, or another thrombolytic agent, or mixtures thereof; a fibrinolytic agent; a vasospasm inhibitor; a calcium channel blocker, a nitrate, nitric oxide, a nitric oxide promoter or another vasodilator; an antimicrobial agent or antibiotic; aspirin, ticlopidine, a glycoprotein IIb/IIIa inhibitor or another inhibitor of surface glycoprotein receptors, or another antiplatelet agent; colchicine or another antimitotic, or another microtubule inhibitor, dimethyl sulfoxide (DMSO), a retinoid or another antisecretory agent;
cytochalasin or another actin inhibitor; or a remodeling inhibitor; deoxyribonucleic acid, an antisense nucleotide or another agent for molecular genetic intervention; methotrexate or another antimetabolite or antiproliferative agent; tamoxifen citrate, Taxol? or derivatives thereof, or other anti-cancer chemotherapeutic agents; dexamethasone, dexamethasone sodium phosphate, dexamethasone acetate or another dexamethasone derivative, or another anti-inflammatory steroid or non-steroidal anti-inflammatory agent; cyclosporin or another immunosuppressive agent; trapidal (a PDGF antagonist), angiopeptin (a growth hormone antagonist), angiogenin, or other growth factors, or an anti-growth factor antibody, or another growth factor antagonist;
dopamine, bromocriptine mesylate, pergolide mesylate or another dopamine agonist; 60Co, 192Ir 3?, 111In, ?, 9?c or another radiotherapeutic agent; iodine-containing compounds, barium-containing compounds, gold, tantalum, platinum, tungsten or another heavy metal functioning as a radiopaque agent; a peptide, a protein, an enzyme, an extracellular matrix component, a cellular component or another biologic agent; captopril, enalapril or another angiotensin converting enzyme (ACE) inhibitor; ascorbic acid, alpha tocopherol, superoxide dismutase, deferoxamine, a 21-amino steroid (lasaroid) or another free radical scavenger, iron chelator or antioxidant; a 14C-, 3H-, 131I-, 32P- or 36S-radiolabelled form or other radiolabelled form of any of the foregoing; estrogen or another sex hormone; AZT or other antipolymerases; acyclovir, famciclovir, rimantadine hydrochloride, ganciclovir sodium or other antiviral agents;
5-aminolevulinic acid, meta-tetrahydroxyphenylchlorin, hexadecafluoro zinc phthalocyanine, tetramethyl hematoporphyrin, rhodamine 123 or other photodynamic therapy agents; an IgG2 Kappa antibody against Pseudomonas aeruginosa exotoxin A and reactive with A431 epidermoid carcinoma cells, monoclonal antibody against the noradrenergic enzyme dopamine beta-hydroxylase conjugated to saporin or other antibody targeted therapy agents; enalapril or other prodrugs; gene therapy agents, or a mixture of any of these;
and various forms of small intestine submucosa (SIS).
cytochalasin or another actin inhibitor; or a remodeling inhibitor; deoxyribonucleic acid, an antisense nucleotide or another agent for molecular genetic intervention; methotrexate or another antimetabolite or antiproliferative agent; tamoxifen citrate, Taxol? or derivatives thereof, or other anti-cancer chemotherapeutic agents; dexamethasone, dexamethasone sodium phosphate, dexamethasone acetate or another dexamethasone derivative, or another anti-inflammatory steroid or non-steroidal anti-inflammatory agent; cyclosporin or another immunosuppressive agent; trapidal (a PDGF antagonist), angiopeptin (a growth hormone antagonist), angiogenin, or other growth factors, or an anti-growth factor antibody, or another growth factor antagonist;
dopamine, bromocriptine mesylate, pergolide mesylate or another dopamine agonist; 60Co, 192Ir 3?, 111In, ?, 9?c or another radiotherapeutic agent; iodine-containing compounds, barium-containing compounds, gold, tantalum, platinum, tungsten or another heavy metal functioning as a radiopaque agent; a peptide, a protein, an enzyme, an extracellular matrix component, a cellular component or another biologic agent; captopril, enalapril or another angiotensin converting enzyme (ACE) inhibitor; ascorbic acid, alpha tocopherol, superoxide dismutase, deferoxamine, a 21-amino steroid (lasaroid) or another free radical scavenger, iron chelator or antioxidant; a 14C-, 3H-, 131I-, 32P- or 36S-radiolabelled form or other radiolabelled form of any of the foregoing; estrogen or another sex hormone; AZT or other antipolymerases; acyclovir, famciclovir, rimantadine hydrochloride, ganciclovir sodium or other antiviral agents;
5-aminolevulinic acid, meta-tetrahydroxyphenylchlorin, hexadecafluoro zinc phthalocyanine, tetramethyl hematoporphyrin, rhodamine 123 or other photodynamic therapy agents; an IgG2 Kappa antibody against Pseudomonas aeruginosa exotoxin A and reactive with A431 epidermoid carcinoma cells, monoclonal antibody against the noradrenergic enzyme dopamine beta-hydroxylase conjugated to saporin or other antibody targeted therapy agents; enalapril or other prodrugs; gene therapy agents, or a mixture of any of these;
and various forms of small intestine submucosa (SIS).
28. The device (10) according to claim 25, wherein the at least one layer (18) of bioactive material contains about 1 to 4 mg of the bioactive material per cm2 of the gross surface area of the structure (12).
29. The device according to claim 25, wherein different bioactive materials are posited on the different surfaces of the stent structure.
30. The device according to claim 25 wherein a bioactive material (18) is posited on one surface of the stent structure (12), a porous layer (20) is posited over the bioactive material (18) on the one surface of the stent structure (12) and over the bioactive-material-free surface of the stent structure (12), and a second bioactive material (18) is posited on the porous layer (20) and forms the outermost layer for the stent structure (12).
31. The device according to claim 30 wherein a different and third bioactive material (18) is posited on the bioactive-material-free surface of the stent structure (12) further having a porous layer (20) posited over the bioactive materials (18) and wherein the second bioactive material (18) forming the outermost layer is covalent heparin bound to the porous layer.
32. The device according to claim 25 wherein the stent structure comprises either a single bioactive material on one surface of said structure (12) or different bioactive materials (18) on the different surfaces of the stent structure (12) with a porous layer over said bioactive material (18) or materials (18) and said second bioactive material forms the outermost layer over the porous layer.
33. The device according to claim 25 wherein multiple layers comprise the stent surfaces wherein such layers comprise alternating porous layers and at least one bioactive material layer and wherein different bioactive materials are posited on the different surfaces of the stent structure with the proviso that the same bioactive material is not posited on the different surfaces of the stent structure within the same layer and that a porous layer is posited over each bioactive material layer and the outermost layer may comprise either a porous layer or a bioactive material layer.
34. The device according to claim 25 wherein said bioactive material (18) is posited on said one surface of stent structure (12) in a geometric pattern.
35. The device according to claim 34 wherein the bioactive material (18) is posited on one surface of the stent structure (12) in a pattern of parallel lines or a pattern wherein the bioactive material is not posited on the tips of the stent.
36. The device according to claim 25 wherein two or more different bioactive materials (18) are posited on one surface of the stent structure (12).
37. The device according to claim 36 wherein the two or more bioactive materials (18) are posited on adjacent areas of the one surface of the stent structure (12).
38. A method of medically treating a patient by the step of inserting an implantable medical device (10) into the patient, the device (10) comprising a structure (12) adapted for introduction into the patient, and the structure (12) being composed of a base material (14), the method comprising the preliminary steps of:
depositing at least one layer (18) of a bioactive material on one surface of the structure (12); and depositing at least one porous layer (20) over the at least one bioactive material layer (18) and the bioactive-material-free surface of structure (12), the at least one porous layer being composed of a polymer and having a thickness adequate to provide a controlled release of the bioactive material.
depositing at least one layer (18) of a bioactive material on one surface of the structure (12); and depositing at least one porous layer (20) over the at least one bioactive material layer (18) and the bioactive-material-free surface of structure (12), the at least one porous layer being composed of a polymer and having a thickness adequate to provide a controlled release of the bioactive material.
39. The method according to claim 38, wherein the at least one porous layer (20) is deposited on the one surface of structure (12) by polymerizing the at least one layer (20) from a catalyst-free monomer vapor.
40. The method according to claim 38, wherein at least one porous layer (20) comprise a polymer selected from the group consisting essentially of polyamide, polymers of parylene, or derivative thereof, poly(ethylene oxide), poly(ethylene glycol), poly(propylene oxide), silicone based polymers, polymers of methane, tetrafluoroethylene or tetramethyldisiloxane or polymers of photopolymerizable monomers.
41. The method according to claim 40 wherein the at least one porous layer (20) is applied to thickness of about 5,000 to 250,000 .ANG..
42. The method according to claim 38, comprising the further step of depositing at least one additional coating layer (16) between the structure (12) and the at least one bioactive material layer (18).
43. The method according to claim 42, wherein the step of depositing the at least one additional coating layer (16) is carried out so that the at least one additional coating layer (16) is less porous than, but composed of the same or different polymer as, the at least one porous layer (20).
44. The method according to claim 43, wherein the at least one additional coating layer (16) comprises a polymer selected from the group consisting essentially of polyimides, polymers derived from parylene or a parylene derivative, and the at least one coating layer (16) is applied to a thickness of about 50,000 to 500,000 .ANG..
45. The method according to claim 38, wherein the method is carried out with a structure (12) configured as a vascular stent, and wherein the method comprises the step of inserting the vascular stent into the vascular system of the patient, subsequent to the deposition of the different layers.
46. The method according to claim 26, wherein the method is carried out with a base material (14) which is biocompatible.
47. The method according to claim 46, wherein the method is carried out with a structure (12) whose base material (14) includes at least one of: stainless steel, tantalum, titanium, Nitinol, gold, platinum, inconel, iridium, silver, tungsten, or another biocompatible metal, or alloys of any of these; carbon or carbon fiber; cellulose acetate, cellulose nitrate, silicone, polyethylene teraphthalate, polyurethane, polyamide, polyester, polyorthoester, polyanhydride, polyether sulfone, polycarbonate, polypropylene, high molecular weight polyethylene, polytetrafluoroethylene, or another biocompatible polymeric material, or mixtures or copolymers of these; polylactic acid, polyglycolic acid or copolymers thereof, a polyanhydride, polycaprolactone, polyhydroxy-butyrate valerate or another biodegradable polymer, or mixtures or copolymers of these; a protein, an extracellular matrix component, collagen, fibrin or another biologic agent; or a mixture of any of these.
48. The method according to claim 26, wherein the step of depositing the at least one bioactive material layer (18) is carried out with a bioactive material which includes at least one of: heparin, covalent heparin or another thrombin inhibitor, hirudin, hirulog, argatroban, D-phenylalanyl-L-poly-L-arginyl chloromethyl ketone, or another antithrombogenic agent, or mixtures thereof; urokinase, streptokinase, a tissue plasminogen activator, or another thrombolytic agent, or mixtures thereof; a fibrinolytic agent; a vasospasm inhibitor; a calcium channel blocker, a nitrate, nitric oxide, a nitric oxide promoter or another vasodilator; an antimicrobial agent or antibiotic;
aspirin, ticlopidine, a glycoprotein IIb/IIIa inhibitor or another inhibitor of surface glycoprotein receptors, or another antiplatelet agent; colchicine or another antimitotic, or another microtubule inhibitor, dimethyl sulfoxide (DMSO), a retinoid or another antisecretory agent; cytochalasin or another actin inhibitor; or a remodeling inhibitor; deoxyribonucleic acid, an antisense nucleotide or another agent for molecular genetic intervention; GP Iib/IIIa, GP Ib-IX or another inhibitor or surface glycoprotein receptor; methotrexate or another antimetabolite or antiproliferative agent; tamoxifen citrate, Taxol? or derivatives thereof, or other anti-cancer chemotherapeutic agents; dexamethasone, dexamethasone sodium phosphate, dexamethasone acetate or another dexamethasone derivative, or another anti-inflammatory steroid or non-steroidal anti-inflammatory agent; cyclosporin or another immunosuppressive agent; trapidal (a PDGF antagonist), angiopeptin (a growth hormone antagonist), angiogenin, a growth factor or an anti-growth factor antibody, or another growth factor antagonist; dopamine, bromocriptine mesylate, pergolide mesylate or another dopamine agonist; 60Co, 192Ir, 32P, 111In, 90Y, 99mTc or another radiotherapeutic agent; iodine-containing compounds, barium-containing compounds, gold, tantalum, platinum, tungsten or another heavy metal functioning as a radiopaque agent; a peptide, a protein, an enzyme, an extracellular matrix component, a cellular component or another biologic agent; captopril, enalapril or another angiotensin converting enzyme (ACE) inhibitor; ascorbic acid, alpha tocopherol, superoxide dismutase, deferoxamine, a 21-amino steroid (lasaroid) or another free radical scavenger, iron chelator or antioxidant; a 14C-, 3H-, 131I-, 32P- or 36S-radiolabelled form or other radiolabelled form of any of the foregoing; estrogen or another sex hormone; AZT or other antipolymerases; acyclovir, famciclovir, rimantadine hydrochloride, ganciclovir sodium or other antiviral agents; 5-aminolevulinic acid, meta-tetrahydroxyphenylchlorin, hexadecafluoro zinc phthalocyanine, tetramethyl hematoporphyrin, rhodamine 123 or other photodynamic therapy agents; an IgG2 Kappa antibody against Pseudomonas aeruginosa exotoxin A and reactive with A431 epidermoid carcinoma cells, monoclonal antibody against the noradrenergic enzyme dopamine beta-hydroxylase conjugated to saporin or other antibody target therapy agents; enalapril or other prodrugs; gene therapy agents, or a mixture of any of these;
and various forms of small intestine submucosa (SIS).
aspirin, ticlopidine, a glycoprotein IIb/IIIa inhibitor or another inhibitor of surface glycoprotein receptors, or another antiplatelet agent; colchicine or another antimitotic, or another microtubule inhibitor, dimethyl sulfoxide (DMSO), a retinoid or another antisecretory agent; cytochalasin or another actin inhibitor; or a remodeling inhibitor; deoxyribonucleic acid, an antisense nucleotide or another agent for molecular genetic intervention; GP Iib/IIIa, GP Ib-IX or another inhibitor or surface glycoprotein receptor; methotrexate or another antimetabolite or antiproliferative agent; tamoxifen citrate, Taxol? or derivatives thereof, or other anti-cancer chemotherapeutic agents; dexamethasone, dexamethasone sodium phosphate, dexamethasone acetate or another dexamethasone derivative, or another anti-inflammatory steroid or non-steroidal anti-inflammatory agent; cyclosporin or another immunosuppressive agent; trapidal (a PDGF antagonist), angiopeptin (a growth hormone antagonist), angiogenin, a growth factor or an anti-growth factor antibody, or another growth factor antagonist; dopamine, bromocriptine mesylate, pergolide mesylate or another dopamine agonist; 60Co, 192Ir, 32P, 111In, 90Y, 99mTc or another radiotherapeutic agent; iodine-containing compounds, barium-containing compounds, gold, tantalum, platinum, tungsten or another heavy metal functioning as a radiopaque agent; a peptide, a protein, an enzyme, an extracellular matrix component, a cellular component or another biologic agent; captopril, enalapril or another angiotensin converting enzyme (ACE) inhibitor; ascorbic acid, alpha tocopherol, superoxide dismutase, deferoxamine, a 21-amino steroid (lasaroid) or another free radical scavenger, iron chelator or antioxidant; a 14C-, 3H-, 131I-, 32P- or 36S-radiolabelled form or other radiolabelled form of any of the foregoing; estrogen or another sex hormone; AZT or other antipolymerases; acyclovir, famciclovir, rimantadine hydrochloride, ganciclovir sodium or other antiviral agents; 5-aminolevulinic acid, meta-tetrahydroxyphenylchlorin, hexadecafluoro zinc phthalocyanine, tetramethyl hematoporphyrin, rhodamine 123 or other photodynamic therapy agents; an IgG2 Kappa antibody against Pseudomonas aeruginosa exotoxin A and reactive with A431 epidermoid carcinoma cells, monoclonal antibody against the noradrenergic enzyme dopamine beta-hydroxylase conjugated to saporin or other antibody target therapy agents; enalapril or other prodrugs; gene therapy agents, or a mixture of any of these;
and various forms of small intestine submucosa (SIS).
49. The method according to claim 38, wherein the step of depositing the at least one layer (18) of bioactive material is carried out so that the at least one layer (18) contains about 1 to 4 mg of the bioactive material per cm2 of the gross surface area of the structure (12).
50. The method according to claim 38, wherein different bioactive materials are deposited on the different surfaces of the structure (12).
51. The method according to claim 38 wherein a bioactive material is deposited on one surface of structure (12), a porous layer (20) is posited over the bioactive material (18) on one surface of structure (12) and over the bioactive-material-free surface of structure (12), and a second bioactive material is posited on porous layer (20) and forms the outermost layer for structure (12).
52. The method according to claim 51 wherein a different and third bioactive material is deposited on the bioactive-material-free side of structure (12) further having porous layer (20) deposited over the different bioactive materials and wherein the second bioactive material forming the outermost layer is covalent heparin bound to porous layer (20).
53. The method according to claim 38 wherein the structure 12 comprises either a single bioactive material on one side of said structure (12) or different bioactive materials on the different sides of structure (12) with a porous layer (20) over said bioactive material or materials and said second bioactive material forms the outermost layer over porous layer (12).
54. The method according to claim 38 wherein multiple layers comprise the stent surfaces wherein such layers comprise alternating porous layers and at least one bioactive material and wherein different bioactive materials are posited on the different surfaces of structure (12) with the proviso that the same bioactive material is not posited on both surfaces of the structure (12) within the same layer and that the outermost layer may comprise either a porous layer or a bioactive material.
55. The method according to claim 38 wherein said bioactive material is deposited on one surface of structure (12) in a geometric pattern.
56. The method according to claim 55 wherein said device is a stent and said bioactive material (18) is deposited on one surface of the stent is a discontinuous geometric pattern.
57. The method according to claim 56 wherein bioactive material (18) is deposited on one surface of the stent in a pattern of parallel lines or a pattern wherein the bioactive material is not posited on the tips [arms?] of the stent.
58. The method according to claim 38 wherein two or more different bioactive materials (18) are deposited on one side of the structure (12).
59. The method according to claim 58 wherein the two or more bioactive materials (18) are deposited on adjacent areas of the one surface of structure (12).
60. The method according to claim 38, wherein the method is carried out with a device (10) further comprising a connector (26) securing the at least one porous layer (20) to the base material (14) of the structure (12).
61. A method of making an implantable medical device (10), the device (10) including a structure (12) adapted for introduction into a patient, and the structure (12) being composed of a base material (14); wherein the method comprises the steps of:
A. depositing at least one layer (18) of a bioactive material on one surface the structure (12); and B. depositing at least one porous layer (20) over the at least one bioactive material layer (18) and the bioactive-material-free surface of structure (12), the at least one porous layer (20) being composed of a polymer and being of a thickness adequate to provide a controlled release of the bioactive material.
A. depositing at least one layer (18) of a bioactive material on one surface the structure (12); and B. depositing at least one porous layer (20) over the at least one bioactive material layer (18) and the bioactive-material-free surface of structure (12), the at least one porous layer (20) being composed of a polymer and being of a thickness adequate to provide a controlled release of the bioactive material.
62. The method according to claim 61, wherein the step of depositing the at least one porous layer (20) comprises polymerizing the at least one layer (20) from a catalyst-free monomer vapor.
63. The method according to claim 61, wherein the at least one porous layer (20) comprises a polymer selected from the group consisting essentially of polyimides, polymers derived from parylene or derivatives thereof, poly(ethylene oxide), poly(ethylene glycol), poly(propylene oxide), silicone based polymer, polymers of methane, tetrafluoroethylene or tetramethyldisiloxane or polymers derived from photopolymerizeable monomers.
64. The method according to claim 61 wherein the bioactive material (18) layer is deposited by a process selected from the group consisting essentially of adsorption, absorption, vapor phase deposition, plasma deposition, chemically binding to the surface of the device, utilizing surfactants as an adhesion medium, electrode position, or combinations thereof.
65. The method according to claim 64 wherein the bioactive material (18) layer is applied by vapor phase deposition, plasma deposition or by chemically binding to the substrate structure (12) and the bioactive material (18) is in the form of a powder, microencapsulated particles or a matrix incorporated material.
66. The method according to claim 61 wherein different bioactive materials are deposited on the different surfaces of the structure (12).
67. The method according to claim 61 wherein a first bioactive material is deposited on one surface of structure (12), a porous layer (20) is deposited over the bioactive material on one surface of the structure (12) and over the bioactive-material-free surface of structure 12 and a second bioactive material is deposited on the porous layer (20) and forms the outermost layer for structure (12).
68. The method according to claim 67 wherein a different and third bioactive material is deposited on the bioactive-material-free surface of structure (12) prior to the deposition of the porous layer (20) and the subsequent deposition of the second bioactive material on porous layer (20) forming the outermost layer for structure (12).
69. The method according to claim 61 wherein multiple layers are deposited on the surfaces of structure (12) wherein such layers comprise alternating porous layers and at least one bioactive material and wherein different bioactive materials are deposited on the different surfaces of structure (12) with the proviso that the same bioactive material is not deposited on both surfaces of structure (12) within the same layer and that a porous layer is deposited over each bioactive material layer wherein the outermost layer of structure (12) may comprise either a porous layer or a bioactive material layer.
70. The method according to claim 61 wherein the bioactive material (18) is deposited on one surface of structure (12) in a geometric pattern.
71. The method according to claim 70 wherein the device is a stent and the bioactive material (18) is deposited on one surface of the stent in a discontinuous geometric pattern.
72. The method according to claim 71 wherein the bioactive material (18) is deposited on one surface of the stent in a pattern of parallel lines or in a pattern wherein the bioactive material is not deposited on the tips of the stent.
73. The method according to claim 61 wherein two or more bioactive materials are deposited on one side or surface of the structure (12).
74. The method according to claim 73 wherein the two or more bioactive materials are deposited on adjacent areas of the one surface of structure (12).
75. The method according to claim 61, wherein the at least one porous layer (20) is applied to thickness of about 5,000 to 250,000 .ANG..
76. The method according to claim 61, wherein at least one porous layer (20) is carried out by sublimating and cracking di-p-xylylene or a derivative thereof to yield monomeric p-xylylene or a derivative thereof, and allowing the monomer so formed to simultaneously condense and polymerize over the bioactive material layer (18).
77. The method according to claim 76, wherein the sublimating and cracking step is carried out with dichloro-di-p-xylylene.
78. The method according to claim 61, wherein the step of depositing the at least one porous layer (20) is carried out in the absence of a solvent or catalyst for the polymer.
79. The method according to claim 61, wherein the step of depositing the at least one layer (18) of a bioactive material is carried out by applying over the structure (12) a mixture of the bioactive material and a fluid, and removing the fluid prior to the step of depositing the at least one porous layer (20).
80. The method according to claim 79, wherein the fluid is volatile, and the fluid removing step is carried out by allowing the fluid to evaporate from the structure (12) and bioactive material before the step of depositing the at least one porous layer (20).
81. The method according to claim 61, wherein the at least one additional coating layer (16) comprises a polymer selected from the group consisting essentially of polyamide, parylene or a parylene derivative, and the at least one coating layer (16) is applied to a thickness of about 50,000 to 500,000 .ANG..
82. The method according to claim 61, wherein the method is carried out with a structure (12) configured as a vascular stent.
83. The method according to claim 61, wherein the step of depositing the at least one bioactive material layer (18) is carried out with a bioactive material which includes at least one of: heparin, covalent heparin or another thrombin inhibitor, hirudin, hirulog, argatroban, D-phenylalanyl-L-poly-L-arginyl chloromethyl ketone, or another antithrombogenic agent, or mixtures thereof; urokinase, streptokinase, a tissue plasminogen activator, or another thrombolytic agent, or mixtures thereof; a fibrinolytic agent; a vasospasm inhibitor; a calcium channel blocker, a nitrate, nitric oxide, a nitric oxide promoter or another vasodilator; an antimicrobial agent or antibiotic;
aspirin, ticlopidine, a glycoprotein IIb/IIIa inhibitor or another inhibitor of surface glycoprotein receptors, or another antiplatelet agent; colchicine or another antimitotic, or another microtubule inhibitor, dimethyl sulfoxide (DMSO), a retinoid or another antisecretory agent; cytochalasin or another actin inhibitor; or a remodeling inhibitor; deoxyribonucleic acid, an antisense nucleotide or another agent for molecular genetic intervention; methotrexate or another antimetabolite or antiproliferative agent; tamoxifen citrate, Taxol? or derivatives thereof, or other anti-cancer chemotherapeutic agents;
dexamethasone, dexamethasone sodium phosphate, dexamethasone acetate or another dexamethasone derivative, or another anti-inflammatory steroid or non-steroidal anti-inflammatory agent; cyclosporin or another immunosuppressive agent; tripodal (a PDGF antagonist), angiopeptin (a growth hormone antagonist), angiogenin or other growth factors, or an anti-growth factor antibody, or another growth factor antagonist; dopamine, bromocriptine mesylate, pergolide mesylate or another dopamine agonist; 60Co 192Ir 32P, 111In, 90Y, 99mTc or another radiotherapeutic agent; iodine-containing compounds, barium-containing compounds, gold, tantalum, platinum, tungsten or another heavy metal functioning as a radiopaque agent; a peptide, a protein, an enzyme, an extracellular matrix component, a cellular component or another biologic agent; captopril, enalapril or another angiotensin converting enzyme (ACE) inhibitor; ascorbic acid, alpha tocopherol, superoxide dismutase, deferoxamine, a 21-amino steroid (lasaroid) or another free radical scavenger, iron chelator or antioxidant; a 14C-, 3H-, 131I-, 32P- or 36S-radiolabelled form or other radiolabelled form of any of the foregoing; estrogen or another sex hormone; AZT or other antipolymerases; acyclovir, famciclovir, rimantadine hydrochloride, ganciclovir sodium or other antiviral agents; 5-aminolevulinic acid, meta-tetrahydroxyphenylchlorin, hexadecafluoro zinc phthalocyanine, tetramethyl hematoporphyrin, rhodamine 123 or other photodynamic therapy agents; an IgG2 Kappa antibody against Pseudomonas aeruginosa exotoxin A and reactive with A431 epidermoid carcinoma cells, monoclonal antibody against the noradrenergic enzyme dopamine beta-hydroxylase conjugated to saporin or other antibody target therapy agents; enalapril or other prodrugs; and gene therapy agents, or a mixture of any of these.
aspirin, ticlopidine, a glycoprotein IIb/IIIa inhibitor or another inhibitor of surface glycoprotein receptors, or another antiplatelet agent; colchicine or another antimitotic, or another microtubule inhibitor, dimethyl sulfoxide (DMSO), a retinoid or another antisecretory agent; cytochalasin or another actin inhibitor; or a remodeling inhibitor; deoxyribonucleic acid, an antisense nucleotide or another agent for molecular genetic intervention; methotrexate or another antimetabolite or antiproliferative agent; tamoxifen citrate, Taxol? or derivatives thereof, or other anti-cancer chemotherapeutic agents;
dexamethasone, dexamethasone sodium phosphate, dexamethasone acetate or another dexamethasone derivative, or another anti-inflammatory steroid or non-steroidal anti-inflammatory agent; cyclosporin or another immunosuppressive agent; tripodal (a PDGF antagonist), angiopeptin (a growth hormone antagonist), angiogenin or other growth factors, or an anti-growth factor antibody, or another growth factor antagonist; dopamine, bromocriptine mesylate, pergolide mesylate or another dopamine agonist; 60Co 192Ir 32P, 111In, 90Y, 99mTc or another radiotherapeutic agent; iodine-containing compounds, barium-containing compounds, gold, tantalum, platinum, tungsten or another heavy metal functioning as a radiopaque agent; a peptide, a protein, an enzyme, an extracellular matrix component, a cellular component or another biologic agent; captopril, enalapril or another angiotensin converting enzyme (ACE) inhibitor; ascorbic acid, alpha tocopherol, superoxide dismutase, deferoxamine, a 21-amino steroid (lasaroid) or another free radical scavenger, iron chelator or antioxidant; a 14C-, 3H-, 131I-, 32P- or 36S-radiolabelled form or other radiolabelled form of any of the foregoing; estrogen or another sex hormone; AZT or other antipolymerases; acyclovir, famciclovir, rimantadine hydrochloride, ganciclovir sodium or other antiviral agents; 5-aminolevulinic acid, meta-tetrahydroxyphenylchlorin, hexadecafluoro zinc phthalocyanine, tetramethyl hematoporphyrin, rhodamine 123 or other photodynamic therapy agents; an IgG2 Kappa antibody against Pseudomonas aeruginosa exotoxin A and reactive with A431 epidermoid carcinoma cells, monoclonal antibody against the noradrenergic enzyme dopamine beta-hydroxylase conjugated to saporin or other antibody target therapy agents; enalapril or other prodrugs; and gene therapy agents, or a mixture of any of these.
84. The method according to claim 61, wherein the step of depositing the at least one layer (18) of bioactive material is carried out so that the at least one layer (18) contains about 1 to 4 mg of the bioactive material per cm of the gross surface area of the structure (12).
85. The method according to claim 61, comprising the further step of surface processing the base material (14) before depositing the at least one bioactive material layer (18) over the structure (12).
86. An implantable medical device, comprising:
a structure adapted for introduction into a patient, the structure being comprised of a base material; wherein the base material comprises apertures within the surface of the base material and containing at least one bioactive material within said apertures wherein at least one porous layer is posited over said base material and said bioactive material contained within said apertures and wherein said porous layer is comprised of a polymer and having a thickness sufficient to provide a controlled release of the bioactive material.
a structure adapted for introduction into a patient, the structure being comprised of a base material; wherein the base material comprises apertures within the surface of the base material and containing at least one bioactive material within said apertures wherein at least one porous layer is posited over said base material and said bioactive material contained within said apertures and wherein said porous layer is comprised of a polymer and having a thickness sufficient to provide a controlled release of the bioactive material.
87. The medical device according to claim 86 wherein said apertures are holes, slots, grooves or wells and may have the sectional shape of a half circle, of the letter V or of a truncated square.
88. The medical device according to claim 87 wherein said hole, slot, groove or well may be formed by etching using a photo resist pattern; by cutting with laser or EBM; or by stamping.
89. The medical device according to claim 88 wherein the same or different bioactive materials are contained within the holes, grooves, slots or wells.
90. The medical device according to claim 89 wherein the at least one bioactive material is selected from the group consisting essentially of heparin, covalent heparin or another thrombin inhibitor, hirudin, hirulog, argatroban, D-phenylalanyl-L-poly-L-arginyl chloromethyl ketone, or another antithrombogenic agent, or mixtures thereof; urokinase, streptokinase, a tissue plasminogen activator, or another thrombolytic agent, or mixtures thereof; a fibrinolytic agent; a vasospasm inhibitor; a calcium channel blocker, a nitrate, nitric oxide, a nitric oxide promoter or another vasodilator; an antimicrobial agent or antibiotic;
aspirin, ticlopidine, a glycoprotein IIb/IIIa inhibitor or another inhibitor of surface glycoprotein receptors, or another antiplatelet agent; colchicine or another antimitotic, or another microtubule inhibitor, dimethylsulfoxide (DMSO), a retinoid or another antisecretory agent; cytochalasin or another actin inhibitor; or a remodeling inhibitor; deoxyribonucleic acid, an antisense nucleotide or another agent for molecular genetic intervention; methotrexate or another antimetabolite or antiproliferative agent; tamoxifen citrate, Taxol? or derivatives thereof, or other anti-cancer chemotherapeutic agents;
dexamethasone, dexamethasone sodium phosphate, dexamethasone acetate or another dexamethasone derivative, or another anti-inflammatory steroid or non-steroidal anti-inflammatory agent;
cyclosporin or another immunosuppressive agent; tripodal (aPDGF
antagonist), angiopeptin (a growth hormone antagonist), angiogenin or other growth factors, or an anti-growth factor antibody, or another growth factor antagonist; dopamine, bromocriptine mesylate, pergolide mesylate or another dopamine agonist; 60Co, 192Ir, 32P, 111In, 90Y, 99mTc or another radiotherapeutic agent;
iodine-containing compounds, barium-containing compounds, gold, tantalum, platinum, tungsten or another heavy metal functioning as a radiopaque agent; a peptide, a protein, an enzyme, an extracellular matrix component, a cellular component or another biologic agent; captopril, enalapril or another angiotensin converting enzyme (ACE) inhibitor; ascorbic acid, alpha tocopherol, superoxide dismutase, deferoxamine, a 21-amino steroid (lasaroid) or another free radical scavenger, iron chelator or antioxidant; a 14C-, 3H-, 131I-, 32P- or 36S-radiolabelled form or other radiolabelled form of any of the foregoing; estrogen or another sex hormone; AZT or other antipolymerases; acyclovir, famciclovir, rimantadine hydrochloride, ganciclovir sodium or other antiviral agents; 5-aminolevulinic acid, meta-tetrahydroxyphenylchlorin, hexadecaflouoro zinc phthalocyanine, tetramethyl hematoporphyrin, rhodamine 123 or other photodynamic therapy agents; an IgG2 Kappa antibody against Pseudomonas aeruginosa exotoxin A and reactive with A431 epidermoid carcinoma cells, monoclonal antibody against the noradrenergic enzyme dopamine beta-hydroxylase conjugated to saporin or other antibody target therapy agents; enalapril or other prodrugs; and gene therapy agents, or a mixture of any of these.
aspirin, ticlopidine, a glycoprotein IIb/IIIa inhibitor or another inhibitor of surface glycoprotein receptors, or another antiplatelet agent; colchicine or another antimitotic, or another microtubule inhibitor, dimethylsulfoxide (DMSO), a retinoid or another antisecretory agent; cytochalasin or another actin inhibitor; or a remodeling inhibitor; deoxyribonucleic acid, an antisense nucleotide or another agent for molecular genetic intervention; methotrexate or another antimetabolite or antiproliferative agent; tamoxifen citrate, Taxol? or derivatives thereof, or other anti-cancer chemotherapeutic agents;
dexamethasone, dexamethasone sodium phosphate, dexamethasone acetate or another dexamethasone derivative, or another anti-inflammatory steroid or non-steroidal anti-inflammatory agent;
cyclosporin or another immunosuppressive agent; tripodal (aPDGF
antagonist), angiopeptin (a growth hormone antagonist), angiogenin or other growth factors, or an anti-growth factor antibody, or another growth factor antagonist; dopamine, bromocriptine mesylate, pergolide mesylate or another dopamine agonist; 60Co, 192Ir, 32P, 111In, 90Y, 99mTc or another radiotherapeutic agent;
iodine-containing compounds, barium-containing compounds, gold, tantalum, platinum, tungsten or another heavy metal functioning as a radiopaque agent; a peptide, a protein, an enzyme, an extracellular matrix component, a cellular component or another biologic agent; captopril, enalapril or another angiotensin converting enzyme (ACE) inhibitor; ascorbic acid, alpha tocopherol, superoxide dismutase, deferoxamine, a 21-amino steroid (lasaroid) or another free radical scavenger, iron chelator or antioxidant; a 14C-, 3H-, 131I-, 32P- or 36S-radiolabelled form or other radiolabelled form of any of the foregoing; estrogen or another sex hormone; AZT or other antipolymerases; acyclovir, famciclovir, rimantadine hydrochloride, ganciclovir sodium or other antiviral agents; 5-aminolevulinic acid, meta-tetrahydroxyphenylchlorin, hexadecaflouoro zinc phthalocyanine, tetramethyl hematoporphyrin, rhodamine 123 or other photodynamic therapy agents; an IgG2 Kappa antibody against Pseudomonas aeruginosa exotoxin A and reactive with A431 epidermoid carcinoma cells, monoclonal antibody against the noradrenergic enzyme dopamine beta-hydroxylase conjugated to saporin or other antibody target therapy agents; enalapril or other prodrugs; and gene therapy agents, or a mixture of any of these.
91. The medical device according to claim 87 wherein the base material comprises a substantially non-porous coating and a porous layer overlies the holes, grooves, slots or wells containing at least one bioactive layer.
92. The medical device according to claim 91 wherein said device comprises further layers of bioactive materials and porous layer coatings.
93. An implantable medical device (10), comprising:
a structure (12) for introduction into a patient, the structure (12) being composed of base material (14);
at least one bioactive material posited on at least one part of the structure (12); and porous material(s) posited over the bioactive material (18), said porous material(s) being of a thickness and having properties to enable controlled release of the bioactive material.
a structure (12) for introduction into a patient, the structure (12) being composed of base material (14);
at least one bioactive material posited on at least one part of the structure (12); and porous material(s) posited over the bioactive material (18), said porous material(s) being of a thickness and having properties to enable controlled release of the bioactive material.
94. The device according to claim 93, wherein said porous material(s) is/are polymeric and formed as one or more porous layers (20), each polymerized from a catalyst-free monomer vapor, and is/are formed over the bioactive material and any part of the structure surface not covered by the bioactive material.
95. The device according to claim 94, wherein the polymer is selected from a polyamide, polymers of parylene or derivatives thereof, polyalkylene oxide, polyalkylene glycol, polypropylene oxide, silicone based polymers, polymers of methane, tetrafluoroethylene or tetramethyldisiloxane or a polymer derived from photopolymerizeable monomers; and/or the base material (14) of the structure (12) includes at least one of: stainless steel, tantalum, titanium, Nitinol, gold, platinum, inconel, iridium, silver, tungsten, or another biocompatible metal, or alloys of any of these; carbon or carbon fiber; cellulose acetate, cellulose nitrate, silicone, polyethylene teraphthalate, polyurethane, polyamide, polyester, polyorthoester, polyanhydride, polyether sulfone, polycarbonate, polypropylene, high molecular weight polyethylene, polytetrafluoroethylene, or another biocompatible polymeric material, or mixtures or copolymers thereof; polylactic acid, polyglycolic acid or copolymers thereof, a polyanhydride, polycaprolactone, polyhydroxy-butyrate valerate or another biodegradable polymer, or mixtures or copolymers of these; a protein, an extracellular matrix component, collagen, fibrin or another biologic agent; or a mixture thereof; and/or the bioactive material includes at least one of: heparin, covalent heparin, or another thrombin inhibitor, hirudin, hirulog, argatroban, D-phenylalanyl-L-poly-L-arginyl chloromethyl ketone, or another antithrombogenic agent, or mixtures thereof; urokinase, streptokinase, a tissue plasminogen activator, or another thrombolytic agent, or mixtures thereof; a fibrinolytic agent; a vasospasm inhibitor; a calcium channel blocker, a nitrate, nitric oxide, a nitric oxide promoter or another vasodilator; an antimicrobial agent or antibiotic; aspirin, ticlopidine, a glycoprotein IIb/IIIa inhibitor or another inhibitor of surface glycoprotein receptors, or another antiplatelet agent; colchicine or another antimitotic, or another microtubule inhibitor, dimethyl sulfoxide (DMSO), a retinoid or another antisecretory agent;
cytochalasin or another actin inhibitor; or a remodeling inhibitor; deoxyribonucleic acid, an antisense nucleotide or another agent for molecular genetic intervention; methotrexate or another antimetabolite or antiproliferative agent; tamoxifen citrate, Taxol? or derivatives thereof, or other anti-cancer chemotherapeutic agents; dexamethasone, dexamethasone sodium phosphate, dexamethasone acetate or another dexamethasone derivative, or another anti-inflammatory steroid or non-steroidal anti-inflammatory agent; cyclosporin or another immunosuppressive agent; trapidal (a PDGF antagonist), angiogenin, angiopeptin (a growth hormone antagonist), a growth factor or an anti-growth factor antibody, or another growth factor antagonist; dopamine, bromocriptine mesylate, pergolide mesylate or another dopamine agonist; 60Co, 192Ir, 32P, 111In, 90Y, 99mTc or another radiotherapeutic agent; iodine-containing compounds, barium-containing compounds, gold, tantalum, platinum, tungsten or another heavy metal functioning as a radiopaque agent; a peptide, a protein, an enzyme, an extracellular matrix component, a cellular component or another biologic agent; captopril, enalapril or another angiotensin converting enzyme (ACE) inhibitor; ascorbic acid, alpha tocopherol, superoxide dismutase, deferoxamine, a 21-amino steroid (lasaroid) or another free radical scavenger, iron chelator or antioxidant; a 14C-, 3H-, 131I-, 32P- or 36S-radiolabelled form or other radiolabelled form of any of the foregoing; estrogen or another sex hormone; AZT or other antipolymerases; acyclovir, famciclovir, rimantadine hydrochloride, ganciclovir sodium or other antiviral agents; 5-aminolevulinic acid, meta-tetrahydroxyphenylchlorin, hexadecafluoro zinc phthalocyanine, tetramethyl hematoporphyrin, rhodamine 123 or other photodynamic therapy agents; an IgG2 Kappa antibody against Pseudomonas aeruginosa exotoxin A and reactive with A431 epidermoid carcinoma cells, monoclonal antibody against the noradrenergic enzyme dopamine beta-hydroxylase conjugated to saporin or other antibody targeted therapy agents; gene therapy agents; and enalapril and other prodrugs, or a mixture of any of these.
cytochalasin or another actin inhibitor; or a remodeling inhibitor; deoxyribonucleic acid, an antisense nucleotide or another agent for molecular genetic intervention; methotrexate or another antimetabolite or antiproliferative agent; tamoxifen citrate, Taxol? or derivatives thereof, or other anti-cancer chemotherapeutic agents; dexamethasone, dexamethasone sodium phosphate, dexamethasone acetate or another dexamethasone derivative, or another anti-inflammatory steroid or non-steroidal anti-inflammatory agent; cyclosporin or another immunosuppressive agent; trapidal (a PDGF antagonist), angiogenin, angiopeptin (a growth hormone antagonist), a growth factor or an anti-growth factor antibody, or another growth factor antagonist; dopamine, bromocriptine mesylate, pergolide mesylate or another dopamine agonist; 60Co, 192Ir, 32P, 111In, 90Y, 99mTc or another radiotherapeutic agent; iodine-containing compounds, barium-containing compounds, gold, tantalum, platinum, tungsten or another heavy metal functioning as a radiopaque agent; a peptide, a protein, an enzyme, an extracellular matrix component, a cellular component or another biologic agent; captopril, enalapril or another angiotensin converting enzyme (ACE) inhibitor; ascorbic acid, alpha tocopherol, superoxide dismutase, deferoxamine, a 21-amino steroid (lasaroid) or another free radical scavenger, iron chelator or antioxidant; a 14C-, 3H-, 131I-, 32P- or 36S-radiolabelled form or other radiolabelled form of any of the foregoing; estrogen or another sex hormone; AZT or other antipolymerases; acyclovir, famciclovir, rimantadine hydrochloride, ganciclovir sodium or other antiviral agents; 5-aminolevulinic acid, meta-tetrahydroxyphenylchlorin, hexadecafluoro zinc phthalocyanine, tetramethyl hematoporphyrin, rhodamine 123 or other photodynamic therapy agents; an IgG2 Kappa antibody against Pseudomonas aeruginosa exotoxin A and reactive with A431 epidermoid carcinoma cells, monoclonal antibody against the noradrenergic enzyme dopamine beta-hydroxylase conjugated to saporin or other antibody targeted therapy agents; gene therapy agents; and enalapril and other prodrugs, or a mixture of any of these.
96. The device (10) according to claim 94 or 95, wherein the thickness of the at least one porous layer (20) is about 5,000 to 250,000 .ANG., and the bioactive material(s) are, for example, present in about 1 to 4 mg. per cm2.
97. The device according to claim 93, 94, 95 or 96, further comprising at least one additional coating layer, for example, a less or substantially non-porous polymer layer (16), between the structure (12) and the at least one bioactive material layer (18).
98. The device (10) according to claim 97, wherein the polymer of the additional coating layer is selected from polyamide, polymers of parylene or derivatives thereof, or a polymer derived from photopolymerizable monomers of bisphenol A diglycidyl ether and acrylic acid or methacrylic acid, and the at least one additional coating layer (16) is about 50,000 to 500,000 .ANG. thick.
99. The device (10) according to claim 93, wherein the structure (12) is biocompatible and is configured as at least one of a stent, a vascular or other graft, a vascular or other graft in combination with a stent, heart valve, an orthopedic device, appliance, implant or replacement, or portion thereof; or a portion of any of these.
100. The device (10) according to claim 93, wherein different bioactive materials are posited at different locations on one surface or side of the structure, and are formed either directly on or in the structure, or partly on or in the structure at one location and partly on the porous layer, at another location.
101. The device (10) according to claim 100, wherein a third or different bioactive material is posited on or in another side of the structure, wherein the porous layer is positioned over the said third or different material and is also posited over one of the bioactive materials on the one side of the structure, and wherein another bioactive material, for example covalent heparin, is bonded to the outer surface of the porous layer.
102. The device (10) according to claim 93, 94, 95, 96, 97, 98, 99, 100, or 101, wherein the bioactive material(s) (18) is/are posited on said one part or surface in a geometric pattern, or in a discontinuous geometric pattern when the structure is a stent, or in a pattern of parallel lines, or a pattern of parallel lines but not on the tips of the stent, or are posited on or in adjacent parts of the same surface of the structure (12).
103. The device (10) according to claim 93, 94, 95, 96, 97, 98, 99, 100, 101, or 102, further comprising a connector (26) securing the at least one porous layer (20) to the base material (14) of the structure (12).
104. The device according to claim 101, 102, or 103, wherein the structure, for example a stent, is surface coated with a substantially non-porous coating layer have a thickness of about 50,000 .ANG. to about 500,000 .ANG. wherein the coating layer comprises a polymer selected from polyamide, a polymer derived from parylene or derivatives thereof, polyalkylene oxides, polyalkylene glycols, silicon based polymers, polymers derived from methane, tetrafluoro-ethylene, tetramethyldisiloxane, or polymers derived from photopolymerizeable monomers or mixtures of such polymers or copolymers thereof.
105. The device according to claim 100 or 101, wherein multiple layers comprise stent surfaces, such layers comprising alternating porous layers and at least one bioactive material layer and wherein different bioactive materials are posited on the different surfaces of the stent structure with the proviso that the same bioactive material is not posited on the different surfaces of the stent structure within the same layer and that a porous layer is posited over each bioactive material layer and the outermost layer may comprise either a porous layer or a bioactive material layer.
106. A method of making the device according to claim 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, or 105, wherein the bioactive material (18) layer is posited by a process of adsorption, absorption, vapor phase deposition, plasma deposition, chemically binding to the surface of the device, utilizing surfactants as an adhesion medium, electrode position, or combinations thereof.
107. The method according to claim 106, wherein the bioactive material (18) layer has been applied by vapor phase deposition, plasma deposition or by chemically binding to the substrate structure (12) and the bioactive material (18) is in the form of a powder, microencapsulated particles or a matrix incorporated material.
108. A method of making the device according to claim 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, or 107, wherein at least one porous layer (20) has been formed by sublimating and cracking di-p-xylylene or a derivative thereof to yield monomeric p-xylylene or a derivative thereof, and allowing the monomer so formed to simultaneously condense and polymerize over the bioactive material layer (18), the sublimation and cracking step, for example, being carried out with dichloro-di-p-xylylene.
109. The method according to claim 108, wherein the step of depositing the at least one layer (18) of a bioactive material is carried out by applying over the structure (12) a mixture of the bioactive material and a fluid, and removing the fluid prior to the step of depositing the at least one porous layer (20).
110. The method according to claim 109, wherein the fluid is volatile, and the fluid removing step is carried out by allowing the fluid to evaporate from the structure (12) and bioactive material before the step of depositing the at least one porous layer (20).
111. A device according to any one of claims 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, or 105, wherein the base material comprises apertures within the surface of the base material and the bioactive material(s) are positioned within the apertures, said apertures being in the form of holes, slots, grooves or wells or the like, for example having etched or stamped sectional shapes of a half circle, a letter V or of a truncated square, same or different bioactive materials being contained within the holes, grooves, slots or wells.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US484,532 | 1995-06-07 | ||
US08/484,532 US5609629A (en) | 1995-06-07 | 1995-06-07 | Coated implantable medical device |
US645,646 | 1996-05-16 | ||
US08/645,646 US6096070A (en) | 1995-06-07 | 1996-05-16 | Coated implantable medical device |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2178541A1 true CA2178541A1 (en) | 1996-12-08 |
CA2178541C CA2178541C (en) | 2009-11-24 |
Family
ID=27048040
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002178541A Expired - Lifetime CA2178541C (en) | 1995-06-07 | 1996-06-07 | Implantable medical device |
Country Status (3)
Country | Link |
---|---|
US (3) | US5824049A (en) |
AU (1) | AU716005B2 (en) |
CA (1) | CA2178541C (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005046748A1 (en) * | 2003-11-12 | 2005-05-26 | James Keenan | Device and method for attracting diseased cells and foreign substances |
EP2033667A2 (en) | 1997-04-15 | 2009-03-11 | Abbott Cardiovascular Systems, Inc. | Porous medicated stent |
US7713297B2 (en) | 1998-04-11 | 2010-05-11 | Boston Scientific Scimed, Inc. | Drug-releasing stent with ceramic-containing layer |
Families Citing this family (1066)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5843089A (en) * | 1990-12-28 | 1998-12-01 | Boston Scientific Corporation | Stent lining |
US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6663881B2 (en) | 1993-01-28 | 2003-12-16 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
EP1304085A3 (en) * | 1994-09-16 | 2004-01-21 | Ethicon Endo-Surgery, Inc. | Biodegradable tissue marking device |
US20030083733A1 (en) * | 1997-10-10 | 2003-05-01 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6099562A (en) * | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
US20020091433A1 (en) * | 1995-04-19 | 2002-07-11 | Ni Ding | Drug release coated stent |
US5837313A (en) * | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
US20020193828A1 (en) * | 2001-06-14 | 2002-12-19 | Cook Incorporated | Endovascular filter |
US7896914B2 (en) | 1995-06-07 | 2011-03-01 | Cook Incorporated | Coated implantable medical device |
US7611533B2 (en) * | 1995-06-07 | 2009-11-03 | Cook Incorporated | Coated implantable medical device |
US7867275B2 (en) | 1995-06-07 | 2011-01-11 | Cook Incorporated | Coated implantable medical device method |
US20070203520A1 (en) * | 1995-06-07 | 2007-08-30 | Dennis Griffin | Endovascular filter |
US7846202B2 (en) | 1995-06-07 | 2010-12-07 | Cook Incorporated | Coated implantable medical device |
US6774278B1 (en) | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
US7550005B2 (en) | 1995-06-07 | 2009-06-23 | Cook Incorporated | Coated implantable medical device |
US7266725B2 (en) * | 2001-09-03 | 2007-09-04 | Pact Xpp Technologies Ag | Method for debugging reconfigurable architectures |
US6428571B1 (en) | 1996-01-22 | 2002-08-06 | Scimed Life Systems, Inc. | Self-sealing PTFE vascular graft and manufacturing methods |
US5800512A (en) * | 1996-01-22 | 1998-09-01 | Meadox Medicals, Inc. | PTFE vascular graft |
ATE314843T1 (en) | 1996-03-12 | 2006-02-15 | Pg Txl Co Lp | WATER SOLUBLE PACLITAXEL PRODRUGS |
US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
EP0909148A1 (en) * | 1996-05-31 | 1999-04-21 | The University Of Western Ontario | Expansible bioprosthetic valve stent |
US20060025726A1 (en) * | 1996-06-04 | 2006-02-02 | Vance Products Incorporated, D/B/A Cook Urological Incorporated | Implantable medical device with pharmacologically active layer |
US20060030826A1 (en) * | 1996-06-04 | 2006-02-09 | Vance Products Incorporated,d/b/a Cook Urological Incorporated | Implantable medical device with anti-neoplastic drug |
US20060052757A1 (en) * | 1996-06-04 | 2006-03-09 | Vance Products Incorporated, D/B/A Cook Urological Incorporated | Implantable medical device with analgesic or anesthetic |
US6666883B1 (en) | 1996-06-06 | 2003-12-23 | Jacques Seguin | Endoprosthesis for vascular bifurcation |
US8728143B2 (en) * | 1996-06-06 | 2014-05-20 | Biosensors International Group, Ltd. | Endoprosthesis deployment system for treating vascular bifurcations |
US7238197B2 (en) * | 2000-05-30 | 2007-07-03 | Devax, Inc. | Endoprosthesis deployment system for treating vascular bifurcations |
US7686846B2 (en) * | 1996-06-06 | 2010-03-30 | Devax, Inc. | Bifurcation stent and method of positioning in a body lumen |
US7070590B1 (en) | 1996-07-02 | 2006-07-04 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
US6530951B1 (en) * | 1996-10-24 | 2003-03-11 | Cook Incorporated | Silver implantable medical device |
US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
US20030157187A1 (en) * | 1996-12-02 | 2003-08-21 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for treating or preventing inflammatory diseases |
US6495579B1 (en) | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
JP4084420B2 (en) * | 1996-12-10 | 2008-04-30 | パーデュー・リサーチ・ファウンデーション | Tubular submucosa graft composition |
IT1289815B1 (en) * | 1996-12-30 | 1998-10-16 | Sorin Biomedica Cardio Spa | ANGIOPLASTIC STENT AND RELATED PRODUCTION PROCESS |
US10028851B2 (en) | 1997-04-15 | 2018-07-24 | Advanced Cardiovascular Systems, Inc. | Coatings for controlling erosion of a substrate of an implantable medical device |
US6240616B1 (en) | 1997-04-15 | 2001-06-05 | Advanced Cardiovascular Systems, Inc. | Method of manufacturing a medicated porous metal prosthesis |
US8172897B2 (en) | 1997-04-15 | 2012-05-08 | Advanced Cardiovascular Systems, Inc. | Polymer and metal composite implantable medical devices |
US6273913B1 (en) | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
TW586934B (en) * | 1997-05-19 | 2004-05-11 | Sumitomo Pharma | Immunopotentiating composition |
US6245760B1 (en) * | 1997-05-28 | 2001-06-12 | Aventis Pharmaceuticals Products, Inc | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases |
US6159978A (en) | 1997-05-28 | 2000-12-12 | Aventis Pharmaceuticals Product, Inc. | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases |
US6180632B1 (en) | 1997-05-28 | 2001-01-30 | Aventis Pharmaceuticals Products Inc. | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases |
US20030199425A1 (en) * | 1997-06-27 | 2003-10-23 | Desai Neil P. | Compositions and methods for treatment of hyperplasia |
US6156061A (en) * | 1997-08-29 | 2000-12-05 | Target Therapeutics, Inc. | Fast-detaching electrically insulated implant |
US6890546B2 (en) | 1998-09-24 | 2005-05-10 | Abbott Laboratories | Medical devices containing rapamycin analogs |
US20030129215A1 (en) * | 1998-09-24 | 2003-07-10 | T-Ram, Inc. | Medical devices containing rapamycin analogs |
US8057816B2 (en) * | 1997-09-26 | 2011-11-15 | Abbott Laboratories | Compositions and methods of administering paclitaxel with other drugs using medical devices |
US8257726B2 (en) * | 1997-09-26 | 2012-09-04 | Abbott Laboratories | Compositions, systems, kits, and methods of administering rapamycin analogs with paclitaxel using medical devices |
DE69828963T2 (en) * | 1997-10-01 | 2006-01-26 | Medtronic AVE, Inc., Santa Rosa | Drug delivery and gene therapy delivery system |
US6151525A (en) * | 1997-11-07 | 2000-11-21 | Medtronic, Inc. | Method and system for myocardial identifier repair |
US6775574B1 (en) * | 1997-11-07 | 2004-08-10 | Medtronic, Inc. | Method and system for myocardial infarction repair |
US6270464B1 (en) * | 1998-06-22 | 2001-08-07 | Artemis Medical, Inc. | Biopsy localization method and device |
DE69829653T2 (en) * | 1997-11-14 | 2005-09-08 | Sumitomo Osaka Cement Co., Ltd. | METHOD FOR PRODUCING ANTIMICROBIAL METAL PARTS AND METAL PARTS MANUFACTURED THEREFOR |
US6254642B1 (en) * | 1997-12-09 | 2001-07-03 | Thomas V. Taylor | Perorally insertable gastroesophageal anti-reflux valve prosthesis and tool for implantation thereof |
US5976169A (en) * | 1997-12-16 | 1999-11-02 | Cardiovasc, Inc. | Stent with silver coating and method |
US20030036746A1 (en) * | 2001-08-16 | 2003-02-20 | Avi Penner | Devices for intrabody delivery of molecules and systems and methods utilizing same |
WO1999044538A1 (en) * | 1998-01-27 | 1999-09-10 | The Regents Of The University Of California | Biodegradable polymer/protein based coils for intralumenal implants |
US20070093889A1 (en) * | 1999-01-27 | 2007-04-26 | Wu Benjamin M | Non-Fragmenting Low Friction Bioactive Absorbable Coils for Brain Aneurysm Therapy |
US6541116B2 (en) * | 1998-01-30 | 2003-04-01 | Advanced Cardiovascular Systems, Inc. | Superoxide dismutase or superoxide dismutase mimic coating for an intracorporeal medical device |
US6221425B1 (en) | 1998-01-30 | 2001-04-24 | Advanced Cardiovascular Systems, Inc. | Lubricious hydrophilic coating for an intracorporeal medical device |
US7208011B2 (en) * | 2001-08-20 | 2007-04-24 | Conor Medsystems, Inc. | Implantable medical device with drug filled holes |
US20040254635A1 (en) * | 1998-03-30 | 2004-12-16 | Shanley John F. | Expandable medical device for delivery of beneficial agent |
US7208010B2 (en) | 2000-10-16 | 2007-04-24 | Conor Medsystems, Inc. | Expandable medical device for delivery of beneficial agent |
US6241762B1 (en) | 1998-03-30 | 2001-06-05 | Conor Medsystems, Inc. | Expandable medical device with ductile hinges |
US7179289B2 (en) | 1998-03-30 | 2007-02-20 | Conor Medsystems, Inc. | Expandable medical device for delivery of beneficial agent |
US5980566A (en) * | 1998-04-11 | 1999-11-09 | Alt; Eckhard | Vascular and endoluminal stents with iridium oxide coating |
US20020099438A1 (en) * | 1998-04-15 | 2002-07-25 | Furst Joseph G. | Irradiated stent coating |
US20030040790A1 (en) | 1998-04-15 | 2003-02-27 | Furst Joseph G. | Stent coating |
US8029561B1 (en) | 2000-05-12 | 2011-10-04 | Cordis Corporation | Drug combination useful for prevention of restenosis |
US20070087028A1 (en) * | 1998-04-16 | 2007-04-19 | Robert Falotico | Intraluminal devices for the prevention and treatment of vascular disease |
WO1999055396A1 (en) | 1998-04-27 | 1999-11-04 | Surmodics, Inc. | Bioactive agent release coating |
JP4583597B2 (en) * | 1998-05-05 | 2010-11-17 | ボストン サイエンティフィック リミテッド | Smooth end stent |
US20020058882A1 (en) * | 1998-06-22 | 2002-05-16 | Artemis Medical, Incorporated | Biopsy localization method and device |
US6096175A (en) | 1998-07-17 | 2000-08-01 | Micro Therapeutics, Inc. | Thin film stent |
US7967855B2 (en) | 1998-07-27 | 2011-06-28 | Icon Interventional Systems, Inc. | Coated medical device |
US8070796B2 (en) * | 1998-07-27 | 2011-12-06 | Icon Interventional Systems, Inc. | Thrombosis inhibiting graft |
US20020038146A1 (en) * | 1998-07-29 | 2002-03-28 | Ulf Harry | Expandable stent with relief cuts for carrying medicines and other materials |
JP4898991B2 (en) | 1998-08-20 | 2012-03-21 | クック メディカル テクノロジーズ エルエルシー | Sheathed medical device |
US6689121B1 (en) | 1998-09-24 | 2004-02-10 | C. R. Bard, Inc. | Systems and methods for treating ischemia |
US7960405B2 (en) * | 1998-09-24 | 2011-06-14 | Abbott Laboratories | Compounds and methods for treatment and prevention of diseases |
US7455853B2 (en) * | 1998-09-24 | 2008-11-25 | Abbott Cardiovascular Systems Inc. | Medical devices containing rapamycin analogs |
EP1115389B1 (en) * | 1998-09-25 | 2014-03-12 | PhilERA New Zealand Limited | Fructosamine oxidase: antagonists and inhibitors |
US20040043068A1 (en) * | 1998-09-29 | 2004-03-04 | Eugene Tedeschi | Uses for medical devices having a lubricious, nitric oxide-releasing coating |
US6248112B1 (en) | 1998-09-30 | 2001-06-19 | C. R. Bard, Inc. | Implant delivery system |
US6458092B1 (en) | 1998-09-30 | 2002-10-01 | C. R. Bard, Inc. | Vascular inducing implants |
US6432126B1 (en) * | 1998-09-30 | 2002-08-13 | C.R. Bard, Inc. | Flexible vascular inducing implants |
US6364902B1 (en) * | 1998-10-05 | 2002-04-02 | Noble-Met, Ltd. | Metal composite tube for biomedical applications |
US6494879B2 (en) | 1998-10-15 | 2002-12-17 | Scimed Life Systems, Inc. | Treating urinary retention |
US6475234B1 (en) * | 1998-10-26 | 2002-11-05 | Medinol, Ltd. | Balloon expandable covered stents |
US6293967B1 (en) | 1998-10-29 | 2001-09-25 | Conor Medsystems, Inc. | Expandable medical device with ductile hinges |
US6187024B1 (en) | 1998-11-10 | 2001-02-13 | Target Therapeutics, Inc. | Bioactive coating for vaso-occlusive devices |
US6723112B2 (en) | 1998-11-10 | 2004-04-20 | Scimed Life Systems, Inc. | Bioactive three loop coil |
US6569179B2 (en) | 1998-11-10 | 2003-05-27 | Scimed Life Systems, Inc. | Bioactive three loop coil |
US8016852B2 (en) * | 1998-11-10 | 2011-09-13 | Stryker Corporation | Bioactive components for incorporation with vaso-occlusive members |
US6692520B1 (en) | 1998-12-15 | 2004-02-17 | C. R. Bard, Inc. | Systems and methods for imbedded intramuscular implants |
US9669113B1 (en) | 1998-12-24 | 2017-06-06 | Devicor Medical Products, Inc. | Device and method for safe location and marking of a biopsy cavity |
US6356782B1 (en) * | 1998-12-24 | 2002-03-12 | Vivant Medical, Inc. | Subcutaneous cavity marking device and method |
US6371904B1 (en) * | 1998-12-24 | 2002-04-16 | Vivant Medical, Inc. | Subcutaneous cavity marking device and method |
US6258117B1 (en) | 1999-04-15 | 2001-07-10 | Mayo Foundation For Medical Education And Research | Multi-section stent |
US6620170B1 (en) | 1999-04-26 | 2003-09-16 | C. R. Bard, Inc. | Devices and methods for treating ischemia by creating a fibrin plug |
US6679824B1 (en) * | 1999-04-28 | 2004-01-20 | Medi-Physics, Inc. | Products and methods for brachytherapy |
US6986784B1 (en) | 1999-05-14 | 2006-01-17 | C. R. Bard, Inc. | Implant anchor systems |
US6290673B1 (en) * | 1999-05-20 | 2001-09-18 | Conor Medsystems, Inc. | Expandable medical device delivery system and method |
US20040110722A1 (en) * | 1999-05-27 | 2004-06-10 | Ornberg Richard L. | Modified hyaluronic acid polymers |
EP1185312B1 (en) * | 1999-05-27 | 2005-03-23 | Monsanto Company | Biomaterials modified with superoxide dismutase mimics |
US6719805B1 (en) * | 1999-06-09 | 2004-04-13 | C. R. Bard, Inc. | Devices and methods for treating tissue |
US20040073155A1 (en) * | 2000-01-14 | 2004-04-15 | Broncus Technologies, Inc. | Methods and devices for maintaining patency of surgically created channels in tissue |
US20050060044A1 (en) * | 1999-08-05 | 2005-03-17 | Ed Roschak | Methods and devices for maintaining patency of surgically created channels in a body organ |
US6692494B1 (en) * | 1999-08-05 | 2004-02-17 | Broncus Technologies, Inc. | Methods and devices for creating collateral channels in the lungs |
US20030070676A1 (en) * | 1999-08-05 | 2003-04-17 | Cooper Joel D. | Conduits having distal cage structure for maintaining collateral channels in tissue and related methods |
US20030130657A1 (en) * | 1999-08-05 | 2003-07-10 | Tom Curtis P. | Devices for applying energy to tissue |
US20050137715A1 (en) * | 1999-08-05 | 2005-06-23 | Broncus Technologies, Inc. | Methods and devices for maintaining patency of surgically created channels in a body organ |
US7815590B2 (en) * | 1999-08-05 | 2010-10-19 | Broncus Technologies, Inc. | Devices for maintaining patency of surgically created channels in tissue |
US6485735B1 (en) * | 1999-08-31 | 2002-11-26 | Phelps Dodge High Performance Conductors Of Sc & Ga, Inc. | Multilayer thermoset polymer matrix and structures made therefrom |
US6503556B2 (en) | 2000-12-28 | 2003-01-07 | Advanced Cardiovascular Systems, Inc. | Methods of forming a coating for a prosthesis |
US20040029952A1 (en) * | 1999-09-03 | 2004-02-12 | Yung-Ming Chen | Ethylene vinyl alcohol composition and coating |
US6749626B1 (en) | 2000-03-31 | 2004-06-15 | Advanced Cardiovascular Systems, Inc. | Actinomycin D for the treatment of vascular disease |
US6503954B1 (en) | 2000-03-31 | 2003-01-07 | Advanced Cardiovascular Systems, Inc. | Biocompatible carrier containing actinomycin D and a method of forming the same |
US20070032853A1 (en) * | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
US6759054B2 (en) | 1999-09-03 | 2004-07-06 | Advanced Cardiovascular Systems, Inc. | Ethylene vinyl alcohol composition and coating |
US7682647B2 (en) | 1999-09-03 | 2010-03-23 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of a drug eluting implantable medical device |
US6713119B2 (en) | 1999-09-03 | 2004-03-30 | Advanced Cardiovascular Systems, Inc. | Biocompatible coating for a prosthesis and a method of forming the same |
US6790228B2 (en) * | 1999-12-23 | 2004-09-14 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US7807211B2 (en) * | 1999-09-03 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of an implantable medical device |
US6379381B1 (en) | 1999-09-03 | 2002-04-30 | Advanced Cardiovascular Systems, Inc. | Porous prosthesis and a method of depositing substances into the pores |
US6287628B1 (en) * | 1999-09-03 | 2001-09-11 | Advanced Cardiovascular Systems, Inc. | Porous prosthesis and a method of depositing substances into the pores |
US20040229856A1 (en) * | 1999-09-21 | 2004-11-18 | Baskaran Chandrasekar | Local delivery of 17-beta estradiol for preventing vascular intimal hyperplasia and for improving vascular endothelium function after vascular injury |
MXPA02003009A (en) * | 1999-09-21 | 2005-02-17 | Inst Cardiologie Montreal | Local delivery of 17-beta estradiol for preventing vascular intima hyperplasia and for improving vascular endothelium function after vascular injury. |
US6334868B1 (en) | 1999-10-08 | 2002-01-01 | Advanced Cardiovascular Systems, Inc. | Stent cover |
US6733513B2 (en) | 1999-11-04 | 2004-05-11 | Advanced Bioprosthetic Surfaces, Ltd. | Balloon catheter having metal balloon and method of making same |
US6491666B1 (en) * | 1999-11-17 | 2002-12-10 | Microchips, Inc. | Microfabricated devices for the delivery of molecules into a carrier fluid |
US7300457B2 (en) | 1999-11-19 | 2007-11-27 | Advanced Bio Prosthetic Surfaces, Ltd. | Self-supporting metallic implantable grafts, compliant implantable medical devices and methods of making same |
US7235092B2 (en) | 1999-11-19 | 2007-06-26 | Advanced Bio Prosthetic Surfaces, Ltd. | Guidewires and thin film catheter-sheaths and method of making same |
US6849085B2 (en) | 1999-11-19 | 2005-02-01 | Advanced Bio Prosthetic Surfaces, Ltd. | Self-supporting laminated films, structural materials and medical devices manufactured therefrom and method of making same |
US6936066B2 (en) | 1999-11-19 | 2005-08-30 | Advanced Bio Prosthetic Surfaces, Ltd. | Complaint implantable medical devices and methods of making same |
US7736687B2 (en) | 2006-01-31 | 2010-06-15 | Advance Bio Prosthetic Surfaces, Ltd. | Methods of making medical devices |
US6379383B1 (en) * | 1999-11-19 | 2002-04-30 | Advanced Bio Prosthetic Surfaces, Ltd. | Endoluminal device exhibiting improved endothelialization and method of manufacture thereof |
US7195641B2 (en) | 1999-11-19 | 2007-03-27 | Advanced Bio Prosthetic Surfaces, Ltd. | Valvular prostheses having metal or pseudometallic construction and methods of manufacture |
US10172730B2 (en) | 1999-11-19 | 2019-01-08 | Vactronix Scientific, Llc | Stents with metallic covers and methods of making same |
US8458879B2 (en) | 2001-07-03 | 2013-06-11 | Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. | Method of fabricating an implantable medical device |
US6537310B1 (en) | 1999-11-19 | 2003-03-25 | Advanced Bio Prosthetic Surfaces, Ltd. | Endoluminal implantable devices and method of making same |
US20060052865A1 (en) * | 2004-09-09 | 2006-03-09 | Banas Christopher E | Stents with metallic covers and methods of making same |
AU782639B2 (en) * | 1999-12-10 | 2005-08-18 | Massachusetts Institute Of Technology | Microchip devices for delivery of molecules and methods of fabrication thereof |
US6702849B1 (en) * | 1999-12-13 | 2004-03-09 | Advanced Cardiovascular Systems, Inc. | Method of processing open-celled microcellular polymeric foams with controlled porosity for use as vascular grafts and stent covers |
US6613432B2 (en) * | 1999-12-22 | 2003-09-02 | Biosurface Engineering Technologies, Inc. | Plasma-deposited coatings, devices and methods |
US7169187B2 (en) * | 1999-12-22 | 2007-01-30 | Ethicon, Inc. | Biodegradable stent |
US6338739B1 (en) * | 1999-12-22 | 2002-01-15 | Ethicon, Inc. | Biodegradable stent |
US6494908B1 (en) | 1999-12-22 | 2002-12-17 | Ethicon, Inc. | Removable stent for body lumens |
US6981987B2 (en) | 1999-12-22 | 2006-01-03 | Ethicon, Inc. | Removable stent for body lumens |
US6908624B2 (en) * | 1999-12-23 | 2005-06-21 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US20050238686A1 (en) * | 1999-12-23 | 2005-10-27 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
AU2599501A (en) * | 1999-12-29 | 2001-07-09 | Advanced Cardiovascular Systems Inc. | Device and active component for inhibiting formation of thrombus-inflammatory cell matrix |
AU2609401A (en) * | 1999-12-29 | 2001-07-09 | Nicholas Kipshidze | Apparatus and method for delivering compounds to a living organism |
JP2003520830A (en) | 2000-01-25 | 2003-07-08 | エドワーズ ライフサイエンシーズ コーポレイション | Delivery system for treatment of restenosis and anastomotic intimal hyperplasia |
WO2001064344A2 (en) | 2000-03-02 | 2001-09-07 | Microchips, Inc. | Microfabricated devices for the storage and selective exposure of chemicals and devices |
US6613082B2 (en) | 2000-03-13 | 2003-09-02 | Jun Yang | Stent having cover with drug delivery capability |
US6379382B1 (en) | 2000-03-13 | 2002-04-30 | Jun Yang | Stent having cover with drug delivery capability |
US6558315B1 (en) | 2000-03-15 | 2003-05-06 | Ams Research Corporation | Parylene-coated components for inflatable penile prosthesis |
US7011622B2 (en) * | 2000-03-15 | 2006-03-14 | Ams Research Corporation | Parylene coated components for artificial sphincters |
US8088060B2 (en) | 2000-03-15 | 2012-01-03 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
US20050271701A1 (en) * | 2000-03-15 | 2005-12-08 | Orbus Medical Technologies, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
US9522217B2 (en) | 2000-03-15 | 2016-12-20 | Orbusneich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods for using same |
US20020077290A1 (en) * | 2000-03-17 | 2002-06-20 | Rama Bhatt | Polyglutamic acid-camptothecin conjugates and methods of preparation |
ES2222352T3 (en) * | 2000-03-18 | 2005-02-01 | Polyzenix Gmbh | USE OF POLYPHOSPHACENE DERIVATIVES FOR ANTIBACTERIAL COATINGS. |
US6695865B2 (en) | 2000-03-20 | 2004-02-24 | Advanced Bio Prosthetic Surfaces, Ltd. | Embolic protection device |
US6818247B1 (en) | 2000-03-31 | 2004-11-16 | Advanced Cardiovascular Systems, Inc. | Ethylene vinyl alcohol-dimethyl acetamide composition and a method of coating a stent |
US7265199B2 (en) * | 2000-04-11 | 2007-09-04 | Celonova Biosciences Germany Gmbh | Poly-tri-fluoro-ethoxypolyphosphazene coverings and films |
US8109994B2 (en) | 2003-01-10 | 2012-02-07 | Abbott Cardiovascular Systems, Inc. | Biodegradable drug delivery material for stent |
US6527801B1 (en) | 2000-04-13 | 2003-03-04 | Advanced Cardiovascular Systems, Inc. | Biodegradable drug delivery material for stent |
US7875283B2 (en) | 2000-04-13 | 2011-01-25 | Advanced Cardiovascular Systems, Inc. | Biodegradable polymers for use with implantable medical devices |
US20010049422A1 (en) * | 2000-04-14 | 2001-12-06 | Phaneuf Matthew D. | Methods of applying antibiotic compounds to polyurethane biomaterials using textile dyeing technology |
US6270779B1 (en) * | 2000-05-10 | 2001-08-07 | United States Of America | Nitric oxide-releasing metallic medical devices |
US20050002986A1 (en) * | 2000-05-12 | 2005-01-06 | Robert Falotico | Drug/drug delivery systems for the prevention and treatment of vascular disease |
US8236048B2 (en) | 2000-05-12 | 2012-08-07 | Cordis Corporation | Drug/drug delivery systems for the prevention and treatment of vascular disease |
US8845713B2 (en) | 2000-05-12 | 2014-09-30 | Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. | Self-supporting laminated films, structural materials and medical devices manufactured therefrom and methods of making same |
US20040243097A1 (en) * | 2000-05-12 | 2004-12-02 | Robert Falotico | Antiproliferative drug and delivery device |
US6776796B2 (en) | 2000-05-12 | 2004-08-17 | Cordis Corportation | Antiinflammatory drug and delivery device |
US8252044B1 (en) * | 2000-11-17 | 2012-08-28 | Advanced Bio Prosthestic Surfaces, Ltd. | Device for in vivo delivery of bioactive agents and method of manufacture thereof |
US20030139803A1 (en) * | 2000-05-30 | 2003-07-24 | Jacques Sequin | Method of stenting a vessel with stent lumenal diameter increasing distally |
US6395326B1 (en) | 2000-05-31 | 2002-05-28 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for depositing a coating onto a surface of a prosthesis |
US7682648B1 (en) | 2000-05-31 | 2010-03-23 | Advanced Cardiovascular Systems, Inc. | Methods for forming polymeric coatings on stents |
US20040211362A1 (en) * | 2000-05-31 | 2004-10-28 | Daniel Castro | System for coating a stent |
EP1289429B1 (en) | 2000-06-05 | 2006-03-15 | Boston Scientific Limited | devices for the treatment of urinary incontinence |
CA2410632A1 (en) | 2000-06-22 | 2001-12-27 | David S. Garvey | Nitrosated and nitrosylated taxanes, compositions and methods of use |
AU2001266727A1 (en) * | 2000-06-29 | 2002-01-14 | Johnson & Johnson Consumer Companies, Inc | Electrostatic impregnation of powders on substrates |
US6585765B1 (en) * | 2000-06-29 | 2003-07-01 | Advanced Cardiovascular Systems, Inc. | Implantable device having substances impregnated therein and a method of impregnating the same |
US6540775B1 (en) | 2000-06-30 | 2003-04-01 | Cordis Corporation | Ultraflexible open cell stent |
US6974473B2 (en) | 2000-06-30 | 2005-12-13 | Vascular Architects, Inc. | Function-enhanced thrombolytic AV fistula and method |
US6506408B1 (en) * | 2000-07-13 | 2003-01-14 | Scimed Life Systems, Inc. | Implantable or insertable therapeutic agent delivery device |
US6709451B1 (en) * | 2000-07-14 | 2004-03-23 | Norman Noble, Inc. | Channeled vascular stent apparatus and method |
US6451373B1 (en) | 2000-08-04 | 2002-09-17 | Advanced Cardiovascular Systems, Inc. | Method of forming a therapeutic coating onto a surface of an implantable prosthesis |
US20090004240A1 (en) * | 2000-08-11 | 2009-01-01 | Celonova Biosciences, Inc. | Implants with a phosphazene-containing coating |
EP1179353A1 (en) * | 2000-08-11 | 2002-02-13 | B. Braun Melsungen Ag | Antithrombogenic implants with coating of polyphosphazenes and a pharmacologically active agent |
US20020072792A1 (en) | 2000-09-22 | 2002-06-13 | Robert Burgermeister | Stent with optimal strength and radiopacity characteristics |
US6695833B1 (en) * | 2000-09-27 | 2004-02-24 | Nellix, Inc. | Vascular stent-graft apparatus and forming method |
US6953560B1 (en) | 2000-09-28 | 2005-10-11 | Advanced Cardiovascular Systems, Inc. | Barriers for polymer-coated implantable medical devices and methods for making the same |
US6805898B1 (en) * | 2000-09-28 | 2004-10-19 | Advanced Cardiovascular Systems, Inc. | Surface features of an implantable medical device |
US6716444B1 (en) * | 2000-09-28 | 2004-04-06 | Advanced Cardiovascular Systems, Inc. | Barriers for polymer-coated implantable medical devices and methods for making the same |
US6254632B1 (en) * | 2000-09-28 | 2001-07-03 | Advanced Cardiovascular Systems, Inc. | Implantable medical device having protruding surface structures for drug delivery and cover attachment |
US20020051730A1 (en) * | 2000-09-29 | 2002-05-02 | Stanko Bodnar | Coated medical devices and sterilization thereof |
US7261735B2 (en) * | 2001-05-07 | 2007-08-28 | Cordis Corporation | Local drug delivery devices and methods for maintaining the drug coatings thereon |
AU2001294861A1 (en) | 2000-09-29 | 2002-04-08 | Endovasc Ltd., Inc. | Resorbable prosthesis for medical treatment |
US20020111590A1 (en) * | 2000-09-29 | 2002-08-15 | Davila Luis A. | Medical devices, drug coatings and methods for maintaining the drug coatings thereon |
DE60124285T3 (en) | 2000-09-29 | 2011-03-17 | Cordis Corp., Miami Lakes | COATED MEDICAL EQUIPMENT |
US6746773B2 (en) | 2000-09-29 | 2004-06-08 | Ethicon, Inc. | Coatings for medical devices |
US6764507B2 (en) | 2000-10-16 | 2004-07-20 | Conor Medsystems, Inc. | Expandable medical device with improved spatial distribution |
US7024248B2 (en) * | 2000-10-16 | 2006-04-04 | Remon Medical Technologies Ltd | Systems and methods for communicating with implantable devices |
AU9463401A (en) * | 2000-10-16 | 2002-04-29 | Conor Medsystems Inc | Expandable medical device for delivery of beneficial agent |
US6506437B1 (en) | 2000-10-17 | 2003-01-14 | Advanced Cardiovascular Systems, Inc. | Methods of coating an implantable device having depots formed in a surface thereof |
US6551267B1 (en) * | 2000-10-18 | 2003-04-22 | Becton, Dickinson And Company | Medical article having blood-contacting surface |
US6979347B1 (en) | 2000-10-23 | 2005-12-27 | Advanced Cardiovascular Systems, Inc. | Implantable drug delivery prosthesis |
US6558733B1 (en) | 2000-10-26 | 2003-05-06 | Advanced Cardiovascular Systems, Inc. | Method for etching a micropatterned microdepot prosthesis |
US6783793B1 (en) * | 2000-10-26 | 2004-08-31 | Advanced Cardiovascular Systems, Inc. | Selective coating of medical devices |
US6758859B1 (en) * | 2000-10-30 | 2004-07-06 | Kenny L. Dang | Increased drug-loading and reduced stress drug delivery device |
US6761708B1 (en) * | 2000-10-31 | 2004-07-13 | Advanced Cardiovascular Systems, Inc. | Radiopaque marker for a catheter and method of making |
US7803149B2 (en) | 2002-07-12 | 2010-09-28 | Cook Incorporated | Coated medical device |
US6833153B1 (en) | 2000-10-31 | 2004-12-21 | Advanced Cardiovascular Systems, Inc. | Hemocompatible coatings on hydrophobic porous polymers |
US7807210B1 (en) * | 2000-10-31 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Hemocompatible polymers on hydrophobic porous polymers |
JP4583756B2 (en) * | 2000-10-31 | 2010-11-17 | クック インコーポレイテッド | Medical instruments |
WO2002038080A2 (en) | 2000-11-07 | 2002-05-16 | Advanced Bio Prosthetic Surfaces, Ltd. | Endoluminal stent, self-fupporting endoluminal graft and methods of making same |
US10398830B2 (en) * | 2000-11-17 | 2019-09-03 | Vactronix Scientific, Llc | Device for in vivo delivery of bioactive agents and method of manufacture thereof |
US6638205B1 (en) * | 2000-11-17 | 2003-10-28 | Mds (Canada) Inc. | Radioactive medical device for radiation therapy |
WO2002055136A2 (en) * | 2000-12-01 | 2002-07-18 | Nephros Therapeutics Inc | Intrasvascular drug delivery device and use therefor |
US7244272B2 (en) | 2000-12-19 | 2007-07-17 | Nicast Ltd. | Vascular prosthesis and method for production thereof |
US20040030377A1 (en) * | 2001-10-19 | 2004-02-12 | Alexander Dubson | Medicated polymer-coated stent assembly |
WO2002049544A1 (en) * | 2000-12-19 | 2002-06-27 | Vascular Architects, Inc. | Biologically active agent delivery apparatus and method |
US20020084178A1 (en) * | 2000-12-19 | 2002-07-04 | Nicast Corporation Ltd. | Method and apparatus for manufacturing polymer fiber shells via electrospinning |
US7077859B2 (en) | 2000-12-22 | 2006-07-18 | Avantec Vascular Corporation | Apparatus and methods for variably controlled substance delivery from implanted prostheses |
US20020082679A1 (en) * | 2000-12-22 | 2002-06-27 | Avantec Vascular Corporation | Delivery or therapeutic capable agents |
US20030033007A1 (en) * | 2000-12-22 | 2003-02-13 | Avantec Vascular Corporation | Methods and devices for delivery of therapeutic capable agents with variable release profile |
US7018405B2 (en) | 2000-12-22 | 2006-03-28 | Avantec Vascular Corporation | Intravascular delivery of methylprednisolone |
US6824559B2 (en) | 2000-12-22 | 2004-11-30 | Advanced Cardiovascular Systems, Inc. | Ethylene-carboxyl copolymers as drug delivery matrices |
US20030050692A1 (en) * | 2000-12-22 | 2003-03-13 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
US7083642B2 (en) * | 2000-12-22 | 2006-08-01 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
US6471980B2 (en) | 2000-12-22 | 2002-10-29 | Avantec Vascular Corporation | Intravascular delivery of mycophenolic acid |
US6939375B2 (en) | 2000-12-22 | 2005-09-06 | Avantac Vascular Corporation | Apparatus and methods for controlled substance delivery from implanted prostheses |
US20020082678A1 (en) * | 2000-12-22 | 2002-06-27 | Motasim Sirhan | Intravascular delivery of mizoribine |
US6663662B2 (en) * | 2000-12-28 | 2003-12-16 | Advanced Cardiovascular Systems, Inc. | Diffusion barrier layer for implantable devices |
US8632845B2 (en) * | 2000-12-28 | 2014-01-21 | Abbott Cardiovascular Systems Inc. | Method of drying bioabsorbable coating over stents |
US7504125B1 (en) | 2001-04-27 | 2009-03-17 | Advanced Cardiovascular Systems, Inc. | System and method for coating implantable devices |
US6540776B2 (en) | 2000-12-28 | 2003-04-01 | Advanced Cardiovascular Systems, Inc. | Sheath for a prosthesis and methods of forming the same |
US6547812B1 (en) | 2000-12-29 | 2003-04-15 | Advanced Cardiovascular Systems, Inc. | Radiation therapy using a radioactive implantable device and a radiosensitizer agent |
US6641607B1 (en) | 2000-12-29 | 2003-11-04 | Advanced Cardiovascular Systems, Inc. | Double tube stent |
US6635082B1 (en) | 2000-12-29 | 2003-10-21 | Advanced Cardiovascular Systems Inc. | Radiopaque stent |
US6544582B1 (en) * | 2001-01-05 | 2003-04-08 | Advanced Cardiovascular Systems, Inc. | Method and apparatus for coating an implantable device |
GB0100761D0 (en) | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
DE10100961B4 (en) * | 2001-01-11 | 2005-08-04 | Polyzenix Gmbh | Body-compatible material and substrate coated with this material for the cultivation of cells and artificial organic implants constructed or grown from cells |
US9080146B2 (en) * | 2001-01-11 | 2015-07-14 | Celonova Biosciences, Inc. | Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface |
AP2003002828A0 (en) | 2001-01-16 | 2003-09-30 | Vascular Therapies Llc | Implantable device containing resorbable matrix material and anti-proliferative drugs for preventing or treating failure of hemodialysis vascular access and other vascular grafts. |
US6866656B2 (en) * | 2001-01-24 | 2005-03-15 | Becton, Dickinson And Company | Lubricious coating for a medical device |
US20020120333A1 (en) * | 2001-01-31 | 2002-08-29 | Keogh James R. | Method for coating medical device surfaces |
US20040220660A1 (en) * | 2001-02-05 | 2004-11-04 | Shanley John F. | Bioresorbable stent with beneficial agent reservoirs |
US6964680B2 (en) * | 2001-02-05 | 2005-11-15 | Conor Medsystems, Inc. | Expandable medical device with tapered hinge |
US20040073294A1 (en) * | 2002-09-20 | 2004-04-15 | Conor Medsystems, Inc. | Method and apparatus for loading a beneficial agent into an expandable medical device |
US8038708B2 (en) | 2001-02-05 | 2011-10-18 | Cook Medical Technologies Llc | Implantable device with remodelable material and covering material |
US20040204756A1 (en) * | 2004-02-11 | 2004-10-14 | Diaz Stephen Hunter | Absorbent article with improved liquid acquisition capacity |
DE10105592A1 (en) * | 2001-02-06 | 2002-08-08 | Achim Goepferich | Placeholder for drug release in the frontal sinus |
CA2435306C (en) * | 2001-02-16 | 2010-12-21 | Stephan Wnendt | Implants with fk506 |
GB0104383D0 (en) * | 2001-02-22 | 2001-04-11 | Psimedica Ltd | Cancer Treatment |
WO2002069848A2 (en) * | 2001-03-06 | 2002-09-12 | Board Of Regents, The University Of Texas System | Apparatus for stent deployment with delivery of bioactive agents |
EP1365679B1 (en) | 2001-03-09 | 2007-11-14 | Boston Scientific Limited | Medical slings |
US9149261B2 (en) | 2001-03-09 | 2015-10-06 | Boston Scientific Scimed, Inc. | Systems, methods and devices relating to delivery of medical implants |
US8033983B2 (en) | 2001-03-09 | 2011-10-11 | Boston Scientific Scimed, Inc. | Medical implant |
US8915927B2 (en) | 2001-03-09 | 2014-12-23 | Boston Scientific Scimed, Inc. | Systems, methods and devices relating to delivery of medical implants |
DE60239188D1 (en) * | 2001-03-09 | 2011-03-31 | Boston Scient Ltd | SYSTEM FOR INSERTING A SLING |
US7771468B2 (en) * | 2001-03-16 | 2010-08-10 | Angiotech Biocoatings Corp. | Medicated stent having multi-layer polymer coating |
WO2002074194A2 (en) * | 2001-03-16 | 2002-09-26 | Sts Biopolymers, Inc. | Stent with medicated multi-layer hydrid polymer coating |
ATE473082T1 (en) * | 2001-03-20 | 2010-07-15 | Nicast Ltd | PORTABLE ELECTROSPINNER DEVICE |
DE10115740A1 (en) * | 2001-03-26 | 2002-10-02 | Ulrich Speck | Preparation for restenosis prophylaxis |
US6780424B2 (en) * | 2001-03-30 | 2004-08-24 | Charles David Claude | Controlled morphologies in polymer drug for release of drugs from polymer films |
US6764505B1 (en) | 2001-04-12 | 2004-07-20 | Advanced Cardiovascular Systems, Inc. | Variable surface area stent |
US6712845B2 (en) | 2001-04-24 | 2004-03-30 | Advanced Cardiovascular Systems, Inc. | Coating for a stent and a method of forming the same |
US6913762B2 (en) * | 2001-04-25 | 2005-07-05 | Mayo Foundation For Medical Education And Research | Stent having non-woven framework containing cells |
US6887857B2 (en) * | 2001-04-27 | 2005-05-03 | Scimed Life Systems, Inc. | Microparticle protection of therapeutic agents |
US6613083B2 (en) * | 2001-05-02 | 2003-09-02 | Eckhard Alt | Stent device and method |
US20020165601A1 (en) * | 2001-05-04 | 2002-11-07 | Clerc Claude O. | Bioabsorbable stent-graft and covered stent |
US8182527B2 (en) | 2001-05-07 | 2012-05-22 | Cordis Corporation | Heparin barrier coating for controlled drug release |
ITMO20010086A1 (en) * | 2001-05-08 | 2002-11-08 | Worgas Bruciatori Srl | METHOD AND APPARATUS TO REDUCE NITROGEN DIOXIDE (NO2) EMISSIONS IN A CHIMNEY-FREE HEATING APPLIANCE |
US6656506B1 (en) | 2001-05-09 | 2003-12-02 | Advanced Cardiovascular Systems, Inc. | Microparticle coated medical device |
US20030166197A1 (en) * | 2001-05-10 | 2003-09-04 | Ecker Joseph R. | Ethylene insensitive plants |
US6685745B2 (en) | 2001-05-15 | 2004-02-03 | Scimed Life Systems, Inc. | Delivering an agent to a patient's body |
US7651695B2 (en) | 2001-05-18 | 2010-01-26 | Advanced Cardiovascular Systems, Inc. | Medicated stents for the treatment of vascular disease |
ATE287269T1 (en) * | 2001-05-25 | 2005-02-15 | Gorm Danscher | METHOD FOR IMPLANTING HEAVY METAL, SUCH AS A PRECIOUS METAL, E.G. GOLD, AND METAL FOR USE IN IMPLANTATION |
US6973718B2 (en) * | 2001-05-30 | 2005-12-13 | Microchips, Inc. | Methods for conformal coating and sealing microchip reservoir devices |
US6743462B1 (en) * | 2001-05-31 | 2004-06-01 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for coating implantable devices |
AU2002326304A1 (en) * | 2001-05-31 | 2002-12-16 | Massachusetts Institute Of Technology | Microchip devices with improved reservoir opening |
US7862495B2 (en) | 2001-05-31 | 2011-01-04 | Advanced Cardiovascular Systems, Inc. | Radiation or drug delivery source with activity gradient to minimize edge effects |
US7201940B1 (en) * | 2001-06-12 | 2007-04-10 | Advanced Cardiovascular Systems, Inc. | Method and apparatus for thermal spray processing of medical devices |
US7247313B2 (en) * | 2001-06-27 | 2007-07-24 | Advanced Cardiovascular Systems, Inc. | Polyacrylates coatings for implantable medical devices |
US7727221B2 (en) * | 2001-06-27 | 2010-06-01 | Cardiac Pacemakers Inc. | Method and device for electrochemical formation of therapeutic species in vivo |
US7175873B1 (en) | 2001-06-27 | 2007-02-13 | Advanced Cardiovascular Systems, Inc. | Rate limiting barriers for implantable devices and methods for fabrication thereof |
US8741378B1 (en) | 2001-06-27 | 2014-06-03 | Advanced Cardiovascular Systems, Inc. | Methods of coating an implantable device |
US6695920B1 (en) * | 2001-06-27 | 2004-02-24 | Advanced Cardiovascular Systems, Inc. | Mandrel for supporting a stent and a method of using the mandrel to coat a stent |
EP1399135B1 (en) | 2001-06-28 | 2004-12-29 | Microchips, Inc. | Methods for hermetically sealing microchip reservoir devices |
US6656216B1 (en) | 2001-06-29 | 2003-12-02 | Advanced Cardiovascular Systems, Inc. | Composite stent with regioselective material |
EP1273314A1 (en) * | 2001-07-06 | 2003-01-08 | Terumo Kabushiki Kaisha | Stent |
US7246321B2 (en) * | 2001-07-13 | 2007-07-17 | Anoto Ab | Editing data |
US7286877B2 (en) * | 2001-07-13 | 2007-10-23 | Cardiac Pacemakers, Inc. | Device programmer with enclosed imaging capability |
US6704600B2 (en) | 2001-07-13 | 2004-03-09 | Cardiac Pacemakers, Inc. | Device programmer with enclosed imaging capability |
ATE330564T1 (en) * | 2001-07-20 | 2006-07-15 | Sorin Biomedica Cardio Srl | STENT |
US7547321B2 (en) * | 2001-07-26 | 2009-06-16 | Alveolus Inc. | Removable stent and method of using the same |
WO2003009778A2 (en) | 2001-07-26 | 2003-02-06 | Avantec Vascular Corporation | Methods and devices for delivery of therapeutic capable agents with variable release profile |
US7682669B1 (en) | 2001-07-30 | 2010-03-23 | Advanced Cardiovascular Systems, Inc. | Methods for covalently immobilizing anti-thrombogenic material into a coating on a medical device |
PT1432380E (en) * | 2001-08-17 | 2007-01-31 | Polyzenix Gmbh | Device based on nitinol with a polyphosphazene coating |
US7842083B2 (en) | 2001-08-20 | 2010-11-30 | Innovational Holdings, Llc. | Expandable medical device with improved spatial distribution |
US7056338B2 (en) * | 2003-03-28 | 2006-06-06 | Conor Medsystems, Inc. | Therapeutic agent delivery device with controlled therapeutic agent release rates |
US20040249443A1 (en) * | 2001-08-20 | 2004-12-09 | Shanley John F. | Expandable medical device for treating cardiac arrhythmias |
US7708712B2 (en) | 2001-09-04 | 2010-05-04 | Broncus Technologies, Inc. | Methods and devices for maintaining patency of surgically created channels in a body organ |
US20050060042A1 (en) * | 2001-09-04 | 2005-03-17 | Broncus Technologies, Inc. | Methods and devices for maintaining surgically created channels in a body organ |
US20050137611A1 (en) * | 2001-09-04 | 2005-06-23 | Broncus Technologies, Inc. | Methods and devices for maintaining surgically created channels in a body organ |
US8303651B1 (en) | 2001-09-07 | 2012-11-06 | Advanced Cardiovascular Systems, Inc. | Polymeric coating for reducing the rate of release of a therapeutic substance from a stent |
US20080145402A1 (en) * | 2001-09-10 | 2008-06-19 | Abbott Cardiovascular Systems Inc. | Medical Devices Containing Rapamycin Analogs |
US7989018B2 (en) | 2001-09-17 | 2011-08-02 | Advanced Cardiovascular Systems, Inc. | Fluid treatment of a polymeric coating on an implantable medical device |
US7285304B1 (en) | 2003-06-25 | 2007-10-23 | Advanced Cardiovascular Systems, Inc. | Fluid treatment of a polymeric coating on an implantable medical device |
US20030060873A1 (en) * | 2001-09-19 | 2003-03-27 | Nanomedical Technologies, Inc. | Metallic structures incorporating bioactive materials and methods for creating the same |
US7776379B2 (en) * | 2001-09-19 | 2010-08-17 | Medlogics Device Corporation | Metallic structures incorporating bioactive materials and methods for creating the same |
US6863683B2 (en) | 2001-09-19 | 2005-03-08 | Abbott Laboratoris Vascular Entities Limited | Cold-molding process for loading a stent onto a stent delivery system |
EP1429819B1 (en) * | 2001-09-24 | 2010-11-24 | Boston Scientific Limited | Optimized dosing for paclitaxel coated stents |
WO2003028590A1 (en) * | 2001-09-24 | 2003-04-10 | Medtronic Ave Inc. | Rational drug therapy device and methods |
US6827737B2 (en) * | 2001-09-25 | 2004-12-07 | Scimed Life Systems, Inc. | EPTFE covering for endovascular prostheses and method of manufacture |
US7195640B2 (en) * | 2001-09-25 | 2007-03-27 | Cordis Corporation | Coated medical devices for the treatment of vulnerable plaque |
US20030059520A1 (en) | 2001-09-27 | 2003-03-27 | Yung-Ming Chen | Apparatus for regulating temperature of a composition and a method of coating implantable devices |
US6753071B1 (en) * | 2001-09-27 | 2004-06-22 | Advanced Cardiovascular Systems, Inc. | Rate-reducing membrane for release of an agent |
US7223282B1 (en) * | 2001-09-27 | 2007-05-29 | Advanced Cardiovascular Systems, Inc. | Remote activation of an implantable device |
US7108701B2 (en) * | 2001-09-28 | 2006-09-19 | Ethicon, Inc. | Drug releasing anastomosis devices and methods for treating anastomotic sites |
US20030065377A1 (en) * | 2001-09-28 | 2003-04-03 | Davila Luis A. | Coated medical devices |
US20030065382A1 (en) * | 2001-10-02 | 2003-04-03 | Fischell Robert E. | Means and method for the treatment of coronary artery obstructions |
WO2003030964A2 (en) * | 2001-10-06 | 2003-04-17 | Walid Aboul-Hosn | Systems and methods for overcoming or preventing vascular flow restrictions |
US20030077310A1 (en) | 2001-10-22 | 2003-04-24 | Chandrashekhar Pathak | Stent coatings containing HMG-CoA reductase inhibitors |
US8740973B2 (en) | 2001-10-26 | 2014-06-03 | Icon Medical Corp. | Polymer biodegradable medical device |
US7179283B2 (en) * | 2001-11-02 | 2007-02-20 | Scimed Life Systems, Inc. | Vapor deposition process for producing a stent-graft and a stent-graft produced therefrom |
US20030088307A1 (en) * | 2001-11-05 | 2003-05-08 | Shulze John E. | Potent coatings for stents |
US6939376B2 (en) | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US7682387B2 (en) | 2002-04-24 | 2010-03-23 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US7585516B2 (en) | 2001-11-12 | 2009-09-08 | Advanced Cardiovascular Systems, Inc. | Coatings for drug delivery devices |
EP1310242A1 (en) * | 2001-11-13 | 2003-05-14 | SORIN BIOMEDICA CARDIO S.p.A. | Carrier and kit for endoluminal delivery of active principles |
US20030206906A1 (en) * | 2001-11-26 | 2003-11-06 | Genentech, Inc. | Catheter composition and uses thereof |
US6663880B1 (en) | 2001-11-30 | 2003-12-16 | Advanced Cardiovascular Systems, Inc. | Permeabilizing reagents to increase drug delivery and a method of local delivery |
US7175874B1 (en) | 2001-11-30 | 2007-02-13 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for coating implantable devices |
AUPR951501A0 (en) * | 2001-12-14 | 2002-01-24 | Smart Drug Systems Inc | Modified sustained release pharmaceutical system |
US20030216758A1 (en) * | 2001-12-28 | 2003-11-20 | Angiotech Pharmaceuticals, Inc. | Coated surgical patches |
US6709514B1 (en) | 2001-12-28 | 2004-03-23 | Advanced Cardiovascular Systems, Inc. | Rotary coating apparatus for coating implantable medical devices |
DE10200387B4 (en) * | 2002-01-08 | 2009-11-26 | Translumina Gmbh | stent |
WO2003061634A1 (en) * | 2002-01-24 | 2003-07-31 | Smart Drug Systems Inc | Sustained release pharmaceutical composition |
US7326245B2 (en) * | 2002-01-31 | 2008-02-05 | Boston Scientific Scimed, Inc. | Medical device for delivering biologically active material |
US7291165B2 (en) | 2002-01-31 | 2007-11-06 | Boston Scientific Scimed, Inc. | Medical device for delivering biologically active material |
US7445629B2 (en) * | 2002-01-31 | 2008-11-04 | Boston Scientific Scimed, Inc. | Medical device for delivering biologically active material |
US20030220297A1 (en) | 2002-02-01 | 2003-11-27 | Berstein David L. | Phosphorus-containing compounds and uses thereof |
US8685427B2 (en) * | 2002-07-31 | 2014-04-01 | Boston Scientific Scimed, Inc. | Controlled drug delivery |
US8133501B2 (en) | 2002-02-08 | 2012-03-13 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices for controlled drug delivery |
US7008397B2 (en) | 2002-02-13 | 2006-03-07 | Percardia, Inc. | Cardiac implant and methods |
US20030153971A1 (en) * | 2002-02-14 | 2003-08-14 | Chandru Chandrasekaran | Metal reinforced biodegradable intraluminal stents |
JP3993773B2 (en) * | 2002-02-20 | 2007-10-17 | 株式会社日立製作所 | Storage subsystem, storage control device, and data copy method |
US20030157269A1 (en) * | 2002-02-20 | 2003-08-21 | University Of Washington | Method and apparatus for precision coating of molecules on the surfaces of materials and devices |
US20110306997A9 (en) * | 2002-02-21 | 2011-12-15 | Roschak Edmund J | Devices for creating passages and sensing for blood vessels |
CN1649577A (en) * | 2002-03-08 | 2005-08-03 | 普罗特米克斯公司 | Preventing and/or treating cardiovascular disease and/or associated heart failure |
US7919075B1 (en) | 2002-03-20 | 2011-04-05 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices |
US7022334B1 (en) * | 2002-03-20 | 2006-04-04 | Advanced Cardiovascular Systems, Inc. | Therapeutic composition and a method of coating implantable medical devices |
US20030181973A1 (en) * | 2002-03-20 | 2003-09-25 | Harvinder Sahota | Reduced restenosis drug containing stents |
US7288111B1 (en) * | 2002-03-26 | 2007-10-30 | Thoratec Corporation | Flexible stent and method of making the same |
AU2003221744A1 (en) * | 2002-04-19 | 2003-11-03 | Broncus Technologies, Inc. | Devices for maintaining surgically created openings |
US20030199887A1 (en) * | 2002-04-23 | 2003-10-23 | David Ferrera | Filamentous embolization device and method of use |
US20030236457A1 (en) * | 2002-04-24 | 2003-12-25 | Mericle Robert A. | Method of endovascular brain mapping |
US20040024450A1 (en) * | 2002-04-24 | 2004-02-05 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US7083822B2 (en) * | 2002-04-26 | 2006-08-01 | Medtronic Vascular, Inc. | Overlapping coated stents |
US7008979B2 (en) * | 2002-04-30 | 2006-03-07 | Hydromer, Inc. | Coating composition for multiple hydrophilic applications |
AU2003231229A1 (en) * | 2002-04-30 | 2003-11-17 | Cook Biotech Incorporated | Sling for supporting tissue |
US20030208258A1 (en) * | 2002-05-02 | 2003-11-06 | Tom Reilly | Vascular grafts surrounding an expanded stent for transplantation |
US8313760B2 (en) | 2002-05-24 | 2012-11-20 | Angiotech International Ag | Compositions and methods for coating medical implants |
EP1509256B1 (en) * | 2002-05-24 | 2009-07-22 | Angiotech International Ag | Compositions and methods for coating medical implants |
US7160272B1 (en) | 2002-05-31 | 2007-01-09 | Elcam Plastic | Y-site medical valve |
US20040234703A1 (en) * | 2002-06-04 | 2004-11-25 | Frautschi Jack R. | Method of forming a polymer layer on a metal surface |
AU2003243465A1 (en) * | 2002-06-07 | 2003-12-22 | Broncus Technologies, Inc. | Method and devices for maintaining patency of surgically created channels in tissue |
US6835387B2 (en) | 2002-06-11 | 2004-12-28 | Scimed Life Systems, Inc. | Sustained release of superoxide dismutase mimics from implantable or insertable medical devices |
US7097850B2 (en) | 2002-06-18 | 2006-08-29 | Surmodics, Inc. | Bioactive agent release coating and controlled humidity method |
US7105175B2 (en) * | 2002-06-19 | 2006-09-12 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices for controlled delivery of a therapeutic agent |
US7396539B1 (en) * | 2002-06-21 | 2008-07-08 | Advanced Cardiovascular Systems, Inc. | Stent coatings with engineered drug release rate |
US7033602B1 (en) * | 2002-06-21 | 2006-04-25 | Advanced Cardiovascular Systems, Inc. | Polycationic peptide coatings and methods of coating implantable medical devices |
US7217426B1 (en) | 2002-06-21 | 2007-05-15 | Advanced Cardiovascular Systems, Inc. | Coatings containing polycationic peptides for cardiovascular therapy |
US6994867B1 (en) | 2002-06-21 | 2006-02-07 | Advanced Cardiovascular Systems, Inc. | Biocompatible carrier containing L-arginine |
US7070798B1 (en) | 2002-06-21 | 2006-07-04 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine |
US7011842B1 (en) | 2002-06-21 | 2006-03-14 | Advanced Cardiovascular Systems, Inc. | Polycationic peptide coatings and methods of making the same |
US7794743B2 (en) | 2002-06-21 | 2010-09-14 | Advanced Cardiovascular Systems, Inc. | Polycationic peptide coatings and methods of making the same |
US7056523B1 (en) | 2002-06-21 | 2006-06-06 | Advanced Cardiovascular Systems, Inc. | Implantable medical devices incorporating chemically conjugated polymers and oligomers of L-arginine |
US8506617B1 (en) | 2002-06-21 | 2013-08-13 | Advanced Cardiovascular Systems, Inc. | Micronized peptide coated stent |
US20080138377A1 (en) * | 2002-07-05 | 2008-06-12 | Celonova Biosciences, Inc. | Vasodilator Eluting Luminal Stent Devices With A Specific Polyphosphazene Coating and Methods for Their Manufacture and Use |
US20080138433A1 (en) * | 2002-07-05 | 2008-06-12 | Celonova Biosciences, Inc. | Vasodilator eluting blood storage and administration devices with a specific polyphosphazene coating and methods for their manufacture and use |
AU2003250913A1 (en) * | 2002-07-08 | 2004-01-23 | Abbott Laboratories Vascular Enterprises Limited | Drug eluting stent and methods of manufacture |
US7622146B2 (en) * | 2002-07-18 | 2009-11-24 | Advanced Cardiovascular Systems, Inc. | Rate limiting barriers for implantable devices and methods for fabrication thereof |
US7294329B1 (en) * | 2002-07-18 | 2007-11-13 | Advanced Cardiovascular Systems, Inc. | Poly(vinyl acetal) coatings for implantable medical devices |
US20040034275A1 (en) * | 2002-07-29 | 2004-02-19 | Peter Forsell | Multi-material incontinence treatment constriction device |
US20040133219A1 (en) * | 2002-07-29 | 2004-07-08 | Peter Forsell | Multi-material constriction device for forming stoma opening |
DE60330359D1 (en) * | 2002-07-29 | 2010-01-14 | Potentica Ag | PENIS CONSTRUCTION DEVICE MADE FROM SEVERAL MATERIALS |
EP1539262A1 (en) * | 2002-07-29 | 2005-06-15 | Potencia Medical AG | Durable implant |
US8920826B2 (en) * | 2002-07-31 | 2014-12-30 | Boston Scientific Scimed, Inc. | Medical imaging reference devices |
US8016881B2 (en) | 2002-07-31 | 2011-09-13 | Icon Interventional Systems, Inc. | Sutures and surgical staples for anastamoses, wound closures, and surgical closures |
US20040024448A1 (en) | 2002-08-05 | 2004-02-05 | Chang James W. | Thermoplastic fluoropolymer-coated medical devices |
CA2705609C (en) | 2002-08-14 | 2016-10-25 | Boston Scientific Limited | Systems, methods and devices relating to delivery of medical implants |
EP1391184A1 (en) * | 2002-08-16 | 2004-02-25 | Endosense Sàrl | Extensible multilayer tubular structure and production method therefor |
US7951392B2 (en) * | 2002-08-16 | 2011-05-31 | Boston Scientific Scimed, Inc. | Microarray drug delivery coatings |
WO2004017956A1 (en) | 2002-08-20 | 2004-03-04 | Protemix Corporation Limited | Dosage forms and related therapies |
US7363074B1 (en) * | 2002-08-20 | 2008-04-22 | Advanced Cardiovascular Systems, Inc. | Coatings comprising self-assembled molecular structures and a method of delivering a drug using the same |
US7438925B2 (en) * | 2002-08-26 | 2008-10-21 | Biovention Holdings Ltd. | Drug eluting coatings for medical implants |
US7732535B2 (en) * | 2002-09-05 | 2010-06-08 | Advanced Cardiovascular Systems, Inc. | Coating for controlled release of drugs from implantable medical devices |
US20040054104A1 (en) * | 2002-09-05 | 2004-03-18 | Pacetti Stephen D. | Coatings for drug delivery devices comprising modified poly(ethylene-co-vinyl alcohol) |
US7201935B1 (en) | 2002-09-17 | 2007-04-10 | Advanced Cardiovascular Systems, Inc. | Plasma-generated coatings for medical devices and methods for fabricating thereof |
DE10243132B4 (en) | 2002-09-17 | 2006-09-14 | Biocer Entwicklungs Gmbh | Anti-infective, biocompatible titanium oxide coatings for implants and methods of making them |
US20040063805A1 (en) * | 2002-09-19 | 2004-04-01 | Pacetti Stephen D. | Coatings for implantable medical devices and methods for fabrication thereof |
US7438722B1 (en) | 2002-09-20 | 2008-10-21 | Advanced Cardiovascular Systems, Inc. | Method for treatment of restenosis |
US20040127976A1 (en) * | 2002-09-20 | 2004-07-01 | Conor Medsystems, Inc. | Method and apparatus for loading a beneficial agent into an expandable medical device |
US7758636B2 (en) | 2002-09-20 | 2010-07-20 | Innovational Holdings Llc | Expandable medical device with openings for delivery of multiple beneficial agents |
EP2668933A1 (en) * | 2002-09-20 | 2013-12-04 | Innovational Holdings, LLC | Expandable medical device with openings for delivery of multiple beneficial agents |
DE10244847A1 (en) | 2002-09-20 | 2004-04-01 | Ulrich Prof. Dr. Speck | Medical device for drug delivery |
US20040116997A1 (en) | 2002-09-20 | 2004-06-17 | Taylor Charles S. | Stent-graft with positioning anchor |
US20040059409A1 (en) * | 2002-09-24 | 2004-03-25 | Stenzel Eric B. | Method of applying coatings to a medical device |
JP2006500996A (en) * | 2002-09-26 | 2006-01-12 | エンドバスキュラー デバイセス インコーポレイテッド | Apparatus and method for delivering mitomycin via an eluting biocompatible implantable medical device |
EP1549248A4 (en) | 2002-09-26 | 2015-11-25 | Advanced Bio Prosthetic Surfac | High strength vacuum deposited nitionol alloy films, medical thin film graft materials and method of making same |
US7232573B1 (en) * | 2002-09-26 | 2007-06-19 | Advanced Cardiovascular Systems, Inc. | Stent coatings containing self-assembled monolayers |
US8202530B2 (en) * | 2002-09-27 | 2012-06-19 | Advanced Cardiovascular Systems, Inc. | Biocompatible coatings for stents |
US20060100695A1 (en) * | 2002-09-27 | 2006-05-11 | Peacock James C Iii | Implantable stent with modified ends |
US8337937B2 (en) * | 2002-09-30 | 2012-12-25 | Abbott Cardiovascular Systems Inc. | Stent spin coating method |
US7404979B1 (en) | 2002-09-30 | 2008-07-29 | Advanced Cardiovascular Systems Inc. | Spin coating apparatus and a method for coating implantable devices |
US7135038B1 (en) * | 2002-09-30 | 2006-11-14 | Advanced Cardiovascular Systems, Inc. | Drug eluting stent |
US6638301B1 (en) * | 2002-10-02 | 2003-10-28 | Scimed Life Systems, Inc. | Medical device with radiopacity |
US7087263B2 (en) | 2002-10-09 | 2006-08-08 | Advanced Cardiovascular Systems, Inc. | Rare limiting barriers for implantable medical devices |
WO2004037443A1 (en) * | 2002-10-22 | 2004-05-06 | Medtronic Vascular Inc. | Stent with intermittent coating |
US20040093056A1 (en) * | 2002-10-26 | 2004-05-13 | Johnson Lianw M. | Medical appliance delivery apparatus and method of use |
US20040088038A1 (en) * | 2002-10-30 | 2004-05-06 | Houdin Dehnad | Porous metal for drug-loaded stents |
US20060271168A1 (en) * | 2002-10-30 | 2006-11-30 | Klaus Kleine | Degradable medical device |
US7959671B2 (en) * | 2002-11-05 | 2011-06-14 | Merit Medical Systems, Inc. | Differential covering and coating methods |
US7875068B2 (en) | 2002-11-05 | 2011-01-25 | Merit Medical Systems, Inc. | Removable biliary stent |
US7637942B2 (en) | 2002-11-05 | 2009-12-29 | Merit Medical Systems, Inc. | Coated stent with geometry determinated functionality and method of making the same |
US7527644B2 (en) * | 2002-11-05 | 2009-05-05 | Alveolus Inc. | Stent with geometry determinated functionality and method of making the same |
US8221495B2 (en) | 2002-11-07 | 2012-07-17 | Abbott Laboratories | Integration of therapeutic agent into a bioerodible medical device |
US8524148B2 (en) * | 2002-11-07 | 2013-09-03 | Abbott Laboratories | Method of integrating therapeutic agent into a bioerodible medical device |
DE60331854D1 (en) * | 2002-11-07 | 2010-05-06 | Abbott Lab | METHOD FOR ATTACHING A MEDICAMENT TO A PROSTHESIS BY MEANS OF A LIQUID AMOUNT |
KR20130032407A (en) * | 2002-11-08 | 2013-04-01 | 코너 메드시스템즈, 엘엘씨 | Method and apparatus for reducing tissue damage after ischemic injury |
JP2006505364A (en) * | 2002-11-08 | 2006-02-16 | コナー メドシステムズ, インコーポレイテッド | Expandable medical device and method for treating chronic total infarction using a local supply of angiogenic factors |
US20040142014A1 (en) * | 2002-11-08 | 2004-07-22 | Conor Medsystems, Inc. | Method and apparatus for reducing tissue damage after ischemic injury |
DE60231843D1 (en) * | 2002-11-08 | 2009-05-14 | Jacques Seguin | ENDOPROTHESIS FOR VESSEL FORKING |
US8034361B2 (en) * | 2002-11-12 | 2011-10-11 | Advanced Cardiovascular Systems, Inc. | Stent coatings incorporating nanoparticles |
US7169178B1 (en) | 2002-11-12 | 2007-01-30 | Advanced Cardiovascular Systems, Inc. | Stent with drug coating |
US7022372B1 (en) | 2002-11-12 | 2006-04-04 | Advanced Cardiovascular Systems, Inc. | Compositions for coating implantable medical devices |
US6896965B1 (en) | 2002-11-12 | 2005-05-24 | Advanced Cardiovascular Systems, Inc. | Rate limiting barriers for implantable devices |
EP2336318B1 (en) | 2002-11-13 | 2013-04-24 | Genzyme Corporation | Antisense modulation of apolipoprotein b expression |
ES2420914T3 (en) | 2002-11-13 | 2013-08-27 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
US20040098106A1 (en) * | 2002-11-14 | 2004-05-20 | Williams Michael S. | Intraluminal prostheses and carbon dioxide-assisted methods of impregnating same with pharmacological agents |
US20040098090A1 (en) * | 2002-11-14 | 2004-05-20 | Williams Michael S. | Polymeric endoprosthesis and method of manufacture |
US7285287B2 (en) * | 2002-11-14 | 2007-10-23 | Synecor, Llc | Carbon dioxide-assisted methods of providing biocompatible intraluminal prostheses |
US20040102855A1 (en) * | 2002-11-21 | 2004-05-27 | Scimed Life Systems, Inc. | Anti-reflux stent |
US6992127B2 (en) | 2002-11-25 | 2006-01-31 | Ast Products, Inc. | Polymeric coatings containing a pH buffer agent |
US6982004B1 (en) | 2002-11-26 | 2006-01-03 | Advanced Cardiovascular Systems, Inc. | Electrostatic loading of drugs on implantable medical devices |
US20040158289A1 (en) * | 2002-11-30 | 2004-08-12 | Girouard Steven D. | Method and apparatus for cell and electrical therapy of living tissue |
US7627373B2 (en) * | 2002-11-30 | 2009-12-01 | Cardiac Pacemakers, Inc. | Method and apparatus for cell and electrical therapy of living tissue |
US6918869B2 (en) * | 2002-12-02 | 2005-07-19 | Scimed Life Systems | System for administering a combination of therapies to a body lumen |
US7211150B1 (en) | 2002-12-09 | 2007-05-01 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for coating and drying multiple stents |
US7776926B1 (en) | 2002-12-11 | 2010-08-17 | Advanced Cardiovascular Systems, Inc. | Biocompatible coating for implantable medical devices |
US7758880B2 (en) | 2002-12-11 | 2010-07-20 | Advanced Cardiovascular Systems, Inc. | Biocompatible polyacrylate compositions for medical applications |
US7074276B1 (en) * | 2002-12-12 | 2006-07-11 | Advanced Cardiovascular Systems, Inc. | Clamp mandrel fixture and a method of using the same to minimize coating defects |
US7758881B2 (en) | 2004-06-30 | 2010-07-20 | Advanced Cardiovascular Systems, Inc. | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device |
US8435550B2 (en) | 2002-12-16 | 2013-05-07 | Abbot Cardiovascular Systems Inc. | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device |
US7094256B1 (en) | 2002-12-16 | 2006-08-22 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical device containing polycationic peptides |
US20060002968A1 (en) | 2004-06-30 | 2006-01-05 | Gordon Stewart | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders |
AU2003259834A1 (en) | 2002-12-17 | 2004-07-29 | Boston Scientific Limited | Spacer for sling delivery system |
US7338557B1 (en) * | 2002-12-17 | 2008-03-04 | Advanced Cardiovascular Systems, Inc. | Nozzle for use in coating a stent |
US20040236415A1 (en) * | 2003-01-02 | 2004-11-25 | Richard Thomas | Medical devices having drug releasing polymer reservoirs |
US7087115B1 (en) * | 2003-02-13 | 2006-08-08 | Advanced Cardiovascular Systems, Inc. | Nozzle and method for use in coating a stent |
US20050079199A1 (en) * | 2003-02-18 | 2005-04-14 | Medtronic, Inc. | Porous coatings for drug release from medical devices |
US7255891B1 (en) * | 2003-02-26 | 2007-08-14 | Advanced Cardiovascular Systems, Inc. | Method for coating implantable medical devices |
US6926919B1 (en) | 2003-02-26 | 2005-08-09 | Advanced Cardiovascular Systems, Inc. | Method for fabricating a coating for a medical device |
US8715771B2 (en) * | 2003-02-26 | 2014-05-06 | Abbott Cardiovascular Systems Inc. | Coated stent and method of making the same |
US7063884B2 (en) | 2003-02-26 | 2006-06-20 | Advanced Cardiovascular Systems, Inc. | Stent coating |
US7563483B2 (en) | 2003-02-26 | 2009-07-21 | Advanced Cardiovascular Systems Inc. | Methods for fabricating a coating for implantable medical devices |
US7001421B2 (en) * | 2003-02-28 | 2006-02-21 | Medtronic Vascular, Inc. | Stent with phenoxy primer coating |
US7288609B1 (en) * | 2003-03-04 | 2007-10-30 | Advanced Cardiovascular Systems, Inc. | Coatings for drug delivery devices based on poly (orthoesters) |
US6932930B2 (en) * | 2003-03-10 | 2005-08-23 | Synecor, Llc | Intraluminal prostheses having polymeric material with selectively modified crystallinity and methods of making same |
AU2004226327A1 (en) | 2003-03-28 | 2004-10-14 | Innovational Holdings, Llc | Implantable medical device with beneficial agent concentration gradient |
US20040202692A1 (en) * | 2003-03-28 | 2004-10-14 | Conor Medsystems, Inc. | Implantable medical device and method for in situ selective modulation of agent delivery |
US20050010170A1 (en) * | 2004-02-11 | 2005-01-13 | Shanley John F | Implantable medical device with beneficial agent concentration gradient |
US7637934B2 (en) | 2003-03-31 | 2009-12-29 | Merit Medical Systems, Inc. | Medical appliance optical delivery and deployment apparatus and method |
US20040243224A1 (en) * | 2003-04-03 | 2004-12-02 | Medtronic Vascular, Inc. | Methods and compositions for inhibiting narrowing in mammalian vascular pathways |
US8109987B2 (en) | 2003-04-14 | 2012-02-07 | Tryton Medical, Inc. | Method of treating a lumenal bifurcation |
US20040236399A1 (en) * | 2003-04-22 | 2004-11-25 | Medtronic Vascular, Inc. | Stent with improved surface adhesion |
US7563454B1 (en) * | 2003-05-01 | 2009-07-21 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices |
US8791171B2 (en) | 2003-05-01 | 2014-07-29 | Abbott Cardiovascular Systems Inc. | Biodegradable coatings for implantable medical devices |
ATE447904T1 (en) * | 2003-05-07 | 2009-11-15 | Advanced Bio Prosthetic Surfac | METAL IMPLANTABLE PROSTHESES AND PRODUCTION METHOD THEREOF |
US7279174B2 (en) | 2003-05-08 | 2007-10-09 | Advanced Cardiovascular Systems, Inc. | Stent coatings comprising hydrophilic additives |
US7618434B2 (en) * | 2003-05-12 | 2009-11-17 | University Of Florida Research Foundation, Inc. | Devices and methods for disruption and removal of luminal occlusions |
DE10323676A1 (en) * | 2003-05-15 | 2004-12-02 | Aesculap Ag & Co. Kg | Implant with long-term antibiotic effect |
US7323209B1 (en) | 2003-05-15 | 2008-01-29 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for coating stents |
US20050112273A1 (en) * | 2003-05-19 | 2005-05-26 | Stenzel Eric B. | Method of improving the quality and performance of a coating on a coated medical device using a solvent to reflow the coating |
US7731757B2 (en) * | 2003-06-01 | 2010-06-08 | Reflux Corporation | Obesity treatment |
US7169179B2 (en) * | 2003-06-05 | 2007-01-30 | Conor Medsystems, Inc. | Drug delivery device and method for bi-directional drug delivery |
US7186789B2 (en) | 2003-06-11 | 2007-03-06 | Advanced Cardiovascular Systems, Inc. | Bioabsorbable, biobeneficial polyester polymers for use in drug eluting stent coatings |
US20050118344A1 (en) | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
US7341630B1 (en) * | 2003-06-26 | 2008-03-11 | Advanced Cardiovascular Systems, Inc. | Stent coating system |
US7645504B1 (en) | 2003-06-26 | 2010-01-12 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices comprising hydrophobic and hydrophilic polymers |
US7875285B1 (en) | 2003-07-15 | 2011-01-25 | Advanced Cardiovascular Systems, Inc. | Medicated coatings for implantable medical devices having controlled rate of release |
US8308682B2 (en) | 2003-07-18 | 2012-11-13 | Broncus Medical Inc. | Devices for maintaining patency of surgically created channels in tissue |
US8002740B2 (en) * | 2003-07-18 | 2011-08-23 | Broncus Technologies, Inc. | Devices for maintaining patency of surgically created channels in tissue |
US20050021127A1 (en) * | 2003-07-21 | 2005-01-27 | Kawula Paul John | Porous glass fused onto stent for drug retention |
US20050021133A1 (en) * | 2003-07-22 | 2005-01-27 | Dong Li | Tubular stents sandwiched inside of a composite membrane and methods of making and using thereof |
US7056591B1 (en) | 2003-07-30 | 2006-06-06 | Advanced Cardiovascular Systems, Inc. | Hydrophobic biologically absorbable coatings for drug delivery devices and methods for fabricating the same |
US7169404B2 (en) | 2003-07-30 | 2007-01-30 | Advanced Cardiovasular Systems, Inc. | Biologically absorbable coatings for implantable devices and methods for fabricating the same |
US7645474B1 (en) | 2003-07-31 | 2010-01-12 | Advanced Cardiovascular Systems, Inc. | Method and system of purifying polymers for use with implantable medical devices |
US7431959B1 (en) | 2003-07-31 | 2008-10-07 | Advanced Cardiovascular Systems Inc. | Method and system for irradiation of a drug eluting implantable medical device |
US7785512B1 (en) | 2003-07-31 | 2010-08-31 | Advanced Cardiovascular Systems, Inc. | Method and system of controlled temperature mixing and molding of polymers with active agents for implantable medical devices |
CA2539110A1 (en) * | 2003-09-02 | 2005-03-24 | University Of Florida | Polymeric reconstrainable, repositionable, detachable, percutaneous endovascular stentgraft |
US7488343B2 (en) * | 2003-09-16 | 2009-02-10 | Boston Scientific Scimed, Inc. | Medical devices |
US7785653B2 (en) | 2003-09-22 | 2010-08-31 | Innovational Holdings Llc | Method and apparatus for loading a beneficial agent into an expandable medical device |
US7020947B2 (en) * | 2003-09-23 | 2006-04-04 | Fort Wayne Metals Research Products Corporation | Metal wire with filaments for biomedical applications |
US7789891B2 (en) * | 2003-09-23 | 2010-09-07 | Boston Scientific Scimed, Inc. | External activation of vaso-occlusive implants |
US7441513B1 (en) | 2003-09-26 | 2008-10-28 | Advanced Cardiovascular Systems, Inc. | Plasma-generated coating apparatus for medical devices and a method of coating deposition |
US7198675B2 (en) | 2003-09-30 | 2007-04-03 | Advanced Cardiovascular Systems | Stent mandrel fixture and method for selectively coating surfaces of a stent |
US7318932B2 (en) * | 2003-09-30 | 2008-01-15 | Advanced Cardiovascular Systems, Inc. | Coatings for drug delivery devices comprising hydrolitically stable adducts of poly(ethylene-co-vinyl alcohol) and methods for fabricating the same |
US7704544B2 (en) * | 2003-10-07 | 2010-04-27 | Advanced Cardiovascular Systems, Inc. | System and method for coating a tubular implantable medical device |
US7208172B2 (en) * | 2003-11-03 | 2007-04-24 | Medlogics Device Corporation | Metallic composite coating for delivery of therapeutic agents from the surface of implantable devices |
US7435256B2 (en) * | 2003-11-06 | 2008-10-14 | Boston Scientific Scimed, Inc. | Method and apparatus for controlled delivery of active substance |
US7329413B1 (en) | 2003-11-06 | 2008-02-12 | Advanced Cardiovascular Systems, Inc. | Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof |
US20050100577A1 (en) * | 2003-11-10 | 2005-05-12 | Parker Theodore L. | Expandable medical device with beneficial agent matrix formed by a multi solvent system |
US7261946B2 (en) * | 2003-11-14 | 2007-08-28 | Advanced Cardiovascular Systems, Inc. | Block copolymers of acrylates and methacrylates with fluoroalkenes |
US9114198B2 (en) | 2003-11-19 | 2015-08-25 | Advanced Cardiovascular Systems, Inc. | Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same |
AU2004293463A1 (en) * | 2003-11-20 | 2005-06-09 | Angiotech International Ag | Implantable sensors and implantable pumps and anti-scarring agents |
US8192752B2 (en) | 2003-11-21 | 2012-06-05 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable devices including biologically erodable polyesters and methods for fabricating the same |
US20050113904A1 (en) * | 2003-11-25 | 2005-05-26 | Shank Peter J. | Composite stent with inner and outer stent elements and method of using the same |
US8435285B2 (en) * | 2003-11-25 | 2013-05-07 | Boston Scientific Scimed, Inc. | Composite stent with inner and outer stent elements and method of using the same |
US7560492B1 (en) | 2003-11-25 | 2009-07-14 | Advanced Cardiovascular Systems, Inc. | Polysulfone block copolymers as drug-eluting coating material |
US7807722B2 (en) | 2003-11-26 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Biobeneficial coating compositions and methods of making and using thereof |
US20060085062A1 (en) * | 2003-11-28 | 2006-04-20 | Medlogics Device Corporation | Implantable stent with endothelialization factor |
US20050119723A1 (en) * | 2003-11-28 | 2005-06-02 | Medlogics Device Corporation | Medical device with porous surface containing bioerodable bioactive composites and related methods |
ATE531419T1 (en) * | 2003-12-15 | 2011-11-15 | Nitricare Hb | DEVICE FOR ADMINISTRATION OF THERAPEUTIC AGENTS |
US7220816B2 (en) | 2003-12-16 | 2007-05-22 | Advanced Cardiovascular Systems, Inc. | Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same |
US20050149174A1 (en) * | 2003-12-18 | 2005-07-07 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US20050154455A1 (en) * | 2003-12-18 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US20050154451A1 (en) * | 2003-12-18 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US7435788B2 (en) | 2003-12-19 | 2008-10-14 | Advanced Cardiovascular Systems, Inc. | Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents |
US20050137683A1 (en) * | 2003-12-19 | 2005-06-23 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US20050152943A1 (en) * | 2003-12-23 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US20050152942A1 (en) * | 2003-12-23 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US20050152940A1 (en) * | 2003-12-23 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US20050154452A1 (en) * | 2003-12-23 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US8309112B2 (en) | 2003-12-24 | 2012-11-13 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices comprising hydrophilic substances and methods for fabricating the same |
US20050159809A1 (en) * | 2004-01-21 | 2005-07-21 | Medtronic Vascular, Inc. | Implantable medical devices for treating or preventing restenosis |
US7211108B2 (en) | 2004-01-23 | 2007-05-01 | Icon Medical Corp. | Vascular grafts with amphiphilic block copolymer coatings |
US7349971B2 (en) * | 2004-02-05 | 2008-03-25 | Scenera Technologies, Llc | System for transmitting data utilizing multiple communication applications simultaneously in response to user request without specifying recipient's communication information |
DE102004029611A1 (en) * | 2004-02-06 | 2005-08-25 | Restate Patent Ag | Implant for e.g. releasing active substances into a vessel through which body fluids flow, comprises a base consisting of a biodegradable material as the carrier of the active substances |
CA2556212C (en) * | 2004-02-13 | 2013-05-28 | Conor Medsystems, Inc. | Implantable drug delivery device including wire filaments |
US8137397B2 (en) * | 2004-02-26 | 2012-03-20 | Boston Scientific Scimed, Inc. | Medical devices |
US7840263B2 (en) | 2004-02-27 | 2010-11-23 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression |
US8632580B2 (en) | 2004-12-29 | 2014-01-21 | Boston Scientific Scimed, Inc. | Flexible medical devices including metallic films |
US7901447B2 (en) | 2004-12-29 | 2011-03-08 | Boston Scientific Scimed, Inc. | Medical devices including a metallic film and at least one filament |
US8992592B2 (en) | 2004-12-29 | 2015-03-31 | Boston Scientific Scimed, Inc. | Medical devices including metallic films |
US8591568B2 (en) | 2004-03-02 | 2013-11-26 | Boston Scientific Scimed, Inc. | Medical devices including metallic films and methods for making same |
US8998973B2 (en) | 2004-03-02 | 2015-04-07 | Boston Scientific Scimed, Inc. | Medical devices including metallic films |
US8685431B2 (en) | 2004-03-16 | 2014-04-01 | Advanced Cardiovascular Systems, Inc. | Biologically absorbable coatings for implantable devices based on copolymers having ester bonds and methods for fabricating the same |
US8551512B2 (en) | 2004-03-22 | 2013-10-08 | Advanced Cardiovascular Systems, Inc. | Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS |
US20050208093A1 (en) * | 2004-03-22 | 2005-09-22 | Thierry Glauser | Phosphoryl choline coating compositions |
US20050214339A1 (en) | 2004-03-29 | 2005-09-29 | Yiwen Tang | Biologically degradable compositions for medical applications |
US8778014B1 (en) | 2004-03-31 | 2014-07-15 | Advanced Cardiovascular Systems, Inc. | Coatings for preventing balloon damage to polymer coated stents |
US20050220853A1 (en) * | 2004-04-02 | 2005-10-06 | Kinh-Luan Dao | Controlled delivery of therapeutic agents from medical articles |
CN1964748A (en) | 2004-04-06 | 2007-05-16 | 苏莫迪克斯公司 | Coating compositions for bioactive agents |
US20050228490A1 (en) * | 2004-04-09 | 2005-10-13 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US7553377B1 (en) * | 2004-04-27 | 2009-06-30 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for electrostatic coating of an abluminal stent surface |
US20050265960A1 (en) * | 2004-05-26 | 2005-12-01 | Pacetti Stephen D | Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same |
US8293890B2 (en) | 2004-04-30 | 2012-10-23 | Advanced Cardiovascular Systems, Inc. | Hyaluronic acid based copolymers |
US7820732B2 (en) | 2004-04-30 | 2010-10-26 | Advanced Cardiovascular Systems, Inc. | Methods for modulating thermal and mechanical properties of coatings on implantable devices |
US20050255230A1 (en) * | 2004-05-17 | 2005-11-17 | Clerc Claude O | Method of manufacturing a covered stent |
US7390524B1 (en) | 2004-05-20 | 2008-06-24 | Advanced Cardiovascular Systems, Inc. | Method for electrostatic spraying of an abluminal stent surface |
US20050261762A1 (en) * | 2004-05-21 | 2005-11-24 | Medtronic Vascular, Inc. | Medical devices to prevent or inhibit restenosis |
US20050266039A1 (en) * | 2004-05-27 | 2005-12-01 | Jan Weber | Coated medical device and method for making the same |
US9561309B2 (en) | 2004-05-27 | 2017-02-07 | Advanced Cardiovascular Systems, Inc. | Antifouling heparin coatings |
US7764995B2 (en) | 2004-06-07 | 2010-07-27 | Cardiac Pacemakers, Inc. | Method and apparatus to modulate cellular regeneration post myocardial infarct |
KR100596218B1 (en) * | 2004-06-10 | 2006-07-03 | (주)액세스 플러스 | Tube conntecting artery to vein for hemodialysis |
US7563780B1 (en) | 2004-06-18 | 2009-07-21 | Advanced Cardiovascular Systems, Inc. | Heparin prodrugs and drug delivery stents formed therefrom |
WO2006002112A1 (en) * | 2004-06-18 | 2006-01-05 | Surmodics, Inc. | Devices, articles, coatings, and methods for controlled active agent release |
US7794490B2 (en) * | 2004-06-22 | 2010-09-14 | Boston Scientific Scimed, Inc. | Implantable medical devices with antimicrobial and biodegradable matrices |
US20050287287A1 (en) * | 2004-06-24 | 2005-12-29 | Parker Theodore L | Methods and systems for loading an implantable medical device with beneficial agent |
US8568469B1 (en) | 2004-06-28 | 2013-10-29 | Advanced Cardiovascular Systems, Inc. | Stent locking element and a method of securing a stent on a delivery system |
US8241554B1 (en) | 2004-06-29 | 2012-08-14 | Advanced Cardiovascular Systems, Inc. | Method of forming a stent pattern on a tube |
US20050287184A1 (en) | 2004-06-29 | 2005-12-29 | Hossainy Syed F A | Drug-delivery stent formulations for restenosis and vulnerable plaque |
US20060009839A1 (en) * | 2004-07-12 | 2006-01-12 | Scimed Life Systems, Inc. | Composite vascular graft including bioactive agent coating and biodegradable sheath |
WO2006017275A1 (en) | 2004-07-13 | 2006-02-16 | The University Of Tennessee Research Foundation | Adhesive composition for carrying therapeutic agents as delivery vehicle on coatings applied to vascular grafts |
EP1786499A2 (en) * | 2004-07-19 | 2007-05-23 | Broncus Technologies, Inc. | Methods and devices for maintaining patency of surgically created channels in a body organ |
CA2577634C (en) * | 2004-07-19 | 2015-07-07 | Protemix Corporation Limited | Synthesis of triethylenetetramines |
US8409167B2 (en) | 2004-07-19 | 2013-04-02 | Broncus Medical Inc | Devices for delivering substances through an extra-anatomic opening created in an airway |
US8048145B2 (en) | 2004-07-22 | 2011-11-01 | Endologix, Inc. | Graft systems having filling structures supported by scaffolds and methods for their use |
US7971333B2 (en) | 2006-05-30 | 2011-07-05 | Advanced Cardiovascular Systems, Inc. | Manufacturing process for polymetric stents |
US20060020330A1 (en) * | 2004-07-26 | 2006-01-26 | Bin Huang | Method of fabricating an implantable medical device with biaxially oriented polymers |
US8747878B2 (en) | 2006-04-28 | 2014-06-10 | Advanced Cardiovascular Systems, Inc. | Method of fabricating an implantable medical device by controlling crystalline structure |
US8747879B2 (en) | 2006-04-28 | 2014-06-10 | Advanced Cardiovascular Systems, Inc. | Method of fabricating an implantable medical device to reduce chance of late inflammatory response |
US7731890B2 (en) | 2006-06-15 | 2010-06-08 | Advanced Cardiovascular Systems, Inc. | Methods of fabricating stents with enhanced fracture toughness |
US8778256B1 (en) | 2004-09-30 | 2014-07-15 | Advanced Cardiovascular Systems, Inc. | Deformation of a polymer tube in the fabrication of a medical article |
US7494665B1 (en) | 2004-07-30 | 2009-02-24 | Advanced Cardiovascular Systems, Inc. | Polymers containing siloxane monomers |
US8357391B2 (en) | 2004-07-30 | 2013-01-22 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages |
US20060025852A1 (en) * | 2004-08-02 | 2006-02-02 | Armstrong Joseph R | Bioabsorbable self-expanding endolumenal devices |
US7311980B1 (en) | 2004-08-02 | 2007-12-25 | Advanced Cardiovascular Systems, Inc. | Polyactive/polylactic acid coatings for an implantable device |
US8980300B2 (en) | 2004-08-05 | 2015-03-17 | Advanced Cardiovascular Systems, Inc. | Plasticizers for coating compositions |
US7601382B2 (en) * | 2004-08-05 | 2009-10-13 | Boston Scientific Scimed, Inc. | Method of making a coated medical device |
US20060041102A1 (en) * | 2004-08-23 | 2006-02-23 | Advanced Cardiovascular Systems, Inc. | Implantable devices comprising biologically absorbable polymers having constant rate of degradation and methods for fabricating the same |
US9283099B2 (en) | 2004-08-25 | 2016-03-15 | Advanced Cardiovascular Systems, Inc. | Stent-catheter assembly with a releasable connection for stent retention |
US7648727B2 (en) | 2004-08-26 | 2010-01-19 | Advanced Cardiovascular Systems, Inc. | Methods for manufacturing a coated stent-balloon assembly |
US7244443B2 (en) * | 2004-08-31 | 2007-07-17 | Advanced Cardiovascular Systems, Inc. | Polymers of fluorinated monomers and hydrophilic monomers |
US7507433B2 (en) * | 2004-09-03 | 2009-03-24 | Boston Scientific Scimed, Inc. | Method of coating a medical device using an electrowetting process |
US7229471B2 (en) * | 2004-09-10 | 2007-06-12 | Advanced Cardiovascular Systems, Inc. | Compositions containing fast-leaching plasticizers for improved performance of medical devices |
US20060054604A1 (en) * | 2004-09-10 | 2006-03-16 | Saunders Richard J | Laser process to produce drug delivery channel in metal stents |
US7063720B2 (en) * | 2004-09-14 | 2006-06-20 | The Wallace Enterprises, Inc. | Covered stent with controlled therapeutic agent diffusion |
US20060064133A1 (en) | 2004-09-17 | 2006-03-23 | Cardiac Pacemakers, Inc. | System and method for deriving relative physiologic measurements using an external computing device |
US20060062822A1 (en) * | 2004-09-21 | 2006-03-23 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US8110211B2 (en) | 2004-09-22 | 2012-02-07 | Advanced Cardiovascular Systems, Inc. | Medicated coatings for implantable medical devices including polyacrylates |
US7901451B2 (en) | 2004-09-24 | 2011-03-08 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
CA2581855C (en) * | 2004-09-28 | 2012-11-27 | Cordis Corporation | Thin film medical device and delivery system |
US7875233B2 (en) | 2004-09-30 | 2011-01-25 | Advanced Cardiovascular Systems, Inc. | Method of fabricating a biaxially oriented implantable medical device |
US9011831B2 (en) * | 2004-09-30 | 2015-04-21 | Advanced Cardiovascular Systems, Inc. | Methacrylate copolymers for medical devices |
US8173062B1 (en) | 2004-09-30 | 2012-05-08 | Advanced Cardiovascular Systems, Inc. | Controlled deformation of a polymer tube in fabricating a medical article |
US8043553B1 (en) | 2004-09-30 | 2011-10-25 | Advanced Cardiovascular Systems, Inc. | Controlled deformation of a polymer tube with a restraining surface in fabricating a medical article |
EP1814490A2 (en) * | 2004-10-06 | 2007-08-08 | Cook Incorporated | Medical device with bioactive agent |
US7166680B2 (en) | 2004-10-06 | 2007-01-23 | Advanced Cardiovascular Systems, Inc. | Blends of poly(ester amide) polymers |
US20070197538A1 (en) * | 2004-10-07 | 2007-08-23 | Mark Nesbit | Anti-vascular and anti-proliferation methods, therapies, and combinations employing specific tyrosine kinase inhibitors |
US20060085065A1 (en) * | 2004-10-15 | 2006-04-20 | Krause Arthur A | Stent with auxiliary treatment structure |
US20060083770A1 (en) * | 2004-10-15 | 2006-04-20 | Specialty Coating Systems, Inc. | Medical devices and methods of preparation and use |
US20060083859A1 (en) | 2004-10-20 | 2006-04-20 | Todd Robida | Magnetic levitation system for coating a device, a method of using the system, and device made by the system |
US20060088571A1 (en) * | 2004-10-21 | 2006-04-27 | Medtronic Vascular, Inc. | Biocompatible and hemocompatible polymer compositions |
US9114162B2 (en) | 2004-10-25 | 2015-08-25 | Celonova Biosciences, Inc. | Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same |
US9107850B2 (en) | 2004-10-25 | 2015-08-18 | Celonova Biosciences, Inc. | Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
US20210299056A9 (en) | 2004-10-25 | 2021-09-30 | Varian Medical Systems, Inc. | Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods |
US20060089485A1 (en) * | 2004-10-27 | 2006-04-27 | Desnoyer Jessica R | End-capped poly(ester amide) copolymers |
US8603634B2 (en) | 2004-10-27 | 2013-12-10 | Abbott Cardiovascular Systems Inc. | End-capped poly(ester amide) copolymers |
US7390497B2 (en) | 2004-10-29 | 2008-06-24 | Advanced Cardiovascular Systems, Inc. | Poly(ester amide) filler blends for modulation of coating properties |
US20060095122A1 (en) * | 2004-10-29 | 2006-05-04 | Advanced Cardiovascular Systems, Inc. | Implantable devices comprising biologically absorbable star polymers and methods for fabricating the same |
US7481835B1 (en) | 2004-10-29 | 2009-01-27 | Advanced Cardiovascular Systems, Inc. | Encapsulated covered stent |
US20060093642A1 (en) * | 2004-11-03 | 2006-05-04 | Ranade Shrirang V | Method of incorporating carbon nanotubes in a medical appliance, a carbon nanotube medical appliance, and a medical appliance coated using carbon nanotube technology |
US7214759B2 (en) | 2004-11-24 | 2007-05-08 | Advanced Cardiovascular Systems, Inc. | Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same |
US7813808B1 (en) | 2004-11-24 | 2010-10-12 | Remon Medical Technologies Ltd | Implanted sensor system with optimized operational and sensing parameters |
US7588642B1 (en) | 2004-11-29 | 2009-09-15 | Advanced Cardiovascular Systems, Inc. | Abluminal stent coating apparatus and method using a brush assembly |
US8609123B2 (en) | 2004-11-29 | 2013-12-17 | Advanced Cardiovascular Systems, Inc. | Derivatized poly(ester amide) as a biobeneficial coating |
US20060115449A1 (en) * | 2004-11-30 | 2006-06-01 | Advanced Cardiovascular Systems, Inc. | Bioabsorbable, biobeneficial, tyrosine-based polymers for use in drug eluting stent coatings |
US7892592B1 (en) * | 2004-11-30 | 2011-02-22 | Advanced Cardiovascular Systems, Inc. | Coating abluminal surfaces of stents and other implantable medical devices |
JP2008522747A (en) * | 2004-12-08 | 2008-07-03 | クック・インコーポレイテッド | Medical devices coated with contrast media |
US20060127443A1 (en) * | 2004-12-09 | 2006-06-15 | Helmus Michael N | Medical devices having vapor deposited nanoporous coatings for controlled therapeutic agent delivery |
US7632307B2 (en) * | 2004-12-16 | 2009-12-15 | Advanced Cardiovascular Systems, Inc. | Abluminal, multilayer coating constructs for drug-delivery stents |
US8874204B2 (en) | 2004-12-20 | 2014-10-28 | Cardiac Pacemakers, Inc. | Implantable medical devices comprising isolated extracellular matrix |
US8060219B2 (en) * | 2004-12-20 | 2011-11-15 | Cardiac Pacemakers, Inc. | Epicardial patch including isolated extracellular matrix with pacing electrodes |
WO2006068516A1 (en) * | 2004-12-20 | 2006-06-29 | Protemix Corporation Limited | Implantable medical devices coated with or containing copper chelating compounds |
US7981065B2 (en) | 2004-12-20 | 2011-07-19 | Cardiac Pacemakers, Inc. | Lead electrode incorporating extracellular matrix |
US7604818B2 (en) | 2004-12-22 | 2009-10-20 | Advanced Cardiovascular Systems, Inc. | Polymers of fluorinated monomers and hydrocarbon monomers |
US7419504B2 (en) | 2004-12-27 | 2008-09-02 | Advanced Cardiovascular Systems, Inc. | Poly(ester amide) block copolymers |
US8007775B2 (en) | 2004-12-30 | 2011-08-30 | Advanced Cardiovascular Systems, Inc. | Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same |
US7344601B2 (en) * | 2005-01-05 | 2008-03-18 | Boston Scientific Scimed, Inc. | Integrated cross-wire fixture for coating a device, a method of using the fixture, and a device made using the fixture |
US8287583B2 (en) | 2005-01-10 | 2012-10-16 | Taheri Laduca Llc | Apparatus and method for deploying an implantable device within the body |
US7202325B2 (en) | 2005-01-14 | 2007-04-10 | Advanced Cardiovascular Systems, Inc. | Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles |
US7161076B2 (en) * | 2005-02-16 | 2007-01-09 | Chia-Chun Hsu | Button structure of saxophone |
US7491225B2 (en) | 2005-02-16 | 2009-02-17 | Boston Scientific Scimed, Inc. | System and method for deploying a drug-eluting external body and tissue scaffold |
US8735394B2 (en) * | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
MX339142B (en) * | 2005-02-18 | 2016-05-13 | Abraxis Bioscience Llc | Combinations and modes of administration of therapeutic agents and combination therapy. |
US9452001B2 (en) * | 2005-02-22 | 2016-09-27 | Tecres S.P.A. | Disposable device for treatment of infections of human limbs |
US20060193891A1 (en) * | 2005-02-25 | 2006-08-31 | Robert Richard | Medical devices and therapeutic delivery devices composed of bioabsorbable polymers produced at room temperature, method of making the devices, and a system for making the devices |
AU2005100176A4 (en) * | 2005-03-01 | 2005-04-07 | Gym Tv Pty Ltd | Garbage bin clip |
US20060201601A1 (en) * | 2005-03-03 | 2006-09-14 | Icon Interventional Systems, Inc. | Flexible markers |
US20060200048A1 (en) * | 2005-03-03 | 2006-09-07 | Icon Medical Corp. | Removable sheath for device protection |
US20060264914A1 (en) * | 2005-03-03 | 2006-11-23 | Icon Medical Corp. | Metal alloys for medical devices |
US8323333B2 (en) | 2005-03-03 | 2012-12-04 | Icon Medical Corp. | Fragile structure protective coating |
US9107899B2 (en) | 2005-03-03 | 2015-08-18 | Icon Medical Corporation | Metal alloys for medical devices |
WO2006110197A2 (en) | 2005-03-03 | 2006-10-19 | Icon Medical Corp. | Polymer biodegradable medical device |
JP5335244B2 (en) | 2005-03-03 | 2013-11-06 | アイコン メディカル コーポレーション | Medical member using improved metal alloy |
US7540995B2 (en) | 2005-03-03 | 2009-06-02 | Icon Medical Corp. | Process for forming an improved metal alloy stent |
ATE538833T1 (en) * | 2005-03-18 | 2012-01-15 | Cook Medical Technologies Llc | WIRE GUIDES WITH NEW OUTER LAYER AREAS AND CHAMBERS TO IMPROVE HYDROPHILIC PROPERTIES AND RELEASE OF THERAPEUTIC ACTIVE INGREDIENTS |
US7700659B2 (en) | 2005-03-24 | 2010-04-20 | Advanced Cardiovascular Systems, Inc. | Implantable devices formed of non-fouling methacrylate or acrylate polymers |
US9381279B2 (en) | 2005-03-24 | 2016-07-05 | Abbott Cardiovascular Systems Inc. | Implantable devices formed on non-fouling methacrylate or acrylate polymers |
US20060224226A1 (en) * | 2005-03-31 | 2006-10-05 | Bin Huang | In-vivo radial orientation of a polymeric implantable medical device |
CA2604419C (en) | 2005-04-05 | 2015-03-24 | Elixir Medical Corporation | Degradable implantable medical devices |
US7381048B2 (en) | 2005-04-12 | 2008-06-03 | Advanced Cardiovascular Systems, Inc. | Stents with profiles for gripping a balloon catheter and molds for fabricating stents |
US7795467B1 (en) | 2005-04-26 | 2010-09-14 | Advanced Cardiovascular Systems, Inc. | Bioabsorbable, biobeneficial polyurethanes for use in medical devices |
US20060246210A1 (en) * | 2005-04-29 | 2006-11-02 | Vascular Architects Inc., A Delaware Corporation | Method for making a covered drug-eluting stent |
US8778375B2 (en) | 2005-04-29 | 2014-07-15 | Advanced Cardiovascular Systems, Inc. | Amorphous poly(D,L-lactide) coating |
US7637941B1 (en) | 2005-05-11 | 2009-12-29 | Advanced Cardiovascular Systems, Inc. | Endothelial cell binding coatings for rapid encapsulation of bioerodable stents |
US7854760B2 (en) | 2005-05-16 | 2010-12-21 | Boston Scientific Scimed, Inc. | Medical devices including metallic films |
US7291166B2 (en) * | 2005-05-18 | 2007-11-06 | Advanced Cardiovascular Systems, Inc. | Polymeric stent patterns |
WO2006130873A2 (en) * | 2005-06-01 | 2006-12-07 | Broncus Technologies, Inc. | Methods and devices for maintaining surgically created channels in a body organ |
WO2006130836A2 (en) | 2005-06-02 | 2006-12-07 | Cordis Corporation | Patent foramen ovale closure device |
US7622070B2 (en) * | 2005-06-20 | 2009-11-24 | Advanced Cardiovascular Systems, Inc. | Method of manufacturing an implantable polymeric medical device |
US20070009564A1 (en) * | 2005-06-22 | 2007-01-11 | Mcclain James B | Drug/polymer composite materials and methods of making the same |
US7823533B2 (en) | 2005-06-30 | 2010-11-02 | Advanced Cardiovascular Systems, Inc. | Stent fixture and method for reducing coating defects |
US20070038176A1 (en) * | 2005-07-05 | 2007-02-15 | Jan Weber | Medical devices with machined layers for controlled communications with underlying regions |
AU2006269419A1 (en) | 2005-07-07 | 2007-01-18 | Nellix, Inc. | Systems and methods for endovascular aneurysm treatment |
US8021676B2 (en) | 2005-07-08 | 2011-09-20 | Advanced Cardiovascular Systems, Inc. | Functionalized chemically inert polymers for coatings |
CA2615452C (en) | 2005-07-15 | 2015-03-31 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
US20090062909A1 (en) * | 2005-07-15 | 2009-03-05 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
US20070020312A1 (en) * | 2005-07-20 | 2007-01-25 | Desnoyer Jessica R | Method of fabricating a bioactive agent-releasing implantable medical device |
US7785647B2 (en) | 2005-07-25 | 2010-08-31 | Advanced Cardiovascular Systems, Inc. | Methods of providing antioxidants to a drug containing product |
US20070027530A1 (en) * | 2005-07-26 | 2007-02-01 | Medtronic Vascular, Inc. | Intraluminal device, catheter assembly, and method of use thereof |
WO2007016251A2 (en) * | 2005-07-28 | 2007-02-08 | Cook Incorporated | Implantable thromboresistant valve |
US7735449B1 (en) | 2005-07-28 | 2010-06-15 | Advanced Cardiovascular Systems, Inc. | Stent fixture having rounded support structures and method for use thereof |
US7658880B2 (en) | 2005-07-29 | 2010-02-09 | Advanced Cardiovascular Systems, Inc. | Polymeric stent polishing method and apparatus |
US7297758B2 (en) * | 2005-08-02 | 2007-11-20 | Advanced Cardiovascular Systems, Inc. | Method for extending shelf-life of constructs of semi-crystallizable polymers |
US20070038290A1 (en) * | 2005-08-15 | 2007-02-15 | Bin Huang | Fiber reinforced composite stents |
US7476245B2 (en) * | 2005-08-16 | 2009-01-13 | Advanced Cardiovascular Systems, Inc. | Polymeric stent patterns |
US9248034B2 (en) | 2005-08-23 | 2016-02-02 | Advanced Cardiovascular Systems, Inc. | Controlled disintegrating implantable medical devices |
US20070045255A1 (en) * | 2005-08-23 | 2007-03-01 | Klaus Kleine | Laser induced plasma machining with an optimized process gas |
US20070045252A1 (en) * | 2005-08-23 | 2007-03-01 | Klaus Kleine | Laser induced plasma machining with a process gas |
WO2007028092A1 (en) | 2005-09-01 | 2007-03-08 | Cordis Corporation | Patent foramen ovale closure method |
DE102005042372B3 (en) * | 2005-09-07 | 2007-01-18 | Dräger Medical AG & Co. KG | Artificial respiration and/or anesthetic device comprises hydrophilic polymer material surface that contains silver particle and mineral filler such as zeolite, silicon dioxide, titanium dioxide, alumina, and zircon oxide |
US20070061006A1 (en) * | 2005-09-14 | 2007-03-15 | Nathan Desatnik | Methods of making shape memory films by chemical vapor deposition and shape memory devices made thereby |
US8663308B2 (en) * | 2005-09-19 | 2014-03-04 | Cook Medical Technologies Llc | Graft with bioabsorbable support frame |
US20070067020A1 (en) * | 2005-09-22 | 2007-03-22 | Medtronic Vasular, Inc. | Intraluminal stent, delivery system, and a method of treating a vascular condition |
US20070077435A1 (en) * | 2005-10-05 | 2007-04-05 | Schachter Deborah M | Process for coating a medical device |
US7838023B2 (en) * | 2005-11-16 | 2010-11-23 | Nitromed, Inc. | Furoxan compounds, compositions and methods of use |
US20070128342A1 (en) * | 2005-12-02 | 2007-06-07 | Stenzel Eric B | Method and system for coating a medical device |
US20070128246A1 (en) * | 2005-12-06 | 2007-06-07 | Hossainy Syed F A | Solventless method for forming a coating |
US20070135909A1 (en) * | 2005-12-08 | 2007-06-14 | Desnoyer Jessica R | Adhesion polymers to improve stent retention |
US10029034B2 (en) * | 2005-12-15 | 2018-07-24 | CARDINAL HEALTH SWITZERLAND 515 GmbH | Drug-eluting articles with improved drug release profiles |
US7591841B2 (en) | 2005-12-16 | 2009-09-22 | Advanced Cardiovascular Systems, Inc. | Implantable devices for accelerated healing |
US7976891B1 (en) | 2005-12-16 | 2011-07-12 | Advanced Cardiovascular Systems, Inc. | Abluminal stent coating apparatus and method of using focused acoustic energy |
US7638156B1 (en) | 2005-12-19 | 2009-12-29 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for selectively coating a medical article |
US7867547B2 (en) | 2005-12-19 | 2011-01-11 | Advanced Cardiovascular Systems, Inc. | Selectively coating luminal surfaces of stents |
US8647654B2 (en) * | 2005-12-22 | 2014-02-11 | The Penn State Research Foundation | Method and systems for forming and using nanoengineered sculptured thin films |
US20070148390A1 (en) * | 2005-12-27 | 2007-06-28 | Specialty Coating Systems, Inc. | Fluorinated coatings |
US20070151961A1 (en) * | 2006-01-03 | 2007-07-05 | Klaus Kleine | Fabrication of an implantable medical device with a modified laser beam |
US20070156230A1 (en) * | 2006-01-04 | 2007-07-05 | Dugan Stephen R | Stents with radiopaque markers |
US8840660B2 (en) | 2006-01-05 | 2014-09-23 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US20080286325A1 (en) * | 2006-01-05 | 2008-11-20 | Med Institute, Inc. | Cyclodextrin elution media for medical device coatings comprising a taxane therapeutic agent |
US7919108B2 (en) * | 2006-03-10 | 2011-04-05 | Cook Incorporated | Taxane coatings for implantable medical devices |
US7951185B1 (en) | 2006-01-06 | 2011-05-31 | Advanced Cardiovascular Systems, Inc. | Delivery of a stent at an elevated temperature |
US20070179219A1 (en) * | 2006-01-31 | 2007-08-02 | Bin Huang | Method of fabricating an implantable medical device using gel extrusion and charge induced orientation |
US8089029B2 (en) | 2006-02-01 | 2012-01-03 | Boston Scientific Scimed, Inc. | Bioabsorbable metal medical device and method of manufacture |
WO2007092735A2 (en) | 2006-02-02 | 2007-08-16 | Innovative Bio Therapies | An extracorporeal cell-based therapeutic device and delivery system |
US20070190104A1 (en) * | 2006-02-13 | 2007-08-16 | Kamath Kalpana R | Coating comprising an adhesive polymeric material for a medical device and method of preparing the same |
US20070196428A1 (en) | 2006-02-17 | 2007-08-23 | Thierry Glauser | Nitric oxide generating medical devices |
US7601383B2 (en) | 2006-02-28 | 2009-10-13 | Advanced Cardiovascular Systems, Inc. | Coating construct containing poly (vinyl alcohol) |
US7713637B2 (en) | 2006-03-03 | 2010-05-11 | Advanced Cardiovascular Systems, Inc. | Coating containing PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid polymer |
US7875284B2 (en) * | 2006-03-10 | 2011-01-25 | Cook Incorporated | Methods of manufacturing and modifying taxane coatings for implantable medical devices |
US20070224235A1 (en) | 2006-03-24 | 2007-09-27 | Barron Tenney | Medical devices having nanoporous coatings for controlled therapeutic agent delivery |
US8187620B2 (en) | 2006-03-27 | 2012-05-29 | Boston Scientific Scimed, Inc. | Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents |
US20070231361A1 (en) * | 2006-03-28 | 2007-10-04 | Medtronic Vascular, Inc. | Use of Fatty Acids to Inhibit the Growth of Aneurysms |
US20070231363A1 (en) * | 2006-03-29 | 2007-10-04 | Yung-Ming Chen | Coatings formed from stimulus-sensitive material |
US7964210B2 (en) | 2006-03-31 | 2011-06-21 | Abbott Cardiovascular Systems Inc. | Degradable polymeric implantable medical devices with a continuous phase and discrete phase |
US8048150B2 (en) | 2006-04-12 | 2011-11-01 | Boston Scientific Scimed, Inc. | Endoprosthesis having a fiber meshwork disposed thereon |
US8303648B2 (en) * | 2006-04-25 | 2012-11-06 | Cook Medical Technologies Llc | Artificial venous valve containing therapeutic agent |
CA2996768C (en) | 2006-04-26 | 2020-12-08 | Micell Technologies, Inc. | Coatings containing multiple drugs |
US20070254012A1 (en) * | 2006-04-28 | 2007-11-01 | Ludwig Florian N | Controlled degradation and drug release in stents |
US20070259101A1 (en) * | 2006-05-02 | 2007-11-08 | Kleiner Lothar W | Microporous coating on medical devices |
US8304012B2 (en) | 2006-05-04 | 2012-11-06 | Advanced Cardiovascular Systems, Inc. | Method for drying a stent |
US7985441B1 (en) | 2006-05-04 | 2011-07-26 | Yiwen Tang | Purification of polymers for coating applications |
US8003156B2 (en) | 2006-05-04 | 2011-08-23 | Advanced Cardiovascular Systems, Inc. | Rotatable support elements for stents |
WO2007133479A2 (en) * | 2006-05-10 | 2007-11-22 | Cook Incorporated | Delivery of elastin-stabilizing compound within a body lumen |
US20070264303A1 (en) * | 2006-05-12 | 2007-11-15 | Liliana Atanasoska | Coating for medical devices comprising an inorganic or ceramic oxide and a therapeutic agent |
US20070275035A1 (en) * | 2006-05-24 | 2007-11-29 | Microchips, Inc. | Minimally Invasive Medical Implant Devices for Controlled Drug Delivery |
US7761968B2 (en) | 2006-05-25 | 2010-07-27 | Advanced Cardiovascular Systems, Inc. | Method of crimping a polymeric stent |
US8752268B2 (en) | 2006-05-26 | 2014-06-17 | Abbott Cardiovascular Systems Inc. | Method of making stents with radiopaque markers |
US7775178B2 (en) * | 2006-05-26 | 2010-08-17 | Advanced Cardiovascular Systems, Inc. | Stent coating apparatus and method |
US7951194B2 (en) | 2006-05-26 | 2011-05-31 | Abbott Cardiovascular Sysetms Inc. | Bioabsorbable stent with radiopaque coating |
US7842737B2 (en) | 2006-09-29 | 2010-11-30 | Abbott Cardiovascular Systems Inc. | Polymer blend-bioceramic composite implantable medical devices |
US7959940B2 (en) | 2006-05-30 | 2011-06-14 | Advanced Cardiovascular Systems, Inc. | Polymer-bioceramic composite implantable medical devices |
US20070282434A1 (en) * | 2006-05-30 | 2007-12-06 | Yunbing Wang | Copolymer-bioceramic composite implantable medical devices |
US8343530B2 (en) | 2006-05-30 | 2013-01-01 | Abbott Cardiovascular Systems Inc. | Polymer-and polymer blend-bioceramic composite implantable medical devices |
US9561351B2 (en) | 2006-05-31 | 2017-02-07 | Advanced Cardiovascular Systems, Inc. | Drug delivery spiral coil construct |
US20080058916A1 (en) * | 2006-05-31 | 2008-03-06 | Bin Huang | Method of fabricating polymeric self-expandable stent |
US8568764B2 (en) | 2006-05-31 | 2013-10-29 | Advanced Cardiovascular Systems, Inc. | Methods of forming coating layers for medical devices utilizing flash vaporization |
US8486135B2 (en) | 2006-06-01 | 2013-07-16 | Abbott Cardiovascular Systems Inc. | Implantable medical devices fabricated from branched polymers |
US20070281073A1 (en) * | 2006-06-01 | 2007-12-06 | Gale David C | Enhanced adhesion of drug delivery coatings on stents |
US8034287B2 (en) | 2006-06-01 | 2011-10-11 | Abbott Cardiovascular Systems Inc. | Radiation sterilization of medical devices |
US20070282433A1 (en) * | 2006-06-01 | 2007-12-06 | Limon Timothy A | Stent with retention protrusions formed during crimping |
US8703167B2 (en) | 2006-06-05 | 2014-04-22 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug |
US20080124372A1 (en) * | 2006-06-06 | 2008-05-29 | Hossainy Syed F A | Morphology profiles for control of agent release rates from polymer matrices |
US20070286882A1 (en) * | 2006-06-09 | 2007-12-13 | Yiwen Tang | Solvent systems for coating medical devices |
US8778376B2 (en) | 2006-06-09 | 2014-07-15 | Advanced Cardiovascular Systems, Inc. | Copolymer comprising elastin pentapeptide block and hydrophilic block, and medical device and method of treating |
US20070286941A1 (en) * | 2006-06-13 | 2007-12-13 | Bin Huang | Surface treatment of a polymeric stent |
US20080095918A1 (en) * | 2006-06-14 | 2008-04-24 | Kleiner Lothar W | Coating construct with enhanced interfacial compatibility |
US8114150B2 (en) | 2006-06-14 | 2012-02-14 | Advanced Cardiovascular Systems, Inc. | RGD peptide attached to bioabsorbable stents |
US8603530B2 (en) | 2006-06-14 | 2013-12-10 | Abbott Cardiovascular Systems Inc. | Nanoshell therapy |
US8048448B2 (en) | 2006-06-15 | 2011-11-01 | Abbott Cardiovascular Systems Inc. | Nanoshells for drug delivery |
US8535372B1 (en) | 2006-06-16 | 2013-09-17 | Abbott Cardiovascular Systems Inc. | Bioabsorbable stent with prohealing layer |
US20070290412A1 (en) * | 2006-06-19 | 2007-12-20 | John Capek | Fabricating a stent with selected properties in the radial and axial directions |
US8333000B2 (en) | 2006-06-19 | 2012-12-18 | Advanced Cardiovascular Systems, Inc. | Methods for improving stent retention on a balloon catheter |
US8017237B2 (en) | 2006-06-23 | 2011-09-13 | Abbott Cardiovascular Systems, Inc. | Nanoshells on polymers |
US9072820B2 (en) | 2006-06-26 | 2015-07-07 | Advanced Cardiovascular Systems, Inc. | Polymer composite stent with polymer particles |
US8128688B2 (en) | 2006-06-27 | 2012-03-06 | Abbott Cardiovascular Systems Inc. | Carbon coating on an implantable device |
US20070299511A1 (en) * | 2006-06-27 | 2007-12-27 | Gale David C | Thin stent coating |
US8815275B2 (en) | 2006-06-28 | 2014-08-26 | Boston Scientific Scimed, Inc. | Coatings for medical devices comprising a therapeutic agent and a metallic material |
WO2008005297A2 (en) * | 2006-06-29 | 2008-01-10 | Massachusetts Institute Of Technology | Coating of devices with effector compounds |
US7794776B1 (en) | 2006-06-29 | 2010-09-14 | Abbott Cardiovascular Systems Inc. | Modification of polymer stents with radiation |
CA2655793A1 (en) | 2006-06-29 | 2008-01-03 | Boston Scientific Limited | Medical devices with selective coating |
US8956640B2 (en) * | 2006-06-29 | 2015-02-17 | Advanced Cardiovascular Systems, Inc. | Block copolymers including a methoxyethyl methacrylate midblock |
US7740791B2 (en) | 2006-06-30 | 2010-06-22 | Advanced Cardiovascular Systems, Inc. | Method of fabricating a stent with features by blow molding |
US20080008736A1 (en) * | 2006-07-06 | 2008-01-10 | Thierry Glauser | Random copolymers of methacrylates and acrylates |
US9028859B2 (en) | 2006-07-07 | 2015-05-12 | Advanced Cardiovascular Systems, Inc. | Phase-separated block copolymer coatings for implantable medical devices |
US20080009938A1 (en) * | 2006-07-07 | 2008-01-10 | Bin Huang | Stent with a radiopaque marker and method for making the same |
US7823263B2 (en) | 2006-07-11 | 2010-11-02 | Abbott Cardiovascular Systems Inc. | Method of removing stent islands from a stent |
US20080014244A1 (en) * | 2006-07-13 | 2008-01-17 | Gale David C | Implantable medical devices and coatings therefor comprising physically crosslinked block copolymers |
US7998404B2 (en) | 2006-07-13 | 2011-08-16 | Advanced Cardiovascular Systems, Inc. | Reduced temperature sterilization of stents |
US7757543B2 (en) | 2006-07-13 | 2010-07-20 | Advanced Cardiovascular Systems, Inc. | Radio frequency identification monitoring of stents |
WO2008008291A2 (en) * | 2006-07-13 | 2008-01-17 | Icon Medical Corp. | Stent |
US8685430B1 (en) | 2006-07-14 | 2014-04-01 | Abbott Cardiovascular Systems Inc. | Tailored aliphatic polyesters for stent coatings |
US7794495B2 (en) | 2006-07-17 | 2010-09-14 | Advanced Cardiovascular Systems, Inc. | Controlled degradation of stents |
US7886419B2 (en) | 2006-07-18 | 2011-02-15 | Advanced Cardiovascular Systems, Inc. | Stent crimping apparatus and method |
US7955268B2 (en) * | 2006-07-21 | 2011-06-07 | Cardiac Pacemakers, Inc. | Multiple sensor deployment |
US20080091262A1 (en) * | 2006-10-17 | 2008-04-17 | Gale David C | Drug delivery after biodegradation of the stent scaffolding |
US8016879B2 (en) | 2006-08-01 | 2011-09-13 | Abbott Cardiovascular Systems Inc. | Drug delivery after biodegradation of the stent scaffolding |
US9265866B2 (en) * | 2006-08-01 | 2016-02-23 | Abbott Cardiovascular Systems Inc. | Composite polymeric and metallic stent with radiopacity |
JP2009545407A (en) * | 2006-08-02 | 2009-12-24 | ボストン サイエンティフィック サイムド,インコーポレイテッド | End prosthesis with 3D decomposition control |
US8703169B1 (en) | 2006-08-15 | 2014-04-22 | Abbott Cardiovascular Systems Inc. | Implantable device having a coating comprising carrageenan and a biostable polymer |
US9173733B1 (en) | 2006-08-21 | 2015-11-03 | Abbott Cardiovascular Systems Inc. | Tracheobronchial implantable medical device and methods of use |
EP2089072B1 (en) * | 2006-09-06 | 2014-06-04 | Boston Scientific Limited | Medical devices having a coating for promoting endothelial cell adhesion |
US7923022B2 (en) | 2006-09-13 | 2011-04-12 | Advanced Cardiovascular Systems, Inc. | Degradable polymeric implantable medical devices with continuous phase and discrete phase |
JP2010503469A (en) | 2006-09-14 | 2010-02-04 | ボストン サイエンティフィック リミテッド | Medical device having drug-eluting film |
WO2008034013A2 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Medical devices and methods of making the same |
DE602007011114D1 (en) * | 2006-09-15 | 2011-01-20 | Boston Scient Scimed Inc | BIODEGRADABLE ENDOPROTHESIS WITH BIOSTABILES INORGANIC LAYERS |
JP2010503489A (en) | 2006-09-15 | 2010-02-04 | ボストン サイエンティフィック リミテッド | Biodegradable endoprosthesis and method for producing the same |
WO2008034066A1 (en) * | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Bioerodible endoprostheses and methods of making the same |
WO2008034047A2 (en) * | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Endoprosthesis with adjustable surface features |
WO2008036554A2 (en) * | 2006-09-18 | 2008-03-27 | Boston Scientific Limited | Endoprostheses |
WO2008036548A2 (en) | 2006-09-18 | 2008-03-27 | Boston Scientific Limited | Endoprostheses |
WO2008039749A2 (en) * | 2006-09-25 | 2008-04-03 | Surmodics, Inc. | Multi-layered coatings and methods for controlling elution of active agents |
US10188826B2 (en) * | 2006-09-29 | 2019-01-29 | Covidien Lp | Catheters including antimicrobial sleeve and methods of making catheters |
WO2008042909A2 (en) | 2006-10-02 | 2008-04-10 | Micell Technologies Inc. | Surgical sutures having increased strength |
WO2008045184A1 (en) * | 2006-10-05 | 2008-04-17 | Boston Scientific Limited | Polymer-free coatings for medical devices formed by plasma electrolytic deposition |
ES2378905T3 (en) * | 2006-10-10 | 2012-04-19 | Celonova Biosciences, Inc. | Bioprotics heart valve with polyphosphazene |
JP2010533505A (en) * | 2006-10-10 | 2010-10-28 | セロノバ バイオサイエンシーズ, インコーポレイテッド | Compositions and devices comprising silicone and certain polyphosphazenes |
US20080097591A1 (en) | 2006-10-20 | 2008-04-24 | Biosensors International Group | Drug-delivery endovascular stent and method of use |
US8067055B2 (en) * | 2006-10-20 | 2011-11-29 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method of use |
US20080097577A1 (en) * | 2006-10-20 | 2008-04-24 | Boston Scientific Scimed, Inc. | Medical device hydrogen surface treatment by electrochemical reduction |
CA2667228C (en) | 2006-10-23 | 2015-07-14 | Micell Technologies, Inc. | Holder for electrically charging a substrate during coating |
US20080103584A1 (en) * | 2006-10-25 | 2008-05-01 | Biosensors International Group | Temporal Intraluminal Stent, Methods of Making and Using |
EP2086571A2 (en) | 2006-11-07 | 2009-08-12 | Genentech, Inc. | Tissue plasminogen activator variant uses |
US7981150B2 (en) | 2006-11-09 | 2011-07-19 | Boston Scientific Scimed, Inc. | Endoprosthesis with coatings |
US8414525B2 (en) * | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
US8430055B2 (en) | 2008-08-29 | 2013-04-30 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
US20080175887A1 (en) | 2006-11-20 | 2008-07-24 | Lixiao Wang | Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs |
EP2097119A4 (en) * | 2006-11-21 | 2012-10-17 | Abbott Lab | Use of a terpolymer of tetrafluoroethylene, hexafluoropropylene, and vinylidene fluoride in drug eluting coatings |
US7713541B1 (en) | 2006-11-21 | 2010-05-11 | Abbott Cardiovascular Systems Inc. | Zwitterionic terpolymers, method of making and use on medical devices |
US20080118541A1 (en) * | 2006-11-21 | 2008-05-22 | Abbott Laboratories | Use of a terpolymer of tetrafluoroethylene, hexafluoropropylene, and vinylidene fluoride in drug eluting coatings on medical devices |
WO2008063935A2 (en) * | 2006-11-22 | 2008-05-29 | Broncus Technologies, Inc. | Devices for creating passages and sensing for blood vessels |
US8099849B2 (en) | 2006-12-13 | 2012-01-24 | Abbott Cardiovascular Systems Inc. | Optimizing fracture toughness of polymeric stent |
US8597673B2 (en) | 2006-12-13 | 2013-12-03 | Advanced Cardiovascular Systems, Inc. | Coating of fast absorption or dissolution |
US8017141B2 (en) * | 2006-12-15 | 2011-09-13 | Advanced Cardiovascular Systems, Inc. | Coatings of acrylamide-based copolymers |
ES2506144T3 (en) | 2006-12-28 | 2014-10-13 | Boston Scientific Limited | Bioerodible endoprosthesis and their manufacturing procedure |
US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
CA2679712C (en) | 2007-01-08 | 2016-11-15 | Micell Technologies, Inc. | Stents having biodegradable layers |
WO2008097511A2 (en) * | 2007-02-07 | 2008-08-14 | Cook Incorporated | Medical device coatings for releasing a therapeutic agent at multiple rates |
JP2010517703A (en) | 2007-02-09 | 2010-05-27 | タヘリ ラドュカ エルエルシー | Vascular graft and method for processing the same |
US8221505B2 (en) | 2007-02-22 | 2012-07-17 | Cook Medical Technologies Llc | Prosthesis having a sleeve valve |
US8070797B2 (en) | 2007-03-01 | 2011-12-06 | Boston Scientific Scimed, Inc. | Medical device with a porous surface for delivery of a therapeutic agent |
US8431149B2 (en) | 2007-03-01 | 2013-04-30 | Boston Scientific Scimed, Inc. | Coated medical devices for abluminal drug delivery |
ATE554819T1 (en) * | 2007-03-14 | 2012-05-15 | Terumo Corp | GUIDE WIRE |
US8646444B2 (en) * | 2007-03-27 | 2014-02-11 | Electrolux Home Products, Inc. | Glide rack |
US20080243228A1 (en) * | 2007-03-28 | 2008-10-02 | Yunbing Wang | Implantable medical devices fabricated from block copolymers |
US8067054B2 (en) | 2007-04-05 | 2011-11-29 | Boston Scientific Scimed, Inc. | Stents with ceramic drug reservoir layer and methods of making and using the same |
US8262723B2 (en) | 2007-04-09 | 2012-09-11 | Abbott Cardiovascular Systems Inc. | Implantable medical devices fabricated from polymer blends with star-block copolymers |
WO2008127966A1 (en) * | 2007-04-11 | 2008-10-23 | Boston Scientific Scimed, Inc. | Photoresist coating to apply a coating to select areas of a medical device |
CA2684482C (en) * | 2007-04-17 | 2014-08-12 | Micell Technologies, Inc. | Stents having biodegradable layers |
US20080286332A1 (en) | 2007-05-14 | 2008-11-20 | Pacetti Stephen D | Implantable medical devices with a topcoat layer of phosphoryl choline acrylate polymer for reduced thrombosis, and improved mechanical properties |
US8147769B1 (en) | 2007-05-16 | 2012-04-03 | Abbott Cardiovascular Systems Inc. | Stent and delivery system with reduced chemical degradation |
US7976915B2 (en) | 2007-05-23 | 2011-07-12 | Boston Scientific Scimed, Inc. | Endoprosthesis with select ceramic morphology |
AU2008256684B2 (en) | 2007-05-25 | 2012-06-14 | Micell Technologies, Inc. | Polymer films for medical device coating |
US9056155B1 (en) | 2007-05-29 | 2015-06-16 | Abbott Cardiovascular Systems Inc. | Coatings having an elastic primer layer |
US7829008B2 (en) | 2007-05-30 | 2010-11-09 | Abbott Cardiovascular Systems Inc. | Fabricating a stent from a blow molded tube |
US7959857B2 (en) | 2007-06-01 | 2011-06-14 | Abbott Cardiovascular Systems Inc. | Radiation sterilization of medical devices |
US8202528B2 (en) | 2007-06-05 | 2012-06-19 | Abbott Cardiovascular Systems Inc. | Implantable medical devices with elastomeric block copolymer coatings |
US20080306582A1 (en) * | 2007-06-05 | 2008-12-11 | Yunbing Wang | Implantable medical devices with elastomeric copolymer coatings |
US8293260B2 (en) | 2007-06-05 | 2012-10-23 | Abbott Cardiovascular Systems Inc. | Elastomeric copolymer coatings containing poly (tetramethyl carbonate) for implantable medical devices |
JP2008305262A (en) * | 2007-06-08 | 2008-12-18 | Konica Minolta Business Technologies Inc | Printer introduction method in server and thin client environment |
US8425591B1 (en) | 2007-06-11 | 2013-04-23 | Abbott Cardiovascular Systems Inc. | Methods of forming polymer-bioceramic composite medical devices with bioceramic particles |
JP2010530769A (en) * | 2007-06-14 | 2010-09-16 | カーディアック ペースメイカーズ, インコーポレイテッド | Body pressure measuring device and method |
US8048441B2 (en) | 2007-06-25 | 2011-11-01 | Abbott Cardiovascular Systems, Inc. | Nanobead releasing medical devices |
US8109904B1 (en) | 2007-06-25 | 2012-02-07 | Abbott Cardiovascular Systems Inc. | Drug delivery medical devices |
US7901452B2 (en) | 2007-06-27 | 2011-03-08 | Abbott Cardiovascular Systems Inc. | Method to fabricate a stent having selected morphology to reduce restenosis |
US7955381B1 (en) | 2007-06-29 | 2011-06-07 | Advanced Cardiovascular Systems, Inc. | Polymer-bioceramic composite implantable medical device with different types of bioceramic particles |
US7942926B2 (en) | 2007-07-11 | 2011-05-17 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US8002823B2 (en) | 2007-07-11 | 2011-08-23 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
WO2009011895A1 (en) * | 2007-07-17 | 2009-01-22 | Silverleaf Materials, Inc | Wound closure method apparatus and system |
WO2009012353A2 (en) | 2007-07-19 | 2009-01-22 | Boston Scientific Limited | Endoprosthesis having a non-fouling surface |
DE102007034364A1 (en) * | 2007-07-24 | 2009-01-29 | Biotronik Vi Patent Ag | Degradable metal stent with active ingredient-containing coating |
DE102007034363A1 (en) * | 2007-07-24 | 2009-01-29 | Biotronik Vi Patent Ag | endoprosthesis |
US8815273B2 (en) | 2007-07-27 | 2014-08-26 | Boston Scientific Scimed, Inc. | Drug eluting medical devices having porous layers |
US7931683B2 (en) | 2007-07-27 | 2011-04-26 | Boston Scientific Scimed, Inc. | Articles having ceramic coated surfaces |
WO2009018340A2 (en) | 2007-07-31 | 2009-02-05 | Boston Scientific Scimed, Inc. | Medical device coating by laser cladding |
JP2010535541A (en) | 2007-08-03 | 2010-11-25 | ボストン サイエンティフィック リミテッド | Coating for medical devices with large surface area |
US20090041845A1 (en) * | 2007-08-08 | 2009-02-12 | Lothar Walter Kleiner | Implantable medical devices having thin absorbable coatings |
US8271101B2 (en) * | 2007-08-29 | 2012-09-18 | Advanced Bionics | Modular drug delivery system for minimizing trauma during and after insertion of a cochlear lead |
WO2009029866A2 (en) * | 2007-08-29 | 2009-03-05 | Advanced Bionics, Llc | Minimizing trauma during and after insertion of a cochlear lead |
US8052745B2 (en) | 2007-09-13 | 2011-11-08 | Boston Scientific Scimed, Inc. | Endoprosthesis |
JP2010539245A (en) | 2007-09-14 | 2010-12-16 | 日東電工株式会社 | Drug carrier |
KR100930167B1 (en) * | 2007-09-19 | 2009-12-07 | 삼성전기주식회사 | Ultra wide angle optical system |
WO2009051780A1 (en) * | 2007-10-19 | 2009-04-23 | Micell Technologies, Inc. | Drug coated stents |
US8142490B2 (en) | 2007-10-24 | 2012-03-27 | Cordis Corporation | Stent segments axially connected by thin film |
US20090110730A1 (en) * | 2007-10-30 | 2009-04-30 | Celonova Biosciences, Inc. | Loadable Polymeric Particles for Marking or Masking Individuals and Methods of Preparing and Using the Same |
US8216632B2 (en) | 2007-11-02 | 2012-07-10 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US8029554B2 (en) | 2007-11-02 | 2011-10-04 | Boston Scientific Scimed, Inc. | Stent with embedded material |
US20090118809A1 (en) * | 2007-11-02 | 2009-05-07 | Torsten Scheuermann | Endoprosthesis with porous reservoir and non-polymer diffusion layer |
US20090118813A1 (en) * | 2007-11-02 | 2009-05-07 | Torsten Scheuermann | Nano-patterned implant surfaces |
US7938855B2 (en) | 2007-11-02 | 2011-05-10 | Boston Scientific Scimed, Inc. | Deformable underlayer for stent |
US20090118818A1 (en) * | 2007-11-02 | 2009-05-07 | Boston Scientific Scimed, Inc. | Endoprosthesis with coating |
WO2009065087A1 (en) | 2007-11-14 | 2009-05-22 | Biosensors International Group, Ltd. | Automated coating apparatus and method |
US7828840B2 (en) * | 2007-11-15 | 2010-11-09 | Med Institute, Inc. | Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists |
US8257434B2 (en) | 2007-12-18 | 2012-09-04 | Cormatrix Cardiovascular, Inc. | Prosthetic tissue valve |
US8679176B2 (en) | 2007-12-18 | 2014-03-25 | Cormatrix Cardiovascular, Inc | Prosthetic tissue valve |
US8361538B2 (en) | 2007-12-19 | 2013-01-29 | Abbott Laboratories | Methods for applying an application material to an implantable device |
US8211489B2 (en) * | 2007-12-19 | 2012-07-03 | Abbott Cardiovascular Systems, Inc. | Methods for applying an application material to an implantable device |
US20090162417A1 (en) * | 2007-12-21 | 2009-06-25 | Cook Incorporated | Drug eluting ocular conformer |
US20090186068A1 (en) * | 2008-01-18 | 2009-07-23 | Chameleon Scientific Corporation | Atomic plasma deposited coatings for drug release |
US20090192580A1 (en) * | 2008-01-28 | 2009-07-30 | Shrojalkumar Desai | Medical electrical lead with biocompatible lead body coating |
US20090192577A1 (en) * | 2008-01-28 | 2009-07-30 | Shrojalkumar Desai | Medical electrical lead with coated conductor |
FR2928084A1 (en) * | 2008-02-28 | 2009-09-04 | Cie Euro Etude Rech Paroscopie | IMPLANTABLE DEVICE AND METHOD FOR MANUFACTURING THE SAME |
EP2271294B1 (en) | 2008-04-17 | 2018-03-28 | Micell Technologies, Inc. | Stents having bioabsorbable layers |
EP2271380B1 (en) | 2008-04-22 | 2013-03-20 | Boston Scientific Scimed, Inc. | Medical devices having a coating of inorganic material |
WO2009132176A2 (en) | 2008-04-24 | 2009-10-29 | Boston Scientific Scimed, Inc. | Medical devices having inorganic particle layers |
CA2721950A1 (en) | 2008-04-25 | 2009-10-29 | Nellix, Inc. | Stent graft delivery system |
US7998192B2 (en) | 2008-05-09 | 2011-08-16 | Boston Scientific Scimed, Inc. | Endoprostheses |
AU2009256084A1 (en) | 2008-06-04 | 2009-12-10 | Nellix, Inc. | Sealing apparatus and methods of use |
US8236046B2 (en) | 2008-06-10 | 2012-08-07 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
US20090312832A1 (en) * | 2008-06-13 | 2009-12-17 | Cook Incorporated | Slip layer delivery catheter |
WO2010071692A2 (en) * | 2008-06-18 | 2010-06-24 | Innovative Biotherapies, Inc. | Methods for enhanced propagation of cells |
EP2303350A2 (en) | 2008-06-18 | 2011-04-06 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US20090319026A1 (en) * | 2008-06-20 | 2009-12-24 | Boston Scientific Scimed, Inc. | Composite Stent with Reservoirs for Drug Delivery and Methods of Manufacturing |
US10898620B2 (en) * | 2008-06-20 | 2021-01-26 | Razmodics Llc | Composite stent having multi-axial flexibility and method of manufacture thereof |
US8206635B2 (en) | 2008-06-20 | 2012-06-26 | Amaranth Medical Pte. | Stent fabrication via tubular casting processes |
US20100042202A1 (en) * | 2008-08-13 | 2010-02-18 | Kamal Ramzipoor | Composite stent having multi-axial flexibility |
JP2011528275A (en) | 2008-07-17 | 2011-11-17 | ミセル テクノロジーズ,インク. | Drug delivery medical device |
US7985252B2 (en) | 2008-07-30 | 2011-07-26 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
JP5393684B2 (en) * | 2008-08-11 | 2014-01-22 | テルモ株式会社 | Medical tools |
US9198968B2 (en) | 2008-09-15 | 2015-12-01 | The Spectranetics Corporation | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US8114429B2 (en) | 2008-09-15 | 2012-02-14 | Cv Ingenuity Corp. | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US8257722B2 (en) | 2008-09-15 | 2012-09-04 | Cv Ingenuity Corp. | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US9220811B2 (en) * | 2008-09-22 | 2015-12-29 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices |
US8226603B2 (en) | 2008-09-25 | 2012-07-24 | Abbott Cardiovascular Systems Inc. | Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery |
US8049061B2 (en) | 2008-09-25 | 2011-11-01 | Abbott Cardiovascular Systems, Inc. | Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery |
US8076529B2 (en) | 2008-09-26 | 2011-12-13 | Abbott Cardiovascular Systems, Inc. | Expandable member formed of a fibrous matrix for intraluminal drug delivery |
US8382824B2 (en) | 2008-10-03 | 2013-02-26 | Boston Scientific Scimed, Inc. | Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides |
US20100106242A1 (en) * | 2008-10-23 | 2010-04-29 | Abbott Cardiovascular Systems Inc. | Stent and method for making a stent |
US20100137908A1 (en) * | 2008-12-01 | 2010-06-03 | Zimmer Spine, Inc. | Dynamic Stabilization System Components Including Readily Visualized Polymeric Compositions |
US8231980B2 (en) | 2008-12-03 | 2012-07-31 | Boston Scientific Scimed, Inc. | Medical implants including iridium oxide |
DE102008054920A1 (en) * | 2008-12-18 | 2010-07-01 | Biotronik Vi Patent Ag | Implant and method for producing a layer structure |
US8834913B2 (en) | 2008-12-26 | 2014-09-16 | Battelle Memorial Institute | Medical implants and methods of making medical implants |
WO2010091100A1 (en) | 2009-02-03 | 2010-08-12 | Abbott Cardiovascular Systems Inc. | Multiple beam laser system for forming stents |
US8872062B2 (en) * | 2009-02-03 | 2014-10-28 | Abbott Cardiovascular Systems Inc. | Laser cutting process for forming stents |
WO2010091106A1 (en) * | 2009-02-03 | 2010-08-12 | Abbott Cardiovascular Systems Inc. | Improved laser cutting system |
CA2752899A1 (en) * | 2009-02-18 | 2010-08-26 | Cormatrix Cardiovascular, Inc. | Compositions and methods for preventing cardiac arrhythmia |
EP2403546A2 (en) | 2009-03-02 | 2012-01-11 | Boston Scientific Scimed, Inc. | Self-buffering medical implants |
US8574612B2 (en) * | 2009-03-04 | 2013-11-05 | Boston Scientific Scimed, Inc. | Medical devices having a coating of biologic macromolecules |
US8071156B2 (en) | 2009-03-04 | 2011-12-06 | Boston Scientific Scimed, Inc. | Endoprostheses |
CA2756307C (en) * | 2009-03-23 | 2017-08-08 | Micell Technologies, Inc. | Peripheral stents having layers and reinforcement fibers |
WO2010111238A2 (en) * | 2009-03-23 | 2010-09-30 | Micell Technologies, Inc. | Improved biodegradable polymers |
US20100239635A1 (en) * | 2009-03-23 | 2010-09-23 | Micell Technologies, Inc. | Drug delivery medical device |
US20100247600A1 (en) * | 2009-03-24 | 2010-09-30 | Warsaw Orthopedic, Inc. | Therapeutic drug eluting implant cover and method of making the same |
CN102481195B (en) | 2009-04-01 | 2015-03-25 | 米歇尔技术公司 | Drug delivery medical device |
US9414864B2 (en) | 2009-04-15 | 2016-08-16 | Warsaw Orthopedic, Inc. | Anterior spinal plate with preformed drug-eluting device affixed thereto |
US9078712B2 (en) | 2009-04-15 | 2015-07-14 | Warsaw Orthopedic, Inc. | Preformed drug-eluting device to be affixed to an anterior spinal plate |
WO2010121187A2 (en) | 2009-04-17 | 2010-10-21 | Micell Techologies, Inc. | Stents having controlled elution |
US8287937B2 (en) | 2009-04-24 | 2012-10-16 | Boston Scientific Scimed, Inc. | Endoprosthese |
US20100274352A1 (en) * | 2009-04-24 | 2010-10-28 | Boston Scientific Scrimed, Inc. | Endoprosthesis with Selective Drug Coatings |
US9289540B2 (en) * | 2009-05-08 | 2016-03-22 | Greatbatch Ltd. | Surface modification for coating |
WO2010151269A1 (en) | 2009-06-26 | 2010-12-29 | Biotic Laboratories, Inc. | Para-xylylene based multilayer drug elution devices |
US8382818B2 (en) | 2009-07-02 | 2013-02-26 | Tryton Medical, Inc. | Ostium support for treating vascular bifurcations |
EP2453834A4 (en) | 2009-07-16 | 2014-04-16 | Micell Technologies Inc | Drug delivery medical device |
JP2011528608A (en) * | 2009-09-29 | 2011-11-24 | エム. アイ. テック カンパニー, インコーポレイテッド | Transplantation tube and coating method thereof |
BR112012007578B1 (en) * | 2009-09-30 | 2021-04-20 | Terumo Kabushiki Kaisha | stent |
US8016872B2 (en) * | 2009-12-22 | 2011-09-13 | Cook Medical Technologies Llc | Deployment and dilation with an expandable roll sock delivery system |
US20110276078A1 (en) | 2009-12-30 | 2011-11-10 | Nellix, Inc. | Filling structure for a graft system and methods of use |
US8568471B2 (en) | 2010-01-30 | 2013-10-29 | Abbott Cardiovascular Systems Inc. | Crush recoverable polymer scaffolds |
US8808353B2 (en) | 2010-01-30 | 2014-08-19 | Abbott Cardiovascular Systems Inc. | Crush recoverable polymer scaffolds having a low crossing profile |
US11369498B2 (en) | 2010-02-02 | 2022-06-28 | MT Acquisition Holdings LLC | Stent and stent delivery system with improved deliverability |
US8398916B2 (en) | 2010-03-04 | 2013-03-19 | Icon Medical Corp. | Method for forming a tubular medical device |
WO2011119536A1 (en) | 2010-03-22 | 2011-09-29 | Abbott Cardiovascular Systems Inc. | Stent delivery system having a fibrous matrix covering with improved stent retention |
US8668732B2 (en) | 2010-03-23 | 2014-03-11 | Boston Scientific Scimed, Inc. | Surface treated bioerodible metal endoprostheses |
US8795762B2 (en) | 2010-03-26 | 2014-08-05 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
NZ703047A (en) | 2010-03-29 | 2016-11-25 | Abraxis Bioscience Llc | Methods of enhancing drug delivery and effectiveness of therapeutic agents |
CA3087813A1 (en) | 2010-03-29 | 2011-10-06 | Abraxis Bioscience, Llc | Methods of treating cancer |
US8685433B2 (en) | 2010-03-31 | 2014-04-01 | Abbott Cardiovascular Systems Inc. | Absorbable coating for implantable device |
US9801738B2 (en) | 2010-04-14 | 2017-10-31 | Northwestern University | Liquid cast biodegradable arterial stent |
WO2011133655A1 (en) | 2010-04-22 | 2011-10-27 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
NZ604031A (en) | 2010-06-04 | 2015-05-29 | Abraxis Bioscience Llc | Methods of treatment of pancreatic cancer |
US8389041B2 (en) | 2010-06-17 | 2013-03-05 | Abbott Cardiovascular Systems, Inc. | Systems and methods for rotating and coating an implantable device |
CA2805631C (en) | 2010-07-16 | 2018-07-31 | Micell Technologies, Inc. | Drug delivery medical device |
US8556511B2 (en) | 2010-09-08 | 2013-10-15 | Abbott Cardiovascular Systems, Inc. | Fluid bearing to support stent tubing during laser cutting |
WO2012034079A2 (en) | 2010-09-09 | 2012-03-15 | Micell Technologies, Inc. | Macrolide dosage forms |
SG188636A1 (en) | 2010-10-01 | 2013-05-31 | Univ Tennessee Res Foundation | Multigraft copolymers as superelastomers |
US8833402B2 (en) * | 2010-12-30 | 2014-09-16 | Cook Medical Technologies Llc | Woven fabric having composite yarns for endoluminal devices |
US8801768B2 (en) | 2011-01-21 | 2014-08-12 | Endologix, Inc. | Graft systems having semi-permeable filling structures and methods for their use |
US8936827B2 (en) | 2011-02-25 | 2015-01-20 | Abbott Cardiovascular Systems Inc. | Methods of loading a hollow stent with a drug or drug formulation |
US20120216908A1 (en) | 2011-02-25 | 2012-08-30 | Abbott Cardiovascular Systems Inc. | Methods Of Drug Loading A Hollow Stent By Immersion |
US9238514B2 (en) | 2011-02-25 | 2016-01-19 | Abbott Cardiovascular Systems Inc. | Vacuum chamber and apparatus for loading material into a stent strut |
US8757219B2 (en) | 2011-02-25 | 2014-06-24 | Abbott Cardiovascular Systems Inc. | Suction pump and apparatus for loading material into a stent strut |
US9585780B2 (en) | 2011-02-25 | 2017-03-07 | Abbott Cardiovascular Systems Inc. | Pressure chamber and apparatus for loading material into a stent strut |
US8733408B2 (en) | 2011-02-25 | 2014-05-27 | Abbott Cardiovascular Systems Inc. | Cover sleeve and apparatus for loading material into a stent strut |
US8927047B2 (en) | 2011-02-25 | 2015-01-06 | Abbott Cardiovascular Systems Inc. | Methods of drug loading a hollow stent with a high viscosity formulation |
JP5976777B2 (en) | 2011-04-06 | 2016-08-24 | エンドーロジックス インコーポレイテッド | Methods and systems for the treatment of intravascular aneurysms |
JP2014521381A (en) | 2011-05-13 | 2014-08-28 | ブロンカス テクノロジーズ, インコーポレイテッド | Methods and devices for tissue ablation |
US8709034B2 (en) | 2011-05-13 | 2014-04-29 | Broncus Medical Inc. | Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall |
AU2012262549B2 (en) | 2011-05-27 | 2016-02-11 | Cormatrix Cardiovascular, Inc. | Extracellular matrix material valve conduit and methods of making thereof |
WO2012166819A1 (en) | 2011-05-31 | 2012-12-06 | Micell Technologies, Inc. | System and process for formation of a time-released, drug-eluting transferable coating |
CA2841360A1 (en) | 2011-07-15 | 2013-01-24 | Micell Technologies, Inc. | Drug delivery medical device |
US8726483B2 (en) | 2011-07-29 | 2014-05-20 | Abbott Cardiovascular Systems Inc. | Methods for uniform crimping and deployment of a polymer scaffold |
US20130046375A1 (en) | 2011-08-17 | 2013-02-21 | Meng Chen | Plasma modified medical devices and methods |
US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
ITMI20112121A1 (en) * | 2011-11-22 | 2013-05-23 | Getters Spa | SYSTEM FOR THE PRODUCTION OF HOT WATER AND AUTOMATIC DRINK OF DRINKS THAT USES IT |
WO2013078235A1 (en) | 2011-11-23 | 2013-05-30 | Broncus Medical Inc | Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall |
US10940167B2 (en) | 2012-02-10 | 2021-03-09 | Cvdevices, Llc | Methods and uses of biological tissues for various stent and other medical applications |
US8998977B2 (en) * | 2012-04-13 | 2015-04-07 | Medtronic Vascular, Inc. | Hollow drug-filled stent and method of forming hollow drug-filled stent |
KR101362446B1 (en) * | 2012-05-10 | 2014-02-11 | 이훈범 | Filler for wrinkle removing |
US9956385B2 (en) | 2012-06-28 | 2018-05-01 | The Spectranetics Corporation | Post-processing of a medical device to control morphology and mechanical properties |
EP2912121B1 (en) | 2012-10-29 | 2019-09-25 | Ariste Medical, LLC | Polymer coating compositions and coated products |
US8847412B2 (en) * | 2012-11-09 | 2014-09-30 | Invensas Corporation | Microelectronic assembly with thermally and electrically conductive underfill |
AU2014214700B2 (en) | 2013-02-11 | 2018-01-18 | Cook Medical Technologies Llc | Expandable support frame and medical device |
KR20150143476A (en) | 2013-03-12 | 2015-12-23 | 미셀 테크놀로지즈, 인코포레이티드 | Bioabsorbable biomedical implants |
US9289536B2 (en) | 2013-03-14 | 2016-03-22 | Endologix, Inc. | Method for forming materials in situ within a medical device |
US9545301B2 (en) | 2013-03-15 | 2017-01-17 | Covidien Lp | Coated medical devices and methods of making and using same |
US9320592B2 (en) | 2013-03-15 | 2016-04-26 | Covidien Lp | Coated medical devices and methods of making and using same |
WO2014182542A1 (en) | 2013-05-06 | 2014-11-13 | Abbott Cardiovascular Systems Inc. | A hollow stent filled with a therapeutic agent formulation |
KR102079613B1 (en) | 2013-05-15 | 2020-02-20 | 미셀 테크놀로지즈, 인코포레이티드 | Bioabsorbable biomedical implants |
EP3498239B1 (en) | 2013-08-01 | 2021-04-21 | Cook Medical Technologies LLC | Tissue adjustment implant |
US9433763B2 (en) | 2013-09-27 | 2016-09-06 | Acclarent, Inc. | Sinus wall implant |
US9668890B2 (en) | 2013-11-22 | 2017-06-06 | Covidien Lp | Anti-thrombogenic medical devices and methods |
US10525171B2 (en) | 2014-01-24 | 2020-01-07 | The Spectranetics Corporation | Coatings for medical devices |
EP2994175A1 (en) | 2014-02-04 | 2016-03-16 | Abbott Cardiovascular Systems, Inc. | Drug delivery scaffold or stent with a novolimus and lactide based coating such that novolimus has a minimum amount of bonding to the coating |
GB2537770B (en) | 2014-04-22 | 2017-09-13 | Ariste Medical Llc | Methods and processes for application of drug delivery polymeric coatings |
US9163122B1 (en) | 2014-05-30 | 2015-10-20 | Pall Corporation | Self-assembling polymers—II |
US9441078B2 (en) | 2014-05-30 | 2016-09-13 | Pall Corporation | Self-assembling polymers—I |
US9593219B2 (en) | 2014-05-30 | 2017-03-14 | Pall Corporation | Membrane comprising self-assembled block copolymer and process for producing the same by spin coating (IIa) |
US9604181B2 (en) | 2014-05-30 | 2017-03-28 | Pall Corporation | Membrane comprising self-assembled block copolymer and process for producing the same by spray coating (IIc) |
US9598543B2 (en) | 2014-05-30 | 2017-03-21 | Pall Corporation | Self-assembled structure and membrane comprising block copolymer and process for producing the same by spin coating (VIa) |
US9616395B2 (en) | 2014-05-30 | 2017-04-11 | Pall Corportaion | Membrane comprising self-assembled block copolymer and process for producing the same by spray coating (Ic) |
US9593217B2 (en) | 2014-05-30 | 2017-03-14 | Pall Corporation | Self-assembled structure and membrane comprising block copolymer and process for producing the same by spin coating (Va) |
US9193835B1 (en) | 2014-05-30 | 2015-11-24 | Pall Corporation | Self-assembling polymers—IV |
US9328206B2 (en) | 2014-05-30 | 2016-05-03 | Pall Corporation | Self-assembling polymers—III |
US9162189B1 (en) | 2014-05-30 | 2015-10-20 | Pall Corporation | Membrane comprising self-assembled block copolymer and process for producing the same by spin coating (Ia) |
US9765171B2 (en) | 2014-05-30 | 2017-09-19 | Pall Corporation | Self-assembling polymers—V |
US9593218B2 (en) | 2014-05-30 | 2017-03-14 | Pall Corporation | Self-assembled structure and membrane comprising block copolymer and process for producing the same by spin coating (IIIa) |
US9469733B2 (en) | 2014-05-30 | 2016-10-18 | Pall Corporation | Self-assembled structure and membrane comprising block copolymer and process for producing the same by spin coating (IVa) |
US9592476B2 (en) | 2014-05-30 | 2017-03-14 | Pall Corporation | Membrane comprising self-assembled block copolymer and process for producing the same by hybrid casting (IIb) |
US9592477B2 (en) | 2014-05-30 | 2017-03-14 | Pall Corporation | Membrane comprising self-assembled block copolymer and process for producing the same by hybrid casting (Ib) |
US9169361B1 (en) | 2014-05-30 | 2015-10-27 | Pall Corporation | Self-assembling polymers—VI |
DE112015002920T5 (en) | 2014-06-20 | 2017-03-02 | University Of Tennessee Research Foundation | Multiprop Copolymer Superelastomers by Emulsion Polymerization |
BR112016030273A8 (en) | 2014-06-24 | 2021-05-18 | Icon Medical Corp | medical device and method of forming said device |
US9254466B2 (en) | 2014-06-30 | 2016-02-09 | Pall Corporation | Crosslinked cellulosic membranes |
US9260569B2 (en) | 2014-06-30 | 2016-02-16 | Pall Corporation | Hydrophilic block copolymers and method of preparation thereof (III) |
US9718924B2 (en) | 2014-06-30 | 2017-08-01 | Pall Corporation | Hydrophilic block copolymers and membranes prepared therefrom (II) |
US9309367B2 (en) | 2014-06-30 | 2016-04-12 | Pall Corporation | Membranes comprising cellulosic material and hydrophilic block copolymer (V) |
US9394407B2 (en) | 2014-06-30 | 2016-07-19 | Pall Corporation | Hydrophilic block copolymers and membranes prepared therefrom (I) |
US9962662B2 (en) | 2014-06-30 | 2018-05-08 | Pall Corporation | Fluorinated polymer and use thereof in the preparation of hydrophilic membranes (vi) |
US9303133B2 (en) | 2014-06-30 | 2016-04-05 | Pall Corporation | Hydrophilic membranes and method of preparation thereof (IV) |
US9895243B2 (en) | 2014-07-17 | 2018-02-20 | W. L. Gore & Associates, Inc. | Stent having adjacent elements connected by narrow flexible webs |
WO2016033424A1 (en) | 2014-08-29 | 2016-03-03 | Genzyme Corporation | Methods for the prevention and treatment of major adverse cardiovascular events using compounds that modulate apolipoprotein b |
US9789228B2 (en) | 2014-12-11 | 2017-10-17 | Covidien Lp | Antimicrobial coatings for medical devices and processes for preparing such coatings |
US9801983B2 (en) | 2014-12-18 | 2017-10-31 | Cook Medical Technologies Llc | Medical devices for delivering a bioactive to a point of treatment and methods of making medical devices |
US9238090B1 (en) | 2014-12-24 | 2016-01-19 | Fettech, Llc | Tissue-based compositions |
US9999527B2 (en) | 2015-02-11 | 2018-06-19 | Abbott Cardiovascular Systems Inc. | Scaffolds having radiopaque markers |
US9700443B2 (en) | 2015-06-12 | 2017-07-11 | Abbott Cardiovascular Systems Inc. | Methods for attaching a radiopaque marker to a scaffold |
JP6426068B2 (en) * | 2015-08-10 | 2018-11-21 | 朝日インテック株式会社 | Catheter and balloon catheter |
US11766506B2 (en) | 2016-03-04 | 2023-09-26 | Mirus Llc | Stent device for spinal fusion |
CN109715224B (en) | 2016-09-19 | 2022-02-22 | 百多力股份公司 | Polymer-free drug-eluting vascular stent |
CN110267627B (en) | 2016-12-09 | 2023-07-11 | 真复灵公司 | Systems, devices, and methods for accurately deploying implants in the prostatic urethra |
EP3589243A1 (en) | 2017-02-28 | 2020-01-08 | University College Cork - National University of Ireland, Cork | An intravascular cell therapy device |
US11325991B2 (en) | 2017-04-25 | 2022-05-10 | University Of Tennessee Research Foundation | All-acrylic multigraft copolymer superelastomers |
CN107469156B (en) * | 2017-09-30 | 2020-04-14 | 郑州大学第一附属医院 | Laminated Y-shaped bile duct stent partially covered with chemotherapeutic drugs |
JP2023502997A (en) | 2019-11-19 | 2023-01-26 | ゼンフロー, インコーポレイテッド | Systems, devices and methods for accurate deployment and imaging of implants within the prostatic urethra |
Family Cites Families (257)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3240616A (en) * | 1962-08-27 | 1966-03-15 | Harasowski Jerzy | Method of activating bentonite clays |
US3699956A (en) * | 1970-10-01 | 1972-10-24 | Tecna Corp | Percutaneous lead device |
US4101984A (en) * | 1975-05-09 | 1978-07-25 | Macgregor David C | Cardiovascular prosthetic devices and implants with porous systems |
US4225647B1 (en) * | 1977-12-02 | 1995-05-09 | Richard A Parent | Articles having thin, continuous, impervious coatings |
US5108424A (en) * | 1984-01-30 | 1992-04-28 | Meadox Medicals, Inc. | Collagen-impregnated dacron graft |
US5197977A (en) * | 1984-01-30 | 1993-03-30 | Meadox Medicals, Inc. | Drug delivery collagen-impregnated synthetic vascular graft |
WO1986007541A1 (en) * | 1985-06-19 | 1986-12-31 | Yasushi Zyo | Composition which can impart antithrombotic ability and medical apparatus to be in contact with blood |
US4795475A (en) | 1985-08-09 | 1989-01-03 | Walker Michael M | Prosthesis utilizing salt-forming oxyacids for bone fixation |
IL76079A (en) | 1985-08-13 | 1991-03-10 | Univ Ramot | Collagen implants |
FR2601675B1 (en) | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | TAXOL DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
FR2601676B1 (en) | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | PROCESS FOR THE PREPARATION OF TAXOL AND DESACETYL-10 TAXOL |
US5019096A (en) * | 1988-02-11 | 1991-05-28 | Trustees Of Columbia University In The City Of New York | Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same |
US4942184A (en) | 1988-03-07 | 1990-07-17 | The United States Of America As Represented By The Department Of Health And Human Services | Water soluble, antineoplastic derivatives of taxol |
WO1989011500A1 (en) * | 1988-05-17 | 1989-11-30 | Commonwealth Scientific And Industrial Research Or | Hydrophilic non-swelling multilayer polymeric materials and process for their manufacture |
US5213580A (en) | 1988-08-24 | 1993-05-25 | Endoluminal Therapeutics, Inc. | Biodegradable polymeric endoluminal sealing process |
DE68922497T2 (en) | 1988-08-24 | 1995-09-14 | Marvin J Slepian | ENDOLUMINAL SEAL WITH BISDEGRADABLE POLYMERS. |
US5053048A (en) * | 1988-09-22 | 1991-10-01 | Cordis Corporation | Thromboresistant coating |
US5298255A (en) * | 1988-10-28 | 1994-03-29 | Terumo Kabushiki Kaisha | Antithrombic medical material, artificial internal organ, and method for production of antithrombic medical material |
US5067491A (en) * | 1989-12-08 | 1991-11-26 | Becton, Dickinson And Company | Barrier coating on blood contacting devices |
US5059166A (en) * | 1989-12-11 | 1991-10-22 | Medical Innovative Technologies R & D Limited Partnership | Intra-arterial stent with the capability to inhibit intimal hyperplasia |
US5304121A (en) * | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
AU7998091A (en) * | 1990-05-17 | 1991-12-10 | Harbor Medical Devices, Inc. | Medical device polymer |
US5112457A (en) * | 1990-07-23 | 1992-05-12 | Case Western Reserve University | Process for producing hydroxylated plasma-polymerized films and the use of the films for enhancing the compatiblity of biomedical implants |
US5455040A (en) * | 1990-07-26 | 1995-10-03 | Case Western Reserve University | Anticoagulant plasma polymer-modified substrate |
US5278324A (en) | 1990-08-28 | 1994-01-11 | Virginia Tech Intellectual Properties, Inc. | Water soluble derivatives of taxol |
US5059699A (en) | 1990-08-28 | 1991-10-22 | Virginia Tech Intellectual Properties, Inc. | Water soluble derivatives of taxol |
US5344411A (en) * | 1991-02-27 | 1994-09-06 | Leonard Bloom | Method and device for inhibiting HIV, hepatitis B and other viruses and germs when using a catheter in a medical environment |
TW197439B (en) | 1991-04-04 | 1993-01-01 | Ueno Pharmaceutics Applic Res Co Ltd | |
NL9101159A (en) * | 1991-07-03 | 1993-02-01 | Industrial Res Bv | FORMATTABLE EXPANDABLE RING, CYLINDER OR SLEEVE. |
CA2071160A1 (en) | 1991-07-31 | 1993-02-01 | Vittorio Farina | Asymmetric synthesis of taxol side chain |
US5356433A (en) * | 1991-08-13 | 1994-10-18 | Cordis Corporation | Biocompatible metal surfaces |
SG46582A1 (en) | 1991-09-23 | 1998-02-20 | Univ Florida State | 10-Desacetoxytaxol derivatives |
US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5464450A (en) * | 1991-10-04 | 1995-11-07 | Scimed Lifesystems Inc. | Biodegradable drug delivery vascular stent |
JP3093375B2 (en) * | 1991-11-01 | 2000-10-03 | 株式会社東海メディカルプロダクツ | Immobilization method of antithrombotic substance |
US5270047A (en) * | 1991-11-21 | 1993-12-14 | Kauffman Raymond F | Local delivery of dipyridamole for the treatment of proliferative diseases |
WO1993010076A1 (en) | 1991-11-22 | 1993-05-27 | The University Of Mississippi | Synthesis and optical resolution of the taxol side chain and related compounds |
US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
US5200534A (en) | 1992-03-13 | 1993-04-06 | University Of Florida | Process for the preparation of taxol and 10-deacetyltaxol |
US5282823A (en) * | 1992-03-19 | 1994-02-01 | Medtronic, Inc. | Intravascular radially expandable stent |
US5599352A (en) | 1992-03-19 | 1997-02-04 | Medtronic, Inc. | Method of making a drug eluting stent |
US5440056A (en) | 1992-04-17 | 1995-08-08 | Abbott Laboratories | 9-deoxotaxane compounds |
US5288711A (en) | 1992-04-28 | 1994-02-22 | American Home Products Corporation | Method of treating hyperproliferative vascular disease |
US5383927A (en) * | 1992-05-07 | 1995-01-24 | Intervascular Inc. | Non-thromogenic vascular prosthesis |
CA2136213A1 (en) | 1992-05-21 | 1993-11-25 | Richard N. Arteca | Cultured taxu tissues as a source of taxol, related taxanes and other novel anti-tumor/anti-viral compounds |
AU4406793A (en) | 1992-06-04 | 1993-12-30 | Clover Consolidated, Limited | Water-soluble polymeric carriers for drug delivery |
US5383928A (en) * | 1992-06-10 | 1995-01-24 | Emory University | Stent sheath for local drug delivery |
US5248796A (en) | 1992-06-18 | 1993-09-28 | Bristol-Myers Squibb Company | Taxol derivatives |
GB9213077D0 (en) | 1992-06-19 | 1992-08-05 | Erba Carlo Spa | Polymerbound taxol derivatives |
US5274137A (en) | 1992-06-23 | 1993-12-28 | Nicolaou K C | Intermediates for preparation of taxols |
US5254580A (en) | 1993-01-19 | 1993-10-19 | Bristol-Myers Squibb Company | 7,8-cyclopropataxanes |
US5294637A (en) | 1992-07-01 | 1994-03-15 | Bristol-Myers Squibb Company | Fluoro taxols |
US5202448A (en) | 1992-08-14 | 1993-04-13 | Napro Biotherapeutics, Inc. | Processes of converting taxanes into baccatin III |
WO1994005282A1 (en) | 1992-09-04 | 1994-03-17 | The Scripps Research Institute | Water soluble taxol derivatives |
US5274132A (en) | 1992-09-30 | 1993-12-28 | Transitions Optical, Inc. | Photochromic naphthopyran compounds |
CA2100808A1 (en) | 1992-10-01 | 1994-04-02 | Vittorio Farina | Deoxy paclitaxels |
FR2696464B1 (en) | 1992-10-05 | 1994-11-10 | Rhone Poulenc Rorer Sa | New esterification process for baccatin III and 10-deacetyl baccatin III. |
FR2696462B1 (en) | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Process for obtaining 10-deacetyl baccatin III. |
FR2696463B1 (en) | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Process for obtaining 10-deacetyl baccatin III. |
US5411984A (en) | 1992-10-16 | 1995-05-02 | Virginia Tech Intellectual Properties, Inc. | Water soluble analogs and prodrugs of taxol |
US5449382A (en) * | 1992-11-04 | 1995-09-12 | Dayton; Michael P. | Minimally invasive bioactivated endoprosthesis for vessel repair |
US5578075B1 (en) * | 1992-11-04 | 2000-02-08 | Daynke Res Inc | Minimally invasive bioactivated endoprosthesis for vessel repair |
US5342348A (en) * | 1992-12-04 | 1994-08-30 | Kaplan Aaron V | Method and device for treating and enlarging body lumens |
US5380751A (en) | 1992-12-04 | 1995-01-10 | Bristol-Myers Squibb Company | 6,7-modified paclitaxels |
US5279949A (en) | 1992-12-07 | 1994-01-18 | Board Of Trustees Operating Michigan State University | Process for the isolation and purification of taxol and taxanes from Taxus spp |
US5443458A (en) * | 1992-12-22 | 1995-08-22 | Advanced Cardiovascular Systems, Inc. | Multilayered biodegradable stent and method of manufacture |
US5419760A (en) * | 1993-01-08 | 1995-05-30 | Pdt Systems, Inc. | Medicament dispensing stent for prevention of restenosis of a blood vessel |
US5595722A (en) * | 1993-01-28 | 1997-01-21 | Neorx Corporation | Method for identifying an agent which increases TGF-beta levels |
WO1994020089A1 (en) | 1993-03-09 | 1994-09-15 | Enzon, Inc. | Taxol-based compositions with enhanced bioactivity |
US5412092A (en) | 1993-04-23 | 1995-05-02 | Bristol-Myers Squibb Company | N-substituted 2-azetidinones |
US5464650A (en) * | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
US5824048A (en) | 1993-04-26 | 1998-10-20 | Medtronic, Inc. | Method for delivering a therapeutic substance to a body lumen |
US5849035A (en) | 1993-04-28 | 1998-12-15 | Focal, Inc. | Methods for intraluminal photothermoforming |
US5994341A (en) * | 1993-07-19 | 1999-11-30 | Angiogenesis Technologies, Inc. | Anti-angiogenic Compositions and methods for the treatment of arthritis |
EP0711158B2 (en) * | 1993-07-29 | 2008-07-23 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Method of treating atherosclerosis or restenosis using microtubule stabilizing agent |
US5380299A (en) * | 1993-08-30 | 1995-01-10 | Med Institute, Inc. | Thrombolytic treated intravascular medical device |
US5457113A (en) * | 1993-10-15 | 1995-10-10 | Eli Lilly And Company | Methods for inhibiting vascular smooth muscle cell proliferation and restinosis |
US5759205A (en) | 1994-01-21 | 1998-06-02 | Brown University Research Foundation | Negatively charged polymeric electret implant |
US5395850A (en) | 1994-03-10 | 1995-03-07 | Bristol-Myers Squibb Company | 6,7-epoxy paclitaxels |
CA2147813A1 (en) | 1994-04-28 | 1995-10-29 | Richard Dixon | Intravascular prosthesis with anti-thrombogenic coating |
US5554181A (en) * | 1994-05-04 | 1996-09-10 | Regents Of The University Of Minnesota | Stent |
US5629077A (en) | 1994-06-27 | 1997-05-13 | Advanced Cardiovascular Systems, Inc. | Biodegradable mesh and film stent |
DE69534405T2 (en) * | 1994-07-01 | 2006-03-09 | Edwards Lifesciences Corp., Irvine | APPARATUS FOR OBTAINING AUTOMATED, MICROVASCULAR ENDOTHELIAL CELLS CONTAINING FAT TISSUE |
US5788979A (en) | 1994-07-22 | 1998-08-04 | Inflow Dynamics Inc. | Biodegradable coating with inhibitory properties for application to biocompatible materials |
US5649977A (en) | 1994-09-22 | 1997-07-22 | Advanced Cardiovascular Systems, Inc. | Metal reinforced polymer stent |
US5637113A (en) * | 1994-12-13 | 1997-06-10 | Advanced Cardiovascular Systems, Inc. | Polymer film for wrapping a stent structure |
US5876743A (en) | 1995-03-21 | 1999-03-02 | Den-Mat Corporation | Biocompatible adhesion in tissue repair |
US5605696A (en) * | 1995-03-30 | 1997-02-25 | Advanced Cardiovascular Systems, Inc. | Drug loaded polymeric material and method of manufacture |
WO1996037165A1 (en) | 1995-05-26 | 1996-11-28 | Bsi Corporation | Method and implantable article for promoting endothelialization |
US5674242A (en) | 1995-06-06 | 1997-10-07 | Quanam Medical Corporation | Endoprosthetic device with therapeutic compound |
US5609629A (en) * | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
US5773019A (en) | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
US5968972A (en) * | 1995-10-26 | 1999-10-19 | Baker Norton Pharmaceuticals, Inc. | Method for increasing the oral bioactivity of pharmaceutical agents |
US20040106985A1 (en) | 1996-04-26 | 2004-06-03 | Jang G. David | Intravascular stent |
EP1616563A3 (en) | 1996-05-24 | 2006-01-25 | Angiotech Pharmaceuticals, Inc. | Perivascular administration of anti-angiogenic factors for treating or preventing vascular diseases |
US5797887A (en) | 1996-08-27 | 1998-08-25 | Novovasc Llc | Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation |
US7351421B2 (en) | 1996-11-05 | 2008-04-01 | Hsing-Wen Sung | Drug-eluting stent having collagen drug carrier chemically treated with genipin |
US20020111603A1 (en) | 1996-12-02 | 2002-08-15 | Societe De Conseils De Recherches Et D'application | Device for local administration of solid or semi-solid formulations and delayed-release formulations for proposal parental administration and preparation process |
US6495579B1 (en) | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
US20030157187A1 (en) | 1996-12-02 | 2003-08-21 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for treating or preventing inflammatory diseases |
US5980551A (en) | 1997-02-07 | 1999-11-09 | Endovasc Ltd., Inc. | Composition and method for making a biodegradable drug delivery stent |
US8172897B2 (en) | 1997-04-15 | 2012-05-08 | Advanced Cardiovascular Systems, Inc. | Polymer and metal composite implantable medical devices |
US6240616B1 (en) | 1997-04-15 | 2001-06-05 | Advanced Cardiovascular Systems, Inc. | Method of manufacturing a medicated porous metal prosthesis |
US6818016B1 (en) | 1997-06-27 | 2004-11-16 | The Regents Of The University Of Michigan | Methods for coating stents with DNA and expression of recombinant genes from DNA coated stents in vivo |
FR2766092B1 (en) | 1997-07-16 | 1999-10-08 | Centre Nat Rech Scient | IMPLANTABLE DEVICE COATED WITH A POLYMER CAPABLE OF RELEASING BIOLOGICALLY ACTIVE SUBSTANCES |
US6306426B1 (en) | 1997-08-11 | 2001-10-23 | Allergan Sales, Inc. | Implant device with a retinoid for improved biocompatibility |
US6485514B1 (en) | 1997-12-12 | 2002-11-26 | Supergen, Inc. | Local delivery of therapeutic agents |
US5957975A (en) | 1997-12-15 | 1999-09-28 | The Cleveland Clinic Foundation | Stent having a programmed pattern of in vivo degradation |
US20040254635A1 (en) | 1998-03-30 | 2004-12-16 | Shanley John F. | Expandable medical device for delivery of beneficial agent |
US6153252A (en) * | 1998-06-30 | 2000-11-28 | Ethicon, Inc. | Process for coating stents |
US6652581B1 (en) | 1998-07-07 | 2003-11-25 | Boston Scientific Scimed, Inc. | Medical device with porous surface for controlled drug release and method of making the same |
JP4898991B2 (en) * | 1998-08-20 | 2012-03-21 | クック メディカル テクノロジーズ エルエルシー | Sheathed medical device |
US7662409B2 (en) | 1998-09-25 | 2010-02-16 | Gel-Del Technologies, Inc. | Protein matrix materials, devices and methods of making and using thereof |
US20050033399A1 (en) | 1998-12-03 | 2005-02-10 | Jacob Richter | Hybrid stent |
US6333347B1 (en) | 1999-01-29 | 2001-12-25 | Angiotech Pharmaceuticals & Advanced Research Tech | Intrapericardial delivery of anti-microtubule agents |
US6903244B1 (en) | 1999-02-26 | 2005-06-07 | University Of Utah Research Foundation | Mice which are +/− or −/− for the elastin gene as models for vascular disease |
EP2305324B1 (en) | 1999-03-25 | 2014-09-17 | Metabolix, Inc. | Medical devices and applications of polyhydroxyalkanoate polymers |
US6716445B2 (en) | 1999-04-12 | 2004-04-06 | Cornell Research Foundation, Inc. | Hydrogel entrapping therapeutic agent and stent with coating comprising this |
US6258121B1 (en) | 1999-07-02 | 2001-07-10 | Scimed Life Systems, Inc. | Stent coating |
US20050060044A1 (en) | 1999-08-05 | 2005-03-17 | Ed Roschak | Methods and devices for maintaining patency of surgically created channels in a body organ |
US6709427B1 (en) | 1999-08-05 | 2004-03-23 | Kensey Nash Corporation | Systems and methods for delivering agents into targeted tissue of a living being |
US20050137715A1 (en) | 1999-08-05 | 2005-06-23 | Broncus Technologies, Inc. | Methods and devices for maintaining patency of surgically created channels in a body organ |
US7462162B2 (en) | 2001-09-04 | 2008-12-09 | Broncus Technologies, Inc. | Antiproliferative devices for maintaining patency of surgically created channels in a body organ |
US7682647B2 (en) | 1999-09-03 | 2010-03-23 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of a drug eluting implantable medical device |
US7807211B2 (en) | 1999-09-03 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of an implantable medical device |
US20070032853A1 (en) * | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
US6790228B2 (en) | 1999-12-23 | 2004-09-14 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US20030144570A1 (en) | 1999-11-12 | 2003-07-31 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors |
AU1374601A (en) | 1999-11-12 | 2001-05-30 | Angiotech International Ag | Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors |
US6491666B1 (en) | 1999-11-17 | 2002-12-10 | Microchips, Inc. | Microfabricated devices for the delivery of molecules into a carrier fluid |
US6702849B1 (en) | 1999-12-13 | 2004-03-09 | Advanced Cardiovascular Systems, Inc. | Method of processing open-celled microcellular polymeric foams with controlled porosity for use as vascular grafts and stent covers |
US20040127475A1 (en) | 1999-12-29 | 2004-07-01 | Estrogen Vascular Technology, Llc | Apparatus and method for delivering compounds to a living organism |
US6471979B2 (en) | 1999-12-29 | 2002-10-29 | Estrogen Vascular Technology, Llc | Apparatus and method for delivering compounds to a living organism |
JP2003520830A (en) | 2000-01-25 | 2003-07-08 | エドワーズ ライフサイエンシーズ コーポレイション | Delivery system for treatment of restenosis and anastomotic intimal hyperplasia |
SE0000363L (en) | 2000-02-04 | 2001-08-05 | Zoucas Kirurgkonsult Ab | Coated medical device |
US20030229393A1 (en) | 2001-03-15 | 2003-12-11 | Kutryk Michael J. B. | Medical device with coating that promotes cell adherence and differentiation |
EP1263484B1 (en) | 2000-03-15 | 2007-05-16 | OrbusNeich Medical, Inc. | Coating which promotes endothelial cell adherence |
US7875283B2 (en) | 2000-04-13 | 2011-01-25 | Advanced Cardiovascular Systems, Inc. | Biodegradable polymers for use with implantable medical devices |
US6585765B1 (en) | 2000-06-29 | 2003-07-01 | Advanced Cardiovascular Systems, Inc. | Implantable device having substances impregnated therein and a method of impregnating the same |
US6555157B1 (en) | 2000-07-25 | 2003-04-29 | Advanced Cardiovascular Systems, Inc. | Method for coating an implantable device and system for performing the method |
US6451373B1 (en) | 2000-08-04 | 2002-09-17 | Advanced Cardiovascular Systems, Inc. | Method of forming a therapeutic coating onto a surface of an implantable prosthesis |
US7766956B2 (en) | 2000-09-22 | 2010-08-03 | Boston Scientific Scimed, Inc. | Intravascular stent and assembly |
US6506437B1 (en) | 2000-10-17 | 2003-01-14 | Advanced Cardiovascular Systems, Inc. | Methods of coating an implantable device having depots formed in a surface thereof |
US20020161168A1 (en) | 2000-10-27 | 2002-10-31 | Shalaby Shalaby W. | Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom |
US6794485B2 (en) | 2000-10-27 | 2004-09-21 | Poly-Med, Inc. | Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom |
US20050123583A1 (en) | 2000-12-18 | 2005-06-09 | Hsing-Wen Sung | Medical use of reuterin |
US6939375B2 (en) | 2000-12-22 | 2005-09-06 | Avantac Vascular Corporation | Apparatus and methods for controlled substance delivery from implanted prostheses |
US20020082679A1 (en) | 2000-12-22 | 2002-06-27 | Avantec Vascular Corporation | Delivery or therapeutic capable agents |
US6752829B2 (en) | 2001-01-30 | 2004-06-22 | Scimed Life Systems, Inc. | Stent with channel(s) for containing and delivering a biologically active material and method for manufacturing the same |
WO2002072167A1 (en) | 2001-03-13 | 2002-09-19 | Implant Sciences Corporation. | Drug eluting encapsulated stent |
EP1379197A4 (en) | 2001-03-23 | 2009-06-03 | Durect Corp | Delivery of drugs from sustained release devices implanted in myocardial tissue or in the pericardial space |
US7048939B2 (en) | 2001-04-20 | 2006-05-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for the inhibition of neointima formation |
US7056339B2 (en) | 2001-04-20 | 2006-06-06 | The Board Of Trustees Of The Leland Stanford Junior University | Drug delivery platform |
WO2002089865A2 (en) | 2001-05-04 | 2002-11-14 | Concentric Medical | Coated combination vaso-occlusive device |
US7128755B2 (en) | 2001-06-01 | 2006-10-31 | Texas Stent Technologies, Inc. | Expandable biodegradable polymeric stents for combined mechanical support and pharmacological or radiation therapy |
US6585755B2 (en) | 2001-06-29 | 2003-07-01 | Advanced Cardiovascular | Polymeric stent suitable for imaging by MRI and fluoroscopy |
EP1275442A1 (en) | 2001-07-13 | 2003-01-15 | Stichting voor de Technische Wetenschappen | Electrostatic spray deposition (ESD) of biocompatible coatings on metallic substrates |
SE523216C2 (en) | 2001-07-27 | 2004-04-06 | Zoucas Kirurgkonsult Ab | heparin stent |
US20040249443A1 (en) | 2001-08-20 | 2004-12-09 | Shanley John F. | Expandable medical device for treating cardiac arrhythmias |
US7056338B2 (en) | 2003-03-28 | 2006-06-06 | Conor Medsystems, Inc. | Therapeutic agent delivery device with controlled therapeutic agent release rates |
KR100455343B1 (en) | 2001-08-29 | 2004-11-12 | 학교법인 인하학원 | Covering composition for drug releasing stent and drug releasing stent manufactured using same |
US20050060041A1 (en) | 2001-09-04 | 2005-03-17 | Broncus Technologies, Inc. | Methods and devices for maintaining surgically created channels in a body organ |
US7708712B2 (en) | 2001-09-04 | 2010-05-04 | Broncus Technologies, Inc. | Methods and devices for maintaining patency of surgically created channels in a body organ |
US20050060042A1 (en) | 2001-09-04 | 2005-03-17 | Broncus Technologies, Inc. | Methods and devices for maintaining surgically created channels in a body organ |
US20050137611A1 (en) | 2001-09-04 | 2005-06-23 | Broncus Technologies, Inc. | Methods and devices for maintaining surgically created channels in a body organ |
IN2014DN10834A (en) | 2001-09-17 | 2015-09-04 | Psivida Inc | |
US20030158598A1 (en) | 2001-09-17 | 2003-08-21 | Control Delivery Systems, Inc. | System for sustained-release delivery of anti-inflammatory agents from a coated medical device |
US6753071B1 (en) * | 2001-09-27 | 2004-06-22 | Advanced Cardiovascular Systems, Inc. | Rate-reducing membrane for release of an agent |
US20030077310A1 (en) | 2001-10-22 | 2003-04-24 | Chandrashekhar Pathak | Stent coatings containing HMG-CoA reductase inhibitors |
US7572287B2 (en) | 2001-10-25 | 2009-08-11 | Boston Scientific Scimed, Inc. | Balloon expandable polymer stent with reduced elastic recoil |
US6939376B2 (en) | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US20030088307A1 (en) | 2001-11-05 | 2003-05-08 | Shulze John E. | Potent coatings for stents |
US7682387B2 (en) | 2002-04-24 | 2010-03-23 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US7473273B2 (en) | 2002-01-22 | 2009-01-06 | Medtronic Vascular, Inc. | Stent assembly with therapeutic agent exterior banding |
US7326245B2 (en) | 2002-01-31 | 2008-02-05 | Boston Scientific Scimed, Inc. | Medical device for delivering biologically active material |
US7993390B2 (en) | 2002-02-08 | 2011-08-09 | Boston Scientific Scimed, Inc. | Implantable or insertable medical device resistant to microbial growth and biofilm formation |
US20030153972A1 (en) | 2002-02-14 | 2003-08-14 | Michael Helmus | Biodegradable implantable or insertable medical devices with controlled change of physical properties leading to biomechanical compatibility |
US20030153971A1 (en) | 2002-02-14 | 2003-08-14 | Chandru Chandrasekaran | Metal reinforced biodegradable intraluminal stents |
KR20040097126A (en) | 2002-02-15 | 2004-11-17 | 씨브이 쎄러퓨틱스, 인코포레이티드 | Polymer coating for medical devices |
US7264822B2 (en) | 2002-04-03 | 2007-09-04 | Poly-Med, Inc. | Conjugated drug-polymer coated stent |
US20030195611A1 (en) | 2002-04-11 | 2003-10-16 | Greenhalgh Skott E. | Covering and method using electrospinning of very small fibers |
US20050187605A1 (en) | 2002-04-11 | 2005-08-25 | Greenhalgh Skott E. | Electrospun skin capable of controlling drug release rates and method |
US7261734B2 (en) * | 2002-04-23 | 2007-08-28 | Boston Scientific Scimed, Inc. | Resorption-controllable medical implants |
US20040024450A1 (en) | 2002-04-24 | 2004-02-05 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
AU2003228858A1 (en) * | 2002-05-02 | 2003-11-17 | Scimed Life Systems, Inc. | Energetically-controlled delivery of biologically active material from an implanted medical device |
ATE466281T1 (en) | 2002-05-07 | 2010-05-15 | Univ New York State Res Found | ßHIGH THROUGPUTß METHOD TO LABEL BIOMOLECULE DELIVERY FORMULATIONS |
CN1655738A (en) | 2002-05-20 | 2005-08-17 | 奥勃斯医学技术股份有限公司 | Drug eluting implantable medical device |
US7005137B1 (en) | 2002-06-21 | 2006-02-28 | Advanceed Cardiovascular Systems, Inc. | Coating for implantable medical devices |
EP1516597A4 (en) | 2002-06-27 | 2010-11-10 | Microport Medical Shanghai Co | Drug eluting stent |
US20040002755A1 (en) | 2002-06-28 | 2004-01-01 | Fischell David R. | Method and apparatus for treating vulnerable coronary plaques using drug-eluting stents |
AU2003250913A1 (en) | 2002-07-08 | 2004-01-23 | Abbott Laboratories Vascular Enterprises Limited | Drug eluting stent and methods of manufacture |
US7332160B2 (en) | 2002-07-12 | 2008-02-19 | Boston Scientific Scimed, Inc. | Medical device and method for tissue removal and repair |
JP4723244B2 (en) | 2002-07-19 | 2011-07-13 | オメロス コーポレイション | Biodegradable triblock copolymers, methods for their synthesis, and hydrogels and biomaterials made therefrom |
US7025777B2 (en) | 2002-07-31 | 2006-04-11 | Unison Therapeutics, Inc. | Flexible and conformable stent and method of forming same |
US7951392B2 (en) | 2002-08-16 | 2011-05-31 | Boston Scientific Scimed, Inc. | Microarray drug delivery coatings |
US6702850B1 (en) | 2002-09-30 | 2004-03-09 | Mediplex Corporation Korea | Multi-coated drug-eluting stent for antithrombosis and antirestenosis |
DE60336158D1 (en) | 2002-10-11 | 2011-04-07 | Univ Connecticut | ON SEMICRISTALLINE THERMOPLASTIC POLYURETHANES BASED FOR NANOSTRUCTURED HARD SEGMENTS BASED FORM MEMORY PILARMERS |
US7794494B2 (en) | 2002-10-11 | 2010-09-14 | Boston Scientific Scimed, Inc. | Implantable medical devices |
US20060121080A1 (en) | 2002-11-13 | 2006-06-08 | Lye Whye K | Medical devices having nanoporous layers and methods for making the same |
US7285287B2 (en) | 2002-11-14 | 2007-10-23 | Synecor, Llc | Carbon dioxide-assisted methods of providing biocompatible intraluminal prostheses |
US20040098106A1 (en) | 2002-11-14 | 2004-05-20 | Williams Michael S. | Intraluminal prostheses and carbon dioxide-assisted methods of impregnating same with pharmacological agents |
US20040098090A1 (en) | 2002-11-14 | 2004-05-20 | Williams Michael S. | Polymeric endoprosthesis and method of manufacture |
US7491234B2 (en) | 2002-12-03 | 2009-02-17 | Boston Scientific Scimed, Inc. | Medical devices for delivery of therapeutic agents |
US20040172127A1 (en) | 2002-12-09 | 2004-09-02 | John Kantor | Modular stent having polymer bridges at modular unit contact sites |
AU2003300022A1 (en) | 2002-12-30 | 2004-07-29 | Angiotech International Ag | Silk-containing stent graft |
US20040236415A1 (en) | 2003-01-02 | 2004-11-25 | Richard Thomas | Medical devices having drug releasing polymer reservoirs |
US20040260386A1 (en) | 2003-01-31 | 2004-12-23 | Shalaby Shalaby W. | Absorbable / biodegradable tubular stent and methods of making the same |
US6932930B2 (en) | 2003-03-10 | 2005-08-23 | Synecor, Llc | Intraluminal prostheses having polymeric material with selectively modified crystallinity and methods of making same |
US20050010170A1 (en) | 2004-02-11 | 2005-01-13 | Shanley John F | Implantable medical device with beneficial agent concentration gradient |
DE602004018908D1 (en) | 2003-03-31 | 2009-02-26 | Memry Corp | MEDICAL DEVICES WITH MEDICAMENT ELUTION PROPERTIES AND METHOD OF PREPARATION THEREOF |
US7163555B2 (en) | 2003-04-08 | 2007-01-16 | Medtronic Vascular, Inc. | Drug-eluting stent for controlled drug delivery |
US20050107870A1 (en) | 2003-04-08 | 2005-05-19 | Xingwu Wang | Medical device with multiple coating layers |
US20050070996A1 (en) | 2003-04-08 | 2005-03-31 | Dinh Thomas Q. | Drug-eluting stent for controlled drug delivery |
US20040215315A1 (en) | 2003-04-25 | 2004-10-28 | Jones Ryan A. | Drug-eluting stent with sheath and balloon deployment assembly |
US20040215335A1 (en) | 2003-04-25 | 2004-10-28 | Brin David S. | Methods and apparatus for treatment of aneurysmal tissue |
US20060025713A1 (en) | 2003-05-12 | 2006-02-02 | Alex Rosengart | Magnetic particle-based therapy |
WO2004101017A2 (en) | 2003-05-16 | 2004-11-25 | Blue Membranes Gmbh | Medical implants comprising biocompatible coatings |
WO2005018683A2 (en) | 2003-05-23 | 2005-03-03 | Angiotech International Ag | Anastomotic connector devices |
US20030216803A1 (en) | 2003-05-28 | 2003-11-20 | Ledergerber Walter J. | Textured and drug eluting stent-grafts |
US7041127B2 (en) | 2003-05-28 | 2006-05-09 | Ledergerber Walter J | Textured and drug eluting coronary artery stent |
US6979348B2 (en) | 2003-06-04 | 2005-12-27 | Medtronic Vascular, Inc. | Reflowed drug-polymer coated stent and method thereof |
US7186789B2 (en) | 2003-06-11 | 2007-03-06 | Advanced Cardiovascular Systems, Inc. | Bioabsorbable, biobeneficial polyester polymers for use in drug eluting stent coatings |
US20050118344A1 (en) | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
US7169404B2 (en) | 2003-07-30 | 2007-01-30 | Advanced Cardiovasular Systems, Inc. | Biologically absorbable coatings for implantable devices and methods for fabricating the same |
US20050055078A1 (en) | 2003-09-04 | 2005-03-10 | Medtronic Vascular, Inc. | Stent with outer slough coating |
US7055237B2 (en) | 2003-09-29 | 2006-06-06 | Medtronic Vascular, Inc. | Method of forming a drug eluting stent |
US7232461B2 (en) | 2003-10-29 | 2007-06-19 | Cordis Neurovascular, Inc. | Neck covering device for an aneurysm |
US20050100577A1 (en) | 2003-11-10 | 2005-05-12 | Parker Theodore L. | Expandable medical device with beneficial agent matrix formed by a multi solvent system |
CA2536041A1 (en) | 2003-11-10 | 2005-05-26 | Angiotech International Ag | Medical implants and fibrosis-inducing agents |
US20050112170A1 (en) | 2003-11-20 | 2005-05-26 | Hossainy Syed F. | Coatings for implantable devices comprising polymers of lactic acid and methods for fabricating the same |
US7807722B2 (en) | 2003-11-26 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Biobeneficial coating compositions and methods of making and using thereof |
US7435788B2 (en) | 2003-12-19 | 2008-10-14 | Advanced Cardiovascular Systems, Inc. | Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents |
US20050187607A1 (en) | 2004-02-20 | 2005-08-25 | Akhtar Adil J. | Drug delivery device |
US8685431B2 (en) | 2004-03-16 | 2014-04-01 | Advanced Cardiovascular Systems, Inc. | Biologically absorbable coatings for implantable devices based on copolymers having ester bonds and methods for fabricating the same |
ATE534424T1 (en) | 2004-03-19 | 2011-12-15 | Abbott Lab | MULTIPLE MEDICINAL DELIVERY FROM A BALLOON AND A PROSTHESIS |
US7820732B2 (en) | 2004-04-30 | 2010-10-26 | Advanced Cardiovascular Systems, Inc. | Methods for modulating thermal and mechanical properties of coatings on implantable devices |
US8293890B2 (en) | 2004-04-30 | 2012-10-23 | Advanced Cardiovascular Systems, Inc. | Hyaluronic acid based copolymers |
US20060246109A1 (en) | 2005-04-29 | 2006-11-02 | Hossainy Syed F | Concentration gradient profiles for control of agent release rates from polymer matrices |
US7758892B1 (en) | 2004-05-20 | 2010-07-20 | Boston Scientific Scimed, Inc. | Medical devices having multiple layers |
US9561309B2 (en) | 2004-05-27 | 2017-02-07 | Advanced Cardiovascular Systems, Inc. | Antifouling heparin coatings |
US8357391B2 (en) | 2004-07-30 | 2013-01-22 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages |
US20060041102A1 (en) | 2004-08-23 | 2006-02-23 | Advanced Cardiovascular Systems, Inc. | Implantable devices comprising biologically absorbable polymers having constant rate of degradation and methods for fabricating the same |
US7244443B2 (en) | 2004-08-31 | 2007-07-17 | Advanced Cardiovascular Systems, Inc. | Polymers of fluorinated monomers and hydrophilic monomers |
US7229471B2 (en) | 2004-09-10 | 2007-06-12 | Advanced Cardiovascular Systems, Inc. | Compositions containing fast-leaching plasticizers for improved performance of medical devices |
US9011831B2 (en) | 2004-09-30 | 2015-04-21 | Advanced Cardiovascular Systems, Inc. | Methacrylate copolymers for medical devices |
US20060095122A1 (en) | 2004-10-29 | 2006-05-04 | Advanced Cardiovascular Systems, Inc. | Implantable devices comprising biologically absorbable star polymers and methods for fabricating the same |
US8609123B2 (en) | 2004-11-29 | 2013-12-17 | Advanced Cardiovascular Systems, Inc. | Derivatized poly(ester amide) as a biobeneficial coating |
US20060115449A1 (en) | 2004-11-30 | 2006-06-01 | Advanced Cardiovascular Systems, Inc. | Bioabsorbable, biobeneficial, tyrosine-based polymers for use in drug eluting stent coatings |
US7604818B2 (en) | 2004-12-22 | 2009-10-20 | Advanced Cardiovascular Systems, Inc. | Polymers of fluorinated monomers and hydrocarbon monomers |
US7419504B2 (en) | 2004-12-27 | 2008-09-02 | Advanced Cardiovascular Systems, Inc. | Poly(ester amide) block copolymers |
US8007775B2 (en) | 2004-12-30 | 2011-08-30 | Advanced Cardiovascular Systems, Inc. | Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same |
US20060147491A1 (en) * | 2005-01-05 | 2006-07-06 | Dewitt David M | Biodegradable coating compositions including multiple layers |
US7202325B2 (en) | 2005-01-14 | 2007-04-10 | Advanced Cardiovascular Systems, Inc. | Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles |
US8778375B2 (en) | 2005-04-29 | 2014-07-15 | Advanced Cardiovascular Systems, Inc. | Amorphous poly(D,L-lactide) coating |
US20070005130A1 (en) | 2005-06-29 | 2007-01-04 | Thierry Glauser | Biodegradable polymer for coating |
-
1996
- 1996-06-07 AU AU55888/96A patent/AU716005B2/en not_active Expired
- 1996-06-07 CA CA002178541A patent/CA2178541C/en not_active Expired - Lifetime
- 1996-10-31 US US08/741,565 patent/US5824049A/en not_active Expired - Lifetime
-
1997
- 1997-02-24 US US08/803,843 patent/US5873904A/en not_active Expired - Lifetime
-
2006
- 2006-11-15 US US11/599,859 patent/US8313521B2/en not_active Expired - Lifetime
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2033667A2 (en) | 1997-04-15 | 2009-03-11 | Abbott Cardiovascular Systems, Inc. | Porous medicated stent |
EP2033667A3 (en) * | 1997-04-15 | 2009-06-24 | Abbott Cardiovascular Systems, Inc. | Porous medicated stent |
US7713297B2 (en) | 1998-04-11 | 2010-05-11 | Boston Scientific Scimed, Inc. | Drug-releasing stent with ceramic-containing layer |
WO2005046748A1 (en) * | 2003-11-12 | 2005-05-26 | James Keenan | Device and method for attracting diseased cells and foreign substances |
Also Published As
Publication number | Publication date |
---|---|
CA2178541C (en) | 2009-11-24 |
US5824049A (en) | 1998-10-20 |
US8313521B2 (en) | 2012-11-20 |
US20070150047A1 (en) | 2007-06-28 |
AU716005B2 (en) | 2000-02-17 |
AU5588896A (en) | 1996-12-19 |
US5873904A (en) | 1999-02-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2178541A1 (en) | Implantable medical device | |
KR970000275A (en) | Coated and Implantable Medical Devices | |
US6530951B1 (en) | Silver implantable medical device | |
US8758428B2 (en) | Coated implantable medical device | |
EP0968013B1 (en) | Coated implantable medical device | |
US7611532B2 (en) | Coated implantable medical device | |
US7862605B2 (en) | Coated implantable medical device | |
WO1998017331A1 (en) | Silver implantable medical device | |
US7896914B2 (en) | Coated implantable medical device | |
EP3103487B1 (en) | Bioactive material coated medical device | |
US20150150696A1 (en) | Coated implantable medical device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20160607 |